Christopher C. W. Hughes Molecular Biology and Biochemistry University of California, Irvine Biography Publications Institution JoVE Articles Christopher C. W. Hughes has not added a biography. If you are Christopher C. W. Hughes and would like to personalize this page please email our Author Liaison for assistance. Publications A Human Vascularized Microtumor Model of Patient-derived Colorectal Cancer Recapitulates Clinical Disease Translational Research : the Journal of Laboratory and Clinical Medicine. May, 2023 | Pubmed ID: 36481562 Organotypic Stromal Cells Impact Endothelial Cell Transcriptome in 3D Microvessel Networks Scientific Reports. Nov, 2022 | Pubmed ID: 36443378 Adoptive T-Cell Therapy in Advanced Colorectal Cancer: A Systematic Review The Oncologist. Mar, 2022 | Pubmed ID: 35274719 Correction: The Vascular Niche in Next Generation Microphysiological Systems Lab on a Chip. Sep, 2021 | Pubmed ID: 34472547 The Vascular Niche in Next Generation Microphysiological Systems Lab on a Chip. Sep, 2021 | Pubmed ID: 34396383 An in Vitro Vascularized Micro-tumor Model of Human Colorectal Cancer Recapitulates in Vivo Responses to Standard-of-care Therapy Lab on a Chip. Apr, 2021 | Pubmed ID: 33605955 Slug Regulates the Dll4-Notch-VEGFR2 Axis to Control Endothelial Cell Activation and Angiogenesis Nature Communications. Oct, 2020 | Pubmed ID: 33106502 Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions Stem Cell Reports. Mar, 2019 | Pubmed ID: 30745035 Pazopanib May Reduce Bleeding in Hereditary Hemorrhagic Telangiectasia Angiogenesis. Feb, 2019 | Pubmed ID: 30191360 Executive Summary of the 12th HHT International Scientific Conference Angiogenesis. Feb, 2018 | Pubmed ID: 29147802 3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28634954 A Vascularized and Perfused Organ-on-a-chip Platform for Large-scale Drug Screening Applications Lab on a Chip. Jan, 2017 | Pubmed ID: 28092382 Recapitulating the Human Tumor Microenvironment: Colon Tumor-derived Extracellular Matrix Promotes Angiogenesis and Tumor Cell Growth Biomaterials. Feb, 2017 | Pubmed ID: 27914984 MTORC2 Mediates CXCL12-induced Angiogenesis Angiogenesis. Jul, 2016 | Pubmed ID: 27106789 Engineering Anastomosis Between Living Capillary Networks and Endothelial Cell-lined Microfluidic Channels Lab on a Chip. Jan, 2016 | Pubmed ID: 26616908 Executive Summary of the 11th HHT International Scientific Conference Angiogenesis. Oct, 2015 | Pubmed ID: 26391603 A Role for Partial Endothelial-mesenchymal Transitions in Angiogenesis? Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2015 | Pubmed ID: 25425619 Interferon-induced Transmembrane Protein 1 Regulates Endothelial Lumen Formation During Angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2014 | Pubmed ID: 24603679 Angiogenic Sprouting is Regulated by Endothelial Cell Expression of Slug Journal of Cell Science. May, 2014 | Pubmed ID: 24554431 Analysis of Stromal Cell Secretomes Reveals a Critical Role for Stromal Cell-derived Hepatocyte Growth Factor and Fibronectin in Angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2013 | Pubmed ID: 23288153 Macrophages and Angiogenesis: a Role for Wnt Signaling Vascular Cell. 2012 | Pubmed ID: 22938389 BMP9 Induces EphrinB2 Expression in Endothelial Cells Through an Alk1-BMPRII/ActRII-ID1/ID3-dependent Pathway: Implications for Hereditary Hemorrhagic Telangiectasia Type II Angiogenesis. Sep, 2012 | Pubmed ID: 22622516 アダプター分子Grb2はスルーインテグリンシグナル伝達とβ-カテニン依存性のWnt経路の統合 PloS One. 2009 | Pubmed ID: 19924227 血管内皮細胞におけるジャグ-1のTNF誘導は帰着に依存します Gene. Apr, 2009 | Pubmed ID: 19393188 フィブリンベースの組織構造体のPrevascularizationは、ホスト血管系の機能的吻合の形成を促進する Tissue Engineering. Part A. Jun, 2009 | Pubmed ID: 18976155 血管新生の解析用に最適化されたin Vitroにおける三次元モデル Methods in Enzymology. 2008 | Pubmed ID: 18772011 血管新生における内皮間質相互作用 Current Opinion in Hematology. May, 2008 | Pubmed ID: 18391786 Wntシグナルは、マトリックスメタロプロテイナーゼの発現を誘導し、T細胞の移住を調節する Immunity. Feb, 2007 | Pubmed ID: 17306568 間葉系幹細胞は初期のマトリックスメタロプロテイナーゼの発現亢進経由で機械的に生存Prevascularized組織における血管新生を強化 Tissue Engineering. Oct, 2006 | Pubmed ID: 17518656 HESR1/CHF2は、E-ボックスに結合する独立したVEGFR2転写を抑制 Biochemical and Biophysical Research Communications. Aug, 2006 | Pubmed ID: 16782059 細胞自律的なNotchシグナル伝達は血管細管形成の間に内皮細胞の分岐と増殖を調節する FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2005 | Pubmed ID: 15774577 VEGF(121)とVEGF(165)はin Vitro血管新生モデルにおいて血管内皮増殖因子受容体2を介して血管径を調節する Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2003 | Pubmed ID: 14691306 In Vitroでの内皮細胞のネットワーク形成時のノッチのアクティベーションは、基本HLH転写因子HESR-1を標的としVEGFR-2/KDR発現をダウンレギュレート Microvascular Research. Nov, 2002 | Pubmed ID: 12453432 Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research (Video) | JoVE Stephanie J. Hachey1, Daniela Gaebler1, Christopher C. W. Hughes1,2 1Molecular Biology and Biochemistry, University of California, Irvine, 2Biomedical Engineering, University of California, Irvine JoVE 65865 Pesquisa do câncer
Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research (Video) | JoVE Stephanie J. Hachey1, Daniela Gaebler1, Christopher C. W. Hughes1,2 1Molecular Biology and Biochemistry, University of California, Irvine, 2Biomedical Engineering, University of California, Irvine JoVE 65865 Pesquisa do câncer