Catrin Pritchard Leicester Cancer Research Center University of Leicester Biography Publications Institution JoVE Articles Catrin Pritchard has not added a biography. If you are Catrin Pritchard and would like to personalize this page please email our Author Liaison for assistance. Publications Digoxin Treatment Reactivates in Vivo Radioactive Iodide Uptake and Correlates with Favorable Clinical Outcome in Non-medullary Thyroid Cancer Cellular Oncology (Dordrecht). Feb, 2021 | Pubmed ID: 33534128 Ras/MAPK Dysregulation in Development Causes a Skeletal Myopathy in an Activating Braf Mouse Model for Cardio-facio-cutaneous Syndrome Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2021 | Pubmed ID: 33522658 Development of a Patient-derived Explant Model for Prediction of Drug Responses in Endometrial Cancer Gynecologic Oncology. Feb, 2021 | Pubmed ID: 33309417 Evaluating and Comparing Immunostaining and Computational Methods for Spatial Profiling of Drug Response in Patient-derived Explants Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2020 | Pubmed ID: 33318618 Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development Cell Reports. 06, 2020 | Pubmed ID: 32579928 Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors Analytical Chemistry. 07, 2020 | Pubmed ID: 32545955 Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma JNCI Cancer Spectrum. Apr, 2020 | Pubmed ID: 32190817 DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation IScience. Feb, 2020 | Pubmed ID: 32058953 Patient-derived Explants (PDEs) As a Powerful Preclinical Platform for Anti-cancer Drug and Biomarker Discovery British Journal of Cancer. 03, 2020 | Pubmed ID: 31894140 Patient-derived Explants, Xenografts and Organoids: 3-dimensional Patient-relevant Pre-clinical Models in Endometrial Cancer Gynecologic Oncology. 01, 2020 | Pubmed ID: 31767187 Early Detection of Pre-malignant Lesions in a KRAS-driven Mouse Lung Cancer Model by Monitoring Circulating Free DNA Disease Models & Mechanisms. 02, 2019 | Pubmed ID: 30760495 Over-expressed, N-terminally Truncated BRAF is Detected in the Nucleus of Cells with Nuclear Phosphorylated MEK and ERK Heliyon. Dec, 2018 | Pubmed ID: 30603699 Profiling Tumour Heterogeneity Through Circulating Tumour DNA in Patients with Pancreatic Cancer Oncotarget. Oct, 2017 | Pubmed ID: 29152076 KRAS Expression in Lung-resident Myeloid Cells Promotes Pulmonary LCH-like Neoplasm Sensitive to Statin Treatment Blood. 07, 2017 | Pubmed ID: 28550040 Attenuation Limits Progression of -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAF Inhibitor PLX4720 Cancer Research. 04, 2017 | Pubmed ID: 28242615 Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy Cancer Research. 04, 2017 | Pubmed ID: 28202521 Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development The Journal of Biological Chemistry. 02, 2017 | Pubmed ID: 28073913 Inactivation of TGFβ Receptors in Stem Cells Drives Cutaneous Squamous Cell Carcinoma Nature Communications. Aug, 2016 | Pubmed ID: 27558455 Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine PloS One. 2016 | Pubmed ID: 27284979 Regulation of BRAF Protein Stability by a Negative Feedback Loop Involving the MEK-ERK Pathway but Not the FBXW7 Tumour Suppressor Cellular Signalling. Jun, 2016 | Pubmed ID: 26898828 The Cholesterol-binding Protein NPC2 Restrains Recruitment of Stromal Macrophage-lineage Cells to Early-stage Lung Tumours EMBO Molecular Medicine. Sep, 2015 | Pubmed ID: 26183450 MGL Ligand Expression is Correlated to BRAF Mutation and Associated with Poor Survival of Stage III Colon Cancer Patients Oncotarget. Sep, 2015 | Pubmed ID: 26172302 KRAS(G12D)-mediated Oncogenic Transformation of Thyroid Follicular Cells Requires Long-term TSH Stimulation and is Regulated by SPRY1 Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2015 | Pubmed ID: 26146959 Tracking Genomic Cancer Evolution for Precision Medicine: the Lung TRACERx Study PLoS Biology. Jul, 2014 | Pubmed ID: 25003521 Long-term Channel Block is Required to Inhibit Cellular Transformation by Human Ether-à-go-go-related Gene (hERG1) Potassium Channels Molecular Pharmacology. Aug, 2014 | Pubmed ID: 24830940 Hematopoietic Expression of Oncogenic BRAF Promotes Aberrant Growth of Monocyte-lineage Cells Resistant to PLX4720 Molecular Cancer Research : MCR. Dec, 2013 | Pubmed ID: 24152792 A Complex Secretory Program Orchestrated by the Inflammasome Controls Paracrine Senescence Nature Cell Biology. Aug, 2013 | Pubmed ID: 23770676 A New Mode of RAF Autoregulation: a Further Complication in the Inhibitor Paradox Cancer Cell. May, 2013 | Pubmed ID: 23680140 Mice Carrying a Complete Deletion of the Talin2 Coding Sequence Are Viable and Fertile Biochemical and Biophysical Research Communications. Sep, 2012 | Pubmed ID: 22925892 The Intermediate-activity (L597V)BRAF Mutant Acts As an Epistatic Modifier of Oncogenic RAS by Enhancing Signaling Through the RAF/MEK/ERK Pathway Genes & Development. Sep, 2012 | Pubmed ID: 22892241 Regulation of MEK/ERK Pathway Output by Subcellular Localization of B-Raf Biochemical Society Transactions. Feb, 2012 | Pubmed ID: 22260667 Cdx2 Determines the Fate of Postnatal Intestinal Endoderm Development (Cambridge, England). Feb, 2012 | Pubmed ID: 22190642 Mechanisms of Aneuploidy Induction by RAS and RAF Oncogenes American Journal of Cancer Research. 2011 | Pubmed ID: 22016838 Thyrotrophin Receptor Signaling Dependence of Braf-induced Thyroid Tumor Initiation in Mice Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21220306 Endothelial Cell Talin1 is Essential for Embryonic Angiogenesis Developmental Biology. Jan, 2011 | Pubmed ID: 21081121 BRAF Inactivation Drives Aneuploidy by Deregulating CRAF Cancer Research. Nov, 2010 | Pubmed ID: 20978199 V600EBraf Induces Gastrointestinal Crypt Senescence and Promotes Tumour Progression Through Enhanced CpG Methylation of P16INK4a EMBO Molecular Medicine. Nov, 2010 | Pubmed ID: 20941790 Studies on the Morphology and Spreading of Human Endothelial Cells Define Key Inter- and Intramolecular Interactions for Talin1 European Journal of Cell Biology. Sep, 2010 | Pubmed ID: 20605055 Kinase-dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression Through CRAF Cell. Jan, 2010 | Pubmed ID: 20141835 Talin 2 is a Large and Complex Gene Encoding Multiple Transcripts and Protein Isoforms The FEBS Journal. Mar, 2009 | Pubmed ID: 19220457 CRAF Autophosphorylation of Serine 621 is Required to Prevent Its Proteasome-mediated Degradation Molecular Cell. Sep, 2008 | Pubmed ID: 18922468 Cdx2 Initiates Histodifferentiation of the Midgut Endoderm FEBS Letters. Jul, 2008 | Pubmed ID: 18577384 Lineage Tracing of Cardiac Explant Derived Cells PloS One. Apr, 2008 | Pubmed ID: 18414652 Mouse Models for BRAF-induced Cancers Biochemical Society Transactions. Nov, 2007 | Pubmed ID: 17956344 Expression of Endogenous Oncogenic V600EB-raf Induces Proliferation and Developmental Defects in Mice and Transformation of Primary Fibroblasts Cancer Research. Dec, 2005 | Pubmed ID: 16357158 A-Raf and Raf-1 Work Together to Influence Transient ERK Phosphorylation and Gl/S Cell Cycle Progression Oncogene. Aug, 2005 | Pubmed ID: 15856007 A Critical Function for B-Raf at Multiple Stages of Myelopoiesis Blood. Aug, 2005 | Pubmed ID: 15784729 B-Raf Acts Via the ROCKII/LIMK/cofilin Pathway to Maintain Actin Stress Fibers in Fibroblasts Molecular and Cellular Biology. Jul, 2004 | Pubmed ID: 15199148 Raf Proteins and Cancer: B-Raf is Identified As a Mutational Target Biochimica Et Biophysica Acta. Jun, 2003 | Pubmed ID: 12781369 Analysis of the Role of the SA Gene in Blood Pressure Regulation by Gene Targeting Hypertension (Dallas, Tex. : 1979). Jun, 2003 | Pubmed ID: 12707288 CAMP-dependent Protein Kinase and Ca2+ Influx Through L-type Voltage-gated Calcium Channels Mediate Raf-independent Activation of Extracellular Regulated Kinase in Response to Glucagon-like Peptide-1 in Pancreatic Beta-cells The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12364324 Expression of Kinase Suppressor of Ras in the Normal Adult and Embryonic Mouse Cell Growth & Differentiation : the Molecular Biology Journal of the American Association for Cancer Research. Jul, 2002 | Pubmed ID: 12133899 MEKK1 Plays a Critical Role in Activating the Transcription Factor C/EBP-beta-dependent Gene Expression in Response to IFN-gamma Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002 | Pubmed ID: 12048245 ERK Signalling and Oncogene Transformation Are Not Impaired in Cells Lacking A-Raf Oncogene. Jan, 2002 | Pubmed ID: 11821947 MEK Kinase Activity is Not Necessary for Raf-1 Function The EMBO Journal. Apr, 2001 | Pubmed ID: 11296227 患者の薬剤耐性を予測するための「生きた」前臨床プラットフォームとしての患者由来腫瘍エクスプラント Giuditta Viticchié1, Ian Powley1, Constantinos Demetriou1, James Cooper1, Michael Butterworth1, Meeta Patel1, Naila Abid1, Gareth Miles1, Lynne Howells1, Howard Pringle1, Marion MacFarlane2, Catrin Pritchard1 1Leicester Cancer Research Center, University of Leicester, 2MRC Toxicology Unit JoVE 62130 Pesquisa do câncer
患者の薬剤耐性を予測するための「生きた」前臨床プラットフォームとしての患者由来腫瘍エクスプラント Giuditta Viticchié1, Ian Powley1, Constantinos Demetriou1, James Cooper1, Michael Butterworth1, Meeta Patel1, Naila Abid1, Gareth Miles1, Lynne Howells1, Howard Pringle1, Marion MacFarlane2, Catrin Pritchard1 1Leicester Cancer Research Center, University of Leicester, 2MRC Toxicology Unit JoVE 62130 Pesquisa do câncer