Han Yifan Department of Applied Biology and Chemistry Technology, Institute of Modern Chinese Medicine The Hong Kong Polytechnic University Biography Publications Institution JoVE Articles Han Yifan has not added a biography. If you are Han Yifan and would like to personalize this page please email our Author Liaison for assistance. Publications L-F001, a Novel Multifunctional ROCK Inhibitor, Suppresses Neuroinflammation in Vitro and in Vivo: Involvement of NF-κB Inhibition and Nrf2 Pathway Activation European Journal of Pharmacology. Mar, 2017 | Pubmed ID: 28320516 Inhibition of AGEs/RAGE/Rho/ROCK Pathway Suppresses Non-specific Neuroinflammation by Regulating BV2 Microglial M1/M2 Polarization Through the NF-κB Pathway Journal of Neuroimmunology. Apr, 2017 | Pubmed ID: 28284330 Discovery of Novel Rivastigmine-hydroxycinnamic Acid Hybrids As Multi-targeted Agents for Alzheimer's Disease European Journal of Medicinal Chemistry. Jan, 2017 | Pubmed ID: 27736684 Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis Via Concurrently Inhibiting GSK3β and the ERK Pathway Cellular and Molecular Neurobiology. May, 2017 | Pubmed ID: 27412761 Neuroprotection Against Glutamate-induced Excitotoxicity and Induction of Neurite Outgrowth by T-006, a Novel Multifunctional Derivative of Tetramethylpyrazine in Neuronal Cell Models Neurochemistry International. Oct, 2016 | Pubmed ID: 27445088 Potent Protection Against MPP(+)-Induced Neurotoxicity Via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Neuromolecular Medicine. Dec, 2016 | Pubmed ID: 27277280 Multifunction of Chrysin in Parkinson's Model: Anti-Neuronal Apoptosis, Neuroprotection Via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B Journal of Agricultural and Food Chemistry. Jul, 2016 | Pubmed ID: 27245668 Gallic Acid-l-leucine (GAL) Conjugate Enhances Macrophage Phagocytosis Via Inducing Leukotriene B4 12-hydroxydehydrogenase (LTB4DH) Expression Molecular Immunology. Jun, 2016 | Pubmed ID: 27148819 Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice ACS Chemical Neuroscience. Aug, 2016 | Pubmed ID: 27046396 Plant Natural Product Formononetin Protects Rat Cardiomyocyte H9c2 Cells Against Oxygen Glucose Deprivation and Reoxygenation Via Inhibiting ROS Formation and Promoting GSK-3β Phosphorylation Oxidative Medicine and Cellular Longevity. 2016 | Pubmed ID: 27034732 Miracle Fruit (Synsepalum Dulcificum) Exhibits As a Novel Anti-Hyperuricaemia Agent Molecules (Basel, Switzerland). Jan, 2016 | Pubmed ID: 26821007 Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits As Well As Synaptic Formation and Plasticity Impairments Via the Activation of PI3-K Pathway Molecular Neurobiology. Aug, 2016 | Pubmed ID: 26160762 A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells Journal of Cellular Biochemistry. Jan, 2016 | Pubmed ID: 26058377 In Vitro and in Vivo Anticancer Activity of Pardaxin Against Proliferation and Growth of Oral Squamous Cell Carcinoma Marine Drugs. Dec, 2015 | Pubmed ID: 26703631 Tanshinone II A, a Multiple Target Neuroprotectant, Promotes Caveolae-dependent Neuronal Differentiation European Journal of Pharmacology. Oct, 2015 | Pubmed ID: 26363255 Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells Via Activating MEF2D Through the Inhibition of GSK3β Journal of Molecular Neuroscience : MN. Dec, 2015 | Pubmed ID: 26346600 Protection Against β-amyloid-induced Synaptic and Memory Impairments Via Altering β-amyloid Assembly by Bis(heptyl)-cognitin Scientific Reports. Jul, 2015 | Pubmed ID: 26194093 Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin Via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer ACS Chemical Neuroscience. Sep, 2015 | Pubmed ID: 26147504 PLU-1/JARID1B Overexpression Predicts Proliferation Properties in Head and Neck Squamous Cell Carcinoma Oncology Reports. May, 2015 | Pubmed ID: 25777981 Silk-based Biomaterials in Biomedical Textiles and Fiber-based Implants Advanced Healthcare Materials. Jun, 2015 | Pubmed ID: 25772248 Examining the Neuroprotective Effects of Protocatechuic Acid and Chrysin on in Vitro and in Vivo Models of Parkinson Disease Free Radical Biology & Medicine. Jul, 2015 | Pubmed ID: 25769424 An Analysis of Chemical Ingredients Network of Chinese Herbal Formulae for the Treatment of Coronary Heart Disease PloS One. 2015 | Pubmed ID: 25658855 Synthesis and Pharmacological Evaluation of Multifunctional Tacrine Derivatives Against Several Disease Pathways of AD Bioorganic & Medicinal Chemistry Letters. Feb, 2015 | Pubmed ID: 25597007 Inhibiting β-amyloid-associated Alzheimer's Pathogenesis in Vitro and in Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue Journal of Molecular Neuroscience : MN. Apr, 2015 | Pubmed ID: 25407821 Synthesis, Biological Activity, and Biopharmaceutical Characterization of Tacrine Dimers As Acetylcholinesterase Inhibitors International Journal of Pharmaceutics. Dec, 2014 | Pubmed ID: 25445524 Synergistic Inhibition on Acetylcholinesterase by the Combination of Berberine and Palmatine Originally Isolated from Chinese Medicinal Herbs Journal of Molecular Neuroscience : MN. Jul, 2014 | Pubmed ID: 24793543 The Novel Tetramethylpyrazine Bis-nitrone (TN-2) Protects Against MPTP/MPP+-induced Neurotoxicity Via Inhibition of Mitochondrial-dependent Apoptosis Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Mar, 2014 | Pubmed ID: 24233519 Sulfur-oxidizing Bacteria Dominate the Microbial Diversity Shift During the Pyrite and Low-grade Pyrolusite Bioleaching Process Journal of Bioscience and Bioengineering. May, 2013 | Pubmed ID: 23673133 Bis(propyl)-cognitin Protects Against Glutamate-induced Neuro-excitotoxicity Via Concurrent Regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β Pathways Neurochemistry International. Mar, 2013 | Pubmed ID: 23357479 Bis(12)-hupyridone, a Novel Acetylcholinesterase Inhibitor, Protects Against Glutamate-induced Neuronal Excitotoxicity Via Activating α7 Nicotinic Acetylcholine Receptor/phosphoinositide 3-kinase/Akt Cascade Chemico-biological Interactions. Mar, 2013 | Pubmed ID: 23085120 The Anti-cancer Agent SU4312 Unexpectedly Protects Against MPP(+) -induced Neurotoxicity Via Selective and Direct Inhibition of Neuronal NOS British Journal of Pharmacology. Mar, 2013 | Pubmed ID: 23062100 Unexpected Neuronal Protection of SU5416 Against 1-Methyl-4-phenylpyridinium Ion-induced Toxicity Via Inhibiting Neuronal Nitric Oxide Synthase PloS One. 2012 | Pubmed ID: 23049997 Activation of Transcription Factor MEF2D by Bis(3)-cognitin Protects Dopaminergic Neurons and Ameliorates Parkinsonian Motor Defects The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22891246 Baicalein Protects Against 6-OHDA-induced Neurotoxicity Through Activation of Keap1/Nrf2/HO-1 and Involving PKCα and PI3K/AKT Signaling Pathways Journal of Agricultural and Food Chemistry. Aug, 2012 | Pubmed ID: 22838648 Z-ligustilide Potentiates the Cytotoxicity of Dopamine in Rat Dopaminergic PC12 Cells Neurotoxicity Research. Nov, 2012 | Pubmed ID: 22451226 소설 다기능 Dimer Tacrine 6 Ferulic 산 아 밀 로이드 β 중재 알 츠 하이 머 병 관련 Pathogenesis를 시험관 및 비보를 억제 한다 PloS One. 2012 | Pubmed ID: 22384101 Acetylcholinesterase is Associated with Apoptosis in β Cells and Contributes to Insulin-dependent Diabetes Mellitus Pathogenesis Acta Biochimica Et Biophysica Sinica. Mar, 2012 | Pubmed ID: 22236578 Potential Roles of PI3K/Akt and Nrf2-Keap1 Pathways in Regulating Hormesis of Z-ligustilide in PC12 Cells Against Oxygen and Glucose Deprivation Neuropharmacology. Mar, 2012 | Pubmed ID: 22146407 Excitotoxic 및 Bis (12)-hupyridone, 여러 대상에 연기를 통해 가능 하 게 새로운 Anti-acetylcholinesterase 이합체에 의해 허 혈 성 모욕 Neuroprotection Brain Research. Nov, 2011 | Pubmed ID: 21978549 Tacrine(2)-ferulic Acid, a Novel Multifunctional Dimer, Attenuates 6-hydroxydopamine-induced Apoptosis in PC12 Cells by Activating Akt Pathway Neurochemistry International. Dec, 2011 | Pubmed ID: 21939707 PI3-K/Akt and ERK Pathways Activated by VEGF Play Opposite Roles in MPP+-induced Neuronal Apoptosis Neurochemistry International. Nov, 2011 | Pubmed ID: 21781996 Pharmacological Induction of Leukotriene B4-12-hydroxydehydrogenase Suppresses the Oncogenic Transformation of Human Hepatoma HepG2 Cells International Journal of Oncology. Sep, 2011 | Pubmed ID: 21687936 Bis(12)-hupyridone, a Novel Multifunctional Dimer, Promotes Neuronal Differentiation More Potently Than Its Monomeric Natural Analog Huperzine A Possibly Through α7 NAChR Brain Research. Jul, 2011 | Pubmed ID: 21665194 Protection Against 1-methyl-4-phenylpyridinium Ion (MPP+)-induced Apoptosis by Water Extract of Ginseng (Panax Ginseng C.A. Meyer) in SH-SY5Y Cells Journal of Ethnopharmacology. Apr, 2011 | Pubmed ID: 21349320 VEGFR-2/Akt 신호 통로 소설 Dimeric Antiacetylcholinesterase 두번째 (12)-hupyridone를 사용 하 여 조절 하 여 소 뇌과 립 신경에 있는 H₂O₂ 유도 Apoptosis를 방지 Brain Research. Jun, 2011 | Pubmed ID: 21315693 병 적 없는 빠른 오프-속도와 소설 다기능 Dimer Bis (프로필)에 의해 N-메 틸-D-aspartate 수용 체 봉쇄를 통해 Neuroprotection 활성화-cognitin The Journal of Biological Chemistry. Jun, 2010 | Pubmed ID: 20404346 Human Cytomegalovirus Induces Caspase-dependent Apoptosis of Megakaryocytic CHRF-288-11 Cells by Activating the JNK Pathway International Journal of Hematology. May, 2010 | Pubmed ID: 20376580 Proteomic Characterization of the Cellular Response to Chemopreventive Triterpenoid Astragaloside IV in Human Hepatocellular Carcinoma Cell Line HepG2 International Journal of Oncology. Mar, 2010 | Pubmed ID: 20126993 Senkyunolides Reduce Hydrogen Peroxide-induced Oxidative Damage in Human Liver HepG2 Cells Via Induction of Heme Oxygenase-1 Chemico-biological Interactions. Feb, 2010 | Pubmed ID: 19961840 동시에 알파-secretase BACE 1의 활동을 조절 유망 다기능 안티-Alzheimer의 Dimer 두번째 (7)-Cognitin의 단백질 키 니 아 제 C 활성 제 역할 European Journal of Pharmacology. Nov, 2009 | Pubmed ID: 19765582 P38 and ERK, but Not JNK, Are Involved in Copper-induced Apoptosis in Cultured Cerebellar Granule Neurons Biochemical and Biophysical Research Communications. Feb, 2009 | Pubmed ID: 19138669 Novel Anti-Alzheimer's Dimer Bis(7)-cognitin: Cellular and Molecular Mechanisms of Neuroprotection Through Multiple Targets Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2009 | Pubmed ID: 19110209 Exposure to Metal Ions Regulates MRNA Levels of APP and BACE1 in PC12 Cells: Blockage by Curcumin Neuroscience Letters. Aug, 2008 | Pubmed ID: 18583042 Bis(7)-tacrine, a Promising Anti-Alzheimer's Dimer, Affords Dose- and Time-dependent Neuroprotection Against Transient Focal Cerebral Ischemia Neuroscience Letters. Jul, 2008 | Pubmed ID: 18515007 Maternal Low-level Lead Exposure Reduces the Expression of PSA-NCAM and the Activity of Sialyltransferase in the Hippocampi of Neonatal Rat Pups Neurotoxicology. Jul, 2008 | Pubmed ID: 18499259 Mecamylamine 조미료 및 차동 Anticholinergic 독립적인 메커니즘을 통해 낮은 칼륨에 의해 유도 된 신경 Apoptosis를 방지 합니다 Neuropharmacology. Mar, 2008 | Pubmed ID: 18222492 유망 안티 츠 Dimer 두번째 (7)-tacrine 직접 BACE 1 활동을 억제 함으로써 베타-아 밀 로이드 생성을 감소 시킨다 Biochemical and Biophysical Research Communications. Feb, 2008 | Pubmed ID: 18039469 소설 Dimeric 두번째 (7)-tacrine 양성자 독립적으로 NMDA 활성 전류를 억제 한다 Biochemical and Biophysical Research Communications. Sep, 2007 | Pubmed ID: 17655827 Mitochondrial Proteomic Analysis and Characterization of the Intracellular Mechanisms of Bis(7)-tacrine in Protecting Against Glutamate-induced Excitotoxicity in Primary Cultured Neurons Journal of Proteome Research. Jul, 2007 | Pubmed ID: 17530875 Inhibition of Glycogen Synthase Kinase-3beta Protects Dopaminergic Neurons from MPTP Toxicity Neuropharmacology. Jun, 2007 | Pubmed ID: 17517424 두번째 (7)-tacrine N-메 틸-D-aspartate 수용 체와 신경 Nitric 산화물 Synthase의 동시 봉쇄를 통해 여 Neuroprotection 시너지 Molecular Pharmacology. May, 2007 | Pubmed ID: 17299028 Alkylene Tether-length Dependent Gamma-aminobutyric Acid Type A Receptor Competitive Antagonism by Tacrine Dimers Neuropharmacology. Feb, 2007 | Pubmed ID: 17056074 Extracellular Signal-regulated Kinases Are Not Involved in Activity-dependent Survival or Apoptosis in Cerebellar Granule Neurons Neuroscience Letters. Oct, 2006 | Pubmed ID: 16973276 두번째 (7)-tacrine L 타입 칼슘 채널을 조절 하 여 베타 아 밀 로이드 유도 신경 Apoptosis를 약화 Journal of Neurochemistry. Sep, 2006 | Pubmed ID: 16771827 Impact of Growth Kinetics on Morphology and Pore Structure of TiO2-one-pot Synthesis of Macroporous TiO2 Microspheres Inorganic Chemistry. Jun, 2006 | Pubmed ID: 16749824 Neuroprotection Via Inhibition of Nitric Oxide Synthase by Bis(7)-tacrine Neuroreport. Apr, 2006 | Pubmed ID: 16543809 Effects of a Memory Enhancing Peptide on Cognitive Abilities of Brain-lesioned Mice: Additivity with Huperzine A and Relative Potency to Tacrine Journal of Peptide Science : an Official Publication of the European Peptide Society. Jan, 2006 | Pubmed ID: 15942937 Identification of a Novel Wee1 Isoform Biochimica Et Biophysica Acta. May, 2005 | Pubmed ID: 15804487 Tacrine-소설 Dimeric Acetylcholinesterase 억제 물 Bis7, 하지만 하지 Donepezil N-메 틸-D-aspartate 수용 체를 차단 하 여 신경 Apoptosis Glutamate 유발을 방지 합니다 The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15710623 Activity Deprivation-dependent Induction of the Proapoptotic BH3-only Protein Bim is Independent of JNK/c-Jun Activation During Apoptosis in Cerebellar Granule Neurons Neuroscience Letters. Feb, 2005 | Pubmed ID: 15664113 Minocycline Prevents Glutamate-induced Apoptosis of Cerebellar Granule Neurons by Differential Regulation of P38 and Akt Pathways Journal of Neurochemistry. Dec, 2004 | Pubmed ID: 15569265 SP600125, a New JNK Inhibitor, Protects Dopaminergic Neurons in the MPTP Model of Parkinson's Disease Neuroscience Research. Feb, 2004 | Pubmed ID: 14741394 소뇌 과립 신경 세포 배양에서 Fluorescein Diacetate-Propidium Iodide 이중 염색을 이용한 신경 생존력의 평가 Lin Jiajia*1, Mak Shinghung*2, Zheng Jiacheng1, Wang Jialing1, Xu Dilin1, Hu Shengquan2, Zhang Zaijun3, Wang Qinwen1, Han Yifan2,4, Cui Wei1,2 1Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 2Department of Applied Biology and Chemistry Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, 3Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, 4International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong JoVE 55442 Neurociência
소뇌 과립 신경 세포 배양에서 Fluorescein Diacetate-Propidium Iodide 이중 염색을 이용한 신경 생존력의 평가 Lin Jiajia*1, Mak Shinghung*2, Zheng Jiacheng1, Wang Jialing1, Xu Dilin1, Hu Shengquan2, Zhang Zaijun3, Wang Qinwen1, Han Yifan2,4, Cui Wei1,2 1Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 2Department of Applied Biology and Chemistry Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, 3Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, 4International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong JoVE 55442 Neurociência
