Kapil Bharti

Publications

• Considerations for Developing an Autologous Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) Replacement Therapy
  Cold Spring Harbor Perspectives in Medicine. Jul, 2023  |   Pubmed ID: 37487631
• Retina and RPE Lipid Profile Changes Linked with ABCA4 Associated Stargardt's Maculopathy
  Pharmacology & Therapeutics. Jun, 2023  |   Pubmed ID: 37385300
• Protocol to Generate Endothelial Cells, Pericytes, and Fibroblasts in One Differentiation Round from Human-induced Pluripotent Stem Cells
  STAR Protocols. May, 2023  |   Pubmed ID: 37149860
• Stem Cell Sources and Characterization in the Development of Cell-based Products for Treating Retinal Disease: An NEI Town Hall Report
  Stem Cell Research & Therapy. Mar, 2023  |   Pubmed ID: 36978104
• Bioprinted 3D Outer Retina Barrier Uncovers RPE-dependent Choroidal Phenotype in Advanced Macular Degeneration
  Nature Methods. Jan, 2023  |   Pubmed ID: 36550275
• Cell-autonomous Lipid-handling Defects in Stargardt IPSC-derived Retinal Pigment Epithelium Cells
  Stem Cell Reports. Nov, 2022  |   Pubmed ID: 36306781
• Triphasic Developmentally Guided Protocol to Generate Retinal Pigment Epithelium from Induced Pluripotent Stem Cells
  STAR Protocols. Sep, 2022  |   Pubmed ID: 35880133
• Cell Culture Models to Study Retinal Pigment Epithelium-related Pathogenesis in Age-related Macular Degeneration
  Experimental Eye Research. Sep, 2022  |   Pubmed ID: 35835183
• In vitro Disease Modeling of Oculocutaneous Albinism Type 1 and 2 Using Human Induced Pluripotent Stem Cell-derived Retinal Pigment Epithelium
  Stem Cell Reports. Jan, 2022  |   Pubmed ID: 35021041
• Epithelial Phenotype Restoring Drugs Suppress Macular Degeneration Phenotypes in an IPSC Model
  Nature Communications. Dec, 2021  |   Pubmed ID: 34911940
• AMPK Modulation Ameliorates Dominant Disease Phenotypes of CTRP5 Variant in Retinal Degeneration
  Communications Biology. Dec, 2021  |   Pubmed ID: 34887495
• CSF1R Blockade Induces Macrophage Ablation and Results in Mouse Choroidal Vascular Atrophy and RPE Disorganization
  ELife. Apr, 2020  |   Pubmed ID: 32234210
• Retinal Pigment Epithelium Replacement Therapy for Age-Related Macular Degeneration: Are We There Yet?
  Annual Review of Pharmacology and Toxicology. 01, 2020  |   Pubmed ID: 31914900
• Retinal Stem Cell Transplantation: Balancing Safety and Potential
  Progress in Retinal and Eye Research. 03, 2020  |   Pubmed ID: 31494256
• High-yield, Automated Intracellular Electrophysiology in Retinal Pigment Epithelia
  Journal of Neuroscience Methods. 12, 2019  |   Pubmed ID: 31562888
• Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice
  Investigative Ophthalmology & Visual Science. 12, 2018  |   Pubmed ID: 30590377
• Identifying Core Biological Processes Distinguishing Human Eye Tissues with Precise Systems-level Gene Expression Analyses and Weighted Correlation Networks
  Human Molecular Genetics. 10, 2018  |   Pubmed ID: 30239781
• Report of the International Conference on Manufacturing and Testing of Pluripotent Stem Cells
  Biologicals : Journal of the International Association of Biological Standardization. Nov, 2018  |   Pubmed ID: 30150108
• Allogeneic IPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates
  Investigative Ophthalmology & Visual Science. 03, 2018  |   Pubmed ID: 29625461
• Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells
  Cell Reports. 01, 2018  |   Pubmed ID: 29298421
• Polarized Human Retinal Pigment Epithelium Exhibits Distinct Surface Proteome on Apical and Basal Plasma Membranes
  Methods in Molecular Biology (Clifton, N.J.). 2018  |   Pubmed ID: 29264809
• MITF - A Controls Branching Morphogenesis and Nephron Endowment
  PLoS Genetics. 12, 2017  |   Pubmed ID: 29240767
• A Switchable Positive and Negative Air Pressure Device for Efficient and Gentle Handling of Nanofiber Scaffolds
  The Review of Scientific Instruments. Oct, 2017  |   Pubmed ID: 29092483
• A Basis for Comparison: Sensitive Authentication of Stem Cell Derived RPE Using Physiological Responses of Intact RPE Monolayers
  Stem Cell and Translational Investigation. 2017  |   Pubmed ID: 28286868
• Training to Improve Precision and Accuracy in the Measurement of Fiber Morphology
  PloS One. 2016  |   Pubmed ID: 27907145
• In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications
  Stem Cells Translational Medicine. Jul, 2016  |   Pubmed ID: 27400791
• Nanofiber Scaffold-Based Tissue-Engineered Retinal Pigment Epithelium to Treat Degenerative Eye Diseases
  Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Jun, 2016  |   Pubmed ID: 27110730
• Human Adult Retinal Pigment Epithelial Stem Cell-Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue
  Investigative Ophthalmology & Visual Science. Nov, 2015  |   Pubmed ID: 26540654
• Dataset for the Validation and Use of DiameterJ an Open Source Nanofiber Diameter Measurement Tool
  Data in Brief. Dec, 2015  |   Pubmed ID: 26380840
• Small-molecule-directed, Efficient Generation of Retinal Pigment Epithelium from Human Pluripotent Stem Cells
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2015  |   Pubmed ID: 26269569
• DiameterJ: A Validated Open Source Nanofiber Diameter Measurement Tool
  Biomaterials. Aug, 2015  |   Pubmed ID: 26043061
• PAX6 Regulates Melanogenesis in the Retinal Pigmented Epithelium Through Feed-forward Regulatory Interactions with MITF
  PLoS Genetics. 2014  |   Pubmed ID: 24875170
• Developing Cellular Therapies for Retinal Degenerative Diseases
  Investigative Ophthalmology & Visual Science. Feb, 2014  |   Pubmed ID: 24573369
• The Indirect Role of Fibroblast Growth Factor-8 in Defining Neurogenic Niches of the Olfactory/GnRH Systems
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2013  |   Pubmed ID: 24336726
• Efficient and Rapid Derivation of Primitive Neural Stem Cells and Generation of Brain Subtype Neurons from Human Pluripotent Stem Cells
  Stem Cells Translational Medicine. Nov, 2013  |   Pubmed ID: 24113065
• Vax1/2 Genes Counteract Mitf-induced Respecification of the Retinal Pigment Epithelium
  PloS One. 2013  |   Pubmed ID: 23555005
• Conditional Knockdown of DNA Methyltransferase 1 Reveals a Key Role of Retinal Pigment Epithelium Integrity in Photoreceptor Outer Segment Morphogenesis
  Development (Cambridge, England). Mar, 2013  |   Pubmed ID: 23406904
• A Regulatory Loop Involving PAX6, MITF, and WNT Signaling Controls Retinal Pigment Epithelium Development
  PLoS Genetics. Jul, 2012  |   Pubmed ID: 22792072
• Lack of the Ventral Anterior Homeodomain Transcription Factor VAX1 Leads to Induction of a Second Pituitary
  Development (Cambridge, England). Mar, 2011  |   Pubmed ID: 21247964
• The New Paradigm: Retinal Pigment Epithelium Cells Generated from Embryonic or Induced Pluripotent Stem Cells
  Pigment Cell & Melanoma Research. Feb, 2011  |   Pubmed ID: 20846177
• The Basic-helix-loop-helix-leucine Zipper Gene Mitf: Analysis of Alternative Promoter Choice and Splicing
  Methods in Molecular Biology (Clifton, N.J.). 2010  |   Pubmed ID: 20694671
• Lack of the Mesodermal Homeodomain Protein MEOX1 Disrupts Sclerotome Polarity and Leads to a Remodeling of the Cranio-cervical Joints of the Axial Skeleton
  Developmental Biology. Aug, 2009  |   Pubmed ID: 19520072
• Expression Profiling During Ocular Development Identifies 2 Nlz Genes with a Critical Role in Optic Fissure Closure
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009  |   Pubmed ID: 19171890
• Alternative Promoter Use in Eye Development: the Complex Role and Regulation of the Transcription Factor MITF
  Development (Cambridge, England). Mar, 2008  |   Pubmed ID: 18272592
• Src-dependent Phosphorylation of ASAP1 Regulates Podosomes
  Molecular and Cellular Biology. Dec, 2007  |   Pubmed ID: 17893324
• The Other Pigment Cell: Specification and Development of the Pigmented Epithelium of the Vertebrate Eye
  Pigment Cell Research. Oct, 2006  |   Pubmed ID: 16965267
• When Pigment Cells Turn into Neurons
  The Journal of Investigative Dermatology. Oct, 2005  |   Pubmed ID: 16185257