Jon P. Mochel Department of Biomedical Sciences Iowa State University Biography Publications Institution JoVE Articles Jon P. Mochel Dr. Jon Mochel obtained his Veterinary Medical Degree from the National Veterinary School of Alfort. He completed his Doctorate studying Neurosciences in collaboration with the College de France and received the Silver Medal from Paris XII for his work. Dr. Mochel holds a MS in Pharmacology and Pharmacokinetics and is a Diplomate of the European College of Veterinary Pharmacology and Toxicology (ECVPT). He completed his Ph.D at Leiden University, with a focus on the mathematical modeling of the renin-angiotensin system for cardiovascular diseases. He is a founder of the Animal Health Modeling & Simulation Society which aims at promoting the dissemination of mathematical modeling in Veterinary Sciences. Dr. Mochel is a Professor of Systems Pharmacology in the Department of Biomedical Sciences at Iowa State University and a Fellow of the American Academy of Veterinary Pharmacology and Therapeutics. He is an ad hoc Study Section Reviewer for the US National Science Foundation, the UK Medical Research Council and the CNRS/INSERM ATIP-Avenir Program. He is currently the President Elect of the European Association of Veterinary Pharmacology and Toxicology and the recipient of the 2022 Research Award from the American Academy of Veterinary Pharmacology and Therapeutics. His research pertains to the analysis of clinical data obtained from spontaneous animal models of human diseases to bridge the knowledge gap between experimental models and patients. He has authored more than 100 peer-reviewed publications in select biomedical journals and is the co-founder of LifEngine Animal Health, a Y Combinator company developing gene editing solutions for canine oncology, and 3D Health Solutions, a platform for efficient drug screening in pharmaceutical research. Publications Suspected Primary Hyperreninism in a Cat with Malignant Renal Sarcoma and Global Renin-angiotensin-aldosterone System Upregulation Journal of Veterinary Internal Medicine. Jan, 2022 | Pubmed ID: 34859924 Albumin in Tears Modulates Bacterial Susceptibility to Topical Antibiotics in Ophthalmology Frontiers in Medicine. Month, 2021 | Pubmed ID: 34917625 Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report Frontiers in Veterinary Science. Month, 2021 | Pubmed ID: 34631865 Pharmacokinetics of Tulathromycin in Pregnant Ewes (Ovis Aries) Challenged with Campylobacter Jejuni PloS One. Month, 2021 | Pubmed ID: 34449832 Retrospective Evaluation of a Dose-dependent Effect of Angiotensin-converting Enzyme Inhibitors on Long-term Outcome in Dogs with Cardiac Disease Journal of Veterinary Internal Medicine. Sep, 2021 | Pubmed ID: 34387901 Computed Tomography Evaluation of Proposed Implant Corridors in Canine Thoracic Vertebrae Veterinary Surgery : VS. Oct, 2021 | Pubmed ID: 34251686 Corrigendum: Comparative Pharmacokinetics of Meloxicam Between Healthy Post-partum Vs. Mid-lactation Dairy Cattle Frontiers in Veterinary Science. Month, 2021 | Pubmed ID: 34124224 Focused Ultrasound of the Caudal Vena Cava in Dogs with Cavitary Effusions or Congestive Heart Failure: A Prospective, Observational Study PloS One. Month, 2021 | Pubmed ID: 34048483 Radiation Exposure Associated with Percutaneous Fluoroscopically Guided Lag Screw Fixation for Sacroiliac Luxation in Dogs Veterinary Surgery : VS. Jul, 2021 | Pubmed ID: 33955568 Short-term Outcomes of 59 Dogs Treated for Ilial Body Fractures with Locking or Non-locking Plates Veterinary Surgery : VS. Jul, 2021 | Pubmed ID: 33955036 Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences That Impact Drug Pharmacokinetics The AAPS Journal. 04, 2021 | Pubmed ID: 33907906 Effect of Prazosin on Feline Recurrent Urethral Obstruction Journal of Feline Medicine and Surgery. 12, 2021 | Pubmed ID: 33749375 Influence of Schirmer Strip Wetness on Volume Absorbed, Volume Recovered, and Total Protein Content in Canine Tears Veterinary Ophthalmology. Jul, 2021 | Pubmed ID: 33720492 A Multi-Institutional Retrospective Analysis of Toceranib Phosphate for Presumed or Confirmed Canine Aortic Body Chemodectomas Frontiers in Veterinary Science. Month, 2021 | Pubmed ID: 33614771 Letter to the Editor Regarding "Efficacy of Adding Ramipril (VAsotop) to the Combination of Furosemide (Lasix) and Pimobendan (VEtmedin) in Dogs with Mitral Valve Degeneration: The VALVE Trial" Journal of Veterinary Internal Medicine. 03, 2021 | Pubmed ID: 33502753 Serum Albumin and Total Protein Concentration in the Tear Film of Horses with Healthy or Diseased Eyes Veterinary Ophthalmology. Jan, 2021 | Pubmed ID: 32920954 Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration Frontiers in Veterinary Science. Month, 2020 | Pubmed ID: 33330703 Pharmacokinetics of Oral Prednisone at Various Doses in Dogs: Preliminary Findings Using a Naïve Pooled-Data Approach Frontiers in Veterinary Science. Month, 2020 | Pubmed ID: 33195563 Tear Film Pharmacokinetics and Systemic Absorption Following Topical Administration of 1% Prednisolone Acetate Ophthalmic Suspension in Dogs Frontiers in Veterinary Science. Month, 2020 | Pubmed ID: 33195562 Impact of Diurnal Variation, Sex, Tear Collection Method, and Disease State on Tear Protein Levels in Dogs Veterinary Ophthalmology. Nov, 2020 | Pubmed ID: 33118315 Non-Linear Mixed-Effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Cats Frontiers in Veterinary Science. Month, 2020 | Pubmed ID: 33102567 Comparative Pharmacokinetics of Meloxicam Between Healthy Post-partum Vs. Mid-lactation Dairy Cattle Frontiers in Veterinary Science. Month, 2020 | Pubmed ID: 33102542 Pharmacokinetics of Intravenous, Intramuscular, Oral, and Transdermal Administration of Flunixin Meglumine in Pre-wean Piglets Frontiers in Veterinary Science. Month, 2020 | Pubmed ID: 33005646 Evaluation of a Respiratory Disease Induction Model for Goats () Comparative Medicine. 10, 2020 | Pubmed ID: 32907695 CSF Glucose Tracks Regional Tau Progression Based on Alzheimer's Disease Risk Factors Alzheimer's & Dementia (New York, N. Y.). Month, 2020 | Pubmed ID: 32864418 An Eye on the Dog As the Scientist's Best Friend for Translational Research in Ophthalmology: Focus on the Ocular Surface Medicinal Research Reviews. 11, 2020 | Pubmed ID: 32735080 Impact of Acute Conjunctivitis on Ocular Surface Homeostasis in Dogs Veterinary Ophthalmology. Sep, 2020 | Pubmed ID: 32666689 A Retrospective Clinical Investigation of the Safety and Adverse Effects of Pantoprazole in Hospitalized Ruminants Frontiers in Veterinary Science. Month, 2020 | Pubmed ID: 32258063 Population Modeling of Tumor Growth Curves and the Reduced Gompertz Model Improve Prediction of the Age of Experimental Tumors PLoS Computational Biology. 02, 2020 | Pubmed ID: 32097421 Nerve Growth Factor in Dogs: Assessment of Two Immunoassays and Selected Ocular Parameters Following a Nicergoline Challenge Per Os Veterinary Ophthalmology. Jan, 2020 | Pubmed ID: 31774231 Re: "Evaluation of Enrofloxacin for Use in Cryopreservation of Zebu Bull Semen" by Ishaq Et Al. (Biopreserv Biobank 2019;17(6):546-552, DOI: 10.1089/bio.2018.0133) Biopreservation and Biobanking. 02, 2020 | Pubmed ID: 31674793 Albumin Levels in Tear Film Modulate the Bioavailability of Medically-Relevant Topical Drugs Frontiers in Pharmacology. Month, 2019 | Pubmed ID: 32047429 Kinetics of Fluorescein in Tear Film After Eye Drop Instillation in Beagle Dogs: Does Size Really Matter? Frontiers in Veterinary Science. Month, 2019 | Pubmed ID: 31921915 Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs Frontiers in Veterinary Science. Month, 2019 | Pubmed ID: 31788483 Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs Frontiers in Veterinary Science. Month, 2019 | Pubmed ID: 31681816 Aging-related Changes in Fluid Intelligence, Muscle and Adipose Mass, and Sex-specific Immunologic Mediation: A Longitudinal UK Biobank Study Brain, Behavior, and Immunity. 11, 2019 | Pubmed ID: 31513875 Fluorophotometric Assessment of Tear Volume and Turnover Rate in Healthy Dogs and Cats Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Nov, 2019 | Pubmed ID: 31381493 Nonlinear Mixed-effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Dogs Journal of Veterinary Pharmacology and Therapeutics. Sep, 2019 | Pubmed ID: 31369157 Histamine-Induced Conjunctivitis and Breakdown of Blood-Tear Barrier in Dogs: A Model for Ocular Pharmacology and Therapeutics Frontiers in Pharmacology. Month, 2019 | Pubmed ID: 31354477 Effects of Experimentally Induced Respiratory Disease on the Pharmacokinetics and Tissue Residues of Tulathromycin in Meat Goats Journal of Veterinary Pharmacology and Therapeutics. Jul, 2019 | Pubmed ID: 31183876 Paper Spray High-resolution Accurate Mass Spectrometry for Quantitation of Voriconazole in Equine Tears Analytical and Bioanalytical Chemistry. Aug, 2019 | Pubmed ID: 31123782 Tear Fluid Pharmacokinetics Following Oral Prednisone Administration in Dogs With and Without Conjunctivitis Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Jul/Aug, 2019 | Pubmed ID: 31070497 Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer CPT: Pharmacometrics & Systems Pharmacology. 08, 2019 | Pubmed ID: 31004380 CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies The AAPS Journal. Apr, 2019 | Pubmed ID: 30963322 Sacubitril/valsartan (LCZ696) Significantly Reduces Aldosterone and Increases CGMP Circulating Levels in a Canine Model of RAAS Activation European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Feb, 2019 | Pubmed ID: 30508581 Relative Oral Bioavailability of Two Amoxicillin-Clavulanic Acid Formulations in Healthy Dogs: A Pilot Study Journal of the American Animal Hospital Association. Jan/Feb, 2019 | Pubmed ID: 30427713 Clinical Features of Cats with Aqueous Tear Deficiency: a Retrospective Case Series of 10 Patients (17 Eyes) Journal of Feline Medicine and Surgery. 10, 2019 | Pubmed ID: 30417738 Comparative Plasma and Interstitial Fluid Pharmacokinetics and Tissue Residues of Ceftiofur Crystalline-free Acid in Cattle with Induced Coliform Mastitis Journal of Veterinary Pharmacology and Therapeutics. Dec, 2018 | Pubmed ID: 29971798 Adverse Reactions to Fentanyl Transdermal Patches in Calves: a Preliminary Clinical and Pharmacokinetic Study Veterinary Anaesthesia and Analgesia. Jul, 2018 | Pubmed ID: 29880278 Population Variability in Animal Health: Influence on Dose-exposure-response Relationships: Part II: Modelling and Simulation Journal of Veterinary Pharmacology and Therapeutics. Aug, 2018 | Pubmed ID: 29806231 Impact of Flow Rate, Collection Devices, and Extraction Methods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Jul/Aug, 2018 | Pubmed ID: 29708819 Effect of Tear Collection on Lacrimal Total Protein Content in Dogs and Cats: a Comparison Between Schirmer Strips and Ophthalmic Sponges BMC Veterinary Research. Mar, 2018 | Pubmed ID: 29490661 Tear Fluid Collection in Dogs and Cats Using Ophthalmic Sponges Veterinary Ophthalmology. May, 2018 | Pubmed ID: 28845579 Current Diagnostics for Chronic Enteropathies in Dogs Veterinary Clinical Pathology. Month, | Pubmed ID: 34699081 Clinical Efficacy of Prebiotics and Glycosaminoglycans Versus Placebo In Dogs with Food Responsive Enteropathy Receiving a Hydrolyzed Diet: A Pilot Study PloS One. Month, | Pubmed ID: 34673776 Multiomic Analysis Defines the First MicroRNA Atlas Across All Small Intestinal Epithelial Lineages and Reveals Novel Markers of Almost All Major Cell Types American Journal of Physiology. Gastrointestinal and Liver Physiology. Month, | Pubmed ID: 34643097 Inflammation, Negative Affect, and Amyloid Burden in Alzheimer's Disease: Insights from the Kynurenine Pathway Brain, Behavior, and Immunity. Month, | Pubmed ID: 33775832 Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man's Trash Is Another Man's Treasure Cancers. Month, | Pubmed ID: 33498666 Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study Journal of Alzheimer's Disease : JAD. Month, | Pubmed ID: 33252089 Treatment With Hydrolyzed Diet Supplemented With Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease Frontiers in Veterinary Science. Month, | Pubmed ID: 32851029 Walking in the Light: How History of Physical Activity, Sunlight, and Vitamin D Account for Body Fat-A UK Biobank Study Obesity (Silver Spring, Md.). Month, | Pubmed ID: 32573118 Recapitulation of the Accessible Interface of Biopsy-derived Canine Intestinal Organoids to Study Epithelial-luminal Interactions PloS One. Month, | Pubmed ID: 32302323 Apparent Total Tract Digestibility, Fecal Characteristics, and Blood Parameters of Healthy Adult Dogs Fed High-fat Diets Journal of Animal Science. Month, | Pubmed ID: 32047902 Glucocorticoid and Dietary Effects on Mucosal Microbiota in Canine Inflammatory Bowel Disease PloS One. Month, | Pubmed ID: 31887117 Microbiota-Related Changes in Unconjugated Fecal Bile Acids Are Associated With Naturally Occurring, Insulin-Dependent Diabetes Mellitus in Dogs Frontiers in Veterinary Science. Month, | Pubmed ID: 31316997 The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review Frontiers in Aging Neuroscience. Month, | Pubmed ID: 31275138 Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) MRNA is Over-expressed in the Duodenal Mucosa and is Negatively Correlated with Serum Tryptophan Concentrations in Dogs with Protein-losing Enteropathy PloS One. Month, | Pubmed ID: 31181125 Interleukin-13 and Interleukin-33 MRNA Are Underexpressed in the Duodenal Mucosa of German Shepherd Dogs with Chronic Enteropathy Journal of Veterinary Internal Medicine. Month, | Pubmed ID: 31169944 Derivation of Adult Canine Intestinal Organoids for Translational Research in Gastroenterology BMC Biology. Month, | Pubmed ID: 30975131 Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease Veterinary Pathology. Month, | Pubmed ID: 30563436 Retrospective Evaluation of Toceranib Phosphate (Palladia®) Use in the Treatment of Gastrointestinal Stromal Tumors of Dogs Journal of Veterinary Internal Medicine. Month, | Pubmed ID: 30307656 Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research The AAPS Journal. Month, | Pubmed ID: 29234895 Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative CPT: Pharmacometrics & Systems Pharmacology. Month, | Pubmed ID: 29178333 Canine Intestinal Organoids in a Dual-Chamber Permeable Support System Vojtech Gabriel1, Christopher Zdyrski1, Dipak K. Sahoo2, Kimberly Dao3, Agnes Bourgois-Mochel2, Todd Atherly3, Marilyn N. Martinez4, Donna A. Volpe5, Jamie Kopper2, Karin Allenspach2,3, Jonathan P. Mochel1,3 1Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, 2Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, 33D Health Solutions Inc., 4Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, 5Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration JoVE 63612 Imunologia e Infecção Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research Vojtech Gabriel1, Christopher Zdyrski1, Dipak K. Sahoo2, Kimberly Dao3, Agnes Bourgois-Mochel2, Jamie Kopper2, Xi-Lei Zeng4, Mary K. Estes4, Jonathan P. Mochel1,3, Karin Allenspach2,3 1Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, 2Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, 33D Health Solutions Inc., 4Department of Molecular Virology and Microbiology, Baylor College of Medicine JoVE 63515 Medicina
Canine Intestinal Organoids in a Dual-Chamber Permeable Support System Vojtech Gabriel1, Christopher Zdyrski1, Dipak K. Sahoo2, Kimberly Dao3, Agnes Bourgois-Mochel2, Todd Atherly3, Marilyn N. Martinez4, Donna A. Volpe5, Jamie Kopper2, Karin Allenspach2,3, Jonathan P. Mochel1,3 1Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, 2Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, 33D Health Solutions Inc., 4Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, 5Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration JoVE 63612 Imunologia e Infecção
Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research Vojtech Gabriel1, Christopher Zdyrski1, Dipak K. Sahoo2, Kimberly Dao3, Agnes Bourgois-Mochel2, Jamie Kopper2, Xi-Lei Zeng4, Mary K. Estes4, Jonathan P. Mochel1,3, Karin Allenspach2,3 1Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, 2Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, 33D Health Solutions Inc., 4Department of Molecular Virology and Microbiology, Baylor College of Medicine JoVE 63515 Medicina