Erwin Sigel Institute of Biochemistry and Molecular Medicine University of Bern Biography Publications Institution JoVE Articles Erwin Sigel has not added a biography. If you are Erwin Sigel and would like to personalize this page please email our Author Liaison for assistance. Publications Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors The Journal of Biological Chemistry. Aug, 2016 | Pubmed ID: 27382064 Molecular Mode of Action of CGS 9895 at α1 β2 γ2 GABAA Receptors Journal of Neurochemistry. Sep, 2016 | Pubmed ID: 27319298 Novel Positive Allosteric Modulators of GABAA Receptors with Anesthetic Activity Scientific Reports. May, 2016 | Pubmed ID: 27198062 A New Chromanone Derivative Isolated from Hypericum Lissophloeus (Hypericaceae) Potentiates GABAA Receptor Currents in a Subunit Specific Fashion Bioorganic & Medicinal Chemistry. Feb, 2016 | Pubmed ID: 26791864 Functional Sites Involved in Modulation of the GABAA Receptor Channel by the Intravenous Anesthetics Propofol, Etomidate and Pentobarbital Neuropharmacology. Jun, 2016 | Pubmed ID: 26767954 Modulatory Effects of Eschscholzia Californica Alkaloids on Recombinant GABAA Receptors Biochemistry Research International. 2015 | Pubmed ID: 26509084 Flagellar Membranes Are Rich in Raft-forming Phospholipids Biology Open. Aug, 2015 | Pubmed ID: 26276100 Positive Modulation of Synaptic and Extrasynaptic GABAA Receptors by an Antagonist of the High Affinity Benzodiazepine Binding Site Neuropharmacology. Aug, 2015 | Pubmed ID: 25963418 Trypanosoma Brucei Bloodstream Forms Depend Upon Uptake of Myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth Eukaryotic Cell. Jun, 2015 | Pubmed ID: 25888554 A Heteromeric Potassium Channel Involved in the Modulation of the Plasma Membrane Potential is Essential for the Survival of African Trypanosomes FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2015 | Pubmed ID: 25868728 Monepantel Irreversibly Binds to and Opens Haemonchus Contortus MPTL-1 and Caenorhabditis Elegans ACR-20 Receptors Molecular Pharmacology. Jan, 2015 | Pubmed ID: 25352042 Structural Analogues of the Natural Products Magnolol and Honokiol As Potent Allosteric Potentiators of GABA(A) Receptors Bioorganic & Medicinal Chemistry. Dec, 2014 | Pubmed ID: 25456080 A Pentasymmetric Open Channel Blocker for Cys-loop Receptor Channels PloS One. 2014 | Pubmed ID: 25184303 Trypanosoma Brucei Eflornithine Transporter AAT6 is a Low-affinity Low-selective Transporter for Neutral Amino Acids The Biochemical Journal. Oct, 2014 | Pubmed ID: 24988048 Moderate Concentrations of 4-O-methylhonokiol Potentiate GABAA Receptor Currents Stronger Than Honokiol Biochimica Et Biophysica Acta. Oct, 2014 | Pubmed ID: 24973566 Accelerated Discovery of Novel Benzodiazepine Ligands by Experiment-guided Virtual Screening ACS Chemical Biology. Aug, 2014 | Pubmed ID: 24960548 Relative Positioning of Classical Benzodiazepines to the γ2-subunit of GABAA Receptors ACS Chemical Biology. Aug, 2014 | Pubmed ID: 24918742 Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl Glycerol (2-AG) Share Mode of Action and the Binding Site on the β2 Subunit of GABAA Receptors? PeerJ. 2013 | Pubmed ID: 24058880 Acr-23 Encodes a Monepantel-sensitive Channel in Caenorhabditis Elegans PLoS Pathogens. 2013 | Pubmed ID: 23950710 Characterization of Choline Uptake in Trypanosoma Brucei Procyclic and Bloodstream Forms Molecular and Biochemical Parasitology. Jul, 2013 | Pubmed ID: 23747277 Molecular Analysis of the Site for 2-arachidonylglycerol (2-AG) on the β₂ Subunit of GABA(A) Receptors Journal of Neurochemistry. Jul, 2013 | Pubmed ID: 23600744 Structure, Function, and Modulation of GABA(A) Receptors The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 23038269 Azo-propofols: Photochromic Potentiators of GABA(A) Receptors Angewandte Chemie (International Ed. in English). Oct, 2012 | Pubmed ID: 22968919 Influence of GABA(A) Receptor α Subunit Isoforms on the Benzodiazepine Binding Site PloS One. 2012 | Pubmed ID: 22848717 A Venom-derived Neurotoxin, CsTx-1, from the Spider Cupiennius Salei Exhibits Cytolytic Activities The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22613721 Myo-Inositol Uptake is Essential for Bulk Inositol Phospholipid but Not Glycosylphosphatidylinositol Synthesis in Trypanosoma Brucei The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22351763 The Major Central Endocannabinoid Directly Acts at GABA(A) Receptors Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22025726 A Closer Look at the High Affinity Benzodiazepine Binding Site on GABAA Receptors Current Topics in Medicinal Chemistry. 2011 | Pubmed ID: 21189125 A Residue Close to α1 Loop F Disrupts Modulation of GABAA Receptors by Benzodiazepines While Their Binding is Maintained Journal of Neurochemistry. Dec, 2010 | Pubmed ID: 20946417 Monepantel Allosterically Activates DEG-3/DES-2 Channels of the Gastrointestinal Nematode Haemonchus Contortus Molecular Pharmacology. Nov, 2010 | Pubmed ID: 20679419 Diversity of Structure and Function of Alpha1alpha6beta3delta GABAA Receptors: Comparison with Alpha1beta3delta and Alpha6beta3delta Receptors The Journal of Biological Chemistry. Jun, 2010 | Pubmed ID: 20382738 Highly Potent Modulation of GABA(A) Receptors by Valerenic Acid Derivatives ChemMedChem. May, 2010 | Pubmed ID: 20235267 Use of Concatamers to Study GABAA Receptor Architecture and Function: Application to Delta-subunit-containing Receptors and Possible Pitfalls Biochemical Society Transactions. Dec, 2009 | Pubmed ID: 19909272 Relative Positioning of Diazepam in the Benzodiazepine-binding-pocket of GABA Receptors Journal of Neurochemistry. Dec, 2009 | Pubmed ID: 19804380 Structure of Alpha6 Beta3 Delta GABA(A) Receptors and Their Lack of Ethanol Sensitivity Journal of Neurochemistry. Dec, 2009 | Pubmed ID: 19765192 Unanticipated Structural and Functional Properties of Delta-subunit-containing GABAA Receptors The Journal of Biological Chemistry. Mar, 2009 | Pubmed ID: 19141615 Covalent Modification of GABAA Receptor Isoforms by a Diazepam Analogue Provides Evidence for a Novel Benzodiazepine Binding Site That Prevents Modulation by These Drugs Journal of Neurochemistry. Sep, 2008 | Pubmed ID: 18643789 Novel Chloride Channel Mutations Leading to Mild Myotonia Among Chinese Neuromuscular Disorders : NMD. Aug, 2008 | Pubmed ID: 18579381 Anticipating Antiport in P-type ATPases Trends in Biochemical Sciences. Apr, 2008 | Pubmed ID: 18343670 The Promiscuous Role of the Epsilon Subunit in GABAA Receptor Biogenesis Molecular and Cellular Neurosciences. Mar, 2008 | Pubmed ID: 18206389 Replacement of Histidine in Position 105 in the α₅ Subunit by Cysteine Stimulates Zolpidem Sensitivity of α₅β₂γ₂ GABA(A) Receptors Journal of Neurochemistry. Dec, 2007 | Pubmed ID: 17953656 Two Neighboring Residues of Loop A of the Alpha1 Subunit Point Towards the Benzodiazepine Binding Site of GABAA Receptors FEBS Letters. Oct, 2007 | Pubmed ID: 17854801 Proximity-accelerated Chemical Coupling Reaction in the Benzodiazepine-binding Site of Gamma-aminobutyric Acid Type A Receptors: Superposition of Different Allosteric Modulators The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17626010 A GABA(A) Receptor of Defined Subunit Composition and Positioning: Concatenation of Five Subunits FEBS Letters. Mar, 2006 | Pubmed ID: 16494876 Consequence of the Presence of Two Different Beta Subunit Isoforms in a GABA(A) Receptor Journal of Neurochemistry. Dec, 2005 | Pubmed ID: 16300645 Influence of the Point Mutation Alpha-1-H101R on the Assembly of Gamma-aminobutyric Acid Type A Receptors Neuroreport. Nov, 2005 | Pubmed ID: 16272886 Novel Plant Substances Acting As Beta Subunit Isoform-selective Positive Allosteric Modulators of GABAA Receptors Molecular Pharmacology. Sep, 2005 | Pubmed ID: 15939801 The Xenopus Oocyte: System for the Study of Functional Expression and Modulation of Proteins Molecular Nutrition & Food Research. Mar, 2005 | Pubmed ID: 15704243 Conformational Changes at Benzodiazepine Binding Sites of GABA(A) Receptors Detected with a Novel Technique Journal of Neurochemistry. Feb, 2005 | Pubmed ID: 15686488 Benzodiazepines Affect Channel Opening of GABA A Receptors Induced by Either Agonist Binding Site Molecular Pharmacology. Apr, 2005 | Pubmed ID: 15657366 Techniques: Use of Concatenated Subunits for the Study of Ligand-gated Ion Channels Trends in Pharmacological Sciences. Sep, 2004 | Pubmed ID: 15559253 The Flavone Hispidulin, a Benzodiazepine Receptor Ligand with Positive Allosteric Properties, Traverses the Blood-brain Barrier and Exhibits Anticonvulsive Effects British Journal of Pharmacology. Jul, 2004 | Pubmed ID: 15231642 Positioning of the Alpha-subunit Isoforms Confers a Functional Signature to Gamma-aminobutyric Acid Type A Receptors Proceedings of the National Academy of Sciences of the United States of America. May, 2004 | Pubmed ID: 15136735 Exon 17 Skipping in CLCN1 Leads to Recessive Myotonia Congenita Muscle & Nerve. May, 2004 | Pubmed ID: 15116370 On the Benzodiazepine Binding Pocket in GABAA Receptors The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14612433 Individual Properties of the Two Functional Agonist Sites in GABA(A) Receptors The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2003 | Pubmed ID: 14657175 Naturally Occurring 2'-hydroxyl-substituted Flavonoids As High-affinity Benzodiazepine Site Ligands Biochemical Pharmacology. Dec, 2003 | Pubmed ID: 14637197 On High- and Low-affinity Agonist Sites in GABAA Receptors Journal of Neurochemistry. Oct, 2003 | Pubmed ID: 14511110 Anxiolytic Effect of Wogonin, a Benzodiazepine Receptor Ligand Isolated from Scutellaria Baicalensis Georgi Biochemical Pharmacology. Nov, 2002 | Pubmed ID: 12392823 Forced Subunit Assembly in Alpha1beta2gamma2 GABAA Receptors. Insight into the Absolute Arrangement The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12324466 Functional Characterization of the New Human GABA(A) Receptor Mutation Beta3(R192H) Human Genetics. Aug, 2002 | Pubmed ID: 12189488 Mapping of the Benzodiazepine Recognition Site on GABA(A) Receptors Current Topics in Medicinal Chemistry. Aug, 2002 | Pubmed ID: 12171574 N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: New Positive Allosteric Modulators of the GABA(A) Receptor Sharing Electrophysiological Properties with the Anticonvulsant Loreclezole Journal of Medicinal Chemistry. Jun, 2002 | Pubmed ID: 12061884 Xenopus Oócitos: Métodos otimizados para microinjeção, remoção de camadas de células foliculares e rápidas mudanças Solução em experimentos eletrofisiológicos Maria C. Maldifassi*1, Nisa Wongsamitkul*1, Roland Baur1, Erwin Sigel1 1Institute of Biochemistry and Molecular Medicine, University of Bern Biologia
Xenopus Oócitos: Métodos otimizados para microinjeção, remoção de camadas de células foliculares e rápidas mudanças Solução em experimentos eletrofisiológicos Maria C. Maldifassi*1, Nisa Wongsamitkul*1, Roland Baur1, Erwin Sigel1 1Institute of Biochemistry and Molecular Medicine, University of Bern Biologia