Jeffrey Rosen Molecular & Cellular Biology Baylor College of Medicine Biography Publications Institution JoVE Articles Jeffrey Rosen Jeffrey Rosen studied chemistry at Williams College where he received a BA degree in 1966. His Ph.D. research at the Roswell Park Cancer Institute helped elucidate the mechanisms for glucocorticoid resistance in lymphomas. His postdoctoral studies at Vanderbilt University School of Medicine under the supervision of Dr. Bert W. O’Malley were concerned with the mechanism of action of estrogen in the chick oviduct. His postdoctoral studies involved the isolation of ovalbumin mRNA and the first demonstration of steroid hormone induction of a specific mRNA. He joined the faculty of Baylor College of Medicine in 1973 and was a founder member of the first Department of Cell Biology in the USA. In 1987-88 he spent a sabbatical leave in the laboratories of Drs. George Stark and Ian Kerr at the Imperial Cancer Research Laboratories funded by an American Cancer Society Scholar Grant, where he participated in early studies to elucidate the mechanisms of interferon action that helped lead to the discovery of the Jak/Stat pathway. Dr. Rosen is currently a Distinguished Service Professor, the Vice Chair and the C.C. Bell Professor of Molecular & Cellular Biology and Medicine at Baylor College of Medicine. He was the recipient of two MERIT awards from the National Cancer Institute on a grant entitled, “Hormonal Regulation of Breast Cancer” currently in its forty-fourth year of consecutive funding. His laboratory has authored 300 publications and book chapters. He is the PI on the CPRIT BCM Comprehensive Cancer Training Program. Dr. Rosen has trained 37 graduate students and 51 postdoctoral fellows many of whom are now faculty at major academic institutions in the USA and abroad. He has received the Marc Dresden Excellence in Graduate Education Award, the Barbara & Corbin J. Robertson, Jr. Presidential Award for Excellence in Education at BCM, the Endocrine Society Edwin B. Astwood Lecture Award, the Michael E. DeBakey, M.D., Excellence in Research Award, the Susan G. Komen for the Cure Brinker Basic Science Award, and the AACR Distinguished Lectureship in Breast Cancer Research. He is also an AAAS Fellow. Dr. Rosen is a Susan G. Komen Scholar, and the co-leader of Breast Program of the Dan. L. Duncan NCI-designated Comprehensive Cancer Center. Publications C/EBPß Isoform Specific Gene Regulation: It's a Lot More Complicated Than You Think! Journal of Mammary Gland Biology and Neoplasia. Mar, 2020 | Pubmed ID: 32078094 The SINEB1 Element in the Long Non-coding RNA Malat1 is Necessary for TDP-43 Proteostasis Nucleic Acids Research. 03, 2020 | Pubmed ID: 31863590 Correction: Alterations in Wnt- And/or STAT3 Signaling Pathways and the Immune Microenvironment During Metastatic Progression Oncogene. Jan, 2020 | Pubmed ID: 31558798 Immuno-subtyping of Breast Cancer Reveals Distinct Myeloid Cell Profiles and Immunotherapy Resistance Mechanisms Nature Cell Biology. 09, 2019 | Pubmed ID: 31451770 Alterations in Wnt- And/or STAT3 Signaling Pathways and the Immune Microenvironment During Metastatic Progression Oncogene. 08, 2019 | Pubmed ID: 31289359 The MMTV-Wnt1 Murine Model Produces Two Phenotypically Distinct Subtypes of Mammary Tumors with Unique Therapeutic Responses to an EGFR Inhibitor Disease Models & Mechanisms. 07, 2019 | Pubmed ID: 31213486 Targeting the Interplay Between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy Cancers. May, 2019 | Pubmed ID: 31137625 Metastasis Organotropism: Redefining the Congenial Soil Developmental Cell. 05, 2019 | Pubmed ID: 31063756 GSK3β Regulates Epithelial-mesenchymal Transition and Cancer Stem Cell Properties in Triple-negative Breast Cancer Breast Cancer Research : BCR. 03, 2019 | Pubmed ID: 30845991 MiR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution Stem Cells (Dayton, Ohio). 12, 2018 | Pubmed ID: 30267595 Notch Signaling As a Regulator of the Tumor Immune Response: To Target or Not To Target? Frontiers in Immunology. Month, 2018 | Pubmed ID: 30061899 FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation Cancer Research. 08, 2018 | Pubmed ID: 29844125 Pharmacological Targeting of MYC-regulated IRE1/XBP1 Pathway Suppresses MYC-driven Breast Cancer The Journal of Clinical Investigation. 04, 2018 | Pubmed ID: 29480818 Genome-wide Identification and Differential Analysis of Translational Initiation Nature Communications. 11, 2017 | Pubmed ID: 29170441 WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis Developmental Cell. 11, 2017 | Pubmed ID: 29103953 Repurposing Antiestrogens for Tumor Immunotherapy Cancer Discovery. 01, 2017 | Pubmed ID: 28062672 The Cellular Origin and Evolution of Breast Cancer Cold Spring Harbor Perspectives in Medicine. Mar, 2017 | Pubmed ID: 28062556 Fatal Attraction: TICs and MDSCs Cell Cycle (Georgetown, Tex.). Aug, 2016 | Pubmed ID: 27574951 The Z-cad Dual Fluorescent Sensor Detects Dynamic Changes Between the Epithelial and Mesenchymal Cellular States BMC Biology. 06, 2016 | Pubmed ID: 27317311 Oncogenic MTOR Signalling Recruits Myeloid-derived Suppressor Cells to Promote Tumour Initiation Nature Cell Biology. Jun, 2016 | Pubmed ID: 27183469 Genomic Profiling of Murine Mammary Tumors Identifies Potential Personalized Drug Targets for P53-deficient Mammary Cancers Disease Models & Mechanisms. 07, 2016 | Pubmed ID: 27149990 PTEN is Required to Maintain Luminal Epithelial Homeostasis and Integrity in the Adult Mammary Gland Developmental Biology. Jan, 2016 | Pubmed ID: 26526198 Developmental Insights into Breast Cancer Intratumoral Heterogeneity Trends in Cancer. Dec, 2015 | Pubmed ID: 26753176 Upregulation of EGFR Signaling is Correlated with Tumor Stroma Remodeling and Tumor Recurrence in FGFR1-driven Breast Cancer Breast Cancer Research : BCR. Nov, 2015 | Pubmed ID: 26581390 Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage Stem Cell Reports. Sep, 2015 | Pubmed ID: 26300228 The Mammary Stem Cell Hierarchy: a Looking Glass into Heterogeneous Breast Cancer Landscapes Endocrine-related Cancer. Dec, 2015 | Pubmed ID: 26206777 Cross-species DNA Copy Number Analyses Identifies Multiple 1q21-q23 Subtype-specific Driver Genes for Breast Cancer Breast Cancer Research and Treatment. Jul, 2015 | Pubmed ID: 26109346 Expression of MiR-200c in Claudin-low Breast Cancer Alters Stem Cell Functionality, Enhances Chemosensitivity and Reduces Metastatic Potential Oncogene. Dec, 2015 | Pubmed ID: 25746005 Intratumoral Heterogeneity in a Trp53-null Mouse Model of Human Breast Cancer Cancer Discovery. May, 2015 | Pubmed ID: 25735774 Ror2 Regulates Branching, Differentiation, and Actin-cytoskeletal Dynamics Within the Mammary Epithelium The Journal of Cell Biology. Feb, 2015 | Pubmed ID: 25624393 The Osteogenic Niche Promotes Early-stage Bone Colonization of Disseminated Breast Cancer Cells Cancer Cell. Feb, 2015 | Pubmed ID: 25600338 The Oncogenic STP Axis Promotes Triple-negative Breast Cancer Via Degradation of the REST Tumor Suppressor Cell Reports. Nov, 2014 | Pubmed ID: 25453754 STAT3 Signaling is Activated Preferentially in Tumor-initiating Cells in Claudin-low Models of Human Breast Cancer Stem Cells (Dayton, Ohio). Oct, 2014 | Pubmed ID: 24891218 Wnt-responsive Cancer Stem Cells Are Located Close to Distorted Blood Vessels and Not in Hypoxic Regions in a P53-null Mouse Model of Human Breast Cancer Stem Cells Translational Medicine. Jul, 2014 | Pubmed ID: 24797826 Regulation of Mammary Epithelial Cell Homeostasis by LncRNAs The International Journal of Biochemistry & Cell Biology. Sep, 2014 | Pubmed ID: 24680897 Plk2 Regulates Mitotic Spindle Orientation and Mammary Gland Development Development (Cambridge, England). Apr, 2014 | Pubmed ID: 24598160 Paracrine Signaling in Mammary Gland Development: What Can We Learn About Intratumoral Heterogeneity? Breast Cancer Research : BCR. Jan, 2014 | Pubmed ID: 24476463 Three-dimensional Vasculature Reconstruction of Tumour Microenvironment Via Local Clustering and Classification Interface Focus. Aug, 2013 | Pubmed ID: 24511379 Pygopus 2: Tilting the Wnt-Notch Balance in Mammary Epithelial Lineage Determination Breast Cancer Research : BCR. Dec, 2013 | Pubmed ID: 24365076 Transcriptomic Classification of Genetically Engineered Mouse Models of Breast Cancer Identifies Human Subtype Counterparts Genome Biology. Nov, 2013 | Pubmed ID: 24220145 Epigenetic Silencing of MicroRNA-203 is Required for EMT and Cancer Stem Cell Properties Scientific Reports. Month, 2013 | Pubmed ID: 24045437 Predicting Drug Responsiveness in Human Cancers Using Genetically Engineered Mice Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2013 | Pubmed ID: 23780888 Separation by Cell Size Enriches for Mammary Stem Cell Repopulation Activity Stem Cells Translational Medicine. Mar, 2013 | Pubmed ID: 23408103 FOXC2 Expression Links Epithelial-mesenchymal Transition and Stem Cell Properties in Breast Cancer Cancer Research. Mar, 2013 | Pubmed ID: 23378344 Fibroblast Growth Factor Receptor Signaling is Essential for Normal Mammary Gland Development and Stem Cell Function Stem Cells (Dayton, Ohio). Jan, 2013 | Pubmed ID: 23097355 The Chromatin Landscape of the Casein Gene Locus Hormone Molecular Biology and Clinical Investigation. Mar, 2012 | Pubmed ID: 23914258 Pregnancy-induced Noncoding RNA (PINC) Associates with Polycomb Repressive Complex 2 and Regulates Mammary Epithelial Differentiation PLoS Genetics. Month, 2012 | Pubmed ID: 22911650 On Murine Mammary Epithelial Stem Cells: Discovery, Function, and Current Status Cold Spring Harbor Perspectives in Biology. Apr, 2012 | Pubmed ID: 22474010 Mammary Gland Development & Breast Cancer; Connecting the Dots by Non-coding RNAs Journal of Mammary Gland Biology and Neoplasia. Mar, 2012 | Pubmed ID: 22402939 Noncoding RNAs Involved in Mammary Gland Development and Tumorigenesis: There's a Long Way to Go Journal of Mammary Gland Biology and Neoplasia. Mar, 2012 | Pubmed ID: 22402938 Targeting CreER(T2) Expression to Keratin 8-expressing Murine Simple Epithelia Using Bacterial Artificial Chromosome Transgenesis Transgenic Research. Feb, 2012 | Pubmed ID: 22350718 Activation of Wnt Signaling by Chemically Induced Dimerization of LRP5 Disrupts Cellular Homeostasis PloS One. Month, 2012 | Pubmed ID: 22303459 On Hormone Action in the Mammary Gland Cold Spring Harbor Perspectives in Biology. Feb, 2012 | Pubmed ID: 22300979 Comparative Oncogenomics Identifies Breast Tumors Enriched in Functional Tumor-initiating Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 21633010 Stem Cell Antigen-1 (sca-1) Regulates Mammary Tumor Development and Cell Migration PloS One. Month, 2011 | Pubmed ID: 22140470 Identification and Gene Expression Profiling of Tumor-initiating Cells Isolated from Human Osteosarcoma Cell Lines in an Orthotopic Mouse Model Cancer Biology & Therapy. Aug, 2011 | Pubmed ID: 21617384 Progesterone Receptor Directly Inhibits β-casein Gene Transcription in Mammary Epithelial Cells Through Promoting Promoter and Enhancer Repressive Chromatin Modifications Molecular Endocrinology (Baltimore, Md.). Jun, 2011 | Pubmed ID: 21527503 Prospective Isolation and Characterization of Committed and Multipotent Progenitors from Immortalized Mouse Mammary Epithelial Cells with Morphogenic Potential Breast Cancer Research : BCR. Apr, 2011 | Pubmed ID: 21466693 The PINDUCER Lentiviral Toolkit for Inducible RNA Interference in Vitro and in Vivo Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21307310 The DNA Damage Effector Chk1 Kinase Regulates Cdc14B Nucleolar Shuttling During Cell Cycle Progression Cell Cycle (Georgetown, Tex.). Feb, 2011 | Pubmed ID: 21301228 Altered Differentiation and Paracrine Stimulation of Mammary Epithelial Cell Proliferation by Conditionally Activated Smoothened Developmental Biology. Apr, 2011 | Pubmed ID: 21276786 Early-onset Aging and Defective DNA Damage Response in Cdc14b-deficient Mice Molecular and Cellular Biology. Apr, 2011 | Pubmed ID: 21262768 Thermal Enhancement with Optically Activated Gold Nanoshells Sensitizes Breast Cancer Stem Cells to Radiation Therapy Science Translational Medicine. Oct, 2010 | Pubmed ID: 20980696 P190B RhoGAP Has Pro-tumorigenic Functions During MMTV-Neu Mammary Tumorigenesis and Metastasis Breast Cancer Research : BCR. Month, 2010 | Pubmed ID: 20860838 Wnt and Mammary Stem Cells: Hormones Cannot Fly Wingless Current Opinion in Pharmacology. Dec, 2010 | Pubmed ID: 20810315 Core Epithelial-to-mesenchymal Transition Interactome Gene-expression Signature is Associated with Claudin-low and Metaplastic Breast Cancer Subtypes Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20713713 Genetic Manipulation of Individual Somatic Mammary Cells in Vivo Reveals a Master Role of STAT5a in Inducing Alveolar Fate Commitment and Lactogenesis Even in the Absence of Ovarian Hormones Developmental Biology. Oct, 2010 | Pubmed ID: 20691178 Small Players with Big Roles: MicroRNAs As Targets to Inhibit Breast Cancer Progression Current Drug Targets. Sep, 2010 | Pubmed ID: 20545613 Fibroblast Growth Factor Receptor Signaling Dramatically Accelerates Tumorigenesis and Enhances Oncoprotein Translation in the Mouse Mammary Tumor Virus-Wnt-1 Mouse Model of Breast Cancer Cancer Research. Jun, 2010 | Pubmed ID: 20501844 The Ups and Downs of MiR-205: Identifying the Roles of MiR-205 in Mammary Gland Development and Breast Cancer RNA Biology. May-Jun, 2010 | Pubmed ID: 20436283 Epithelial-mesenchymal Transition (EMT) in Tumor-initiating Cells and Its Clinical Implications in Breast Cancer Journal of Mammary Gland Biology and Neoplasia. Jun, 2010 | Pubmed ID: 20354771 The Epigenetic Landscape of Mammary Gland Development and Functional Differentiation Journal of Mammary Gland Biology and Neoplasia. Mar, 2010 | Pubmed ID: 20157770 Selective Targeting of Radiation-resistant Tumor-initiating Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133717 Defining the ATM-mediated Barrier to Tumorigenesis in Somatic Mammary Cells Following ErbB2 Activation Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133707 A Putative Role for MicroRNA-205 in Mammary Epithelial Cell Progenitors Journal of Cell Science. Feb, 2010 | Pubmed ID: 20103531 CCAAT/enhancer Binding Protein Beta Regulates Stem Cell Activity and Specifies Luminal Cell Fate in the Mammary Gland Stem Cells (Dayton, Ohio). Mar, 2010 | Pubmed ID: 20054865 Chk1 Haploinsufficiency Results in Anemia and Defective Erythropoiesis PloS One. Jan, 2010 | Pubmed ID: 20052416 An Intraductal Human-in-mouse Transplantation Model Mimics the Subtypes of Ductal Carcinoma in Situ Breast Cancer Research : BCR. Month, 2009 | Pubmed ID: 19735549 Haploinsufficiency for P190B RhoGAP Inhibits MMTV-Neu Tumor Progression Breast Cancer Research : BCR. Month, 2009 | Pubmed ID: 19703301 Residual Breast Cancers After Conventional Therapy Display Mesenchymal As Well As Tumor-initiating Features Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19666588 Chking and Executing Cell Division to Prevent Genomic Instability Cell Cycle (Georgetown, Tex.). Aug, 2009 | Pubmed ID: 19571679 The Increasing Complexity of the Cancer Stem Cell Paradigm Science (New York, N.Y.). Jun, 2009 | Pubmed ID: 19556499 Lactogenic Hormonal Induction of Long Distance Interactions Between Beta-casein Gene Regulatory Elements The Journal of Biological Chemistry. Aug, 2009 | Pubmed ID: 19542223 The DNA-damage Effector Checkpoint Kinase 1 is Essential for Chromosome Segregation and Cytokinesis Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19289837 Identification of Tumor-initiating Cells in a P53-null Mouse Model of Breast Cancer Cancer Research. Jun, 2008 | Pubmed ID: 18559513 Minireview: Hormones and Mammary Cell Fate--what Will I Become when I Grow Up? Endocrinology. Sep, 2008 | Pubmed ID: 18556345 Modelling Breast Cancer: One Size Does Not Fit All Nature Reviews. Cancer. Sep, 2007 | Pubmed ID: 17721431 Crosstalk Between the P190-B RhoGAP and IGF Signaling Pathways is Required for Embryonic Mammary Bud Development Developmental Biology. Sep, 2007 | Pubmed ID: 17662267 Estrogen Regulation of Mammary Gland Development and Breast Cancer: Amphiregulin Takes Center Stage Breast Cancer Research : BCR. Month, 2007 | Pubmed ID: 17659070 Distinct Roles of Fibroblast Growth Factor Receptor 1 and 2 in Regulating Cell Survival and Epithelial-mesenchymal Transition Molecular Endocrinology (Baltimore, Md.). Apr, 2007 | Pubmed ID: 17284663 Wnt/beta-catenin Mediates Radiation Resistance of Sca1+ Progenitors in an Immortalized Mammary Gland Cell Line Journal of Cell Science. Feb, 2007 | Pubmed ID: 17227796 WNT/beta-catenin Mediates Radiation Resistance of Mouse Mammary Progenitor Cells Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17202265 Stop! In the Name of Transforming Growth Factor-beta: Keeping Estrogen Receptor-alpha-positive Mammary Epithelial Cells from Proliferating Breast Cancer Research : BCR. Month, 2006 | Pubmed ID: 16834786 Keratin 6 is Not Essential for Mammary Gland Development Breast Cancer Research : BCR. Month, 2006 | Pubmed ID: 16790075 Integration of Prolactin and Glucocorticoid Signaling at the Beta-casein Promoter and Enhancer by Ordered Recruitment of Specific Transcription Factors and Chromatin Modifiers Molecular Endocrinology (Baltimore, Md.). Oct, 2006 | Pubmed ID: 16772529 A Critical Role for the Inflammatory Response in a Mouse Model of Preneoplastic Progression Cancer Research. Jun, 2006 | Pubmed ID: 16740705 Maspin is Physically Associated with [beta]1 Integrin Regulating Cell Adhesion in Mammary Epithelial Cells FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2006 | Pubmed ID: 16720730 A Noncoding RNA is a Potential Marker of Cell Fate During Mammary Gland Development Proceedings of the National Academy of Sciences of the United States of America. Apr, 2006 | Pubmed ID: 16574773 P190-B Rho GTPase-activating Protein Overexpression Disrupts Ductal Morphogenesis and Induces Hyperplastic Lesions in the Developing Mammary Gland Molecular Endocrinology (Baltimore, Md.). Jun, 2006 | Pubmed ID: 16469769 Stem Cells in the Etiology and Treatment of Cancer Current Opinion in Genetics & Development. Feb, 2006 | Pubmed ID: 16377171 Transcriptional Profiling of Mammary Gland Side Population Cells Stem Cells (Dayton, Ohio). Apr, 2006 | Pubmed ID: 16282442 Pleiotropic Effects of FGFR1 on Cell Proliferation, Survival, and Migration in a 3D Mammary Epithelial Cell Model The Journal of Cell Biology. Nov, 2005 | Pubmed ID: 16301332 Cell Cycle Defects Contribute to a Block in Hormone-induced Mammary Gland Proliferation in CCAAT/enhancer-binding Protein (C/EBPbeta)-null Mice The Journal of Biological Chemistry. Oct, 2005 | Pubmed ID: 16120603 Stem/progenitor Cells in Mouse Mammary Gland Development and Breast Cancer Journal of Mammary Gland Biology and Neoplasia. Jan, 2005 | Pubmed ID: 15886883 Will Cancer Stem Cells Provide New Therapeutic Targets? Carcinogenesis. Apr, 2005 | Pubmed ID: 15459022 Chk1 Versus Cdc25: Chking One's Levels of Cellular Proliferation Cell Cycle (Georgetown, Tex.). Nov, 2004 | Pubmed ID: 15483403 Chk1 is Haploinsufficient for Multiple Functions Critical to Tumor Suppression Cancer Cell. Jul, 2004 | Pubmed ID: 15261141 Hormone Receptor Patterning Plays a Critical Role in Normal Lobuloalveolar Development and Breast Cancer Progression Breast Disease. Month, 2003 | Pubmed ID: 15687684 Prostate-specific Expression of P53(R172L) Differentially Regulates P21, Bax, and Mdm2 to Inhibit Prostate Cancer Progression and Prolong Survival Molecular Cancer Research : MCR. Dec, 2003 | Pubmed ID: 14707287 Inducible Prostate Intraepithelial Neoplasia with Reversible Hyperplasia in Conditional FGFR1-expressing Mice Cancer Research. Dec, 2003 | Pubmed ID: 14678983 Evidence That Transgenes Encoding Components of the Wnt Signaling Pathway Preferentially Induce Mammary Cancers from Progenitor Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14668450 The Role of C/EBPbeta in Mammary Gland Development and Breast Cancer Journal of Mammary Gland Biology and Neoplasia. Apr, 2003 | Pubmed ID: 14635794 Transcription Factors Journal of Mammary Gland Biology and Neoplasia. Apr, 2003 | Pubmed ID: 14635790 The Dynamic Mobility of Histone H1 is Regulated by Cyclin/CDK Phosphorylation Molecular and Cellular Biology. Dec, 2003 | Pubmed ID: 14612406 Conditional Activation of Fibroblast Growth Factor Receptor (FGFR) 1, but Not FGFR2, in Prostate Cancer Cells Leads to Increased Osteopontin Induction, Extracellular Signal-regulated Kinase Activation, and in Vivo Proliferation Cancer Research. Oct, 2003 | Pubmed ID: 14559809 Multispecies Comparative Analysis of a Mammalian-specific Genomic Domain Encoding Secretory Proteins Genomics. Oct, 2003 | Pubmed ID: 13679022 Striking It Rich by Data Mining Cell. Aug, 2003 | Pubmed ID: 12914689 Pregnancy-induced Changes in Cell-fate in the Mammary Gland Breast Cancer Research : BCR. Month, 2003 | Pubmed ID: 12817990 P190-B RhoGAP Regulates Mammary Ductal Morphogenesis Molecular Endocrinology (Baltimore, Md.). Jun, 2003 | Pubmed ID: 12637587 Signal Transduction Pathways Regulated by Prolactin and Src Result in Different Conformations of Activated Stat5b The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12621061 Hormone Dependence in Premalignant Mammary Progression Cancer Research. Mar, 2003 | Pubmed ID: 12615724 A Beta-catenin Survival Signal is Required for Normal Lobular Development in the Mammary Gland Journal of Cell Science. Mar, 2003 | Pubmed ID: 12584256 Disruption of Steroid and Prolactin Receptor Patterning in the Mammary Gland Correlates with a Block in Lobuloalveolar Development Molecular Endocrinology (Baltimore, Md.). Dec, 2002 | Pubmed ID: 12456789 The Mineralocorticoid Receptor May Compensate for the Loss of the Glucocorticoid Receptor at Specific Stages of Mammary Gland Development Molecular Endocrinology (Baltimore, Md.). Sep, 2002 | Pubmed ID: 12198239 Inducible Dimerization of FGFR1: Development of a Mouse Model to Analyze Progressive Transformation of the Mammary Gland The Journal of Cell Biology. May, 2002 | Pubmed ID: 12011115 Sca-1(pos) Cells in the Mouse Mammary Gland Represent an Enriched Progenitor Cell Population Developmental Biology. May, 2002 | Pubmed ID: 11969254 Signal Transducer and Activator of Transcription (Stat) 5 Controls the Proliferation and Differentiation of Mammary Alveolar Epithelium The Journal of Cell Biology. Nov, 2001 | Pubmed ID: 11706048 Differential Interactions of Specific Nuclear Factor I Isoforms with the Glucocorticoid Receptor and STAT5 in the Cooperative Regulation of WAP Gene Transcription Molecular and Cellular Biology. Oct, 2001 | Pubmed ID: 11564870 C/EBPbeta, but Not C/EBPalpha, is Essential for Ductal Morphogenesis, Lobuloalveolar Proliferation, and Functional Differentiation in the Mouse Mammary Gland Genes & Development. Jun, 1998 | Pubmed ID: 9637692 Transcriptional Analysis of the Mouse Beta-casein Gene Molecular Endocrinology (Baltimore, Md.). Nov, 1990 | Pubmed ID: 2280771 Detection of Mouse Mammary Tumor Virus RNA in BALB/c Tumor Cell Lines of Nonviral Etiologies Journal of Virology. Dec, 1978 | Pubmed ID: 215778 Differential Expression of Poly(A)-adjacent Sequences of Mammary Tumor Virus RNA in Murine Mammary Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 1978 | Pubmed ID: 83648 Ortotopisk transplantasjon av brystsvulster som prekliniske modeller for brystkreft Xiangdong Lv*1,2,3, Lacey E. Dobrolecki*1,2,3, Yao Ding1,2,3, Jeffrey M. Rosen1,2,3, Michael T. Lewis1,2,3, Xi Chen1,2,3 1Department of Molecular and Cellular Biology, Baylor College of Medicine, 2Lester and Sue Smith Breast Center, Baylor College of Medicine, 3Dan L. Duncan Cancer Center, Baylor College of Medicine JoVE 61173 Pesquisa do câncer
Ortotopisk transplantasjon av brystsvulster som prekliniske modeller for brystkreft Xiangdong Lv*1,2,3, Lacey E. Dobrolecki*1,2,3, Yao Ding1,2,3, Jeffrey M. Rosen1,2,3, Michael T. Lewis1,2,3, Xi Chen1,2,3 1Department of Molecular and Cellular Biology, Baylor College of Medicine, 2Lester and Sue Smith Breast Center, Baylor College of Medicine, 3Dan L. Duncan Cancer Center, Baylor College of Medicine JoVE 61173 Pesquisa do câncer