Jens Lykkesfeldt Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences University of Copenhagen Biography Publications Institution JoVE Articles Jens Lykkesfeldt has not added a biography. If you are Jens Lykkesfeldt and would like to personalize this page please email our Author Liaison for assistance. Publications Positive Charge, Negative Effect: the Impact of Cationic Nanoparticles in the Brain Nanomedicine (London, England). Jul, 2014 | Pubmed ID: 25253492 Does Vitamin C Deficiency Affect Cognitive Development and Function? Nutrients. 2014 | Pubmed ID: 25244370 Elimination of Ascorbic Acid After High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation Basic & Clinical Pharmacology & Toxicology. Sep, 2014 | Pubmed ID: 25220574 In Vivo Toxicity of Cationic Micelles and Liposomes Nanomedicine : Nanotechnology, Biology, and Medicine. Aug, 2014 | Pubmed ID: 25168934 In Vivo Vitamin C Deficiency in Guinea Pigs Increases Ascorbate Transporters in Liver but Not Kidney and Brain Nutrition Research (New York, N.Y.). Jul, 2014 | Pubmed ID: 25150123 Antioxidant Supplementation for Lung Disease in Cystic Fibrosis The Cochrane Database of Systematic Reviews. 2014 | Pubmed ID: 25102015 Melatonin Does Not Affect Oxidative/inflammatory Biomarkers in a Closed-chest Porcine Model of Acute Myocardial Infarction In Vivo (Athens, Greece). Jul-Aug, 2014 | Pubmed ID: 24982213 Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-dependent Vitamin C Transporter 2 Expression Nutrients. May, 2014 | Pubmed ID: 24787032 The Kidneys Play an Important Role in the Clearance of RFVIIa in Rats Thrombosis Research. Jun, 2014 | Pubmed ID: 24731563 High-fat Feeding Increases Hepatic Vitamin C Synthesis and Its Circulatory Mobilization in Mice European Journal of Nutrition. Sep, 2014 | Pubmed ID: 24700376 Functional Network Analysis of Obese and Lean Göttingen Minipigs Elucidates Changes in Oxidative and Inflammatory Networks in Obese Pigs Pflugers Archiv : European Journal of Physiology. Mar, 2014 | Pubmed ID: 24590510 Prenatal Vitamin C Deficiency Results in Differential Levels of Oxidative Stress During Late Gestation in Foetal Guinea Pig Brains Redox Biology. 2014 | Pubmed ID: 24563854 Pronounced Inflammatory Response to Endotoxaemia During Nighttime: a Randomised Cross-over Trial PloS One. 2014 | Pubmed ID: 24475284 Vitamin C Advances in Nutrition (Bethesda, Md.). Jan, 2014 | Pubmed ID: 24425716 Does Vitamin C Enhance Nitric Oxide Bioavailability in a Tetrahydrobiopterin-dependent Manner? In Vitro, in Vivo and Clinical Studies Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Jan, 2014 | Pubmed ID: 24333161 Melatonin Suppresses Markers of Inflammation and Oxidative Damage in a Human Daytime Endotoxemia Model Journal of Critical Care. Feb, 2014 | Pubmed ID: 24140166 Differential Toxicological Response to Positively and Negatively Charged Nanoparticles in the Rat Brain Nanotoxicology. Nov, 2014 | Pubmed ID: 23889261 Guinea Pig Ascorbate Status Predicts Tetrahydrobiopterin Plasma Concentration and Oxidation Ratio in Vivo Nutrition Research (New York, N.Y.). Oct, 2013 | Pubmed ID: 24074744 Circadian Variation in the Response to Experimental Endotoxemia and Modulatory Effects of Exogenous Melatonin Chronobiology International. Nov, 2013 | Pubmed ID: 23998285 Whey Protein Reduces Early Life Weight Gain in Mice Fed a High-fat Diet PloS One. 2013 | Pubmed ID: 23940754 Regulation of Vitamin C Homeostasis During Deficiency Nutrients. Aug, 2013 | Pubmed ID: 23892714 Translational Aspects of Rectal Evoked Potentials: a Comparative Study in Rats and Humans American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2013 | Pubmed ID: 23703652 Does Vitamin C Deficiency Increase Lifestyle-associated Vascular Disease Progression? Evidence Based on Experimental and Clinical Studies Antioxidants & Redox Signaling. Dec, 2013 | Pubmed ID: 23642093 Prolonged Maternal Vitamin C Deficiency Overrides Preferential Fetal Ascorbate Transport but Does Not Influence Perinatal Survival in Guinea Pigs The British Journal of Nutrition. Nov, 2013 | Pubmed ID: 23591139 Nephrectomized and Hepatectomized Animal Models As Tools in Preclinical Pharmacokinetics Basic & Clinical Pharmacology & Toxicology. Aug, 2013 | Pubmed ID: 23586405 Increased Systemic Oxidatively Generated DNA and RNA Damage in Schizophrenia Psychiatry Research. Oct, 2013 | Pubmed ID: 23465294 Kinetics of Acid-induced Degradation of Tetra- and Dihydrobiopterin in Relation to Their Relevance As Biomarkers of Endothelial Function Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Feb, 2013 | Pubmed ID: 23066920 Maternal Vitamin C Deficiency During Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs PloS One. 2012 | Pubmed ID: 23119033 Ascorbate Status Modulates Reticuloendothelial Iron Stores and Response to Deferasirox Iron Chelation in Ascorbate-deficient Rats Experimental Hematology. Oct, 2012 | Pubmed ID: 22713799 Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans? Critical Reviews in Food Science and Nutrition. 2012 | Pubmed ID: 22698272 Oxidative Stress Response After Laparoscopic Versus Conventional Sigmoid Resection: a Randomized, Double-blind Clinical Trial Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. Jun, 2012 | Pubmed ID: 22678316 Ascorbate and Dehydroascorbic Acid As Biomarkers of Oxidative Stress: Validity of Clinical Data Depends on Vacutainer System Used Nutrition Research (New York, N.Y.). Jan, 2012 | Pubmed ID: 22260866 Chronic Vitamin C Deficiency Does Not Accelerate Oxidative Stress in Ageing Brains of Guinea Pigs Basic & Clinical Pharmacology & Toxicology. Jun, 2012 | Pubmed ID: 22212866 Role of Vitamin C and E Supplementation on IL-6 in Response to Training Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2012 | Pubmed ID: 22207723 Poor Antioxidant Status Exacerbates Oxidative Stress and Inflammatory Response to Pseudomonas Aeruginosa Lung Infection in Guinea Pigs Basic & Clinical Pharmacology & Toxicology. Apr, 2012 | Pubmed ID: 22008605 Fluctuating Hyperglycaemia Increases Oxidative Stress Response in Lean Rats Compared to Sustained Hyperglycaemia Despite Lower Glycaemic Exposure Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease. Oct, 2011 | Pubmed ID: 21933843 Effect of Vitamin C and Iron Chelation on Diesel Exhaust Particle and Carbon Black Induced Oxidative Damage and Cell Adhesion Molecule Expression in Human Endothelial Cells Toxicology Letters. Jun, 2011 | Pubmed ID: 21421028 Storage-induced Increase in Biomarkers of Oxidative Stress and Inflammation in Red Blood Cell Components Scandinavian Journal of Clinical and Laboratory Investigation. Jul, 2011 | Pubmed ID: 21385017 Effect of Antioxidant Supplementation on Insulin Sensitivity in Response to Endurance Exercise Training American Journal of Physiology. Endocrinology and Metabolism. May, 2011 | Pubmed ID: 21325105 High Dietary Fat and Cholesterol Exacerbates Chronic Vitamin C Deficiency in Guinea Pigs The British Journal of Nutrition. Jan, 2011 | Pubmed ID: 20875184 Antioxidant Supplementation Does Not Alter Endurance Training Adaptation Medicine and Science in Sports and Exercise. Jul, 2010 | Pubmed ID: 20019626 Is Vitamin C Supplementation Beneficial? Lessons Learned from Randomised Controlled Trials The British Journal of Nutrition. May, 2010 | Pubmed ID: 20003627 Keeping the Intracellular Vitamin C at a Physiologically Relevant Level in Endothelial Cell Culture Analytical Biochemistry. Feb, 2010 | Pubmed ID: 19782654 Vitamin C Deficiency in Early Postnatal Life Impairs Spatial Memory and Reduces the Number of Hippocampal Neurons in Guinea Pigs The American Journal of Clinical Nutrition. Sep, 2009 | Pubmed ID: 19640959 Poor Vitamin C Status is Associated with Increased Carotid Intima-media Thickness, Decreased Microvascular Function, and Delayed Myocardial Repolarization in Young Patients with Type 1 Diabetes The American Journal of Clinical Nutrition. Aug, 2009 | Pubmed ID: 19553299 Role of Marginal Vitamin C Deficiency in Atherogenesis: in Vivo Models and Clinical Studies Basic & Clinical Pharmacology & Toxicology. Jun, 2009 | Pubmed ID: 19489786 Does Vitamin C Deficiency Result in Impaired Brain Development in Infants? Redox Report : Communications in Free Radical Research. 2009 | Pubmed ID: 19161672 Utility of Melatonin to Treat Surgical Stress After Major Vascular Surgery--a Safety Study Journal of Pineal Research. May, 2008 | Pubmed ID: 18205732 Vitamin C Deficiency in Weanling Guinea Pigs: Differential Expression of Oxidative Stress and DNA Repair in Liver and Brain The British Journal of Nutrition. Dec, 2007 | Pubmed ID: 18309548 Ascorbate and Dehydroascorbic Acid As Reliable Biomarkers of Oxidative Stress: Analytical Reproducibility and Long-term Stability of Plasma Samples Subjected to Acidic Deproteinization Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Nov, 2007 | Pubmed ID: 18006947 Oxidative Stress and Damage in Liver, but Not in Brain, of Fischer 344 Rats Subjected to Dietary Iron Supplementation with Lipid-soluble [(3,5,5-trimethylhexanoyl)ferrocene] Journal of Biochemical and Molecular Toxicology. 2007 | Pubmed ID: 17623885 Antioxidant Supplementation Enhances the Exercise-induced Increase in Mitochondrial Uncoupling Protein 3 and Endothelial Nitric Oxide Synthase MRNA Content in Human Skeletal Muscle Free Radical Biology & Medicine. Aug, 2007 | Pubmed ID: 17602951 Malondialdehyde As Biomarker of Oxidative Damage to Lipids Caused by Smoking Clinica Chimica Acta; International Journal of Clinical Chemistry. May, 2007 | Pubmed ID: 17336279 Oxidants and Antioxidants in Disease: Oxidative Stress in Farm Animals Veterinary Journal (London, England : 1997). May, 2007 | Pubmed ID: 16914330 Pharmacokinetics of Amoxicillin Administered in Drinking Water to Recently Weaned 3- to 4-week-old Pigs with Diarrhea Experimentally Induced by Escherichia Coli O149:F4 American Journal of Veterinary Research. Apr, 2006 | Pubmed ID: 16579758 Electroencephalographic Changes After Pediatric Cardiac Surgery with Cardiopulmonary Bypass: is Slow Wave Activity Unfavorable? Pediatric Research. Oct, 2005 | Pubmed ID: 16189208 Age-dependent Change in Vitamin C Status: a Phenomenon of Maturation Rather Than of Ageing Mechanisms of Ageing and Development. Aug, 2005 | Pubmed ID: 15992612 Oxidative Stress Precedes Peak Systemic Inflammatory Response in Pediatric Patients Undergoing Cardiopulmonary Bypass Operation Free Radical Biology & Medicine. May, 2005 | Pubmed ID: 15855050 Effects of Heparin-binding Protein (CAP37/azurocidin) in a Porcine Model of Actinobacillus Pleuropneumoniae-induced Pneumonia Pharmacological Research : the Official Journal of the Italian Pharmacological Society. Jun, 2005 | Pubmed ID: 15829430 Clindamycin is Neuroprotective in Experimental Streptococcus Pneumoniae Meningitis Compared with Ceftriaxone Journal of Neurochemistry. Dec, 2004 | Pubmed ID: 15584921 Vitamin C Pharmacokinetics of Plain and Slow Release Formulations in Smokers Clinical Nutrition (Edinburgh, Scotland). Oct, 2004 | Pubmed ID: 15380894 Plasma Malondialdehyde is Induced by Smoking: a Study with Balanced Antioxidant Profiles The British Journal of Nutrition. Aug, 2004 | Pubmed ID: 15333149 Vitamin C Supplementation Decreases Oxidative DNA Damage in Mononuclear Blood Cells of Smokers European Journal of Nutrition. Oct, 2004 | Pubmed ID: 15309445 Pharmacokinetics of Amoxicillin After Oral Administration in Recently Weaned Piglets with Experimentally Induced Escherichia Coli Subtype O149:F4 Diarrhea American Journal of Veterinary Research. Jul, 2004 | Pubmed ID: 15281660 Long-term High Copper Intake: Effects on Indexes of Copper Status, Antioxidant Status, and Immune Function in Young Men The American Journal of Clinical Nutrition. Jun, 2004 | Pubmed ID: 15159234 Ascorbic Acid Recycling in Human Erythrocytes is Induced by Smoking in Vivo Free Radical Biology & Medicine. Dec, 2003 | Pubmed ID: 14642391 Evaluation of a Single Dose Versus a Divided Dose Regimen of Danofloxacin in Treatment of Actinobacillus Pleuropneumoniae Infection in Pigs Research in Veterinary Science. Jun, 2003 | Pubmed ID: 12726746 Effect of Smoking on Erythorbic Acid Pharmacokinetics The British Journal of Nutrition. May, 2003 | Pubmed ID: 12720586 Measurement of Ascorbic Acid and Dehydroascorbic Acid in Biological Samples Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (editor-in-chief) ... [et Al.]. Aug, 2002 | Pubmed ID: 20954159 Gamma-tocopherol Supplementation Inhibits Protein Nitration and Ascorbate Oxidation in Rats with Inflammation Free Radical Biology & Medicine. Dec, 2002 | Pubmed ID: 12446211 Increased Oxidative Damage in Vitamin C Deficiency is Accompanied by Induction of Ascorbic Acid Recycling Capacity in Young but Not Mature Guinea Pigs Free Radical Research. May, 2002 | Pubmed ID: 12150544 Cerebral Vasculature is the Major Target of Oxidative Protein Alterations in Bacterial Meningitis Journal of Neuropathology and Experimental Neurology. Jul, 2002 | Pubmed ID: 12125739 Feeding Acetyl-L-carnitine and Lipoic Acid to Old Rats Significantly Improves Metabolic Function While Decreasing Oxidative Stress Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11854487 Non-Terminal Blood Sampling Techniques in Guinea Pigs Malene M. Birck1, Pernille Tveden-Nyborg1, Maiken M. Lindblad1, Jens Lykkesfeldt1 1Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen JoVE 51982 Biologia
Non-Terminal Blood Sampling Techniques in Guinea Pigs Malene M. Birck1, Pernille Tveden-Nyborg1, Maiken M. Lindblad1, Jens Lykkesfeldt1 1Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen JoVE 51982 Biologia