John Arcaroli Medicine University of Colorado Denver Anschutz Medical Campus Biography Publications Institution JoVE Articles John Arcaroli has not added a biography. If you are John Arcaroli and would like to personalize this page please email our Author Liaison for assistance. Publications Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2 Journal of the National Cancer Institute. Jan, 2017 | Pubmed ID: 27634934 Antitumor Activity of the Aurora a Selective Kinase Inhibitor, Alisertib, Against Preclinical Models of Colorectal Cancer Oncotarget. Jul, 2016 | Pubmed ID: 27385211 The Novel Tankyrase Inhibitor (AZ1366) Enhances Irinotecan Activity in Tumors That Exhibit Elevated Tankyrase and Irinotecan Resistance Oncotarget. May, 2016 | Pubmed ID: 27070088 Aldehyde Dehydrogenase 1B1 As a Modulator of Pancreatic Adenocarcinoma Pancreas. Jan, 2016 | Pubmed ID: 26566217 A NOTCH1 Gene Copy Number Gain is a Prognostic Indicator of Worse Survival and a Predictive Biomarker to a Notch1 Targeting Antibody in Colorectal Cancer International Journal of Cancer. Jan, 2016 | Pubmed ID: 26152787 Antitumor Activity of a Potent MEK Inhibitor, TAK-733, Against Colorectal Cancer Cell Lines and Patient Derived Xenografts Oncotarget. Oct, 2015 | Pubmed ID: 26439693 Targeting the WNT Signaling Pathway in Cancer Therapeutics The Oncologist. Oct, 2015 | Pubmed ID: 26306903 Combined Inhibition of MEK and Aurora A Kinase in KRAS/PIK3CA Double-mutant Colorectal Cancer Models Frontiers in Pharmacology. 2015 | Pubmed ID: 26136684 ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways PloS One. 2015 | Pubmed ID: 25950950 Potent Antitumor Activity of Cabozantinib, a C-MET and VEGFR2 Inhibitor, in a Colorectal Cancer Patient-derived Tumor Explant Model International Journal of Cancer. Apr, 2015 | Pubmed ID: 25242168 Dual Pharmacological Targeting of the MAP Kinase and PI3K/mTOR Pathway in Preclinical Models of Colorectal Cancer PloS One. 2014 | Pubmed ID: 25401499 An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: an ATP-competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent Marine Drugs. Sep, 2014 | Pubmed ID: 25244109 A Phase II Study of the Gamma Secretase Inhibitor RO4929097 in Patients with Previously Treated Metastatic Pancreatic Adenocarcinoma Investigational New Drugs. Aug, 2014 | Pubmed ID: 24668033 Hsa-miR29b, a Critical Downstream Target of Non-canonical Wnt Signaling, Plays an Anti-proliferative Role in Non-small Cell Lung Cancer Cells Via Targeting MDM2 Expression Biology Open. Jul, 2013 | Pubmed ID: 23862015 Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23757356 A Patient Tumor Transplant Model of Squamous Cell Cancer Identifies PI3K Inhibitors As Candidate Therapeutics in Defined Molecular Bins Molecular Oncology. Aug, 2013 | Pubmed ID: 23607916 Association of the Epithelial-to-mesenchymal Transition Phenotype with Responsiveness to the P21-activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models Frontiers in Pharmacology. 2013 | Pubmed ID: 23543898 Phase I Pharmacokinetic and Pharmacodynamic Study of Cetuximab, Irinotecan and Sorafenib in Advanced Colorectal Cancer Investigational New Drugs. Apr, 2013 | Pubmed ID: 22615057 Biomarker-driven Trial in Metastatic Pancreas Cancer: Feasibility in a Multicenter Study of Saracatinib, an Oral Src Inhibitor, in Previously Treated Pancreatic Cancer Cancer Medicine. Oct, 2012 | Pubmed ID: 23342270 Stromal Cell-derived Factor 1α Mediates Resistance to MTOR-directed Therapy in Pancreatic Cancer Neoplasia (New York, N.Y.). Aug, 2012 | Pubmed ID: 22952422 Common PIK3CA Mutants and a Novel 3' UTR Mutation Are Associated with Increased Sensitivity to Saracatinib Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2012 | Pubmed ID: 22553375 ALDH+ Tumor-initiating Cells Exhibiting Gain in NOTCH1 Gene Copy Number Have Enhanced Regrowth Sensitivity to a γ-secretase Inhibitor and Irinotecan in Colorectal Cancer Molecular Oncology. Jun, 2012 | Pubmed ID: 22521243 Patient-derived Tumour Xenografts As Models for Oncology Drug Development Nature Reviews. Clinical Oncology. Jun, 2012 | Pubmed ID: 22508028 Similarity-based Multimarker Association Tests for Continuous Traits Annals of Human Genetics. May, 2012 | Pubmed ID: 22497480 Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS-mutant Colorectal Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2012 | Pubmed ID: 22173548 Association Between IL-32 Genotypes and Outcome in Infection-associated Acute Lung Injury Critical Care (London, England). 2011 | Pubmed ID: 21649914 Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras-mutated Colorectal Cancer Molecular Cancer Therapeutics. Dec, 2010 | Pubmed ID: 20923857 Gene Array and Fluorescence in Situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2010 | Pubmed ID: 20682712 Extracellular Superoxide Dismutase Haplotypes Are Associated with Acute Lung Injury and Mortality American Journal of Respiratory and Critical Care Medicine. Jan, 2009 | Pubmed ID: 18948423 Association Between Urokinase Haplotypes and Outcome from Infection-associated Acute Lung Injury Intensive Care Medicine. Feb, 2008 | Pubmed ID: 17994220 HMGB1 and LPS Induce Distinct Patterns of Gene Expression and Activation in Neutrophils from Patients with Sepsis-induced Acute Lung Injury Intensive Care Medicine. Oct, 2007 | Pubmed ID: 17581740 Variant IRAK-1 Haplotype is Associated with Increased Nuclear Factor-kappaB Activation and Worse Outcomes in Sepsis American Journal of Respiratory and Critical Care Medicine. Jun, 2006 | Pubmed ID: 16528020 Genetic Polymorphisms and Sepsis Shock (Augusta, Ga.). Oct, 2005 | Pubmed ID: 16205313 Hemorrhage-induced Acute Lung Injury is TLR-4 Dependent American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2004 | Pubmed ID: 15072965 Modulation of Bone Marrow-derived Neutrophil Signaling by H2O2: Disparate Effects on Kinases, NF-kappaB, and Cytokine Expression American Journal of Physiology. Cell Physiology. Mar, 2004 | Pubmed ID: 14656721 Urokinase-type Plasminogen Activator Potentiates Lipopolysaccharide-induced Neutrophil Activation Journal of Immunology (Baltimore, Md. : 1950). Jun, 2003 | Pubmed ID: 12759445 Early Alterations in Neutrophil Activation Are Associated with Outcome in Acute Lung Injury American Journal of Respiratory and Critical Care Medicine. Jun, 2003 | Pubmed ID: 12626346 Activation of Gene Expression in Human Neutrophils by High Mobility Group Box 1 Protein American Journal of Physiology. Cell Physiology. Apr, 2003 | Pubmed ID: 12620891 Evidence for Extracellular Superoxide Dismutase As a Mediator of Hemorrhage-induced Lung Injury American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2003 | Pubmed ID: 12618426 Involvement of Phosphatidylinositol 3-kinase Gamma in Neutrophil Apoptosis Cellular Signalling. Feb, 2003 | Pubmed ID: 12464394 Effects of Catecholamines on Kinase Activation in Lung Neutrophils After Hemorrhage or Endotoxemia Journal of Leukocyte Biology. Sep, 2002 | Pubmed ID: 12223526 Lipopolysaccharide-induced Neutrophil Gene Expression Under in Vivo or in Vitro Conditions Chest. Mar, 2002 | Pubmed ID: 11893694 विकास और एक Preclinical रोगी व्युत्पन्न ट्यूमर उपन्यास विरोधी कैंसर उपचार की जांच के लिए Xenograft मॉडल का रखरखाव Stacey Bagby1, Wells A. Messersmith1, Todd M. Pitts1, Anna Capasso1, Marileila Varella-Garcia1, Peter J. Klauck1, Jihye Kim1, Aik-Choon Tan1, S. Gail Eckhardt1, John J. Tentler1, John Arcaroli1 1Medicine, University of Colorado Denver Anschutz Medical Campus JoVE 54393 Pesquisa do câncer
विकास और एक Preclinical रोगी व्युत्पन्न ट्यूमर उपन्यास विरोधी कैंसर उपचार की जांच के लिए Xenograft मॉडल का रखरखाव Stacey Bagby1, Wells A. Messersmith1, Todd M. Pitts1, Anna Capasso1, Marileila Varella-Garcia1, Peter J. Klauck1, Jihye Kim1, Aik-Choon Tan1, S. Gail Eckhardt1, John J. Tentler1, John Arcaroli1 1Medicine, University of Colorado Denver Anschutz Medical Campus JoVE 54393 Pesquisa do câncer