Jeffrey N Savas Department of Neurolgy Northwestern University, Feinberg School of Medicine Biography Publications Institution JoVE Articles Jeffrey N Savas Jeffrey Savas received a Bachelor of Science in Biochemistry and Molecular Biology at the University of California, Santa Cruz. He received his Doctor of Philosophy from the New York University School of Medicine and performed his postdoctoral training at The Scripps Research Institute in La Jolla California. The Savas Lab opened at Northwestern University in the fall of 2015. We investigate how altered protein turnover contributes to neurodegeneration and impaired neuronal communication during the preclinical stage of AD. We are particularly interested in determining how perturbed proteostasis in axon terminals triggers synaptic dysfunction in the early stage of AD. To achieve these goals, we use biochemistry and chemical biology with mass spectrometry-based proteomic analysis. Publications HSF2 Cooperates with HSF1 to Drive a Transcriptional Program Critical for the Malignant State Science Advances. Mar, 2022 | Pubmed ID: 35294249 Long-lived Mitochondrial Proteins and Why They Exist Trends in Cell Biology. Feb, 2022 | Pubmed ID: 35221146 Shed CNTNAP2 Ectodomain is Detectable in CSF and Regulates Ca Homeostasis and Network Synchrony Via PMCA2/ATP2B2 Neuron. 02, 2022 | Pubmed ID: 34921780 Herpesviruses Assimilate Kinesin to Produce Motorized Viral Particles Nature. 11, 2021 | Pubmed ID: 34789877 Long-lived Mitochondrial Cristae Proteins in Mouse Heart and Brain The Journal of Cell Biology. 09, 2021 | Pubmed ID: 34259807 Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in Knock-in Mice Journal of Proteome Research. 07, 2021 | Pubmed ID: 34106705 NOTCH1-driven UBR7 Stimulates Nucleotide Biosynthesis to Promote T Cell Acute Lymphoblastic Leukemia Science Advances. 01, 2021 | Pubmed ID: 33571115 Using Stable Isotope Labeling to Advance Our Understanding of Alzheimer's Disease Etiology and Pathology Journal of Neurochemistry. 10, 2021 | Pubmed ID: 33434345 Striatal RGS7 Regulates Depression-Related Behaviors and Stress-Induced Reinstatement of Cocaine Conditioned Place Preference ENeuro. Mar-Apr, 2021 | Pubmed ID: 33402347 Homer1 Promotes Dendritic Spine Growth Through Ankyrin-G and Its Loss Reshapes the Synaptic Proteome Molecular Psychiatry. 06, 2021 | Pubmed ID: 33398084 Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals That Synaptic Dysfunction Originates in Presynaptic Terminals Cell Systems. 02, 2021 | Pubmed ID: 33326751 Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network Cell Reports. 11, 2020 | Pubmed ID: 33238128 Synapse Type-specific Proteomic Dissection Identifies IgSF8 As a Hippocampal CA3 Microcircuit Organizer Nature Communications. 10, 2020 | Pubmed ID: 33057002 A Small UTX Stabilization Domain of Trr is Conserved Within Mammalian MLL3-4/COMPASS and is Sufficient to Rescue Loss of Viability in Null Animals Genes & Development. 11, 2020 | Pubmed ID: 33033055 The Dichotomous Role of Extracellular Vesicles in the Central Nervous System IScience. Aug, 2020 | Pubmed ID: 32835924 Nucleocytoplasmic Proteomic Analysis Uncovers ERF1 and Nonsense-Mediated Decay As Modifiers of ALS/FTD C9orf72 Toxicity Neuron. 04, 2020 | Pubmed ID: 32059759 CATACOMB: An Endogenous Inducible Gene That Antagonizes H3K27 Methylation Activity of Polycomb Repressive Complex 2 Via an H3K27M-like Mechanism Science Advances. 07, 2019 | Pubmed ID: 31281901 Critical Period Inhibition of NKCC1 Rectifies Synapse Plasticity in the Somatosensory Cortex and Restores Adult Tactile Response Maps in Fragile X Mice Molecular Psychiatry. 11, 2019 | Pubmed ID: 29703945 Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders Proteomes. Jul, 2018 | Pubmed ID: 30029459 Resetting the Epigenetic Balance of Polycomb and COMPASS Function at Enhancers for Cancer Therapy Nature Medicine. 06, 2018 | Pubmed ID: 29785026 Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology Cell Reports. Nov, 2017 | Pubmed ID: 29186695 Dopamine Oxidation Mediates Mitochondrial and Lysosomal Dysfunction in Parkinson's Disease Science (New York, N.Y.). 09, 2017 | Pubmed ID: 28882997 Genomic Analysis of 220 CTCLs Identifies a Novel Recurrent Gain-of-function Alteration in RLTPR (p.Q575E) Blood. 09, 2017 | Pubmed ID: 28694326 Global Analysis of Protein Expression of Inner Ear Hair Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 02, 2017 | Pubmed ID: 28039372 Proteomic Analysis of Protein Turnover by Metabolic Whole Rodent Pulse-Chase Isotopic Labeling and Shotgun Mass Spectrometry Analysis Methods in Molecular Biology (Clifton, N.J.). Month, 2016 | Pubmed ID: 26867752 The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors Neuron. Aug, 2015 | Pubmed ID: 26291160 Biochemische zuivering en proteomische karakterisering van amyloïde fibrilkernen uit de hersenen Arun Upadhyay1, Robert J. Vassar1, Jeffrey N. Savas1 1Department of Neurology, Northwestern University Feinberg School of Medicine JoVE 63816 Neurociência
Biochemische zuivering en proteomische karakterisering van amyloïde fibrilkernen uit de hersenen Arun Upadhyay1, Robert J. Vassar1, Jeffrey N. Savas1 1Department of Neurology, Northwestern University Feinberg School of Medicine JoVE 63816 Neurociência