Fiona Oakley Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences Newcastle University Biography Publications Institution JoVE Articles Fiona Oakley has not added a biography. If you are Fiona Oakley and would like to personalize this page please email our Author Liaison for assistance. Publications Key Features of the Environment Promoting Liver Cancer in the Absence of Cirrhosis Scientific Reports. Aug, 2021 | Pubmed ID: 34408183 A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is Essential to Activate Lipophagy and Protects Against Hepatosteatosis Hepatology (Baltimore, Md.). Jul, 2021 | Pubmed ID: 34233024 Neutrophils Induce Paracrine Telomere Dysfunction and Senescence in ROS-dependent Manner The EMBO Journal. May, 2021 | Pubmed ID: 33764576 Suppression of Insulin-induced Gene 1 (INSIG1) Function Promotes Hepatic Lipid Remodelling and Restrains NASH Progression Molecular Metabolism. 06, 2021 | Pubmed ID: 33722690 Non-invasive Synchronous Monitoring of Neutrophil Migration Using Whole Body Near-infrared Fluorescence-based Imaging Scientific Reports. 01, 2021 | Pubmed ID: 33446811 Author Correction: C-Rel Orchestrates Energy-dependent Epithelial and Macrophage Reprogramming in Fibrosis Nature Metabolism. Jan, 2021 | Pubmed ID: 33303984 TREM-2 Defends the Liver Against Hepatocellular Carcinoma Through Multifactorial Protective Mechanisms Gut. Jul, 2021 | Pubmed ID: 32907830 Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma Hepatology (Baltimore, Md.). 03, 2021 | Pubmed ID: 32460431 Epigenetic Mechanisms and Metabolic Reprogramming in Fibrogenesis: Dual Targeting of G9a and DNMT1 for the Inhibition of Liver Fibrosis Gut. 02, 2021 | Pubmed ID: 32327527 RNA Sequencing Reveals Changes in the MicroRNAome of Transdifferentiating Hepatic Stellate Cells That Are Conserved Between Human and Rat Scientific Reports. 12, 2020 | Pubmed ID: 33303921 C-Rel Orchestrates Energy-dependent Epithelial and Macrophage Reprogramming in Fibrosis Nature Metabolism. 11, 2020 | Pubmed ID: 33168981 Age-associated Mitochondrial DNA Mutations Cause Metabolic Remodelling That Contributes to Accelerated Intestinal Tumorigenesis Nature Cancer. Oct, 2020 | Pubmed ID: 33073241 Anti-inflammatory Treatment Rescues Memory Deficits During Aging in Nfkb1 Mice Aging Cell. 10, 2020 | Pubmed ID: 32915495 CRel Expression Regulates Distinct Transcriptional and Functional Profiles Driving Fibroblast Matrix Production in Systemic Sclerosis Rheumatology (Oxford, England). 12, 2020 | Pubmed ID: 32725139 Bone Morphogenetic Protein 8B Promotes the Progression of Non-alcoholic Steatohepatitis Nature Metabolism. 06, 2020 | Pubmed ID: 32694734 Renal Injury and Hepatic Effects from the Methylimidazolium Ionic Liquid M8OI in Mouse Ecotoxicology and Environmental Safety. Oct, 2020 | Pubmed ID: 32634706 Long Noncoding RNA H19X is a Key Mediator of TGF-β-driven Fibrosis The Journal of Clinical Investigation. 09, 2020 | Pubmed ID: 32603313 FPR-1 is an Important Regulator of Neutrophil Recruitment and a Tissue-specific Driver of Pulmonary Fibrosis JCI Insight. 02, 2020 | Pubmed ID: 32102985 Loss of ELK1 Has Differential Effects on Age-dependent Organ Fibrosis The International Journal of Biochemistry & Cell Biology. 03, 2020 | Pubmed ID: 31877385 Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease Hepatology (Baltimore, Md.). 03, 2020 | Pubmed ID: 31378982 Implementation of Pre-clinical Methodologies to Study Fibrosis and Test Anti-fibrotic Therapy Current Opinion in Pharmacology. 12, 2019 | Pubmed ID: 31731225 Editorial Overview: Fibrosis Current Opinion in Pharmacology. 12, 2019 | Pubmed ID: 31699602 Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells Gastroenterology. 11, 2019 | Pubmed ID: 31352003 Sinusoidal and Pericellular Fibrosis in Adult Post-transplant Liver Biopsies: Association with Hepatic Stellate Cell Activation and Patient Outcome Virchows Archiv : an International Journal of Pathology. Aug, 2019 | Pubmed ID: 31201503 A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices Hepatology (Baltimore, Md.). 10, 2019 | Pubmed ID: 30963615 Enhanced in Vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice Using a Highly Bright Near-Infrared BODIPY Dye ChemMedChem. 05, 2019 | Pubmed ID: 30920173 Phosphatidylglycerols Are Induced by Gut Dysbiosis and Inflammation, and Favorably Modulate Adipose Tissue Remodeling in Obesity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2019 | Pubmed ID: 30608881 Rapamycin Improves Healthspan but Not Inflammaging in Nfκb1 Mice Aging Cell. 02, 2019 | Pubmed ID: 30468013 Identification of a Novel TIF-IA-NF-κB Nucleolar Stress Response Pathway Nucleic Acids Research. 07, 2018 | Pubmed ID: 29873780 Non-parenchymal TREM-2 Protects the Liver from Immune-mediated Hepatocellular Damage Gut. Jan, 2018 | Pubmed ID: 29374630 The New-generation Pan-peroxisome Proliferator-activated Receptor Agonist IVA337 Protects the Liver from Metabolic Disorders and Fibrosis Hepatology Communications. 08, 2017 | Pubmed ID: 29404476 The NF-κB1 is a Key Regulator of Acute but Not Chronic Renal Injury Cell Death & Disease. 06, 2017 | Pubmed ID: 28617440 A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A Molecular Therapy : the Journal of the American Society of Gene Therapy. 01, 2017 | Pubmed ID: 28129116 A New Fluorescence-based Optical Imaging Method to Non-invasively Monitor Hepatic Myofibroblasts in Vivo Journal of Hepatology. 07, 2016 | Pubmed ID: 27067455 TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury Journal of Immunology (Baltimore, Md. : 1950). 05, 2016 | Pubmed ID: 27053764 Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum Annual Review of Pathology. 05, 2016 | Pubmed ID: 26980160 Inhibition of Lysosomal Protease Cathepsin D Reduces Renal Fibrosis in Murine Chronic Kidney Disease Scientific Reports. Feb, 2016 | Pubmed ID: 26831567 Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2 Arthritis & Rheumatology (Hoboken, N.J.). 06, 2016 | Pubmed ID: 26814616 Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis After Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation PloS One. 2015 | Pubmed ID: 26302150 Ubiquitin C-terminal Hydrolase 1: A Novel Functional Marker for Liver Myofibroblasts and a Therapeutic Target in Chronic Liver Disease Journal of Hepatology. Dec, 2015 | Pubmed ID: 26264933 Chronic Inflammation Induces Telomere Dysfunction and Accelerates Ageing in Mice Nature Communications. Jun, 2014 | Pubmed ID: 24960204 Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response Via TLR3 PloS One. 2014 | Pubmed ID: 24416163 A TLR2/S100A9/CXCL-2 Signaling Network is Necessary for Neutrophil Recruitment in Acute and Chronic Liver Injury in the Mouse Journal of Hepatology. Apr, 2014 | Pubmed ID: 24333183 Noninvasive in Vivo Magnetic Resonance Measures of Glutathione Synthesis in Human and Rat Liver As an Oxidative Stress Biomarker Hepatology (Baltimore, Md.). Jun, 2014 | Pubmed ID: 24242936 Utility of B-13 Progenitor-derived Hepatocytes in Hepatotoxicity and Genotoxicity Studies Toxicological Sciences : an Official Journal of the Society of Toxicology. Feb, 2014 | Pubmed ID: 24235770 The C-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in Mice The American Journal of Pathology. Jun, 2013 | Pubmed ID: 23562440 Tumor Progression Locus 2/Cot is Required for Activation of Extracellular Regulated Kinase in Liver Injury and Toll-like Receptor-induced TIMP-1 Gene Transcription in Hepatic Stellate Cells in Mice Hepatology (Baltimore, Md.). Mar, 2013 | Pubmed ID: 23080298 Serotonin Paracrine Signaling in Tissue Fibrosis Biochimica Et Biophysica Acta. Jul, 2013 | Pubmed ID: 23032152 Inhibition of RelA-Ser536 Phosphorylation by a Competing Peptide Reduces Mouse Liver Fibrosis Without Blocking the Innate Immune Response Hepatology (Baltimore, Md.). Feb, 2013 | Pubmed ID: 22996371 Multigenerational Epigenetic Adaptation of the Hepatic Wound-healing Response Nature Medicine. Sep, 2012 | Pubmed ID: 22941276 Mechanisms and Biomarkers of Apoptosis in Liver Disease and Fibrosis International Journal of Hepatology. 2012 | Pubmed ID: 22567408 Histone Methyltransferase ASH1 Orchestrates Fibrogenic Gene Transcription During Myofibroblast Transdifferentiation Hepatology (Baltimore, Md.). Sep, 2012 | Pubmed ID: 22488473 Roles of C-Rel Signalling in Inflammation and Disease The International Journal of Biochemistry & Cell Biology. Jun, 2012 | Pubmed ID: 22405852 The NF-κB Subunit C-Rel Stimulates Cardiac Hypertrophy and Fibrosis The American Journal of Pathology. Mar, 2012 | Pubmed ID: 22210479 BAG-1 Interacts with the P50-p50 Homodimeric NF-κB Complex: Implications for Colorectal Carcinogenesis Oncogene. May, 2012 | Pubmed ID: 21963853 Stimulating Healthy Tissue Regeneration by Targeting the 5-HT₂B Receptor in Chronic Liver Disease Nature Medicine. Nov, 2011 | Pubmed ID: 22120177 The NF-kappaB P50:p50:HDAC-1 Repressor Complex Orchestrates Transcriptional Inhibition of Multiple Pro-inflammatory Genes Journal of Hepatology. Sep, 2010 | Pubmed ID: 20579762 The C-Rel Subunit of Nuclear Factor-kappaB Regulates Murine Liver Inflammation, Wound-healing, and Hepatocyte Proliferation Hepatology (Baltimore, Md.). Mar, 2010 | Pubmed ID: 20058312 MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis Gastroenterology. Feb, 2010 | Pubmed ID: 19843474 Angiotensin II Activates I KappaB Kinase Phosphorylation of RelA at Ser 536 to Promote Myofibroblast Survival and Liver Fibrosis Gastroenterology. Jun, 2009 | Pubmed ID: 19303015 NF-kappaB is a Critical Regulator of the Survival of Rodent and Human Hepatic Myofibroblasts Journal of Hepatology. Apr, 2008 | Pubmed ID: 18279996 Nuclear Factor-kappaB1: Regulation and Function The International Journal of Biochemistry & Cell Biology. 2008 | Pubmed ID: 17693123 מודל ספרואידי תלת מימדי לחקר האינטראקציה בין גידולים סרטניים בקרצינומה הפטוקולרית Marco Y. W. Zaki*1,2, Shishir Shetty*2, Alex L. Wilkinson2, Daniel A. Patten2, Fiona Oakley*3, Helen Reeves*4,5 1Department of Biochemistry, Faculty of Pharmacy, Minia University, 2National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, 3Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, 4Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, 5The Liver Unit, Department of Medicine, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust JoVE 62868 Pesquisa do câncer
מודל ספרואידי תלת מימדי לחקר האינטראקציה בין גידולים סרטניים בקרצינומה הפטוקולרית Marco Y. W. Zaki*1,2, Shishir Shetty*2, Alex L. Wilkinson2, Daniel A. Patten2, Fiona Oakley*3, Helen Reeves*4,5 1Department of Biochemistry, Faculty of Pharmacy, Minia University, 2National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, 3Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, 4Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, 5The Liver Unit, Department of Medicine, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust JoVE 62868 Pesquisa do câncer