Frauke Neff Institute of Pathology Helmholtz Zentrum Munich Biography Publications Institution JoVE Articles Frauke Neff has not added a biography. If you are Frauke Neff and would like to personalize this page please email our Author Liaison for assistance. Publications Analysis of Mammalian Gene Function Through Broad-based Phenotypic Screens Across a Consortium of Mouse Clinics Nature Genetics. Jul, 2015 | Pubmed ID: 26214591 Genetic Disruption of Uncoupling Protein 1 in Mice Renders Brown Adipose Tissue a Significant Source of FGF21 Secretion Molecular Metabolism. Jul, 2015 | Pubmed ID: 26137441 Efficacy and Tolerability of a GD2-Directed Trifunctional Bispecific Antibody in a Preclinical Model: Subcutaneous Administration Is Superior to Intravenous Delivery Molecular Cancer Therapeutics. Aug, 2015 | Pubmed ID: 26063765 MiR-34a Deficiency Accelerates Medulloblastoma Formation in Vivo International Journal of Cancer. Journal International Du Cancer. May, 2015 | Pubmed ID: 25348795 The Cognitive Defects of Neonatally Irradiated Mice Are Accompanied by Changed Synaptic Plasticity, Adult Neurogenesis and Neuroinflammation Molecular Neurodegeneration. 2014 | Pubmed ID: 25515237 MTO1-deficient Mouse Model Mirrors the Human Phenotype Showing Complex I Defect and Cardiomyopathy PloS One. 2014 | Pubmed ID: 25506927 Inactivation of the Ferroptosis Regulator Gpx4 Triggers Acute Renal Failure in Mice Nature Cell Biology. Dec, 2014 | Pubmed ID: 25402683 Calcitonin Controls Bone Formation by Inhibiting the Release of Sphingosine 1-phosphate from Osteoclasts Nature Communications. 2014 | Pubmed ID: 25333900 Pleiotropic Functions for Transcription Factor Zscan10 PloS One. 2014 | Pubmed ID: 25111779 Longevity, Aging and Rapamycin Cellular and Molecular Life Sciences : CMLS. Nov, 2014 | Pubmed ID: 25015322 Multimodality Multiparametric Imaging of Early Tumor Response to a Novel Antiangiogenic Therapy Based on Anticalins PloS One. 2014 | Pubmed ID: 24801709 Mitochondrial Dysfunction and Decrease in Body Weight of a Transgenic Knock-in Mouse Model for TDP-43 The Journal of Biological Chemistry. Apr, 2014 | Pubmed ID: 24515116 Gene Trap Mice Reveal an Essential Function of Dual Specificity Phosphatase Dusp16/MKP-7 in Perinatal Survival and Regulation of Toll-like Receptor (TLR)-induced Cytokine Production The Journal of Biological Chemistry. Jan, 2014 | Pubmed ID: 24311790 The Zyxin-related Protein Thyroid Receptor Interacting Protein 6 (TRIP6) is Overexpressed in Ewing's Sarcoma and Promotes Migration, Invasion and Cell Growth Biology of the Cell / Under the Auspices of the European Cell Biology Organization. Nov, 2013 | Pubmed ID: 24033704 A Comparative Phenotypic and Genomic Analysis of C57BL/6J and C57BL/6N Mouse Strains Genome Biology. Jul, 2013 | Pubmed ID: 23902802 Rapamycin Extends Murine Lifespan but Has Limited Effects on Aging The Journal of Clinical Investigation. Aug, 2013 | Pubmed ID: 23863708 An ENU Mutagenesis-derived Mouse Model with a Dominant Jak1 Mutation Resembling Phenotypes of Systemic Autoimmune Disease The American Journal of Pathology. Aug, 2013 | Pubmed ID: 23791841 Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator MRNAs and Control Follicular Helper T Cell Differentiation Immunity. Apr, 2013 | Pubmed ID: 23583643 Innovations in Phenotyping of Mouse Models in the German Mouse Clinic Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2012 | Pubmed ID: 22926221 Srgap3⁻/⁻ Mice Present a Neurodevelopmental Disorder with Schizophrenia-related Intermediate Phenotypes FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2012 | Pubmed ID: 22820399 Cytochrome C Oxidase Subunit 4 Isoform 2-knockout Mice Show Reduced Enzyme Activity, Airway Hyporeactivity, and Lung Pathology FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2012 | Pubmed ID: 22730437 Large-scale Phenotyping of an Accurate Genetic Mouse Model of JNCL Identifies Novel Early Pathology Outside the Central Nervous System PloS One. 2012 | Pubmed ID: 22701626 Small-animal PET Imaging of Amyloid-beta Plaques with [11C]PiB and Its Multi-modal Validation in an APP/PS1 Mouse Model of Alzheimer's Disease PloS One. 2012 | Pubmed ID: 22427802 Label-free Protein Profiling of Formalin-fixed Paraffin-embedded (FFPE) Heart Tissue Reveals Immediate Mitochondrial Impairment After Ionising Radiation Journal of Proteomics. Apr, 2012 | Pubmed ID: 22387116 Therapeutic Efficacy and Toxicity of 225Ac-labelled Vs. 213Bi-labelled Tumour-homing Peptides in a Preclinical Mouse Model of Peritoneal Carcinomatosis European Journal of Nuclear Medicine and Molecular Imaging. Apr, 2012 | Pubmed ID: 22237842 STEAP1 is Associated with the Invasive and Oxidative Stress Phenotype of Ewing Tumors Molecular Cancer Research : MCR. Jan, 2012 | Pubmed ID: 22080479 Loss of Roquin Induces Early Death and Immune Deregulation but Not Autoimmunity The Journal of Experimental Medicine. Aug, 2011 | Pubmed ID: 21844204 Rapid Proteomic Remodeling of Cardiac Tissue Caused by Total Body Ionizing Radiation Proteomics. Aug, 2011 | Pubmed ID: 21751382 Naturally Occurring Autoantibodies Against Beta-amyloid: Investigating Their Role in Transgenic Animal and in Vitro Models of Alzheimer's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2011 | Pubmed ID: 21490226 Validation of Preclinical Multiparametric Imaging for Prediction of Necrosis in Hepatocellular Carcinoma After Embolization Journal of Hepatology. Nov, 2011 | Pubmed ID: 21354233 Mouse Phenotyping Methods (San Diego, Calif.). Feb, 2011 | Pubmed ID: 20708688 Pheochromocytoma in Rats with Multiple Endocrine Neoplasia (MENX) Shares Gene Expression Patterns with Human Pheochromocytoma Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010 | Pubmed ID: 20937862 Intravenous Immunoglobulins As a Treatment for Alzheimer's Disease: Rationale and Current Evidence Drugs. Mar, 2010 | Pubmed ID: 20329802 The Role of Macrophage Migration Inhibitory Factor in Alzheimer's Disease Molecular Medicine (Cambridge, Mass.). Mar, 2010 | Pubmed ID: 20200619 APP Transgenic Mice: the Effect of Active and Passive Immunotherapy in Cognitive Tasks Neuroscience and Biobehavioral Reviews. Mar, 2010 | Pubmed ID: 19857518 Immunization As Treatment for Parkinson's Disease Journal of Neural Transmission. Supplementum. 2009 | Pubmed ID: 20411789 Y-box-binding Protein YB-1 Identifies High-risk Patients with Primary Breast Cancer Benefiting from Rapidly Cycled Tandem High-dose Adjuvant Chemotherapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2009 | Pubmed ID: 19901122 Centrosome Abnormalities in Head and Neck Squamous Cell Carcinoma (HNSCC) Acta Oto-laryngologica. Feb, 2009 | Pubmed ID: 18607971 [Therapy of Alzheimer's Disease: Current Status and Future Development] Neuropsychiatrie : Klinik, Diagnostik, Therapie Und Rehabilitation : Organ Der Gesellschaft Österreichischer Nervenärzte Und Psychiater. 2008 | Pubmed ID: 18826870 Immunotherapy and Naturally Occurring Autoantibodies in Neurodegenerative Disorders Autoimmunity Reviews. Jun, 2008 | Pubmed ID: 18558370 Systemic Inflammatory Response Syndrome Increases Immobility-induced Neuromuscular Weakness Critical Care Medicine. Mar, 2008 | Pubmed ID: 18431280 A 35-year-old Woman with an Intrasellar and Suprasellar Lesion Brain Pathology (Zurich, Switzerland). Jan, 2008 | Pubmed ID: 18226104 Evaluation of a Fibroelastoma with Magnetic Resonance Imaging European Heart Journal. Jun, 2008 | Pubmed ID: 18174204 A Functional Polymorphism Within Plasminogen Activator Urokinase (PLAU) is Associated with Alzheimer's Disease Human Molecular Genetics. Aug, 2006 | Pubmed ID: 16825285 Regional Vulnerability of Mesencephalic Dopaminergic Neurons Prone to Degenerate in Parkinson's Disease: a Post-mortem Study in Human Control Subjects Neurobiology of Disease. Aug, 2006 | Pubmed ID: 16753304 Neurologic Outcome After Cardiopulmonary Bypass with Deep Hypothermic Circulatory Arrest in Rats: Description of a New Model The Journal of Thoracic and Cardiovascular Surgery. Apr, 2006 | Pubmed ID: 16580438 Gene Expression Profiling of Lewy Body-bearing Neurons in Parkinson's Disease Experimental Neurology. Sep, 2005 | Pubmed ID: 15944136 Serial Induction of Mutations by Ethylnitrosourea in PC12 Cells: a New Model for a Phenotypical Characterization of the Neurotoxic Response to 6-hydroxydopamine Journal of Neuroscience Methods. Aug, 2004 | Pubmed ID: 15262063 Gene Expression Profiles Derived from Single Cells in Human Postmortem Brain Brain Research. Brain Research Protocols. Apr, 2004 | Pubmed ID: 15063837 Heterotopic Cervical Heart Transplantation in Mice Thomas Ratschiller1,4, Marcus-André Deutsch1, Julia Calzada-Wack2, Frauke Neff2, Christiane Roesch3, Ralf Guenzinger3, Ruediger Lange3, Markus Krane3 1Department of Cardiovascular Surgery, Division of Experimental Surgery, German Heart Center Munich, Technische Universität München, 2Institute of Pathology, Helmholtz Zentrum Munich, 3Department of Cardiovascular Surgery, Division of Experimental Surgery, German Heart Center Munich, Technische Universität München, 4Department of Cardiovascular and Thoracic Surgery, General Hospital Linz JoVE 52907 Medicina
Heterotopic Cervical Heart Transplantation in Mice Thomas Ratschiller1,4, Marcus-André Deutsch1, Julia Calzada-Wack2, Frauke Neff2, Christiane Roesch3, Ralf Guenzinger3, Ruediger Lange3, Markus Krane3 1Department of Cardiovascular Surgery, Division of Experimental Surgery, German Heart Center Munich, Technische Universität München, 2Institute of Pathology, Helmholtz Zentrum Munich, 3Department of Cardiovascular Surgery, Division of Experimental Surgery, German Heart Center Munich, Technische Universität München, 4Department of Cardiovascular and Thoracic Surgery, General Hospital Linz JoVE 52907 Medicina