Gijs R. Van den Brink Tytgat Institute for Liver and Intestinal Research, Department of Gasteroenterology and Hepatology Academical Medical Center Biography Publications Institution JoVE Articles Gijs R. Van den Brink has not added a biography. If you are Gijs R. Van den Brink and would like to personalize this page please email our Author Liaison for assistance. Publications Findings from a Randomized Controlled Trial of Fecal Transplantation for Patients with Ulcerative Colitis Gastroenterology. Mar, 2015 | Pubmed ID: 25836986 Safety and Feasability of Using the Second-Generation Pillcam Colon Capsule to Assess Active Colonic Crohn's Disease Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Mar, 2015 | Pubmed ID: 25804331 HDAC1 and HDAC2 Collectively Regulate Intestinal Stem Cell Homeostasis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2015 | Pubmed ID: 25648995 Stromal Indian Hedgehog Signaling is Required for Intestinal Adenoma Formation in Mice Gastroenterology. Jan, 2015 | Pubmed ID: 25307863 ER Stress Induces Epithelial Differentiation in the Mouse Oesophagus Gut. Feb, 2015 | Pubmed ID: 24789843 Azathioprine Does Not Reduce Adenoma Formation in a Mouse Model of Sporadic Intestinal Tumorigenesis World Journal of Gastroenterology : WJG. Nov, 2014 | Pubmed ID: 25469037 Sex Disparity in Colonic Adenomagenesis Involves Promotion by Male Hormones, Not Protection by Female Hormones Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25368192 Length of Hospital Stay and Associated Hospital Costs with Infliximab Versus Cyclosporine in Severe Ulcerative Colitis European Journal of Gastroenterology & Hepatology. Nov, 2014 | Pubmed ID: 25171024 Repurposing Miltefosine for the Treatment of Immune-mediated Disease? The Journal of Pharmacology and Experimental Therapeutics. Aug, 2014 | Pubmed ID: 24833702 Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis Via Activation of Rho and ROCK Gastroenterology. Jul, 2014 | Pubmed ID: 24704720 Vitamin D Deficiency in Crohn's Disease and Healthy Controls: a Prospective Case-control Study in the Netherlands Journal of Crohn's & Colitis. Oct, 2014 | Pubmed ID: 24666975 Effects of Infliximab Retreatment After Consecutive Discontinuation of Infliximab and Adalimumab in Refractory Crohn's Disease Inflammatory Bowel Diseases. Feb, 2014 | Pubmed ID: 24378599 Selective Inhibition of Mucosal Serotonin As Treatment for IBD? Gut. Jun, 2014 | Pubmed ID: 23868328 Oestrogens Promote Tumorigenesis in a Mouse Model for Colitis-associated Cancer Gut. Feb, 2014 | Pubmed ID: 23408349 Miltefosine Suppresses Inflammation in a Mouse Model of Inflammatory Bowel Disease Inflammatory Bowel Diseases. Aug, 2013 | Pubmed ID: 23811637 Superantigen-induced Steroid Resistance Depends on Activation of Phospholipase Cβ2 Journal of Immunology (Baltimore, Md. : 1950). Jun, 2013 | Pubmed ID: 23690479 ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness Through Activation of the Unfolded Protein Response Cell Reports. Apr, 2013 | Pubmed ID: 23545496 Foxf2: a Mesenchymal Regulator of Intestinal Adenoma Development Gastroenterology. May, 2013 | Pubmed ID: 23523844 Biosimilars in IBD: Hope or Expectation? Gut. Jun, 2013 | Pubmed ID: 23503043 Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-cell-like Properties Cell. Jan, 2013 | Pubmed ID: 23273993 Inactivation of Patched1 in Mice Leads to Development of Gastrointestinal Stromal-like Tumors That Express Pdgfrα but Not Kit Gastroenterology. Jan, 2013 | Pubmed ID: 23041331 Impaired Autophagy Leads to Abnormal Dendritic Cell-epithelial Cell Interactions Journal of Crohn's & Colitis. Aug, 2013 | Pubmed ID: 22981596 Hedgehog Signalling Stimulates Precursor Cell Accumulation and Impairs Epithelial Maturation in the Murine Oesophagus Gut. Mar, 2013 | Pubmed ID: 22504664 Rage Mediated DAMP Signaling in Intestinal Tumorigenesis Oncoimmunology. Oct, 2012 | Pubmed ID: 23170266 Hedgehog Signaling and Maintenance of Homeostasis in the Intestinal Epithelium Physiology (Bethesda, Md.). Jun, 2012 | Pubmed ID: 22689790 Asb11 is a Regulator of Embryonic and Adult Regenerative Myogenesis Stem Cells and Development. Nov, 2012 | Pubmed ID: 22512762 Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse Gastroenterology. Jun, 2012 | Pubmed ID: 22370477 A Major Advance in Ex Vivo Intestinal Organ Culture Gut. Jul, 2012 | Pubmed ID: 22315470 5-Aminosalicylic Acid Inhibits Cell Cycle Progression in a Phospholipase D Dependent Manner in Colorectal Cancer Gut. Dec, 2012 | Pubmed ID: 22187071 Regulatory Macrophages Induced by Infliximab Are Involved in Healing in Vivo and in Vitro Inflammatory Bowel Diseases. Mar, 2012 | Pubmed ID: 21936028 Pretreatment with Interferon-γ Enhances the Therapeutic Activity of Mesenchymal Stromal Cells in Animal Models of Colitis Stem Cells (Dayton, Ohio). Oct, 2011 | Pubmed ID: 21898680 Blimp1 Regulates the Transition of Neonatal to Adult Intestinal Epithelium Nature Communications. 2011 | Pubmed ID: 21878906 Mesenchymal Stromal Cell Function is Not Affected by Drugs Used in the Treatment of Inflammatory Bowel Disease Cytotherapy. Oct, 2011 | Pubmed ID: 21846292 Intestinal Tumorigenesis is Not Affected by Progesterone Signaling in Rodent Models PloS One. 2011 | Pubmed ID: 21818351 Statins Augment the Chemosensitivity of Colorectal Cancer Cells Inducing Epigenetic Reprogramming and Reducing Colorectal Cancer Cell 'stemness' Via the Bone Morphogenetic Protein Pathway Gut. Nov, 2011 | Pubmed ID: 21551187 Neutralizing Antibodies Against Adeno-associated Viruses in Inflammatory Bowel Disease Patients: Implications for Gene Therapy Inflammatory Bowel Diseases. Dec, 2011 | Pubmed ID: 21370319 FXR Activation Inhibits Inflammation and Preserves the Intestinal Barrier in IBD Gut. Apr, 2011 | Pubmed ID: 21270116 Anti-tumor Necrosis Factor-α Antibodies Induce Regulatory Macrophages in an Fc Region-dependent Manner Gastroenterology. Jan, 2011 | Pubmed ID: 20955706 Morphogens and the Parietal Cell: Shaping Up Acid Secretion Gastroenterology. Dec, 2010 | Pubmed ID: 21029799 Autologous Bone Marrow-derived Mesenchymal Stromal Cell Treatment for Refractory Luminal Crohn's Disease: Results of a Phase I Study Gut. Dec, 2010 | Pubmed ID: 20921206 Cyclin D2-cyclin-dependent Kinase 4/6 is Required for Efficient Proliferation and Tumorigenesis Following Apc Loss Cancer Research. Oct, 2010 | Pubmed ID: 20736363 Loss of Indian Hedgehog Activates Multiple Aspects of a Wound Healing Response in the Mouse Intestine Gastroenterology. Nov, 2010 | Pubmed ID: 20682322 The Role of EZH2 and DNA Methylation in the Silencing of the Tumour Suppressor RUNX3 in Colorectal Cancer Carcinogenesis. Sep, 2010 | Pubmed ID: 20631058 The Absence of Functional PI3Kgamma Prevents Leukocyte Recruitment and Ameliorates DSS-induced Colitis in Mice Immunology Letters. Jun, 2010 | Pubmed ID: 20347874 Sonic Hedgehog: a Link Between Inflammation, Gastric Atrophy, and Acid Suppression? Gastroenterology. Feb, 2010 | Pubmed ID: 20034600 Quality of Web-based Information on Inflammatory Bowel Diseases Inflammatory Bowel Diseases. Dec, 2009 | Pubmed ID: 19462423 Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway Gastroenterology. Jun, 2009 | Pubmed ID: 19272384 Cytokine Responses in Very Low Birth Weight Infants Receiving Glutamine-enriched Enteral Nutrition Journal of Pediatric Gastroenterology and Nutrition. Jan, 2009 | Pubmed ID: 19172131 Bone Morphogenetic Protein Signalling in Colorectal Cancer Nature Reviews. Cancer. Oct, 2008 | Pubmed ID: 18756288 The Bone Morphogenetic Protein Pathway is Inactivated in the Majority of Sporadic Colorectal Cancers Gastroenterology. May, 2008 | Pubmed ID: 18471510 The Bone Morphogenetic Protein Pathway is Active in Human Colon Adenomas and Inactivated in Colorectal Cancer Cancer. Jan, 2008 | Pubmed ID: 18008360 Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract Physiological Reviews. Oct, 2007 | Pubmed ID: 17928586 The Effect of Statins in Colorectal Cancer is Mediated Through the Bone Morphogenetic Protein Pathway Gastroenterology. Oct, 2007 | Pubmed ID: 17919499 Bone Morphogenetic Protein Signaling Suppresses Tumorigenesis at Gastric Epithelial Transition Zones in Mice Cancer Research. Sep, 2007 | Pubmed ID: 17804727 Glucocorticoid Signaling: a Nongenomic Mechanism for T-cell Immunosuppression Trends in Molecular Medicine. Apr, 2007 | Pubmed ID: 17293163 The Morphogenetic Code and Colon Cancer Development Cancer Cell. Feb, 2007 | Pubmed ID: 17292823 Bone Morphogenetic Protein-2 is a Negative Regulator of Hepatocyte Proliferation Downregulated in the Regenerating Liver World Journal of Gastroenterology : WJG. Dec, 2006 | Pubmed ID: 17171790 Expression of Hedgehog Pathway Components in the Adult Colon Gastroenterology. Feb, 2006 | Pubmed ID: 16472622 Down-regulation of a Morphogen (sonic Hedgehog) Gradient in the Gastric Epithelium of Helicobacter Pylori-infected Mongolian Gerbils The Journal of Pathology. Jun, 2005 | Pubmed ID: 15818572 Hh Pathway Expression in Human Gut Tissues and in Inflammatory Gut Diseases Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2004 | Pubmed ID: 15502857 Linking Pathways in Colorectal Cancer Nature Genetics. Oct, 2004 | Pubmed ID: 15454939 Regulatory Regions in the Rat Lactase-phlorizin Hydrolase Gene That Control Cell-specific Expression Journal of Pediatric Gastroenterology and Nutrition. Sep, 2004 | Pubmed ID: 15319629 DNA Array Analysis of the Effects of Aspirin on Colon Cancer Cells: Involvement of Rac1 Carcinogenesis. Jul, 2004 | Pubmed ID: 14976132 Indian Hedgehog is an Antagonist of Wnt Signaling in Colonic Epithelial Cell Differentiation Nature Genetics. Mar, 2004 | Pubmed ID: 14770182 Bone Morphogenetic Protein 2 is Expressed By, and Acts Upon, Mature Epithelial Cells in the Colon Gastroenterology. Jan, 2004 | Pubmed ID: 14699493 Infliximab but Not Etanercept Induces Apoptosis in Lamina Propria T-lymphocytes from Patients with Crohn's Disease Gastroenterology. Jun, 2003 | Pubmed ID: 12806611 Conscious Sedation for EUS of the Esophagus and Stomach: a Double-blind, Randomized, Controlled Trial Comparing Midazolam with Placebo Gastrointestinal Endoscopy. Jun, 2003 | Pubmed ID: 12776030 From Extracellular to Intracellular Targets, Inhibiting MAP Kinases in Treatment of Crohn's Disease Annals of the New York Academy of Sciences. Nov, 2002 | Pubmed ID: 12485892 Feed a Cold, Starve a Fever? Clinical and Diagnostic Laboratory Immunology. Jan, 2002 | Pubmed ID: 11777851 A Protocol for Lentiviral Transduction and Downstream Analysis of Intestinal Organoids Jooske F. Van Lidth de Jeude1, Jacqueline L. M. Vermeulen1, Paula S. Montenegro-Miranda1, Gijs R. Van den Brink1, Jarom Heijmans1 1Tytgat Institute for Liver and Intestinal Research, Department of Gasteroenterology and Hepatology, Academical Medical Center JoVE 52531 Biologia
A Protocol for Lentiviral Transduction and Downstream Analysis of Intestinal Organoids Jooske F. Van Lidth de Jeude1, Jacqueline L. M. Vermeulen1, Paula S. Montenegro-Miranda1, Gijs R. Van den Brink1, Jarom Heijmans1 1Tytgat Institute for Liver and Intestinal Research, Department of Gasteroenterology and Hepatology, Academical Medical Center JoVE 52531 Biologia