Dmitri B. Papkovsky School of Biochemistry and Cell Biology University College Cork Biography Publications Institution JoVE Articles Dmitri B. Papkovsky has not added a biography. If you are Dmitri B. Papkovsky and would like to personalize this page please email our Author Liaison for assistance. Publications Heterosubstituted Derivatives of PtPFPP for O Sensing and Cell Analysis: Structure-Activity Relationships Bioconjugate Chemistry. Nov, 2022 | Pubmed ID: 36289566 Ghrelin Rapidly Elevates Protein Synthesis in Vitro by Employing the RpS6K-eEF2K-eEF2 Signalling Axis Cellular and Molecular Life Sciences : CMLS. Jul, 2022 | Pubmed ID: 35841486 Mitochondrial Complex IV Defects Induce Metabolic and Signaling Perturbations That Expose Potential Vulnerabilities in HCT116 Cells FEBS Open Bio. May, 2022 | Pubmed ID: 35302710 A Sensor-based System for Rapid On-site Testing of Microbial Contamination in Meat Samples and Carcasses Journal of Applied Microbiology. Feb, 2022 | Pubmed ID: 34464989 A Simple Sensor System for Onsite Monitoring of O in Vacuum-Packed Meats During the Shelf Life Sensors (Basel, Switzerland). Jun, 2021 | Pubmed ID: 34206251 Cell Energy Budget Platform for Multiparametric Assessment of Cell and Tissue Metabolism Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34060051 Facile Biosensor-based System for On-site Quantification of Total Viable Counts in Food and Environmental Swabs Biosensors & Bioelectronics. Mar, 2021 | Pubmed ID: 33395568 Mapping O Concentration in Ex-vivo Tissue Samples on a Fast PLIM Macro-imager Scientific Reports. Nov, 2020 | Pubmed ID: 33149165 Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells Investigative Ophthalmology & Visual Science. Nov, 2020 | Pubmed ID: 33137197 Unusually Efficient CUG Initiation of an Overlapping Reading Frame in MRNA Yields Novel Protein POLGARF Proceedings of the National Academy of Sciences of the United States of America. Oct, 2020 | Pubmed ID: 32958672 Correction To: Disruption of Hypoxia-inducible Fatty Acid Binding Protein 7 Induces Beige Fat-like Differentiation and Thermogenesis in Breast Cancer Cells Cancer & Metabolism. 2020 | Pubmed ID: 32789015 Visualization of Stem Cell Niche by Fluorescence Lifetime Imaging Microscopy Methods in Molecular Biology (Clifton, N.J.). 2020 | Pubmed ID: 32705636 Translation Initiation Downstream from Annotated Start Codons in Human MRNAs Coevolves with the Kozak Context Genome Research. Jul, 2020 | Pubmed ID: 32669370 Disruption of Hypoxia-inducible Fatty Acid Binding Protein 7 Induces Beige Fat-like Differentiation and Thermogenesis in Breast Cancer Cells Cancer & Metabolism. 2020 | Pubmed ID: 32647572 A Deeper Understanding of Intestinal Organoid Metabolism Revealed by Combining Fluorescence Lifetime Imaging Microscopy (FLIM) and Extracellular Flux Analyses Redox Biology. Feb, 2020 | Pubmed ID: 31935648 Estimation of the Mitochondrial Membrane Potential Using Fluorescence Lifetime Imaging Microscopy Cytometry. Part A : the Journal of the International Society for Analytical Cytology. May, 2020 | Pubmed ID: 31486581 Nanoparticle-based Fluoroionophore for Analysis of Potassium Ion Dynamics in 3D Tissue Models and Advanced Functional Materials. Feb, 2018 | Pubmed ID: 30271316 Cellulose-based Scaffolds for Fluorescence Lifetime Imaging-assisted Tissue Engineering Acta Biomaterialia. Oct, 2018 | Pubmed ID: 30261339 Imaging of Oxygen and Hypoxia in Cell and Tissue Samples Cellular and Molecular Life Sciences : CMLS. Aug, 2018 | Pubmed ID: 29761206 Assessment of Performance of the Industrial Process of Bulk Vacuum Packaging of Raw Meat with Nondestructive Optical Oxygen Sensing Systems Sensors (Basel, Switzerland). May, 2018 | Pubmed ID: 29724024 Multi-Parametric Imaging of Hypoxia and Cell Cycle in Intestinal Organoid Culture Advances in Experimental Medicine and Biology. 2017 | Pubmed ID: 29080132 Live Cell Imaging of Mouse Intestinal Organoids Reveals Heterogeneity in Their Oxygenation Biomaterials. Nov, 2017 | Pubmed ID: 28898760 Insulin-like Growth Factor 1 Signaling is Essential for Mitochondrial Biogenesis and Mitophagy in Cancer Cells The Journal of Biological Chemistry. Oct, 2017 | Pubmed ID: 28821609 Single-cell Time-lapse Imaging of Intracellular O in Response to Metabolic Inhibition and Mitochondrial Cytochrome-c Release Cell Death & Disease. Jun, 2017 | Pubmed ID: 28569778 Phosphorescent Oxygen and Mechanosensitive Nanostructured Materials Based on Hard Elastic Polypropylene Films ACS Applied Materials & Interfaces. Apr, 2017 | Pubmed ID: 28367617 Steering Surface Topographies of Electrospun Fibers: Understanding the Mechanisms Scientific Reports. Mar, 2017 | Pubmed ID: 28279011 Planar Implantable Sensor for in Vivo Measurement of Cellular Oxygen Metabolism in Brain Tissue Journal of Neuroscience Methods. Apr, 2017 | Pubmed ID: 28219725 Low Energy Costs of F1Fo ATP Synthase Reversal in Colon Carcinoma Cells Deficient in Mitochondrial Complex IV Free Radical Biology & Medicine. May, 2017 | Pubmed ID: 28189850 Cellular ROS Imaging with Hydro-Cy3 Dye is Strongly Influenced by Mitochondrial Membrane Potential Biochimica Et Biophysica Acta. General Subjects. Feb, 2017 | Pubmed ID: 27818165 Quantitative Analysis of Mucosal Oxygenation Using Ex Vivo Imaging of Healthy and Inflamed Mammalian Colon Tissue Cellular and Molecular Life Sciences : CMLS. Jan, 2017 | Pubmed ID: 27510419 Use of Fluorescence Lifetime Imaging Microscopy (FLIM) As a Timer of Cell Cycle S Phase PloS One. 2016 | Pubmed ID: 27973570 Phosphorescence Based O Sensors - Essential Tools for Monitoring Cell and Tissue Oxygenation and Its Impact on Metabolism Free Radical Biology & Medicine. Dec, 2016 | Pubmed ID: 27789291 Sulforhodamine Nanothermometer for Multiparametric Fluorescence Lifetime Imaging Microscopy Analytical Chemistry. 11, 2016 | Pubmed ID: 27696826 An Assessment of the Influence of the Industry Distribution Chain on the Oxygen Levels in Commercial Modified Atmosphere Packaged Cheddar Cheese Using Non-Destructive Oxygen Sensor Technology Sensors (Basel, Switzerland). Jun, 2016 | Pubmed ID: 27331815 The Ca2+/Mn2+-transporting SPCA2 Pump is Regulated by Oxygen and Cell Density in Colon Cancer Cells The Biochemical Journal. Aug, 2016 | Pubmed ID: 27316461 Metallochelate Coupling of Phosphorescent Pt-Porphyrins to Peptides, Proteins, and Self-Assembling Protein Nanoparticles Bioconjugate Chemistry. Feb, 2016 | Pubmed ID: 26704593 Hypothermia Protects Brain Mitochondrial Function from Hypoxemia in a Murine Model of Sepsis Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Nov, 2016 | Pubmed ID: 26661160 Intracellular Probes for Imaging Oxygen Concentration: How Good Are They? Methods and Applications in Fluorescence. Apr, 2015 | Pubmed ID: 29148495 A Novel Effect of DMOG on Cell Metabolism: Direct Inhibition of Mitochondrial Function Precedes HIF Target Gene Expression Biochimica Et Biophysica Acta. Oct, 2015 | Pubmed ID: 26143176 Oxygen and Glucose Deprivation Induces Widespread Alterations in MRNA Translation Within 20 Minutes Genome Biology. May, 2015 | Pubmed ID: 25943107 Versatile Conjugated Polymer Nanoparticles for High-Resolution O2 Imaging in Cells and 3D Tissue Models ACS Nano. May, 2015 | Pubmed ID: 25858428 Oxygen-sensing Scaffolds for 3-dimensional Cell and Tissue Culture Acta Biomaterialia. Apr, 2015 | Pubmed ID: 25653216 Cell Energy Budget Platform for Assessment of Cell Metabolism Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25634285 In Vitro Ischemia Decreases Histone H4K16 Acetylation in Neural Cells FEBS Letters. Jan, 2015 | Pubmed ID: 25479088 Differential Contribution of Key Metabolic Substrates and Cellular Oxygen in HIF Signalling Experimental Cell Research. Jan, 2015 | Pubmed ID: 25447307 Multi-parametric O₂ Imaging in Three-dimensional Neural Cell Models with the Phosphorescent Probes Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25431057 Comparison of the Three Optical Platforms for Measurement of Cellular Respiration Analytical Biochemistry. Jan, 2015 | Pubmed ID: 25233002 Imaging Oxygen in Neural Cell and Tissue Models by Means of Anionic Cell-permeable Phosphorescent Nanoparticles Cellular and Molecular Life Sciences : CMLS. Jan, 2015 | Pubmed ID: 25006059 Small Molecule Phosphorescent Probes for O Imaging in 3D Tissue Models Biomaterials Science. Jun, 2014 | Pubmed ID: 32481818 Kinetic Analysis of Local Oxygenation and Respiratory Responses of Mammalian Cells Using Intracellular Oxygen-sensitive Probes and Time-resolved Fluorometry Methods in Enzymology. 2014 | Pubmed ID: 24862267 Oxygen-sensitive Phosphorescent Nanomaterials Produced from High-density Polyethylene Films by Local Solvent-crazing Analytical Chemistry. Feb, 2014 | Pubmed ID: 24422456 Availability of the Key Metabolic Substrates Dictates the Respiratory Response of Cancer Cells to the Mitochondrial Uncoupling Biochimica Et Biophysica Acta. Jan, 2014 | Pubmed ID: 23891695 Use of Optical Oxygen Sensors in Non-Destructively Determining the Levels of Oxygen Present in Combined Vacuum and Modified Atmosphere Packaged Pre-Cooked Convenience-Style Foods and the Use of Ethanol Emitters to Extend Product Shelf-Life Foods (Basel, Switzerland). Nov, 2013 | Pubmed ID: 28239134 Assessment and Use of Optical Oxygen Sensors As Tools to Assist in Optimal Product Component Selection for the Development of Packs of Ready-to-Eat Mixed Salads and for the Non-Destructive Monitoring of In-Pack Oxygen Levels Using Chilled Storage Foods (Basel, Switzerland). May, 2013 | Pubmed ID: 28239110 Imaging of Neurosphere Oxygenation with Phosphorescent Probes Biomaterials. Dec, 2013 | Pubmed ID: 24016849 Measurement of Cell Respiration and Oxygenation in Standard Multichannel Biochips Using Phosphorescent O2-sensitive Probes The Analyst. Sep, 2013 | Pubmed ID: 23803790 Biological Detection by Optical Oxygen Sensing Chemical Society Reviews. Nov, 2013 | Pubmed ID: 23775387 In Vivo Imaging of Brain Metabolism Activity Using a Phosphorescent Oxygen-sensitive Probe Journal of Neuroscience Methods. Jun, 2013 | Pubmed ID: 23624034 Chronic Hypoxia Leads to a Glycolytic Phenotype and Suppressed HIF-2 Signaling in PC12 Cells Biochimica Et Biophysica Acta. Jun, 2013 | Pubmed ID: 23462283 Genome-wide Investigation of Cellular Targets and Mode of Action of the Antifungal Bacterial Metabolite 2,4-diacetylphloroglucinol in Saccharomyces Cerevisiae FEMS Yeast Research. May, 2013 | Pubmed ID: 23445507 Bafilomycin A1 Activates HIF-dependent Signalling in Human Colon Cancer Cells Via Mitochondrial Uncoupling Bioscience Reports. Dec, 2012 | Pubmed ID: 22943412 G2019S Leucine-rich Repeat Kinase 2 Causes Uncoupling Protein-mediated Mitochondrial Depolarization Human Molecular Genetics. Oct, 2012 | Pubmed ID: 22736029 Assessment of Cellular Oxygen Gradients with a Panel of Phosphorescent Oxygen-sensitive Probes Analytical Chemistry. Mar, 2012 | Pubmed ID: 22380020 Optical Probes and Techniques for O2 Measurement in Live Cells and Tissue Cellular and Molecular Life Sciences : CMLS. Jun, 2012 | Pubmed ID: 22249195 Cell-penetrating Conjugates of Coproporphyrins with Oligoarginine Peptides: Rational Design and Application for Sensing Intracellular O2 Bioconjugate Chemistry. Dec, 2011 | Pubmed ID: 22035070 Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival PloS One. 2011 | Pubmed ID: 21912692 Intracellular O2 Sensing Probe Based on Cell-penetrating Phosphorescent Nanoparticles ACS Nano. Jul, 2011 | Pubmed ID: 21671589 Bafilomycin A1 Activates Respiration of Neuronal Cells Via Uncoupling Associated with Flickering Depolarization of Mitochondria Cellular and Molecular Life Sciences : CMLS. Mar, 2011 | Pubmed ID: 20820851 Bactenecin 7 Peptide Fragment As a Tool for Intracellular Delivery of a Phosphorescent Oxygen Sensor The FEBS Journal. Nov, 2010 | Pubmed ID: 20883447 Monitoring of Cell Oxygenation and Responses to Metabolic Stimulation by Intracellular Oxygen Sensing Technique Integrative Biology : Quantitative Biosciences from Nano to Macro. Sep, 2010 | Pubmed ID: 20657921 Extracellular Calcium Depletion Transiently Elevates Oxygen Consumption in Neurosecretory PC12 Cells Through Activation of Mitochondrial Na+/Ca2+ Exchange Biochimica Et Biophysica Acta. Sep, 2010 | Pubmed ID: 20550942 Phosphorescent Oxygen Sensors Based on Nanostructured Polyolefin Substrates Analytical Chemistry. Jan, 2010 | Pubmed ID: 20038091 Imaging of Cellular Oxygen and Analysis of Metabolic Responses of Mammalian Cells Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 19957136 Intracellular Oxygen-sensitive Phosphorescent Probes Based on Cell-penetrating Peptides Analytical Biochemistry. Mar, 2010 | Pubmed ID: 19931212 Analysis of Activity and Inhibition of Oxygen-dependent Enzymes by Optical Respirometry on the LightCycler System Analytical Biochemistry. Feb, 2010 | Pubmed ID: 19849999 In Vitro Analysis of Cell Metabolism Using a Long-decay PH-sensitive Lanthanide Probe and Extracellular Acidification Assay Analytical Biochemistry. Jul, 2009 | Pubmed ID: 19379702 PGC-1alpha is Coupled to HIF-1alpha-dependent Gene Expression by Increasing Mitochondrial Oxygen Consumption in Skeletal Muscle Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19179292 Toxicological Profiling of Chemical and Environmental Samples Using Panels of Test Organisms and Optical Oxygen Respirometry Environmental Toxicology. Apr, 2009 | Pubmed ID: 18442072 Dynamics of Intracellular Oxygen in PC12 Cells Upon Stimulation of Neurotransmission The Journal of Biological Chemistry. Feb, 2008 | Pubmed ID: 18086678 Homogeneous Time-resolved Fluorescence Assays for the Detection of Activity and Inhibition of Phosphatase Enzymes Employing Phosphorescently Labeled Peptide Substrates Analytica Chimica Acta. Feb, 2007 | Pubmed ID: 17386566 Sensing Intracellular Oxygen Using Near-infrared Phosphorescent Probes and Live-cell Fluorescence Imaging American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Apr, 2007 | Pubmed ID: 17170232 Rapid High-throughput Assessment of Aerobic Bacteria in Complex Samples by Fluorescence-based Oxygen Respirometry Applied and Environmental Microbiology. Feb, 2006 | Pubmed ID: 16461677 The Use of a Fluorescence-based Oxygen Uptake Assay in the Analysis of Cytotoxicity Toxicology in Vitro : an International Journal Published in Association with BIBRA. Aug, 2006 | Pubmed ID: 16386874 Fluorescence Based Oxygen Uptake Analysis in the Study of Metabolic Responses to Apoptosis Induction Journal of Immunological Methods. Nov, 2005 | Pubmed ID: 16212976 Emerging Applications of Phosphorescent Metalloporphyrins Journal of Fluorescence. Jul, 2005 | Pubmed ID: 16167215 Optical Oxygen Microrespirometry As a Platform for Environmental Toxicology and Animal Model Studies Environmental Science & Technology. Jul, 2005 | Pubmed ID: 16053104 Homogeneous Assays for Cellular Proteases Employing the Platinum(II)-coproporphyrin Label and Time-resolved Phosphorescence Analytical Biochemistry. Jul, 2005 | Pubmed ID: 15958187 Evaluation of the Phosphorescent Palladium(II)-coproporphyrin Labels in Separation-free Hybridization Assays Analytical Biochemistry. Sep, 2003 | Pubmed ID: 12927834 Fluorescence-based Cell Viability Screening Assays Using Water-soluble Oxygen Probes Journal of Biomolecular Screening. Jun, 2003 | Pubmed ID: 12857380 Synthesis and Evaluation of Phosphorescent Oligonucleotide Probes for Hybridisation Assays Nucleic Acids Research. Nov, 2002 | Pubmed ID: 12409473 Spectral-luminescent Study of the Porphyrin-diketones and Their Complexes Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy. Aug, 2001 | Pubmed ID: 11506042 Fluorescens levetid makro imager til biomedicinske applikationer Rajannya Sen1, Alexander V. Zhdanov1, Ciaran Devoy2, Mark Tangney2, Liisa M. Hirvonen3, Andrei Nomerotski4, Dmitri B. Papkovsky1 1School of Biochemistry and Cell Biology, University College Cork, 2Cancer Research@UCC, University College Cork, 3Centre for Microscopy, Characterisation and Analysis (CMCA), The University of Western Australia, 4Physics Department, Brookhaven National Laboratory JoVE 64321 Biologia
Fluorescens levetid makro imager til biomedicinske applikationer Rajannya Sen1, Alexander V. Zhdanov1, Ciaran Devoy2, Mark Tangney2, Liisa M. Hirvonen3, Andrei Nomerotski4, Dmitri B. Papkovsky1 1School of Biochemistry and Cell Biology, University College Cork, 2Cancer Research@UCC, University College Cork, 3Centre for Microscopy, Characterisation and Analysis (CMCA), The University of Western Australia, 4Physics Department, Brookhaven National Laboratory JoVE 64321 Biologia