Jenny J. Yang Department of Chemistry, Center of Diagnostics and Therapeutics (CDT) Georgia State University Biography Publications Institution JoVE Articles Jenny J. Yang has not added a biography. If you are Jenny J. Yang and would like to personalize this page please email our Author Liaison for assistance. Publications Molecular Basis for Modulation of Metabotropic Glutamate Receptors and Their Drug Actions by Extracellular Ca(2) International Journal of Molecular Sciences. Mar, 2017 | Pubmed ID: 28335551 Molecular Basis of the Extracellular Ligands Mediated Signaling by the Calcium Sensing Receptor Frontiers in Physiology. 2016 | Pubmed ID: 27746744 The Hills and Valleys of Calcium Signaling Science China. Life Sciences. Aug, 2016 | Pubmed ID: 27502903 Structural Basis for Regulation of Human Calcium-sensing Receptor by Magnesium Ions and an Unexpected Tryptophan Derivative Co-agonist Science Advances. May, 2016 | Pubmed ID: 27386547 Rational Design of a Protein That Binds Integrin αvβ3 Outside the Ligand Binding Site Nature Communications. May, 2016 | Pubmed ID: 27241473 Defining Potential Roles of Pb(2+) in Neurotoxicity from a Calciomics Approach Metallomics : Integrated Biometal Science. Jun, 2016 | Pubmed ID: 27108875 ProCA1.GRPR: a New Imaging Agent in Cancer Detection Biomarkers in Medicine. May, 2016 | Pubmed ID: 27071673 Prostate-specific Membrane Antigen Targeted Protein Contrast Agents for Molecular Imaging of Prostate Cancer by MRI Nanoscale. Jul, 2016 | Pubmed ID: 26961235 Towards the Molecular Imaging of Prostate Cancer Biomarkers Using Protein-based MRI Contrast Agents Current Protein & Peptide Science. 2016 | Pubmed ID: 26721404 GRPR-targeted Protein Contrast Agents for Molecular Imaging of Receptor Expression in Cancers by MRI Scientific Reports. Nov, 2015 | Pubmed ID: 26577829 Fast Kinetics of Calcium Signaling and Sensor Design Current Opinion in Chemical Biology. Aug, 2015 | Pubmed ID: 26151819 Protein MRI Contrast Agent with Unprecedented Metal Selectivity and Sensitivity for Liver Cancer Imaging Proceedings of the National Academy of Sciences of the United States of America. May, 2015 | Pubmed ID: 25971726 The Calcium Sensing Receptor: from Calcium Sensing to Signaling Science China. Life Sciences. Jan, 2015 | Pubmed ID: 25576451 Effect of Ca²⁺ on the Steady-state and Time-resolved Emission Properties of the Genetically Encoded Fluorescent Sensor CatchER The Journal of Physical Chemistry. B. Feb, 2015 | Pubmed ID: 24836743 Prostate Cancer Metastatic to Bone Has Higher Expression of the Calcium-sensing Receptor (CaSR) Than Primary Prostate Cancer Receptors & Clinical Investigation. 2014 | Pubmed ID: 26065011 Role of Ca2+ and L-Phe in Regulating Functional Cooperativity of Disease-associated "toggle" Calcium-sensing Receptor Mutations PloS One. 2014 | Pubmed ID: 25420019 Direct Determination of Multiple Ligand Interactions with the Extracellular Domain of the Calcium-sensing Receptor The Journal of Biological Chemistry. Nov, 2014 | Pubmed ID: 25305020 Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-dihydroxyflavone in the Binding and Activation of the TrkB Receptor The Journal of Biological Chemistry. Oct, 2014 | Pubmed ID: 25143381 Pyruvate Kinase M2 in Blood Circulation Facilitates Tumor Growth by Promoting Angiogenesis The Journal of Biological Chemistry. Sep, 2014 | Pubmed ID: 25070887 Enhancing Near IR Luminescence of Thiolate Au Nanoclusters by Thermo Treatments and Heterogeneous Subcellular Distributions Nanoscale. Jul, 2014 | Pubmed ID: 24879334 Identification of a Small Molecular Insulin Receptor Agonist with Potent Antidiabetes Activity Diabetes. Apr, 2014 | Pubmed ID: 24651808 Myoplasmic Resting Ca2+ Regulation by Ryanodine Receptors is Under the Control of a Novel Ca2+-binding Region of the Receptor The Biochemical Journal. Jun, 2014 | Pubmed ID: 24635445 Design of ProCAs (protein-based Gd(3+) MRI Contrast Agents) with High Dose Efficiency and Capability for Molecular Imaging of Cancer Biomarkers Medicinal Research Reviews. Sep, 2014 | Pubmed ID: 24615853 Gap Junction Regulation by Calmodulin FEBS Letters. Apr, 2014 | Pubmed ID: 24440348 Identification of an L-phenylalanine Binding Site Enhancing the Cooperative Responses of the Calcium-sensing Receptor to Calcium The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24394414 Molecular Imaging of EGFR/HER2 Cancer Biomarkers by Protein MRI Contrast Agents Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Feb, 2014 | Pubmed ID: 24366655 Extracellular Calcium Modulates Actions of Orthosteric and Allosteric Ligands on Metabotropic Glutamate Receptor 1α The Journal of Biological Chemistry. Jan, 2014 | Pubmed ID: 24280223 Structural Basis for a Hand-like Site in the Calcium Sensor CatchER with Fast Kinetics Acta Crystallographica. Section D, Biological Crystallography. Dec, 2013 | Pubmed ID: 24311573 Metal Toxicity and Opportunistic Binding of Pb(2+) in Proteins Journal of Inorganic Biochemistry. Aug, 2013 | Pubmed ID: 23692958 Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals The Journal of Biological Chemistry. May, 2013 | Pubmed ID: 23576436 Design of a Novel Class of Protein-based Magnetic Resonance Imaging Contrast Agents for the Molecular Imaging of Cancer Biomarkers Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. Mar-Apr, 2013 | Pubmed ID: 23335551 Interaction Between P68 RNA Helicase and Ca2+-calmodulin Promotes Cell Migration and Metastasis Nature Communications. 2013 | Pubmed ID: 23322042 Probing Ca2+-binding Capability of Viral Proteins with the EF-hand Motif by Grafting Approach Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23296603 Calciomics: Integrative Studies of Ca2+-binding Proteins and Their Interactomes in Biological Systems Metallomics : Integrated Biometal Science. Jan, 2013 | Pubmed ID: 23235533 Predicting Ca2+ -binding Sites Using Refined Carbon Clusters Proteins. Jul, 2012 | Pubmed ID: 22821762 Identification of 70 Calcium-sensing Receptor Mutations in Hyper- and Hypo-calcaemic Patients: Evidence for Clustering of Extracellular Domain Mutations at Calcium-binding Sites Human Molecular Genetics. Jun, 2012 | Pubmed ID: 22422767 Gating of Connexin 43 Gap Junctions by a Cytoplasmic Loop Calmodulin Binding Domain American Journal of Physiology. Cell Physiology. May, 2012 | Pubmed ID: 22422398 Role of Calcium in Metalloenzymes: Effects of Calcium Removal on the Axial Ligation Geometry and Magnetic Properties of the Catalytic Diheme Center in MauG Biochemistry. Feb, 2012 | Pubmed ID: 22320333 Pyruvate Kinase M2 Regulates Gene Transcription by Acting As a Protein Kinase Molecular Cell. Mar, 2012 | Pubmed ID: 22306293 Residual Sarcoplasmic Reticulum Ca2+ Concentration After Ca2+ Release in Skeletal Myofibers from Young Adult and Old Mice Pflugers Archiv : European Journal of Physiology. Apr, 2012 | Pubmed ID: 22249494 PEGylation of Protein-based MRI Contrast Agents Improves Relaxivities and Biocompatibilities Journal of Inorganic Biochemistry. Feb, 2012 | Pubmed ID: 22178673 Design and Application of a Class of Sensors to Monitor Ca2+ Dynamics in High Ca2+ Concentration Cellular Compartments Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21914846 HER2 Targeted Molecular MR Imaging Using a De Novo Designed Protein Contrast Agent PloS One. Mar, 2011 | Pubmed ID: 21455310 Molecular Interaction and Functional Regulation of Connexin50 Gap Junctions by Calmodulin The Biochemical Journal. May, 2011 | Pubmed ID: 21320072 Protein-based MRI Contrast Agents for Molecular Imaging of Prostate Cancer Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Jun, 2011 | Pubmed ID: 20574851 Calmodulin Regulates Ca2+-sensing Receptor-mediated Ca2+ Signaling and Its Cell Surface Expression The Journal of Biological Chemistry. Nov, 2010 | Pubmed ID: 20826781 Site-specific Modification of Calmodulin Ca²(+) Affinity Tunes the Skeletal Muscle Ryanodine Receptor Activation Profile The Biochemical Journal. Nov, 2010 | Pubmed ID: 20815817 Integration of Diverse Research Methods to Analyze and Engineer Ca-Binding Proteins: From Prediction to Production Current Bioinformatics. Mar, 2010 | Pubmed ID: 20802832 Elucidation of a Novel Extracellular Calcium-binding Site on Metabotropic Glutamate Receptor 1{alpha} (mGluR1{alpha}) That Controls Receptor Activation The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20705606 Analysis and Prediction of Calcium-binding Pockets from Apo-protein Structures Exhibiting Calcium-induced Localized Conformational Changes Protein Science : a Publication of the Protein Society. Jun, 2010 | Pubmed ID: 20512971 Calcium-dependent Association of Calmodulin with the Rubella Virus Nonstructural Protease Domain The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 20086014 Inverse Tuning of Metal Binding Affinity and Protein Stability by Altering Charged Coordination Residues in Designed Calcium Binding Proteins PMC Biophysics. Dec, 2009 | Pubmed ID: 20025729 A Single EF-hand Isolated from STIM1 Forms Dimer in the Absence and Presence of Ca2+ The FEBS Journal. Oct, 2009 | Pubmed ID: 19694801 Designing Caspase-3 Sensors for Imaging of Apoptosis in Living Cells Chemistry (Weinheim an Der Bergstrasse, Germany). Sep, 2009 | Pubmed ID: 19655355 Viral Calciomics: Interplays Between Ca2+ and Virus Cell Calcium. Jul, 2009 | Pubmed ID: 19535138 Fluorescence Complementation Via EF-hand Interactions Journal of Biotechnology. Jul, 2009 | Pubmed ID: 19500621 Facilitating Chromophore Formation of Engineered Ca(2+) Binding Green Fluorescent Proteins Archives of Biochemistry and Biophysics. Jun, 2009 | Pubmed ID: 19358822 Calmodulin Mediates the Ca2+-dependent Regulation of Cx44 Gap Junctions Biophysical Journal. Apr, 2009 | Pubmed ID: 19348766 Designing Protease Sensors for Real-time Imaging of Trypsin Activation in Pancreatic Cancer Cells Biochemistry. Apr, 2009 | Pubmed ID: 19271729 Multiple Ca(2+)-binding Sites in the Extracellular Domain of the Ca(2+)-sensing Receptor Corresponding to Cooperative Ca(2+) Response Biochemistry. Jan, 2009 | Pubmed ID: 19102677 Towards Predicting Ca2+-binding Sites with Different Coordination Numbers in Proteins with Atomic Resolution Proteins. Jun, 2009 | Pubmed ID: 19003991 A Cysteine-rich Metal-binding Domain from Rubella Virus Non-structural Protein is Essential for Viral Protease Activity and Virus Replication The Biochemical Journal. Jan, 2009 | Pubmed ID: 18795894 Rational Design of a Conformation-switchable Ca2+- and Tb3+-binding Protein Without the Use of Multiple Coupled Metal-binding Sites The FEBS Journal. Oct, 2008 | Pubmed ID: 18785925 Structural Differences Between Pb2+- and Ca2+-binding Sites in Proteins: Implications with Respect to Toxicity Journal of Inorganic Biochemistry. Oct, 2008 | Pubmed ID: 18684507 Statistical Analysis of Structural Characteristics of Protein Ca2+-binding Sites Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Sep, 2008 | Pubmed ID: 18594878 Rational Design of Protein-based MRI Contrast Agents Journal of the American Chemical Society. Jul, 2008 | Pubmed ID: 18576649 Rational Design of a Novel Calcium-binding Site Adjacent to the Ligand-binding Site on CD2 Increases Its CD48 Affinity Protein Science : a Publication of the Protein Society. Mar, 2008 | Pubmed ID: 18287277 Developing Sensors for Real-time Measurement of High Ca2+ Concentrations Biochemistry. Oct, 2007 | Pubmed ID: 17924653 Identification of the Calmodulin Binding Domain of Connexin 43 The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17901047 Identification and Dissection of Ca(2+)-binding Sites in the Extracellular Domain of Ca(2+)-sensing Receptor The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17478419 Functional Elements on SIRPalpha IgV Domain Mediate Cell Surface Binding to CD47 Journal of Molecular Biology. Jan, 2007 | Pubmed ID: 17070842 Prediction of EF-hand Calcium-binding Proteins and Analysis of Bacterial EF-hand Proteins Proteins. Nov, 2006 | Pubmed ID: 16981205 Using Protein Design to Dissect the Effect of Charged Residues on Metal Binding and Protein Stability Biochemistry. May, 2006 | Pubmed ID: 16669627 Predicting Calcium-binding Sites in Proteins - a Graph Theory and Geometry Approach Proteins. Jul, 2006 | Pubmed ID: 16617426 Amyloid Fibril Formation by a Domain of Rat Cell Adhesion Molecule Cell Biochemistry and Biophysics. 2006 | Pubmed ID: 16456226 ATPase/helicase Activities of P68 RNA Helicase Are Required for Pre-mRNA Splicing but Not for Assembly of the Spliceosome Molecular and Cellular Biology. Sep, 2005 | Pubmed ID: 16107697 The Effects of Ca2+ Binding on the Dynamic Properties of a Designed Ca2+-binding Protein Biochemistry. Jun, 2005 | Pubmed ID: 15938616 Expression and Optical Properties of Green Fluorescent Protein Expressed in Different Cellular Environments Journal of Biotechnology. Oct, 2005 | Pubmed ID: 15935502 Calcium and Lanthanide Affinity of the EF-loops from the C-terminal Domain of Calmodulin Journal of Inorganic Biochemistry. Jun, 2005 | Pubmed ID: 15917089 Probing Site-specific Calmodulin Calcium and Lanthanide Affinity by Grafting Journal of the American Chemical Society. Mar, 2005 | Pubmed ID: 15771508 Design of a Calcium-binding Protein with Desired Structure in a Cell Adhesion Molecule Journal of the American Chemical Society. Feb, 2005 | Pubmed ID: 15713084 Obtaining Site-specific Calcium-binding Affinities of Calmodulin Protein and Peptide Letters. Aug, 2003 | Pubmed ID: 14529487 A Grafting Approach to Obtain Site-specific Metal-binding Properties of EF-hand Proteins Protein Engineering. Jun, 2003 | Pubmed ID: 12874376 Rational Design of a Calcium-binding Protein Journal of the American Chemical Society. May, 2003 | Pubmed ID: 12785848 Design, Synthesis, and Characterization of a Calcium-sensitive Near Infrared Dye Talanta. Apr, 2002 | Pubmed ID: 18968590 Metal-binding Studies for a De Novo Designed Calcium-binding Protein Protein Engineering. Jul, 2002 | Pubmed ID: 12200539 Isolated EF-loop III of Calmodulin in a Scaffold Protein Remains Unpaired in Solution Using Pulsed-field-gradient NMR Spectroscopy Biochimica Et Biophysica Acta. Jul, 2002 | Pubmed ID: 12147347 Structural Analysis, Identification, and Design of Calcium-binding Sites in Proteins Proteins. May, 2002 | Pubmed ID: 11948788 Temperature-induced Formation of a Non-native Intermediate State of the All Beta-sheet Protein CD2 Cell Biochemistry and Biophysics. 2002 | Pubmed ID: 11939369 Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+ Florence N. Reddish1, Cassandra L. Miller1, Rakshya Gorkhali1, Jenny J. Yang1 1Department of Chemistry, Center of Diagnostics and Therapeutics (CDT), Georgia State University JoVE 55822 Biologia
Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+ Florence N. Reddish1, Cassandra L. Miller1, Rakshya Gorkhali1, Jenny J. Yang1 1Department of Chemistry, Center of Diagnostics and Therapeutics (CDT), Georgia State University JoVE 55822 Biologia