Juan Carlos Zapata School of Medicine-University of Maryland. University of Maryland Biography Publications Institution JoVE Articles Juan Carlos ZapataResearch Associate My main research interest is in virus-host interactions using animal models, genomic profiling, and basic molecular virology. I focused not only on host responses but also on changes that occur in the viral population in order to describe virus-host coevolution. I identified mutations in the arenavirus nucleocapsid protein (NP) that are likely to impact viral pathogenesis and the induction of protective immunity. During my postdoctoral training, I worked in detecting and characterizing HIV viral factors related with latency in the reservoir cells and in implanting patient-derived ATL cells into NSG mice to study cancer pathogenesis and treatment options. Currently, I am using humanized animal models to study infectious diseases (HIV, HTLV, HBV, HCV, and Dengue), human cancers and graft vs host disease (GvHD). I have also detected and characterized a CD8+ T cell sub-population, in humanized mice, that correlated with HIV protection in human beings. Publications A Single Dose of Modified Vaccinia Ankara Expressing Lassa Virus-like Particles Protects Mice from Lethal Intra-cerebral Virus Challenge Pathogens (Basel, Switzerland). Aug, 2019 | Pubmed ID: 31466243 Seroprevalence of Human T-lymphotropic Virus HTLV and Its Associated Factors in Donors of a Blood Bank of Medellín-Colombia, 2014-2018 PloS One. Month, 2019 | Pubmed ID: 31404110 HIV Replication in Humanized IL-3/GM-CSF-Transgenic NOG Mice Pathogens (Basel, Switzerland). Mar, 2019 | Pubmed ID: 30871027 T-Cell Response to Viral Hemorrhagic Fevers Vaccines. Jan, 2019 | Pubmed ID: 30678246 Improving the Breadth of the Host's Immune Response to Lassa Virus Pathogens (Basel, Switzerland). Oct, 2018 | Pubmed ID: 30373278 Development of a Serosurveillance Assay for Detection of Necoclí Virus Exposure Archives of Virology. Dec, 2018 | Pubmed ID: 30191374 A Primate Model for Viral Hemorrhagic Fever Methods in Molecular Biology (Clifton, N.J.). Month, 2018 | Pubmed ID: 28986843 Diagnostics for Lassa Fever: Detecting Host Antibody Responses Methods in Molecular Biology (Clifton, N.J.). Month, 2018 | Pubmed ID: 28986826 Modulation of SIV and HIV DNA Vaccine Immunity by Fas-FasL Signaling Viruses. Mar, 2015 | Pubmed ID: 25807052 Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate PLoS Neglected Tropical Diseases. Month, 2013 | Pubmed ID: 24069471 Arenavirus Variations Due to Host-specific Adaptation Viruses. Jan, 2013 | Pubmed ID: 23344562 Gene Expression in Primate Liver During Viral Hemorrhagic Fever Virology Journal. Feb, 2009 | Pubmed ID: 19216742 Early Blood Profiles of Virus Infection in a Monkey Model for Lassa Fever Journal of Virology. Aug, 2007 | Pubmed ID: 17522210 Vaccinia Virus Inhibits T Cell Receptor-dependent Responses by Human Gammadelta T Cells The Journal of Infectious Diseases. Jan, 2007 | Pubmed ID: 17152007 The Proline-rich Homeodomain (PRH/HEX) Protein is Down-regulated in Liver During Infection with Lymphocytic Choriomeningitis Virus Journal of Virology. Feb, 2005 | Pubmed ID: 15681447 Monocytes Treated with Human Immunodeficiency Virus Tat Kill Uninfected CD4(+) Cells by a Tumor Necrosis Factor-related Apoptosis-induced Ligand-mediated Mechanism Journal of Virology. Jun, 2003 | Pubmed ID: 12767990 Хроническая, острая и активированная ВИЧ-инфекция в гуманизированных иммунодефицитных моделях мыши Federico Perdomo-Celis1,2, Sandra Medina-Moreno1, Alonso Heredia1, Harry Davis1, Joseph Bryant1, Juan Carlos Zapata1 1Institute of Human Virology, School of Medicine, University of Maryland, 2Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia JoVE 60315 Imunologia e Infecção
Хроническая, острая и активированная ВИЧ-инфекция в гуманизированных иммунодефицитных моделях мыши Federico Perdomo-Celis1,2, Sandra Medina-Moreno1, Alonso Heredia1, Harry Davis1, Joseph Bryant1, Juan Carlos Zapata1 1Institute of Human Virology, School of Medicine, University of Maryland, 2Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia JoVE 60315 Imunologia e Infecção