Dongsheng Duan Department of Molecular Microbiology and Immunology, School of Medicine University of Missouri Biography Publications Institution JoVE Articles Dongsheng Duan has not added a biography. If you are Dongsheng Duan and would like to personalize this page please email our Author Liaison for assistance. Publications Microdystrophin Ameliorates Muscular Dystrophy in the Canine Model of Duchenne Muscular Dystrophy Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2013 | Pubmed ID: 23319056 α2 and α3 Helices of Dystrophin R16 and R17 Frame a Microdomain in the α1 Helix of Dystrophin R17 for Neuronal NOS Binding Proceedings of the National Academy of Sciences of the United States of America. Jan, 2013 | Pubmed ID: 23185009 A Marginal Level of Dystrophin Partially Ameliorates Hindlimb Muscle Passive Mechanical Properties in Dystrophin-null Mice Muscle & Nerve. Dec, 2012 | Pubmed ID: 23225385 Truncated Dystrophins Reduce Muscle Stiffness in the Extensor Digitorum Longus Muscle of Mdx Mice Journal of Applied Physiology (Bethesda, Md. : 1985). Dec, 2012 | Pubmed ID: 23221959 Dystrophin Deficiency Compromises Force Production of the Extensor Carpi Ulnaris Muscle in the Canine Model of Duchenne Muscular Dystrophy PloS One. 2012 | Pubmed ID: 22973449 AAV Micro-dystrophin Gene Therapy Alleviates Stress-induced Cardiac Death but Not Myocardial Fibrosis in >21-m-old Mdx Mice, an End-stage Model of Duchenne Muscular Dystrophy Cardiomyopathy Journal of Molecular and Cellular Cardiology. Aug, 2012 | Pubmed ID: 22587991 Gender Differences in Contractile and Passive Properties of Mdx Extensor Digitorum Longus Muscle Muscle & Nerve. Feb, 2012 | Pubmed ID: 22246882 Recombinant Adeno-associated Viral Vector Production and Purification Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22130842 Humoral Immunity to AAV-6, 8, and 9 in Normal and Dystrophic Dogs Human Gene Therapy. Mar, 2012 | Pubmed ID: 22040468 A Simplified Immune Suppression Scheme Leads to Persistent Micro-dystrophin Expression in Duchenne Muscular Dystrophy Dogs Human Gene Therapy. Feb, 2012 | Pubmed ID: 21967249 Novel Mini-dystrophin Gene Dual Adeno-associated Virus Vectors Restore Neuronal Nitric Oxide Synthase Expression at the Sarcolemma Human Gene Therapy. Jan, 2012 | Pubmed ID: 21933029 Gene Delivery to the Heart: an Updated Review on Vectors and Methods The Journal of Gene Medicine. Oct, 2011 | Pubmed ID: 22025443 The Evolution of Heart Gene Delivery Vectors The Journal of Gene Medicine. Oct, 2011 | Pubmed ID: 21837689 SERCA2a Gene Transfer Improves Electrocardiographic Performance in Aged Mdx Mice Journal of Translational Medicine. 2011 | Pubmed ID: 21834967 AAV-microdystrophin Therapy Improves Cardiac Performance in Aged Female Mdx Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2011 | Pubmed ID: 21811246 INOS Ablation Does Not Improve Specific Force of the Extensor Digitorum Longus Muscle in Dystrophin-deficient Mdx4cv Mice PloS One. 2011 | Pubmed ID: 21738735 Duchenne Muscular Dystrophy Gene Therapy: Lost in Translation? Research and Reports in Biology. Mar, 2011 | Pubmed ID: 21691429 Age-matched Comparison Reveals Early Electrocardiography and Echocardiography Changes in Dystrophin-deficient Dogs Neuromuscular Disorders : NMD. Jul, 2011 | Pubmed ID: 21570848 The Passive Mechanical Properties of the Extensor Digitorum Longus Muscle Are Compromised in 2- to 20-mo-old Mdx Mice Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2011 | Pubmed ID: 21415170 Genotyping Mdx, Mdx3cv, and Mdx4cv Mice by Primer Competition Polymerase Chain Reaction Muscle & Nerve. Feb, 2011 | Pubmed ID: 21254096 Whole Body Skeletal Muscle Transduction in Neonatal Dogs with AAV-9 Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21194038 Phenotyping Cardiac Gene Therapy in Mice Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21194023 Monitoring Murine Skeletal Muscle Function for Muscle Gene Therapy Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21194022 Nitrosative Stress Elicited by NNOSµ Delocalization Inhibits Muscle Force in Dystrophin-null Mice The Journal of Pathology. Jan, 2011 | Pubmed ID: 21125668 Evidence for Impaired Neurovascular Transmission in a Murine Model of Duchenne Muscular Dystrophy Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2011 | Pubmed ID: 21109597 An Intronic LINE-1 Element Insertion in the Dystrophin Gene Aborts Dystrophin Expression and Results in Duchenne-like Muscular Dystrophy in the Corgi Breed Laboratory Investigation; a Journal of Technical Methods and Pathology. Feb, 2011 | Pubmed ID: 20714321 Efficient Transgene Reconstitution with Hybrid Dual AAV Vectors Carrying the Minimized Bridging Sequences Human Gene Therapy. Jan, 2011 | Pubmed ID: 20662564 Marginal Level Dystrophin Expression Improves Clinical Outcome in a Strain of Dystrophin/utrophin Double Knockout Mice PloS One. 2010 | Pubmed ID: 21187970 Gender Influences Cardiac Function in the Mdx Model of Duchenne Cardiomyopathy Muscle & Nerve. Oct, 2010 | Pubmed ID: 20878741 Adeno-associated Virus Serotype 6 Capsid Tyrosine-to-phenylalanine Mutations Improve Gene Transfer to Skeletal Muscle Human Gene Therapy. Oct, 2010 | Pubmed ID: 20497037 Sarcolemmal NNOS Anchoring Reveals a Qualitative Difference Between Dystrophin and Utrophin Journal of Cell Science. Jun, 2010 | Pubmed ID: 20483958 Adeno-associated Virus Serotype-9 Mediated Retinal Outer Plexiform Layer Transduction is Mainly Through the Photoreceptors Advances in Experimental Medicine and Biology. 2010 | Pubmed ID: 20238072 Evidence for the Failure of Adeno-associated Virus Serotype 5 to Package a Viral Genome > or = 8.2 Kb Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2010 | Pubmed ID: 19904238 Ectopic Catalase Expression in Mitochondria by Adeno-associated Virus Enhances Exercise Performance in Mice PloS One. 2009 | Pubmed ID: 19690612 Systemic Trans-splicing Adeno-associated Viral Delivery Efficiently Transduces the Heart of Adult Mdx Mouse, a Model for Duchenne Muscular Dystrophy Human Gene Therapy. Nov, 2009 | Pubmed ID: 19627234 Adeno-associated Virus Serotype-9 Efficiently Transduces the Retinal Outer Plexiform Layer Molecular Vision. 2009 | Pubmed ID: 19626133 Dystrophins Carrying Spectrin-like Repeats 16 and 17 Anchor NNOS to the Sarcolemma and Enhance Exercise Performance in a Mouse Model of Muscular Dystrophy The Journal of Clinical Investigation. Mar, 2009 | Pubmed ID: 19229108 Sub-physiological Sarcoglycan Expression Contributes to Compensatory Muscle Protection in Mdx Mice Human Molecular Genetics. Apr, 2009 | Pubmed ID: 19131360 Cardiac Expression of a Mini-dystrophin That Normalizes Skeletal Muscle Force Only Partially Restores Heart Function in Aged Mdx Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2009 | Pubmed ID: 19066599 A Single Intravenous Injection of Adeno-associated Virus Serotype-9 Leads to Whole Body Skeletal Muscle Transduction in Dogs Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2008 | Pubmed ID: 18827804 Dystrophin Knockdown Mice Suggest That Early, Transient Dystrophin Expression Might Be Enough to Prevent Later Pathology Neuromuscular Disorders : NMD. Nov, 2008 | Pubmed ID: 18818078 Design of Trans-splicing Adeno-associated Viral Vectors for Duchenne Muscular Dystrophy Gene Therapy Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18679629 Adeno-associated Virus Serotype-9 Microdystrophin Gene Therapy Ameliorates Electrocardiographic Abnormalities in Mdx Mice Human Gene Therapy. Aug, 2008 | Pubmed ID: 18666839 Preservation of Muscle Force in Mdx3cv Mice Correlates with Low-level Expression of a Near Full-length Dystrophin Protein The American Journal of Pathology. May, 2008 | Pubmed ID: 18385524 Myodys, a Full-length Dystrophin Plasmid Vector for Duchenne and Becker Muscular Dystrophy Gene Therapy Current Opinion in Molecular Therapeutics. Feb, 2008 | Pubmed ID: 18228186 A Hybrid Vector System Expands Adeno-associated Viral Vector Packaging Capacity in a Transgene-independent Manner Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2008 | Pubmed ID: 17984978 Prevention of Dystrophin-deficient Cardiomyopathy in Twenty-one-month-old Carrier Mice by Mosaic Dystrophin Expression or Complementary Dystrophin/utrophin Expression Circulation Research. Jan, 2008 | Pubmed ID: 17967782 Expanding Adeno-associated Viral Vector Capacity: a Tale of Two Vectors Biotechnology & Genetic Engineering Reviews. 2007 | Pubmed ID: 18059632 Catalase Overexpression Does Not Impair Extensor Digitorum Longus Muscle Function in Normal Mice Muscle & Nerve. Dec, 2007 | Pubmed ID: 17696155 Efficient Whole-body Transduction with Trans-splicing Adeno-associated Viral Vectors Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2007 | Pubmed ID: 17264855 From the Smallest Virus to the Biggest Gene: Marching Towards Gene Therapy for Duchenne Muscular Dystrophy Discovery Medicine. Jun, 2006 | Pubmed ID: 17234143 Synthetic Intron Improves Transduction Efficiency of Trans-splicing Adeno-associated Viral Vectors Human Gene Therapy. Oct, 2006 | Pubmed ID: 17007565 Challenges and Opportunities in Dystrophin-deficient Cardiomyopathy Gene Therapy Human Molecular Genetics. Oct, 2006 | Pubmed ID: 16987891 C-terminal-truncated Microdystrophin Recruits Dystrobrevin and Syntrophin to the Dystrophin-associated Glycoprotein Complex and Reduces Muscular Dystrophy in Symptomatic Utrophin/dystrophin Double-knockout Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2006 | Pubmed ID: 16563874 Viral Serotype and the Transgene Sequence Influence Overlapping Adeno-associated Viral (AAV) Vector-mediated Gene Transfer in Skeletal Muscle The Journal of Gene Medicine. Mar, 2006 | Pubmed ID: 16385549 Efficient in Vivo Gene Expression by Trans-splicing Adeno-associated Viral Vectors Nature Biotechnology. Nov, 2005 | Pubmed ID: 16244658 Adeno-associated Virus-mediated Microdystrophin Expression Protects Young Mdx Muscle from Contraction-induced Injury Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2005 | Pubmed ID: 15668136 Trans-splicing Adeno-associated Viral Vector-mediated Gene Therapy is Limited by the Accumulation of Spliced MRNA but Not by Dual Vector Coinfection Efficiency Human Gene Therapy. Sep, 2004 | Pubmed ID: 15353044 Full-length Dystrophin Expression in Half of the Heart Cells Ameliorates Beta-isoproterenol-induced Cardiomyopathy in Mdx Mice Human Molecular Genetics. Aug, 2004 | Pubmed ID: 15190010 Microdystrophin Gene Therapy of Cardiomyopathy Restores Dystrophin-glycoprotein Complex and Improves Sarcolemma Integrity in the Mdx Mouse Heart Circulation. Sep, 2003 | Pubmed ID: 12952841 Double Strand Interaction is the Predominant Pathway for Intermolecular Recombination of Adeno-associated Viral Genomes Virology. Aug, 2003 | Pubmed ID: 12951015 Adenovirus-mediated Gene Transfer to Adult Mouse Cardiomyocytes is Selectively Influenced by Culture Medium The Journal of Gene Medicine. Sep, 2003 | Pubmed ID: 12950067 Consequences of DNA-dependent Protein Kinase Catalytic Subunit Deficiency on Recombinant Adeno-associated Virus Genome Circularization and Heterodimerization in Muscle Tissue Journal of Virology. Apr, 2003 | Pubmed ID: 12663782 Dual Vector Expansion of the Recombinant AAV Packaging Capacity Methods in Molecular Biology (Clifton, N.J.). 2003 | Pubmed ID: 12596997 Trans-splicing Vectors Expand the Packaging Limits of Adeno-associated Virus for Gene Therapy Applications Methods in Molecular Medicine. 2003 | Pubmed ID: 12526170 Development of Multiple Cloning Site Cis-vectors for Recombinant Adeno-associated Virus Production BioTechniques. Sep, 2002 | Pubmed ID: 12238777 Recombinant AAV-mediated Gene Delivery Using Dual Vector Heterodimerization Methods in Enzymology. 2002 | Pubmed ID: 11883078 Modular Flexibility of Dystrophin: Implications for Gene Therapy of Duchenne Muscular Dystrophy Nature Medicine. Mar, 2002 | Pubmed ID: 11875496 Evaluering af muskelfunktionen af extensor digitorum longus musklen Chady H. Hakim1, Nalinda B. Wasala1, Dongsheng Duan1 1Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri JoVE 50183 Biologia
Evaluering af muskelfunktionen af extensor digitorum longus musklen Chady H. Hakim1, Nalinda B. Wasala1, Dongsheng Duan1 1Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri JoVE 50183 Biologia