Kenju Shimomura Department of Bioregulation and Pharmacological Medicine Fukushima Medical University Biography Publications Institution JoVE Articles Kenju Shimomura has not added a biography. If you are Kenju Shimomura and would like to personalize this page please email our Author Liaison for assistance. Publications The Deletion of Glucagon-like Peptide-1 Receptors Expressing Neurons in the Dorsomedial Hypothalamic Nucleus Disrupts the Diurnal Feeding Pattern and Induces Hyperphagia and Obesity Nutrition & Metabolism. Jun, 2021 | Pubmed ID: 34098999 Evaluation of Effect of Ninjin'yoeito on Regional Brain Glucose Metabolism by F-FDG Autoradiography With Insulin Loading in Aged Mice Frontiers in Nutrition. 2021 | Pubmed ID: 34055854 Construction of Patient-derived Tumor Models to Evaluate Anticancer Agents and Cancer Immunotherapy Oncology Letters. May, 2021 | Pubmed ID: 33841567 Evaluation of Organ Glucose Metabolism by F-FDG Accumulation with Insulin Loading in Aged Mice Compared with Young Normal Mice Scientific Reports. Apr, 2021 | Pubmed ID: 33795778 Structure Based Analysis of K Channel with a DEND Syndrome Mutation in Murine Skeletal Muscle Scientific Reports. Mar, 2021 | Pubmed ID: 33758250 Urinary Excretion of Nadolol As a Possible In Vivo Probe for Drug Interactions Involving P-Glycoprotein Journal of Clinical Pharmacology. Jun, 2021 | Pubmed ID: 33387374 Opening of Intermediate Conductance Ca-Activated K Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter Via the Akt/Mammalian Target of Rapamycin Pathway The Journal of Pharmacology and Experimental Therapeutics. 03, 2021 | Pubmed ID: 33376149 Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers Clinical and Translational Science. Mar, 2021 | Pubmed ID: 33048477 Targeting Oxytocin Receptor (Oxtr)-expressing Neurons in the Lateral Septum to Restore Social Novelty in Autism Spectrum Disorder Mouse Models Scientific Reports. 12, 2020 | Pubmed ID: 33335150 Detection of NUCB2/nesfatin-1 in Cerebrospinal Fluid of Multiple Sclerosis Patients Aging. 12, 2020 | Pubmed ID: 33318307 Gs/Gq Signaling Switch in β Cells Defines Incretin Effectiveness in Diabetes The Journal of Clinical Investigation. 12, 2020 | Pubmed ID: 33196462 Single Administration of Resveratrol Improves Social Behavior in Adult Mouse Models of Autism Spectrum Disorder Bioscience, Biotechnology, and Biochemistry. Nov, 2020 | Pubmed ID: 32698690 Early Life High-fat Diet Exposure Evokes Normal Weight Obesity Nutrition & Metabolism. 2020 | Pubmed ID: 32595758 Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells BioResearch Open Access. 2020 | Pubmed ID: 32368413 Effects of Single Green Tea Ingestion on Pharmacokinetics of Nadolol in Healthy Volunteers British Journal of Clinical Pharmacology. 11, 2020 | Pubmed ID: 32320490 Oral Oxytocin Delivery with Proton Pump Inhibitor Pretreatment Decreases Food Intake Peptides. 06, 2020 | Pubmed ID: 32298773 Atorvastatin-Green Tea Interaction: Possible Mechanisms Are Complicated, But Clinical Relevance is Not? European Journal of Drug Metabolism and Pharmacokinetics. 06, 2020 | Pubmed ID: 32297048 TAK-242, a Specific Inhibitor of Toll-like Receptor 4 Signalling, Prevents Endotoxemia-induced Skeletal Muscle Wasting in Mice Scientific Reports. 01, 2020 | Pubmed ID: 31959927 Cluster of Differentiation 8 and Programmed Cell Death Ligand 1 Expression in Triple-negative Breast Cancer Combined with Autosomal Dominant Polycystic Kidney Disease and Tuberous Sclerosis Complex: a Case Report Journal of Medical Case Reports. Dec, 2019 | Pubmed ID: 31870441 The Hypothalamus to Brainstem Circuit Suppresses Late-onset Body Weight Gain Scientific Reports. 12, 2019 | Pubmed ID: 31798010 Association Between Cognitive Impairment Patient with Solid Cancer and Insulin Resistance BMC Research Notes. Oct, 2019 | Pubmed ID: 31661025 The SGLT2 Inhibitor Canagliflozin Prevents Carcinogenesis in a Mouse Model of Diabetes and Non-Alcoholic Steatohepatitis-Related Hepatocarcinogenesis: Association with SGLT2 Expression in Hepatocellular Carcinoma International Journal of Molecular Sciences. Oct, 2019 | Pubmed ID: 31652578 The Undeveloped Properties of GABA Neurons in the Ventral Tegmental Area Promote Energy Intake for Growth in Juvenile Rats Scientific Reports. 08, 2019 | Pubmed ID: 31413349 An In Vitro System for Evaluating Molecular Targeted Drugs Using Lung Patient-Derived Tumor Organoids Cells. 05, 2019 | Pubmed ID: 31137590 MLH1 Germline Mutation Associated with Lynch Syndrome in a Family Followed for More Than 45 years BMC Medical Genetics. 05, 2019 | Pubmed ID: 31046708 Noninvasive Continuous Blood Pressure Monitoring Using Microelectromechanical System Technology Blood Pressure Monitoring. Jun, 2019 | Pubmed ID: 30998555 LGR4 is Essential for R-spondin1-mediated Suppression of Food Intake Via Pro-opiomelanocortin Bioscience, Biotechnology, and Biochemistry. Jul, 2019 | Pubmed ID: 30916623 Impact of Dapagliflozin, an SGLT2 Inhibitor, on Serum Levels of Soluble Dipeptidyl Peptidase-4 in Patients with Type 2 Diabetes and Non-alcoholic Fatty Liver Disease International Journal of Clinical Practice. May, 2019 | Pubmed ID: 30810254 Structural Basis of Different Substrate Preferences of Two Old Yellow Enzymes from Yeasts in the Asymmetric Reduction of Enone Compounds Bioscience, Biotechnology, and Biochemistry. Mar, 2019 | Pubmed ID: 30445889 Excitability of Oxytocin Neurons in Paraventricular Nucleus is Regulated by Voltage-gated Potassium Channels Kv4.2 and Kv4.3 Bioscience, Biotechnology, and Biochemistry. Feb, 2019 | Pubmed ID: 30392457 The Effect of Avertin Anesthesia and a Mixture of Three Types of Anesthetic Agents on Food Intakeand Body Weight in High Fat-induced Obese Maleand Female Mice Experimental Animals. Feb, 2019 | Pubmed ID: 30210091 Poland Syndrome Accompanied by Internal Iliac Artery Supply Disruption Sequence: a Case Report Journal of Medical Case Reports. Oct, 2018 | Pubmed ID: 30360754 Memantine Has No Effect on K Channels in Pancreatic β Cells BMC Research Notes. Aug, 2018 | Pubmed ID: 30144824 Similar Effect of Quercetin on CYP2E1 and CYP2C9 Activities in Humans? European Journal of Clinical Pharmacology. Sep, 2018 | Pubmed ID: 29770840 Update of Green Tea Interactions with Cardiovascular Drugs and putative Mechanisms Journal of Food and Drug Analysis. 04, 2018 | Pubmed ID: 29703388 The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication Neuroendocrinology. 2018 | Pubmed ID: 29660735 Action Selection and Flexible Switching Controlled by the Intralaminar Thalamic Neurons Cell Reports. 02, 2018 | Pubmed ID: 29490273 K Channel Mutations and Neonatal Diabetes Internal Medicine (Tokyo, Japan). Sep, 2017 | Pubmed ID: 28824061 Impact of Sex, Fat Distribution and Initial Body Weight on Oxytocin's Body Weight Regulation Scientific Reports. 08, 2017 | Pubmed ID: 28819236 Nesfatin-1 Inhibits Voltage Gated K Channels in Pancreatic Beta Cells Peptides. Sep, 2017 | Pubmed ID: 28697955 Non-alcoholic Fatty Liver Disease Is a Risk Factor for Type 2 Diabetes in Middle-aged Japanese Men and Women Internal Medicine (Tokyo, Japan). 2017 | Pubmed ID: 28381741 Orexin Action on Oxytocin Neurons in the Paraventricular Nucleus of the Hypothalamus Neuroreport. Apr, 2017 | Pubmed ID: 28338525 Islet Insulin Secretion Measurements in the Mouse Current Protocols in Mouse Biology. Sep, 2016 | Pubmed ID: 27584553 Projections from a Single NUCB2/nesfatin-1 Neuron in the Paraventricular Nucleus to Different Brain Regions Involved in Feeding Brain Structure & Function. 12, 2016 | Pubmed ID: 26639940 Central Action of ELABELA Reduces Food Intake and Activates Arginine Vasopressin and Corticotropin-releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus Neuroreport. Sep, 2015 | Pubmed ID: 26237243 Water Intake Disorder in a DEND Syndrome Afflicted Patient with R50P Mutation Endocrine Journal. 2015 | Pubmed ID: 25739471 Oxytocinergic Circuit from Paraventricular and Supraoptic Nuclei to Arcuate POMC Neurons in Hypothalamus FEBS Letters. Nov, 2014 | Pubmed ID: 25448678 Chronic Phencyclidine Treatment Induces Long-lasting Glutamatergic Activation of VTA Dopamine Neurons Neuroscience Letters. Apr, 2014 | Pubmed ID: 24525246 High-Throughput In Vitro Assay ved bruk av pasientavledede tumororganoider Arisa Higa1, Nobuhiko Takahashi2,3, Gen Hiyama2, Hirosumi Tamura2, Hirotaka Hoshi2, Kenju Shimomura3, Shinya Watanabe2, Motoki Takagi2 1FUJIFILM Wako Bio Solutions Corporation, 2Medical-Industrial Translational Research Center, Fukushima Medical University, 3Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University JoVE 62668 Pesquisa do câncer
High-Throughput In Vitro Assay ved bruk av pasientavledede tumororganoider Arisa Higa1, Nobuhiko Takahashi2,3, Gen Hiyama2, Hirosumi Tamura2, Hirotaka Hoshi2, Kenju Shimomura3, Shinya Watanabe2, Motoki Takagi2 1FUJIFILM Wako Bio Solutions Corporation, 2Medical-Industrial Translational Research Center, Fukushima Medical University, 3Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University JoVE 62668 Pesquisa do câncer