Inder M. Verma Laboratory of Genetics The Salk Institute for Biological Studies Biography Publications Institution JoVE Articles Inder M. Verma has not added a biography. If you are Inder M. Verma and would like to personalize this page please email our Author Liaison for assistance. Publications Reduced Cell Proliferation by IKK2 Depletion in a Mouse Lung-cancer Model Nature Cell Biology. Feb, 2012 | Pubmed ID: 22327365 QnAs with Inder M. Verma. Interview by Prashant Nair Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22135469 Targeted Nanoparticle Enhanced Proapoptotic Peptide As Potential Therapy for Glioblastoma Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21969599 Tumor Suppressor P53 Functions As a Negative Regulator in IgE-mediated Mast Cell Activation PloS One. 2011 | Pubmed ID: 21966524 Antiapoptotic Protein Lifeguard is Required for Survival and Maintenance of Purkinje and Granular Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21957071 Tumor Suppressor Protein (p)53, is a Regulator of NF-kappaB Repression by the Glucocorticoid Receptor Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21949408 BRCA1 Tumour Suppression Occurs Via Heterochromatin-mediated Silencing Nature. Sep, 2011 | Pubmed ID: 21901007 Brief Report: Efficient Generation of Hematopoietic Precursors and Progenitors from Human Pluripotent Stem Cell Lines Stem Cells (Dayton, Ohio). Jul, 2011 | Pubmed ID: 21544903 Human Xeno-autoantibodies Against a Non-human Sialic Acid Serve As Novel Serum Biomarkers and Immunotherapeutics in Cancer Cancer Research. May, 2011 | Pubmed ID: 21505105 Peripheral Delivery of a CNS Targeted, Metalo-protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease PloS One. 2011 | Pubmed ID: 21304989 Transdifferentiation of Glioblastoma Cells into Vascular Endothelial Cells Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21262804 A High Proliferation Rate is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity Current Biology : CB. Jan, 2011 | Pubmed ID: 21167714 Sulforaphane Inhibits Endothelial Lipase Expression Through NF-κB in Endothelial Cells Atherosclerosis. Nov, 2010 | Pubmed ID: 20688330 Telomere-independent Rap1 is an IKK Adaptor and Regulates NF-kappaB-dependent Gene Expression Nature Cell Biology. Aug, 2010 | Pubmed ID: 20622870 Human Liver Chimeric Mice Provide a Model for Hepatitis B and C Virus Infection and Treatment The Journal of Clinical Investigation. Mar, 2010 | Pubmed ID: 20179355 CtIP Links DNA Double-strand Break Sensing to Resection Molecular Cell. Dec, 2009 | Pubmed ID: 20064462 Hematopoietic Cell-specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-fat-fed Mice Cell Metabolism. Nov, 2009 | Pubmed ID: 19883619 Disease-corrected Haematopoietic Progenitors from Fanconi Anaemia Induced Pluripotent Stem Cells Nature. Jul, 2009 | Pubmed ID: 19483674 Phosphorylation of P53 by IkappaB Kinase 2 Promotes Its Degradation by Beta-TrCP Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19196987 Genic Regions of a Large Salamander Genome Contain Long Introns and Novel Genes BMC Genomics. 2009 | Pubmed ID: 19144141 Microarray and CDNA Sequence Analysis of Transcription During Nerve-dependent Limb Regeneration BMC Biology. 2009 | Pubmed ID: 19144100 Development of a Novel Mouse Glioma Model Using Lentiviral Vectors Nature Medicine. Jan, 2009 | Pubmed ID: 19122659 Design and Cloning of an ShRNA into a Lentiviral Silencing Vector: Version B CSH Protocols. 2008 | Pubmed ID: 21356885 Design and Cloning of an ShRNA into a Lentiviral Silencing Vector: Version A CSH Protocols. 2008 | Pubmed ID: 21356884 Applications of Lentiviral Vectors for ShRNA Delivery and Transgenesis Current Gene Therapy. Dec, 2008 | Pubmed ID: 19075631 Long-term Neprilysin Gene Transfer is Associated with Reduced Levels of Intracellular Abeta and Behavioral Improvement in APP Transgenic Mice BMC Neuroscience. 2008 | Pubmed ID: 19014502 Phosphorylation of SNAP-23 by IkappaB Kinase 2 Regulates Mast Cell Degranulation Cell. Aug, 2008 | Pubmed ID: 18692471 Neprilysin: an Enzyme Candidate to Slow the Progression of Alzheimer's Disease The American Journal of Pathology. May, 2008 | Pubmed ID: 18403590 Knockdown Transgenic Mice Generated by Silencing Lentiviral Vectors: Zona Pellucida Removal and Subzonal Injection Methods CSH Protocols. 2007 | Pubmed ID: 21357087 Sustained Suppression of Bcr-Abl-driven Lymphoid Leukemia by MicroRNA Mimics Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18079287 Reciprocity Between Phase Shifts and Amplitude Changes in the Mammalian Circadian Clock Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18077393 Repopulation of Adult and Neonatal Mice with Human Hepatocytes: a Chimeric Animal Model Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18077355 A Role for IkappaB Kinase 2 in Bipolar Spindle Assembly Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17939994 Intercellular Coupling Confers Robustness Against Mutations in the SCN Circadian Clock Network Cell. May, 2007 | Pubmed ID: 17482552 Targeted Delivery of Proteins Across the Blood-brain Barrier Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17463083 Neprilysin Protects Neurons Against Abeta Peptide Toxicity Brain Research. Jun, 2007 | Pubmed ID: 17459354 Suppression of PPAR-gamma Attenuates Insulin-stimulated Glucose Uptake by Affecting Both GLUT1 and GLUT4 in 3T3-L1 Adipocytes American Journal of Physiology. Endocrinology and Metabolism. Jul, 2007 | Pubmed ID: 17389706 Efficient Transgenic Rat Production by a Lentiviral Vector American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2007 | Pubmed ID: 17322424 Inflammatory Tales of Liver Cancer Cancer Cell. Feb, 2007 | Pubmed ID: 17292819 A Fourth IkappaB Protein Within the NF-kappaB Signaling Module Cell. Jan, 2007 | Pubmed ID: 17254973 Rapid Generation of Knockdown Transgenic Mice by Silencing Lentiviral Vectors Nature Protocols. 2006 | Pubmed ID: 17406246 Production and Purification of Lentiviral Vectors Nature Protocols. 2006 | Pubmed ID: 17406239 Design and Cloning of Lentiviral Vectors Expressing Small Interfering RNAs Nature Protocols. 2006 | Pubmed ID: 17406238 Essential Role of Tuberous Sclerosis Genes TSC1 and TSC2 in NF-kappaB Activation and Cell Survival Cancer Cell. Sep, 2006 | Pubmed ID: 16959613 Gene Therapy: Therapeutic Gene Causing Lymphoma Nature. Apr, 2006 | Pubmed ID: 16641981 Lentiviral Short Hairpin Ribonucleic Acid-mediated Knockdown of GLUT4 in 3T3-L1 Adipocytes Endocrinology. May, 2006 | Pubmed ID: 16497797 Choroidal Neovascularization in Transgenic Mice Expressing Prokineticin 1: an Animal Model for Age-related Macular Degeneration Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2006 | Pubmed ID: 16263331 Bioscience in India: Times Are Changing Cell. Dec, 2005 | Pubmed ID: 16325565 Glyoxalase 1 and Glutathione Reductase 1 Regulate Anxiety in Mice Nature. Dec, 2005 | Pubmed ID: 16244648 Identification of 14-3-3sigma Mutation Causing Cutaneous Abnormality in Repeated-epilation Mutant Mouse Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005 | Pubmed ID: 16239341 From One Experiment to the Next BioTechniques. Oct, 2005 | Pubmed ID: 16235552 Distinct Roles of IkappaB Proteins in Regulating Constitutive NF-kappaB Activity Nature Cell Biology. Sep, 2005 | Pubmed ID: 16136188 Targeting BACE1 with SiRNAs Ameliorates Alzheimer Disease Neuropathology in a Transgenic Model Nature Neuroscience. Oct, 2005 | Pubmed ID: 16136043 Enhanced NF-kappaB Activation and Cellular Function in Macrophages Lacking IkappaB Kinase 1 (IKK1) Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16116086 Zebrafish IkappaB Kinase 1 Negatively Regulates NF-kappaB Activity Current Biology : CB. Jul, 2005 | Pubmed ID: 16051172 Gene Therapy: Twenty-first Century Medicine Annual Review of Biochemistry. 2005 | Pubmed ID: 15952901 Inflammation-associated Cancer: NF-kappaB is the Lynchpin Trends in Immunology. Jun, 2005 | Pubmed ID: 15922948 Interview with Dr Verma Gene Therapy. Jun, 2005 | Pubmed ID: 15674396 Gene Delivery of Human Apolipoprotein E Alters Brain Abeta Burden in a Mouse Model of Alzheimer's Disease Proceedings of the National Academy of Sciences of the United States of America. Jan, 2005 | Pubmed ID: 15657137 Sustained Correction of Disease in Naive and AAV2-pretreated Hemophilia B Dogs: AAV2/8-mediated, Liver-directed Gene Therapy Blood. Apr, 2005 | Pubmed ID: 15637142 Development of Ecdysone-regulated Lentiviral Vectors Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2005 | Pubmed ID: 15585415 A Role for Bone Marrow-derived Cells in the Vasculature of Noninjured CNS Blood. Mar, 2005 | Pubmed ID: 15572598 The Knockout Mouse Project Nature Genetics. Sep, 2004 | Pubmed ID: 15340423 Doping, Gene Transfer and Sport Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2004 | Pubmed ID: 15336640 Musings for Young Scientists Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2004 | Pubmed ID: 15294164 Agbiotech: Success Depends on Trust Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2004 | Pubmed ID: 15233936 Activation of Transcription Factor NF-kappaB Requires ELKS, an IkappaB Kinase Regulatory Subunit Science (New York, N.Y.). Jun, 2004 | Pubmed ID: 15218148 Visa Crisis Hurts U.S. Science Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2004 | Pubmed ID: 15194044 Characterization of NF-kappa B/I Kappa B Proteins in Zebra Fish and Their Involvement in Notochord Development Molecular and Cellular Biology. Jun, 2004 | Pubmed ID: 15169890 Stem Cell Politics Get Dirty Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2004 | Pubmed ID: 15143773 CRE Recombinase-inducible RNA Interference Mediated by Lentiviral Vectors Proceedings of the National Academy of Sciences of the United States of America. May, 2004 | Pubmed ID: 15123829 Long-term Lowering of Plasma Cholesterol Levels in LDL-receptor-deficient WHHL Rabbits by Gene Therapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2004 | Pubmed ID: 15093185 Silence of the Genes Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004 | Pubmed ID: 15067116 AIDS: No End in Sight Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2004 | Pubmed ID: 14971375 IkappaB Kinase-independent IkappaBalpha Degradation Pathway: Functional NF-kappaB Activity and Implications for Cancer Therapy Molecular and Cellular Biology. Nov, 2003 | Pubmed ID: 14585967 Adenovirus-mediated Overexpression of Follistatin Enlarges Intact Liver of Adult Rats Hepatology (Baltimore, Md.). Nov, 2003 | Pubmed ID: 14578849 Fraud and Deception in Science Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2003 | Pubmed ID: 14565217 Generation of Transgenic Mice Using Lentiviral Vectors: a Novel Preclinical Assessment of Lentiviral Vectors for Gene Therapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2003 | Pubmed ID: 14529840 Little Evidence of Bone Marrow-derived Hepatocytes in the Replacement of Injured Liver Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 12920184 Stem Cells at the Dawn of the 21st Century Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 12915737 Illiteracy, Ignorance, Intolerance=terrorism Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2003 | Pubmed ID: 12872760 SARS: Fear of Global Pandemic Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2003 | Pubmed ID: 12788644 BRCA2 Cooperates with Histone Acetyltransferases in Androgen Receptor-mediated Transcription Proceedings of the National Academy of Sciences of the United States of America. Jun, 2003 | Pubmed ID: 12756300 Good-bye Dolly Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2003 | Pubmed ID: 12755157 The DNA Helix at 50 Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2003 | Pubmed ID: 12731541 Efficient Production of Human FVIII in Hemophilic Mice Using Lentiviral Vectors Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2003 | Pubmed ID: 12718905 Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2003 | Pubmed ID: 12657655 A Voluntary Moratorium? Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2003 | Pubmed ID: 12638540 A General Method for Gene Knockdown in Mice by Using Lentiviral Vectors Expressing Small Interfering RNA Proceedings of the National Academy of Sciences of the United States of America. Feb, 2003 | Pubmed ID: 12552109 Abrogation of Postentry Restriction of HIV-1-based Lentiviral Vector Transduction in Simian Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2003 | Pubmed ID: 12547912 Enhancement of BRCA1 E3 Ubiquitin Ligase Activity Through Direct Interaction with the BARD1 Protein The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12431996 Gene Therapy with Viral Vectors Annual Review of Pharmacology and Toxicology. 2003 | Pubmed ID: 12359866 Making the Promise a Reality Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2002 | Pubmed ID: 12498763 Success and Setback: Another Adverse Event Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2002 | Pubmed ID: 12409253 Politics and Scientific Publishing: Noli Me Tangere Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2002 | Pubmed ID: 12377181 NF-kappaB Regulation in the Immune System Nature Reviews. Immunology. Oct, 2002 | Pubmed ID: 12360211 Gene Therapy of Fanconi Anemia: Preclinical Efficacy Using Lentiviral Vectors Blood. Oct, 2002 | Pubmed ID: 12351379 Efficient Transduction of Liver and Muscle After in Utero Injection of Lentiviral Vectors with Different Pseudotypes Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2002 | Pubmed ID: 12231171 Biodistribution and Toxicity Studies of VSVG-pseudotyped Lentiviral Vector After Intravenous Administration in Mice with the Observation of in Vivo Transduction of Bone Marrow Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2002 | Pubmed ID: 12095299 Hypothesis-driven Science Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2002 | Pubmed ID: 12095295 Restoration of Spermatogenesis by Lentiviral Gene Transfer: Offspring from Infertile Mice Proceedings of the National Academy of Sciences of the United States of America. May, 2002 | Pubmed ID: 12032316 Do Not Ban Therapeutic Cloning Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2002 | Pubmed ID: 12027544 Politics and AIDS: a Bad Mix Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2002 | Pubmed ID: 11991737 Censorship of Scientific Publications: a Bad Idea Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2002 | Pubmed ID: 11945057 A Gene Therapy Institute for NIH? Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2002 | Pubmed ID: 11863406 Effect of Adenovirus-mediated Overexpression of Follistatin and Extracellular Domain of Activin Receptor Type II on Gonadotropin Secretion in Vitro and in Vivo Endocrinology. Mar, 2002 | Pubmed ID: 11861519 Transgenesis by Lentiviral Vectors: Lack of Gene Silencing in Mammalian Embryonic Stem Cells and Preimplantation Embryos Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11854510 Adeno-associated Virus Effectively Mediates Conditional Gene Modification in the Brain Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11842206 Biopiracy: Distrust Widens the Rich-poor Divide Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2002 | Pubmed ID: 11829514 Organotypic Cerebellar Cultures: Apoptotic Challenges and Detection Tatiana Hurtado de Mendoza1, Bartosz Balana2, Paul A. Slesinger2, Inder M. Verma1 1Laboratory of Genetics, The Salk Institute for Biological Studies, 2Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies JoVE 2564 Neurociência
Organotypic Cerebellar Cultures: Apoptotic Challenges and Detection Tatiana Hurtado de Mendoza1, Bartosz Balana2, Paul A. Slesinger2, Inder M. Verma1 1Laboratory of Genetics, The Salk Institute for Biological Studies, 2Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies JoVE 2564 Neurociência