David W. Severson Eck Institute for Global Health University of Notre Dame Biography Publications Institution JoVE Articles David W. Severson has not added a biography. If you are David W. Severson and would like to personalize this page please email our Author Liaison for assistance. Publications Mitotic-Chromosome-Based Physical Mapping of the Culex Quinquefasciatus Genome PloS One. 2015 | Pubmed ID: 25768920 Whole Transcriptome Responses Among Females of the Filariasis and Arbovirus Vector Mosquito Culex Pipiens Implicate TGF-β Signaling and Chromatin Modification As Key Drivers of Diapause Induction Functional & Integrative Genomics. Jan, 2015 | Pubmed ID: 25634120 Bidirectional Promoters of Insects: Genome-wide Comparison, Evolutionary Implication and Influence on Gene Expression Journal of Molecular Biology. Jan, 2015 | Pubmed ID: 25463441 Motif Mismatches in Microsatellites: Insights from Genome-wide Investigation Among 20 Insect Species DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes. Feb, 2015 | Pubmed ID: 25378245 Examination of the Genetic Basis for Sexual Dimorphism in the Aedes Aegypti (dengue Vector Mosquito) Pupal Brain Biology of Sex Differences. 2014 | Pubmed ID: 25729562 Dynamics of Midgut Microflora and Dengue Virus Impact on Life History Traits in Aedes Aegypti Acta Tropica. Dec, 2014 | Pubmed ID: 25193134 Role of Semaphorin-1a in the Developing Visual System of the Disease Vector Mosquito Aedes Aegypti Developmental Dynamics : an Official Publication of the American Association of Anatomists. Nov, 2014 | Pubmed ID: 25045063 Bicluster Pattern of Codon Context Usages Between Flavivirus and Vector Mosquito Aedes Aegypti: Relevance to Infection and Transcriptional Response of Mosquito Genes Molecular Genetics and Genomics : MGG. Oct, 2014 | Pubmed ID: 24838953 Influence of Mosquito Genotype on Transcriptional Response to Dengue Virus Infection Functional & Integrative Genomics. Sep, 2014 | Pubmed ID: 24798794 An Ion-exchange Nanomembrane Sensor for Detection of Nucleic Acids Using a Surface Charge Inversion Phenomenon Biosensors & Bioelectronics. Oct, 2014 | Pubmed ID: 24787123 Genomic Composition and Evolution of Aedes Aegypti Chromosomes Revealed by the Analysis of Physically Mapped Supercontigs BMC Biology. 2014 | Pubmed ID: 24731704 Association of Microsatellite Pairs with Segmental Duplications in Insect Genomes BMC Genomics. 2013 | Pubmed ID: 24359442 Antagonistic Relationships Between Intron Content and Codon Usage Bias of Genes in Three Mosquito Species: Functional and Evolutionary Implications Evolutionary Applications. Nov, 2013 | Pubmed ID: 24187589 Requirement for Commissureless2 Function During Dipteran Insect Nerve Cord Development Developmental Dynamics : an Official Publication of the American Association of Anatomists. Dec, 2013 | Pubmed ID: 24026811 Stage-specific Transcription During Development of Aedes Aegypti BMC Developmental Biology. 2013 | Pubmed ID: 23875547 Composite Linkage Map and Enhanced Genome Map for Culex Pipiens Complex Mosquitoes The Journal of Heredity. Sep-Oct, 2013 | Pubmed ID: 23846985 Overlapping Genes of Aedes Aegypti: Evolutionary Implications from Comparison with Orthologs of Anopheles Gambiae and Other Insects BMC Evolutionary Biology. 2013 | Pubmed ID: 23777277 Disruption of Aedes Aegypti Olfactory System Development Through Chitosan/siRNA Nanoparticle Targeting of Semaphorin-1a PLoS Neglected Tropical Diseases. 2013 | Pubmed ID: 23696908 Comparative Analysis of Midgut Bacterial Communities of Aedes Aegypti Mosquito Strains Varying in Vector Competence to Dengue Virus Parasitology Research. Jul, 2013 | Pubmed ID: 23636307 Functional Genetic Characterization of Salivary Gland Development in Aedes Aegypti EvoDevo. 2013 | Pubmed ID: 23497573 An Integrated Linkage, Chromosome, and Genome Map for the Yellow Fever Mosquito Aedes Aegypti PLoS Neglected Tropical Diseases. 2013 | Pubmed ID: 23459230 Nucleotide Substitutions in Dengue Virus Serotypes from Asian and American Countries: Insights into Intracodon Recombination and Purifying Selection BMC Microbiology. 2013 | Pubmed ID: 23410119 P53-mediated Rapid Induction of Apoptosis Conveys Resistance to Viral Infection in Drosophila Melanogaster PLoS Pathogens. Feb, 2013 | Pubmed ID: 23408884 Codon Usage Bias: Causative Factors, Quantification Methods and Genome-wide Patterns: with Emphasis on Insect Genomes Biological Reviews of the Cambridge Philosophical Society. Feb, 2013 | Pubmed ID: 22889422 Comparative Expression Profiles of Midgut Genes in Dengue Virus Refractory and Susceptible Aedes Aegypti Across Critical Period for Virus Infection PloS One. 2012 | Pubmed ID: 23077596 Comparative Analysis of Codon Usage Bias and Codon Context Patterns Between Dipteran and Hymenopteran Sequenced Genomes PloS One. 2012 | Pubmed ID: 22912801 Translational Selection of Genes Coding for Perfectly Conserved Proteins Among Three Mosquito Vectors Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. Oct, 2012 | Pubmed ID: 22705463 Genome-wide Comparative Analysis of Simple Sequence Coding Repeats Among 25 Insect Species Gene. Aug, 2012 | Pubmed ID: 22633877 Intrinsic Features of Aedes Aegypti Genes Affect Transcriptional Responsiveness of Mosquito Genes to Dengue Virus Infection Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. Oct, 2012 | Pubmed ID: 22579482 Genetic Mapping a Meiotic Driver That Causes Sex Ratio Distortion in the Mosquito Aedes Aegypti The Journal of Heredity. Mar-Apr, 2012 | Pubmed ID: 22308303 Mosquito Genomics: Progress and Challenges Annual Review of Entomology. 2012 | Pubmed ID: 21942845 Global Cross-talk of Genes of the Mosquito Aedes Aegypti in Response to Dengue Virus Infection PLoS Neglected Tropical Diseases. Nov, 2011 | Pubmed ID: 22102922 Imaginal Discs--a New Source of Chromosomes for Genome Mapping of the Yellow Fever Mosquito Aedes Aegypti PLoS Neglected Tropical Diseases. Oct, 2011 | Pubmed ID: 21991400 Enhancing Genome Investigations in the Mosquito Culex Quinquefasciatus Via BAC Library Construction and Characterization BMC Research Notes. 2011 | Pubmed ID: 21914202 Comparative Genomic Analysis of Drosophila Melanogaster and Vector Mosquito Developmental Genes PloS One. 2011 | Pubmed ID: 21754989 Semaphorin-1a is Required for Aedes Aegypti Embryonic Nerve Cord Development PloS One. 2011 | Pubmed ID: 21738767 Transcript Profiling of the Meiotic Drive Phenotype in Testis of Aedes Aegypti Using Suppressive Subtractive Hybridization Journal of Insect Physiology. Sep, 2011 | Pubmed ID: 21708167 Complete Sequences of Mitochondria Genomes of Aedes Aegypti and Culex Quinquefasciatus and Comparative Analysis of Mitochondrial DNA Fragments Inserted in the Nuclear Genomes Insect Biochemistry and Molecular Biology. Oct, 2011 | Pubmed ID: 21640823 SiRNA-mediated Gene Targeting in Aedes Aegypti Embryos Reveals That Frazzled Regulates Vector Mosquito CNS Development PloS One. 2011 | Pubmed ID: 21304954 A Linkage Map of the Asian Tiger Mosquito (Aedes Albopictus) Based on CDNA Markers The Journal of Heredity. Jan-Feb, 2011 | Pubmed ID: 21148282 Heritability and Adaptive Phenotypic Plasticity of Adult Body Size in the Mosquito Aedes Aegypti with Implications for Dengue Vector Competence Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. Jan, 2011 | Pubmed ID: 21070891 Sequencing of Culex Quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics Science (New York, N.Y.). Oct, 2010 | Pubmed ID: 20929810 Genome-based Microsatellite Development in the Culex Pipiens Complex and Comparative Microsatellite Frequency with Aedes Aegypti and Anopheles Gambiae PloS One. 2010 | Pubmed ID: 20927334 Culturing and Egg Collection of Aedes Aegypti Cold Spring Harbor Protocols. Oct, 2010 | Pubmed ID: 20889704 Aedes Aegypti: an Emerging Model for Vector Mosquito Development Cold Spring Harbor Protocols. Oct, 2010 | Pubmed ID: 20889691 Influence of Urban Landscapes on Population Dynamics in a Short-distance Migrant Mosquito: Evidence for the Dengue Vector Aedes Aegypti PLoS Neglected Tropical Diseases. 2010 | Pubmed ID: 20300516 Genome-based Polymorphic Microsatellite Development and Validation in the Mosquito Aedes Aegypti and Application to Population Genetics in Haiti BMC Genomics. 2009 | Pubmed ID: 20003193 Environmental Conditions in Water Storage Drums and Influences on Aedes Aegypti in Trinidad, West Indies Acta Tropica. Oct, 2009 | Pubmed ID: 19539592 VectorBase: a Data Resource for Invertebrate Vector Genomics Nucleic Acids Research. Jan, 2009 | Pubmed ID: 19028744 Surveillance of Dengue Fever Cases Using a Novel Aedes Aegypti Population Sampling Method in Trinidad, West Indies: the Cardinal Points Approach Acta Tropica. Oct, 2007 | Pubmed ID: 17803949 The Aedes Aegypti Glutathione Transferase Family Insect Biochemistry and Molecular Biology. Oct, 2007 | Pubmed ID: 17785190 Evolutionary Dynamics of Immune-related Genes and Pathways in Disease-vector Mosquitoes Science (New York, N.Y.). Jun, 2007 | Pubmed ID: 17588928 Molecular Cloning and Characterization of the Complete Acetylcholinesterase Gene (Ace1) from the Mosquito Aedes Aegypti with Implications for Comparative Genome Analysis Insect Biochemistry and Molecular Biology. Jul, 2007 | Pubmed ID: 17550823 Analysis of 14 BAC Sequences from the Aedes Aegypti Genome: a Benchmark for Genome Annotation and Assembly Genome Biology. 2007 | Pubmed ID: 17519023 Genome Sequence of Aedes Aegypti, a Major Arbovirus Vector Science (New York, N.Y.). Jun, 2007 | Pubmed ID: 17510324 Microsatellite Isolation and Linkage Group Identification in the Yellow Fever Mosquito Aedes Aegypti The Journal of Heredity. May-Jun, 2007 | Pubmed ID: 17420178 VectorBase: a Home for Invertebrate Vectors of Human Pathogens Nucleic Acids Research. Jan, 2007 | Pubmed ID: 17145709 Isolation and Characterization of the RanGAP Gene in the Mosquito Aedes Aegypti DNA Sequence : the Journal of DNA Sequencing and Mapping. Jun, 2006 | Pubmed ID: 17286051 Identification of Quantitative Trait Loci for Larval Morphological Traits in Interspecific Hybrids of Ochlerotatus Triseriatus and Ochlerotatus Hendersoni (Diptera: Culicidae) Genetica. May, 2006 | Pubmed ID: 16850221 Population Dynamics of an Endogenous Meiotic Drive System in Aedes Aegypti in Trinidad The American Journal of Tropical Medicine and Hygiene. Jul, 2006 | Pubmed ID: 16837711 Cage Trials Using an Endogenous Meiotic Drive Gene in the Mosquito Aedes Aegypti to Promote Population Replacement The American Journal of Tropical Medicine and Hygiene. Jan, 2006 | Pubmed ID: 16407347 Michelob_x is the Missing Inhibitor of Apoptosis Protein Antagonist in Mosquito Genomes EMBO Reports. Aug, 2005 | Pubmed ID: 16041319 Quantitative Genetics of Vector Competence for La Crosse Virus and Body Size in Ochlerotatus Hendersoni and Ochlerotatus Triseriatus Interspecific Hybrids Genetics. Mar, 2005 | Pubmed ID: 15654112 Reinvestigation of an Endogenous Meiotic Drive System in the Mosquito, Aedes Aegypti (Diptera: Culicidae) Journal of Medical Entomology. Nov, 2004 | Pubmed ID: 15605641 Aedes Aegypti Genomics Insect Biochemistry and Molecular Biology. Jul, 2004 | Pubmed ID: 15242713 An Amino Acid Substitution Attributable to Insecticide-insensitivity of Acetylcholinesterase in a Japanese Encephalitis Vector Mosquito, Culex Tritaeniorhynchus Biochemical and Biophysical Research Communications. Jan, 2004 | Pubmed ID: 14697262 DNA Barcoding of Parasites and Invertebrate Disease Vectors: What You Don't Know Can Hurt You Trends in Parasitology. Dec, 2003 | Pubmed ID: 14642760 Utility of Comparative Anchor-tagged Sequences As Physical Anchors for Comparative Genome Analysis Among the Culicidae The American Journal of Tropical Medicine and Hygiene. Jul, 2003 | Pubmed ID: 12932106 Dynamics of Molecular Markers Linked to the Resistance Loci in a Mosquito-Plasmodium System Genetics. Jun, 2003 | Pubmed ID: 12807772 The Anopheles Genome and Comparative Insect Genomics Science (New York, N.Y.). Oct, 2002 | Pubmed ID: 12364783 Culicine Genomics Insect Biochemistry and Molecular Biology. Oct, 2002 | Pubmed ID: 12225910 Chitosan/Interfering RNA Nanoparticle Mediated Gene Silencing in Disease Vector Mosquito Larvae Xin Zhang*1, Keshava Mysore*2,3, Ellen Flannery3,4, Kristin Michel1, David W. Severson3,4, Kun Yan Zhu5, Molly Duman-Scheel2,3,4 1Division of Biology, Kansas State University, 2Department of Medical and Molecular Genetics, Indiana University School of Medicine, 3Eck Institute for Global Health, University of Notre Dame, 4Department of Biological Sciences, University of Notre Dame, 5Department of Entomology, Kansas State University JoVE 52523 Biologia
Chitosan/Interfering RNA Nanoparticle Mediated Gene Silencing in Disease Vector Mosquito Larvae Xin Zhang*1, Keshava Mysore*2,3, Ellen Flannery3,4, Kristin Michel1, David W. Severson3,4, Kun Yan Zhu5, Molly Duman-Scheel2,3,4 1Division of Biology, Kansas State University, 2Department of Medical and Molecular Genetics, Indiana University School of Medicine, 3Eck Institute for Global Health, University of Notre Dame, 4Department of Biological Sciences, University of Notre Dame, 5Department of Entomology, Kansas State University JoVE 52523 Biologia