Irena Levitan Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy University of Illinois at Chicago Biography Publications Institution JoVE Articles Irena Levitan has not added a biography. If you are Irena Levitan and would like to personalize this page please email our Author Liaison for assistance. Publications Shear-Stress Sensitive Inwardly-Rectifying K Channels Regulate Developmental Retinal Angiogenesis by Vessel Regression Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2019 | Pubmed ID: 31145841 Comparative Docking Analysis of Cholesterol Analogs to Ion Channels to Discriminate Between Stereospecific Binding Vs. Stereospecific Response Channels (Austin, Tex.). Dec, 2019 | Pubmed ID: 31033379 Endothelial Stiffening in Dyslipidemia Aging. Jan, 2019 | Pubmed ID: 30674709 Chiral Specificity of Cholesterol Orientation Within Cholesterol Binding Sites in Inwardly Rectifying K Channels Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 30649756 Role of Matrix Metalloproteinases and Histone Deacetylase in Oxidative Stress-induced Degradation of the Endothelial Glycocalyx American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2019 | Pubmed ID: 30632766 Potential Strategies to Reduce Blood Pressure in Treatment-Resistant Hypertension Using Food and Drug Administration-Approved Nanodrug Delivery Platforms Hypertension (Dallas, Tex. : 1979). Feb, 2019 | Pubmed ID: 30624988 Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus Current Topics in Membranes. 2018 | Pubmed ID: 30243442 Molecular Dynamics Simulations of Kir2.2 Interactions with an Ensemble of Cholesterol Molecules Biophysical Journal. 10, 2018 | Pubmed ID: 30205899 Comparative Analysis of Endothelial Cell and Sub-endothelial Cell Elastic Moduli in Young and Aged Mice: Role of CD36 Journal of Biomechanics. 07, 2018 | Pubmed ID: 29954596 Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K Channels Journal of the American Heart Association. 03, 2018 | Pubmed ID: 29502106 Hypotonic Challenge of Endothelial Cells Increases Membrane Stiffness with No Effect on Tether Force Biophysical Journal. 02, 2018 | Pubmed ID: 29490252 Proatherogenic Flow Increases Endothelial Stiffness Via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins Arteriosclerosis, Thrombosis, and Vascular Biology. 01, 2018 | Pubmed ID: 29025707 Differential Effects of Sterols on Ion Channels: Stereospecific Binding Vs Stereospecific Response Current Topics in Membranes. 2017 | Pubmed ID: 28863819 OxLDL Induces Endothelial Cell Proliferation Via Rho/ROCK/Akt/p27 Signaling: Opposite Effects of OxLDL and Cholesterol Loading American Journal of Physiology. Cell Physiology. Sep, 2017 | Pubmed ID: 28701359 Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids Biophysical Journal. Jan, 2017 | Pubmed ID: 28122218 Orthogonal Lipid Sensors Identify Transbilayer Asymmetry of Plasma Membrane Cholesterol Nature Chemical Biology. 03, 2017 | Pubmed ID: 28024150 Inwardly Rectifying K Channels Are Major Contributors to Flow-induced Vasodilatation in Resistance Arteries The Journal of Physiology. 04, 2017 | Pubmed ID: 27859264 Paradoxical Impact of Cholesterol on Lipid Packing and Cell Stiffness Frontiers in Bioscience (Landmark Edition). 06, 2016 | Pubmed ID: 27100504 Oxidized LDL Signals Through Rho-GTPase to Induce Endothelial Cell Stiffening and Promote Capillary Formation Journal of Lipid Research. 05, 2016 | Pubmed ID: 26989083 Cholesterol Increases the Open Probability of Cardiac KACh Currents Biochimica Et Biophysica Acta. Oct, 2015 | Pubmed ID: 26196595 Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2 Computational and Structural Biotechnology Journal. Sep, 2014 | Pubmed ID: 25408847 Silencing of Kir2 Channels by Caveolin-1: Cross-talk with Cholesterol The Journal of Physiology. Sep, 2014 | Pubmed ID: 25038242 Cholesterol Binding to Ion Channels Frontiers in Physiology. 2014 | Pubmed ID: 24616704 Upregulated Copper Transporters in Hypoxia-induced Pulmonary Hypertension PloS One. 2014 | Pubmed ID: 24614111 Oxidized Low-density Lipoprotein Alters the Effect of Matrix Stiffness on the Formation of Endothelial Networks and Capillary Lumens Pulmonary Circulation. Sep, 2013 | Pubmed ID: 24618546 Identification of Novel Cholesterol-binding Regions in Kir2 Channels The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24019518 Cholesterol Sensitivity of KIR2.1 Depends on Functional Inter-links Between the N and C Termini Channels (Austin, Tex.). Jul-Aug, 2013 | Pubmed ID: 23807091 Regulation of Ion Channels by Membrane Lipids Comprehensive Physiology. Jan, 2012 | Pubmed ID: 23728970 遥远的游离残留调解双向的分子开关,用于控制胆固醇和 PI (4,5) P2 基里巴斯渠道的调制。 The Journal of Biological Chemistry. Sep, 2012 | Pubmed ID: 22995912 OxLDL 和衬底刚度促进中性粒细胞的收缩力增强血管内皮细胞和细胞间粘附分子-1 的轮回。 Journal of Biomechanics. Jun, 2012 | Pubmed ID: 22560286 氧化型胆固醇在血管内皮的刚度控制的作用。 Journal of Lipid Research. Jul, 2012 | Pubmed ID: 22496390 肺动脉高压的新机制: Ca²⁺ 信号的作用。 American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2012 | Pubmed ID: 22245772 高胆固醇血症诱导 KACh 心脏电流通过磷脂酰肌醇 4,5-二磷酸和 Gβγ 的独立机制的调控。 The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22174416 P66Shc 在 ROS 依赖 VEGF 信号转导和血管内皮细胞生成的新型作用。 American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2012 | Pubmed ID: 22101521 胆固醇消耗有利于恢复从低渗膨胀在 CHO 细胞中的单元格。 Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2011 | Pubmed ID: 22179012 胆固醇调节通过直接绑定到通道蛋白的原核基里巴斯通道。 Biochimica Et Biophysica Acta. Oct, 2011 | Pubmed ID: 21798234 富含胆固醇的膜垂钓 OxLDL 的影响。 Journal of Lipids. 2011 | Pubmed ID: 21490811 炭疽致死因子激活 K(+) 渠道,促使巨噬细胞分泌白细胞介素-1β。 Journal of Immunology (Baltimore, Md. : 1950). May, 2011 | Pubmed ID: 21421849 KIR2.1 胆固醇敏感性由带游离毛孔周围的残留量的控制。 Biophysical Journal. Jan, 2011 | Pubmed ID: 21244834 修改细胞胆固醇含量的影响牵引力、 粘附和细胞蔓延。 Cellular and Molecular Bioengineering. Jun, 2010 | Pubmed ID: 21461187 OxLDL 诱导脂质膜域的顺序跌幅被反比与血管内皮的刚度和网络的形成。 American Journal of Physiology. Cell Physiology. Aug, 2010 | Pubmed ID: 20410437 胆固醇和离子通道。 Sub-cellular Biochemistry. 2010 | Pubmed ID: 20213557 基里巴斯渠道胆固醇敏感性比较分析: 裁谈会循环的作用。 Channels (Austin, Tex.). Jan-Feb, 2010 | Pubmed ID: 19923917 氧化低密度脂蛋白: 多样性、 模式识别和病理生理学。 Antioxidants & Redox Signaling. Jul, 2010 | Pubmed ID: 19888833 原核基里巴斯通道由胆固醇的直接监管。 The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19740741 胆固醇和基里巴斯的渠道。 IUBMB Life. Aug, 2009 | Pubmed ID: 19548316 关键的 Kir2.1 对胆固醇的敏感度 C 总站域的标识。 Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19416905 血管内皮细胞与肌动蛋白刚度调制而成在 2D 和 3D 的衬底刚度。 Journal of Biomechanics. May, 2009 | Pubmed ID: 19356760 OxLDL 方便流致主动脉内皮细胞的重新调整。 American Journal of Physiology. Cell Physiology. Aug, 2008 | Pubmed ID: 18562483 脂筏在膜细胞骨架相互作用和细胞生物力学控制: OxLDL 的行动。 Antioxidants & Redox Signaling. Sep, 2007 | Pubmed ID: 17576163 对膜细胞骨架粘附细胞胆固醇的影响。 Journal of Cell Science. Jul, 2007 | Pubmed ID: 17550968 利用环糊精来操纵细胞膜胆固醇含量: 证据,误解和控制战略。 Biochimica Et Biophysica Acta. Jun, 2007 | Pubmed ID: 17493580 高胆固醇血症抑制猪骨髓祖细胞体内基里巴斯通道。 Biochemical and Biophysical Research Communications. Jun, 2007 | Pubmed ID: 17482574 Kir2.1/Kir2.3 活动及胆固醇和胆固醇穷人膜域之间分布之间的关系。 American Journal of Physiology. Cell Physiology. Jul, 2007 | Pubmed ID: 17459945 高胆固醇血症抑制内心整流 K + 通道的主动脉内皮细胞在体外和体内。 Circulation Research. Apr, 2006 | Pubmed ID: 16556870 OxLDL 增加血管内皮的刚度、 部队组建和网络形成。 Journal of Lipid Research. Apr, 2006 | Pubmed ID: 16418538 Kir2.x 主动脉内皮细胞功能表达: Kir2.2 的主导作用。 American Journal of Physiology. Cell Physiology. Nov, 2005 | Pubmed ID: 15958527 胆固醇敏感性和脂质筏针对 Kir2.1 的渠道。 Biophysical Journal. Dec, 2004 | Pubmed ID: 15465867 胆固醇消耗增加膜刚度的主动脉内皮细胞。 Biophysical Journal. Nov, 2004 | Pubmed ID: 15347591 细胞膜表面随着补片的肺泡上皮细胞。 American Journal of Respiratory Cell and Molecular Biology. Aug, 2004 | Pubmed ID: 15016618 容积调控氯电流到胆固醇结构类似物的敏感性。 The Journal of General Physiology. Jan, 2004 | Pubmed ID: 14699079 剪应力增加 KATP 通道在大鼠和牛肺血管内皮细胞中的表达。 American Journal of Physiology. Cell Physiology. Oct, 2003 | Pubmed ID: 12826604 调制的内皮细胞内向整流 K + 当前的光学异构体的胆固醇。 Biophysical Journal. Dec, 2002 | Pubmed ID: 12496090 流体剪应力对音量调节当前牛主动脉内皮细胞中的阴离子的双重影响。 American Journal of Physiology. Cell Physiology. Apr, 2002 | Pubmed ID: 11880259 在定义良好的剪切应力下单细胞电电流的电生理记录 Ibra S. Fancher1, Irena Levitan1 1Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago JoVE 59776 Imunologia e Infecção 基质贴壁细胞的微管吸吮的估计单元刚度 Myung-Jin Oh1, Frank Kuhr1, Fitzroy Byfield2, Irena Levitan1 1Section of Respiratory, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois, 2Institute for Medicine and Engineering, University of Pennsylvania JoVE 3886 Bioengenharia
在定义良好的剪切应力下单细胞电电流的电生理记录 Ibra S. Fancher1, Irena Levitan1 1Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago JoVE 59776 Imunologia e Infecção
基质贴壁细胞的微管吸吮的估计单元刚度 Myung-Jin Oh1, Frank Kuhr1, Fitzroy Byfield2, Irena Levitan1 1Section of Respiratory, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois, 2Institute for Medicine and Engineering, University of Pennsylvania JoVE 3886 Bioengenharia