Jacco van Rheenen Department of Molecular Pathology The Netherlands Cancer Institute Biography Publications Institution JoVE Articles Jacco van Rheenen has not added a biography. If you are Jacco van Rheenen and would like to personalize this page please email our Author Liaison for assistance. Publications A Living Biobank of Patient-derived Ductal Carcinoma in Situ Mouse-intraductal Xenografts Identifies Risk Factors for Invasive Progression Cancer Cell. May, 2023 | Pubmed ID: 37116492 A Lamb1Dendra2 Mouse Model Identifies Basement-membrane-producing Origins and Dynamics in PyMT Breast Tumors Developmental Cell. Apr, 2023 | Pubmed ID: 36905927 Subtype-specific Kinase Dependency Regulates Growth and Metastasis of Poor-prognosis Mesenchymal Colorectal Cancer Journal of Experimental & Clinical Cancer Research : CR. Mar, 2023 | Pubmed ID: 36869386 Author Correction: Epithelial TGFβ Engages Growth-factor Signalling to Circumvent Apoptosis and Drive Intestinal Tumourigenesis with Aggressive Features Nature Communications. Jan, 2023 | Pubmed ID: 36720858 Coordinated Cancer Chaos Cell. Jan, 2023 | Pubmed ID: 36669470 Multidimensional Imaging of Breast Cancer Cold Spring Harbor Perspectives in Medicine. May, 2023 | Pubmed ID: 36167726 Epithelial TGFβ Engages Growth-factor Signalling to Circumvent Apoptosis and Drive Intestinal Tumourigenesis with Aggressive Features Nature Communications. Dec, 2022 | Pubmed ID: 36477656 Re-purposing the Pro-senescence Properties of Doxorubicin to Introduce Immunotherapy in Breast Cancer Brain Metastasis Cell Reports. Medicine. Nov, 2022 | Pubmed ID: 36384097 A Doxycycline- and Light-inducible Cre Recombinase Mouse Model for Optogenetic Genome Editing Nature Communications. Oct, 2022 | Pubmed ID: 36307419 Author Correction: PHGDH Heterogeneity Potentiates Cancer Cell Dissemination and Metastasis Nature. Sep, 2022 | Pubmed ID: 36042336 Retrograde Movements Determine Effective Stem Cell Numbers in the Intestine Nature. Jul, 2022 | Pubmed ID: 35831497 Epithelial-to-Mesenchymal Transition Drives Invasiveness of Breast Cancer Brain Metastases Cancers. Jun, 2022 | Pubmed ID: 35804890 PHGDH Heterogeneity Potentiates Cancer cell Dissemination and Metastasis Nature. May, 2022 | Pubmed ID: 35585241 GFAP Splice Variants Fine-tune Glioma Cell Invasion and Tumour Dynamics by Modulating Migration Persistence Scientific Reports. Jan, 2022 | Pubmed ID: 35013418 Differential Survival and Therapy Benefit of Breast Cancer Patients Are Characterized by Distinct Epithelial and Immune Cell Microenvironments Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2021 | Pubmed ID: 34965952 Regulation of a Progenitor Gene Program by SOX4 is Essential for Mammary Tumor Proliferation Oncogene. Nov, 2021 | Pubmed ID: 34584219 RASSF1C Oncogene Elicits Amoeboid Invasion, Cancer Stemness, and Extracellular Vesicle Release Via a SRC/Rho Axis The EMBO Journal. Oct, 2021 | Pubmed ID: 34532864 Single-cell Analysis of Regions of Interest (SCARI) Using a Photosensitive Tag Nature Chemical Biology. Nov, 2021 | Pubmed ID: 34504322 Diverse Transcriptional Regulation and Functional Effects Revealed by CRISPR/Cas9-directed Epigenetic Editing Oncotarget. Aug, 2021 | Pubmed ID: 34434494 Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E/M States Journal of Clinical Medicine. May, 2021 | Pubmed ID: 34072345 LGR6 Marks Nephron Progenitor Cells Developmental Dynamics : an Official Publication of the American Association of Anatomists. Apr, 2021 | Pubmed ID: 33848015 Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part Via Hypoxia-Induced Quiescence Cells. Mar, 2021 | Pubmed ID: 33801903 A Comprehensive Enhancer Screen Identifies TRAM2 As a Key and Novel Mediator of YAP Oncogenesis Genome Biology. Jan, 2021 | Pubmed ID: 33514403 Scratch-induced Partial Skin Wounds Re-epithelialize by Sheets of Independently Migrating Keratinocytes Life Science Alliance. 01, 2021 | Pubmed ID: 33257474 Targeting Dormant Tumor Cells to Prevent Cancer Recurrence The FEBS Journal. Nov, 2021 | Pubmed ID: 33190412 Publisher Correction: Long-distance Modulation of Bystander Tumor Cells by CD8 T-cell-secreted IFN-γ Nature Cancer. Jul, 2020 | Pubmed ID: 35122043 An Unanticipated Tumor-suppressive Role of the SUMO Pathway in the Intestine Unveiled by Ubc9 Haploinsufficiency Oncogene. Oct, 2020 | Pubmed ID: 32948837 Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine Cell Reports. 07, 2020 | Pubmed ID: 32698002 Stem Cell Lineage Survival As a Noisy Competition for Niche Access Proceedings of the National Academy of Sciences of the United States of America. 07, 2020 | Pubmed ID: 32611816 Long-distance Modulation of Bystander Tumor Cells by CD8 T Cell-secreted IFNγ Nature Cancer. Mar, 2020 | Pubmed ID: 32566933 Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer Cell Stem Cell. 04, 2020 | Pubmed ID: 32169167 Poor Perfusion of the Microvasculature in Peritoneal Metastases of Ovarian Cancer Clinical & Experimental Metastasis. Apr, 2020 | Pubmed ID: 32008138 Capturing Stem Cell Behavior Using Intravital and Live Cell Microscopy Cold Spring Harbor Perspectives in Biology. Sep, 2020 | Pubmed ID: 31767651 Cellular Plasticity During Metastasis: New Insights Provided by Intravital Microscopy Cold Spring Harbor Perspectives in Medicine. Nov, 2020 | Pubmed ID: 31615867 Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT Cell Reports. 11, 2019 | Pubmed ID: 31775027 Rebalancing of Actomyosin Contractility Enables Mammary Tumor Formation Upon Loss of E-cadherin Nature Communications. Aug, 2019 | Pubmed ID: 31444332 Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids Cell Stem Cell. Jun, 2019 | Pubmed ID: 31130514 Cancer Cells Copy Migratory Behavior and Exchange Signaling Networks Via Extracellular Vesicles The EMBO Journal. 08, 2018 | Pubmed ID: 29907695 Glycosylated Extracellular Vesicles Released by Glioblastoma Cells Are Decorated by CCL18 Allowing for Cellular Uptake Via Chemokine Receptor CCR8 Journal of Extracellular Vesicles. 2018 | Pubmed ID: 29696074 A Surgical Orthotopic Organoid Transplantation Approach in Mice to Visualize and Study Colorectal Cancer Progression Nature Protocols. 02, 2018 | Pubmed ID: 29300390 Intravital Characterization of Tumor Cell Migration in Pancreatic Cancer Intravital. 2016 | Pubmed ID: 28243522 A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility Cell. Apr, 2016 | Pubmed ID: 27058664 Intravital FRET Imaging of Tumor Cell Viability and Mitosis During Chemotherapy PloS One. 2013 | Pubmed ID: 23691140 Tissue-resident Memory CD8+ T Cells Continuously Patrol Skin Epithelia to Quickly Recognize Local Antigen Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23150545 Der Tod-Rezeptor CD95 Aktiviert Die Cofilin-Pathway Um Tumor Zelle Einmarsch Zu Stimulieren EMBO Reports. Sep, 2011 | Pubmed ID: 21760611 Intravital-Mikroskopie: Neue Einblicke in Die Metastasierung Von Tumoren Journal of Cell Science. Feb, 2011 | Pubmed ID: 21242309 Darm Krypta Homöostase Resultiert Aus Neutralen Wettbewerb Zwischen Symmetrisch Geteilt Lgr5 Stammzellen Cell. Oct, 2010 | Pubmed ID: 20887898 Nano-Imaging Membran Topographie Betrifft Interpretationen in Der Zellbiologie Nature Methods. Jul, 2010 | Pubmed ID: 20588265 Klotz Der Phosphatidylinositol-4, 5-bisphosphat-Cofilin-Interaktion Beeinträchtigt Die Zelle Lenkung Molecular Biology of the Cell. Nov, 2009 | Pubmed ID: 19741095 Cortactin Regelt Cofilin Und N-WASp-Aktivitäten Um Die Stufen Der Invadopodium Versammlung Und Reifung Zu Steuern The Journal of Cell Biology. Aug, 2009 | Pubmed ID: 19704022 Kollagen-basierten Zelle Migration Modelle in Vitro Und in Vivo Seminars in Cell & Developmental Biology. Oct, 2009 | Pubmed ID: 19682592 Eine Gemeinsame Aktivität Von Cofilin Zyklus in Invasive Tumorzellen Und Entzündliche Zellen Journal of Cell Science. Feb, 2009 | Pubmed ID: 19158339 Intravital Bildgebung Von Metastasierendem Verhalten Durch Ein Mamma Bildgebung Fenster Nature Methods. Dec, 2008 | Pubmed ID: 18997781 Untersuchung Des Mechanismus Zur Regelung Der MRP-Lokalisierung Experimental Cell Research. Jan, 2008 | Pubmed ID: 17897642 EGF-induzierte PIP2 Hydrolyse Frei Und Aktiviert Cofilin Lokal in Karzinom-Zellen The Journal of Cell Biology. Dec, 2007 | Pubmed ID: 18086920 Serin Phosphorylierung Von Der Integrin-beta4-Untereinheit Ist Notwendig Für Den Epidermalen Wachstumsfaktor-Rezeptor-induzierte Hemidesmosom Störung Molecular Biology of the Cell. Sep, 2007 | Pubmed ID: 17615294 Zelle Motilität Und Zytoskelett Verordnung in Invasion Und Metastasierung Journal of Mammary Gland Biology and Neoplasia. Sep, 2007 | Pubmed ID: 17557195 Intravital Bildgebung Der Fluoreszierenden Markern Und FRET Sonden Von DNA Zu Tätowieren BMC Biotechnology. 2007 | Pubmed ID: 17201912 Eine Rolle Für PtdIns (4,5) P2 Und PIP5Kalpha Bei Der Regulierung Von Stress-induced Apoptosis Current Biology : CB. Sep, 2006 | Pubmed ID: 16979564 Integrin Zytoplasmatischen Domäne-assoziierte Protein-1 (ICAP-1) Interagiert Mit Dem ROCK-ich Kinase an Der Plasmamembran Journal of Cellular Physiology. Sep, 2006 | Pubmed ID: 16741948 Integrine Steuern Bewegliche Strategie Durch Eine Rho-Cofilin Weg The Journal of Cell Biology. May, 2005 | Pubmed ID: 15866889 PIP2 Signalisierung in Lipid-Domänen: Eine Kritische Neubewertung The EMBO Journal. May, 2005 | Pubmed ID: 15861130 Räumliche Trennung Von HLA-DM/HLA-DR Wechselwirkungen Innerhalb Und MIIC Phagosom-induzierte Immun-Escape Immunity. Feb, 2005 | Pubmed ID: 15723810 Korrigieren Von Konfokalen Imaging Von Der Akquisition Bis Fluorescence Resonance Energy Transfer Durch Sensibilisierte Emission Zu Optimieren Biophysical Journal. Apr, 2004 | Pubmed ID: 15041688 Agonist-induzierte PIP (2) Hydrolyse Hemmt Kortikalen Aktin Dynamik: Regulierung Auf Globaler, Aber Nicht Bei Einer Mikrometer-Skala Molecular Biology of the Cell. Sep, 2002 | Pubmed ID: 12221130 Laserablation und Intravitalmikroskopie zur Untersuchung des Darmumbaus Dimitrios Laskaris*1,2, Maria Azkanaz*1,2, Mijke A. de Vreij-Kruidenier3, Doreen van Rijswoud-Ram3, Hendrik A. Messal1,2, Jacco van Rheenen1,2 1Department of Molecular Pathology, The Netherlands Cancer Institute, 2Oncode Institute, 3Animal Laboratory Facility, The Netherlands Cancer Institute JoVE 64756 Biologia Längsschnittliche intravitale Mikroskopie unter Verwendung eines Brustbildgebungsfensters mit austauschbarem Deckel Larissa Mourao1,2, Marta Ciwinska1,2, Jacco van Rheenen3, Colinda L. G. J. Scheele1,2 1Center for Cancer Biology, VIB (BE), 2Department of Oncology, KU Leuven (BE), 3Netherlands Cancer Institute, Department of Molecular Pathology, Oncode Institute (NL) JoVE 63326 Biologia Dendra2 Photoschalten durch die Mammary Imaging Fenster Bojana Gligorijevic1,2, Dmitriy Kedrin1, Jeffrey E Segall1, John Condeelis1,2, Jacco van Rheenen1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine - Yeshiva University, 2Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine - Yeshiva University, 3Hubrecht Institute-KNAW and University Medical Center Utrecht JoVE 1278 Biologia
Laserablation und Intravitalmikroskopie zur Untersuchung des Darmumbaus Dimitrios Laskaris*1,2, Maria Azkanaz*1,2, Mijke A. de Vreij-Kruidenier3, Doreen van Rijswoud-Ram3, Hendrik A. Messal1,2, Jacco van Rheenen1,2 1Department of Molecular Pathology, The Netherlands Cancer Institute, 2Oncode Institute, 3Animal Laboratory Facility, The Netherlands Cancer Institute JoVE 64756 Biologia
Längsschnittliche intravitale Mikroskopie unter Verwendung eines Brustbildgebungsfensters mit austauschbarem Deckel Larissa Mourao1,2, Marta Ciwinska1,2, Jacco van Rheenen3, Colinda L. G. J. Scheele1,2 1Center for Cancer Biology, VIB (BE), 2Department of Oncology, KU Leuven (BE), 3Netherlands Cancer Institute, Department of Molecular Pathology, Oncode Institute (NL) JoVE 63326 Biologia
Dendra2 Photoschalten durch die Mammary Imaging Fenster Bojana Gligorijevic1,2, Dmitriy Kedrin1, Jeffrey E Segall1, John Condeelis1,2, Jacco van Rheenen1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine - Yeshiva University, 2Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine - Yeshiva University, 3Hubrecht Institute-KNAW and University Medical Center Utrecht JoVE 1278 Biologia