Letian Shan The First Affiliated Hospital Zhejiang Chinese Medical University Biography Publications Institution JoVE Articles Letian Shan has not added a biography. If you are Letian Shan and would like to personalize this page please email our Author Liaison for assistance. Publications Nanofat Lysate Ameliorates Pain and Cartilage Degradation of Osteoarthritis Through Activation of TGF-β-Smad2/3 Signaling of Chondrocytes Frontiers in Pharmacology. 2023 | Pubmed ID: 37050907 An Innovative Model of ISS-Based Multiple Fractures and Gastrointestinal Dysfunction Related to C-Kit Protein Expression on Interstitial Cells of Cajal Orthopaedic Surgery. May, 2023 | Pubmed ID: 36919913 Acute Developmental Toxicity of Panax Notoginseng in Zebrafish Larvae Chinese Journal of Integrative Medicine. Apr, 2023 | Pubmed ID: 35089525 Intra-articular Injection of Placental Mesenchymal Stromal Cells Ameliorates Pain and Cartilage Anabolism/catabolism in Knee Osteoarthritis Frontiers in Pharmacology. 2022 | Pubmed ID: 36523496 Identification of Gedunin from a Phytochemical Depository As a Novel Multidrug Resistance-Bypassing Tubulin Inhibitor of Cancer Cells Molecules (Basel, Switzerland). Sep, 2022 | Pubmed ID: 36144591 Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism Stem Cell Reviews and Reports. Aug, 2022 | Pubmed ID: 35864432 Onset of P53/NF-κB Signaling Crosstalk in Human Melanoma Cells in Response to Anti-cancer Theabrownin FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2022 | Pubmed ID: 35779042 Human Umbilical Cord-derived Mesenchymal Stem Cells Not Only Ameliorate Blood Glucose but Also Protect Vascular Endothelium from Diabetic Damage Through a Paracrine Mechanism Mediated by MAPK/ERK Signaling Stem Cell Research & Therapy. Jun, 2022 | Pubmed ID: 35715841 Intra-Articular Injection of Adipose-Derived Stem Cells Ameliorates Pain and Cartilage Anabolism/Catabolism in Osteoarthritis: Preclinical and Clinical Evidences Frontiers in Pharmacology. 2022 | Pubmed ID: 35387326 Fuzi Decoction Ameliorates Pain and Cartilage Degeneration of Osteoarthritic Rats Through PI3K-Akt Signaling Pathway and Its Clinical Retrospective Evidence Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Jun, 2022 | Pubmed ID: 35378415 Tanshinol Suppresses Osteosarcoma by Specifically Inducing Apoptosis of U2-OS Cells Through P53-mediated Mechanism Journal of Ethnopharmacology. Jun, 2022 | Pubmed ID: 35331874 Growth Factors-based Platelet Lysate Rejuvenates Skin Against Ageing Through NF-κB Signalling Pathway: In Vitro and in Vivo Mechanistic and Clinical Studies Cell Proliferation. Apr, 2022 | Pubmed ID: 35274780 Green Tea-derived Theabrownin Suppresses Human Non-small Cell Lung Carcinoma in Xenograft Model Through Activation of Not Only P53 Signaling but Also MAPK/JNK Signaling Pathway Journal of Ethnopharmacology. Jun, 2022 | Pubmed ID: 35271947 Green Tea-derived Theabrownin Induces Cellular Senescence and Apoptosis of Hepatocellular Carcinoma Through P53 Signaling Activation and Bypassed JNK Signaling Suppression Cancer Cell International. Jan, 2022 | Pubmed ID: 35078476 A Novel Mutation of the KLK6 Gene in a Family With Knee Osteoarthritis Frontiers in Genetics. 2021 | Pubmed ID: 34858488 Identification and Validation of Hub Genes of Synovial Tissue for Patients with Osteoarthritis and Rheumatoid Arthritis Hereditas. Sep, 2021 | Pubmed ID: 34583778 Cytotoxicity of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide in Multidrug-resistant Cancer Cells Through Activation of PERK/eIF2α/ATF4 Pathway Biochemical Pharmacology. Nov, 2021 | Pubmed ID: 34582772 Pain Relief and Cartilage Repair by Nanofat Against Osteoarthritis: Preclinical and Clinical Evidence Stem Cell Research & Therapy. Aug, 2021 | Pubmed ID: 34446107 A Systematic Review and Meta-Analysis of the SuperPATH Approach in Hip Arthroplasty BioMed Research International. 2021 | Pubmed ID: 34337015 A Novel Moniliformin Derivative As Pan-inhibitor of Histone Deacetylases Triggering Apoptosis of Leukemia Cells Biochemical Pharmacology. Dec, 2021 | Pubmed ID: 34265280 Urine Metabolomics Profiling of Lumbar Disc Herniation and Its Traditional Chinese Medicine Subtypes in Patients Through Gas Chromatography Coupled With Mass Spectrometry Frontiers in Molecular Biosciences. 2021 | Pubmed ID: 34179074 Selection of Safe Artemisinin Derivatives Using a Machine Learning-based Cardiotoxicity Platform and in Vitro and in Vivo Validation Archives of Toxicology. Jul, 2021 | Pubmed ID: 34021777 Protective Effects of Total Flavonoids from Qu Zhi Qiao (fruit of Citrus Paradisi Cv. Changshanhuyou) on OVA-induced Allergic Airway Inflammation and Remodeling Through MAPKs and Smad2/3 Signaling Pathway Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Jun, 2021 | Pubmed ID: 33752061 Anti-Proliferative, Pro-Apoptotic, Anti-Migrative and Tumor-Inhibitory Effects and Pleiotropic Mechanism of Theaflavin on B16F10 Melanoma Cells OncoTargets and Therapy. 2021 | Pubmed ID: 33658796 Identification of Differentially Expressed Genes, Signaling Pathways and Immune Infiltration in Rheumatoid Arthritis by Integrated Bioinformatics Analysis Hereditas. Jan, 2021 | Pubmed ID: 33397492 Theabrownin Inhibits the Cytoskeleton‑dependent Cell Cycle, Migration and Invasion of Human Osteosarcoma Cells Through NF‑κB Pathway‑related Mechanisms Oncology Reports. Dec, 2020 | Pubmed ID: 33125106 Growth Factors-based Beneficial Effects of Platelet Lysate on Umbilical Cord-derived Stem Cells and Their Synergistic Use in Osteoarthritis Treatment Cell Death & Disease. Oct, 2020 | Pubmed ID: 33057008 Theaflavin Induces Apoptosis of A375 Human Melanoma Cells and Inhibits Tumor Growth in Xenograft Zebrafishes Through P53- and JNK-Related Mechanism Frontiers in Pharmacology. 2020 | Pubmed ID: 32982737 Theabrownin Induces Apoptosis and Tumor Inhibition of Hepatocellular Carcinoma Huh7 Cells Through ASK1-JNK-c-Jun Pathway OncoTargets and Therapy. 2020 | Pubmed ID: 32982289 Evaluation of Long-Time Decoction-Detoxicated (Processed Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis Frontiers in Pharmacology. 2020 | Pubmed ID: 32848727 Vitamin K Chloro Derivative (VKT-2) Inhibits HDAC6, Activates Autophagy and Apoptosis, and Inhibits Aggresome Formation in Hepatocellular Carcinoma Cells Biochemical Pharmacology. Oct, 2020 | Pubmed ID: 32721508 CircAGFG1 Drives Metastasis and Stemness in Colorectal Cancer by Modulating YY1/CTNNB1 Cell Death & Disease. Jul, 2020 | Pubmed ID: 32681092 Inhibition of Cell Migration and Induction of Apoptosis by a Novel Class II Histone Deacetylase Inhibitor, MCC2344 Pharmacological Research. Oct, 2020 | Pubmed ID: 32659428 Hepatoprotective and Anti-Oxidative Effects of Total Flavonoids From Qu Zhi Qiao (Fruit of Citrus Paradisi Cv.Changshanhuyou) on Nonalcoholic Steatohepatitis and Through Nrf2-ARE Signaling Pathway Frontiers in Pharmacology. 2020 | Pubmed ID: 32390839 Cardiotoxicity and Cardioprotection by Artesunate in Larval Zebrafish Dose-response : a Publication of International Hormesis Society. Jan-Mar, 2020 | Pubmed ID: 31975974 Hepatoprotective and Anti-inflammatory Effects of Total Flavonoids of Qu Zhi Ke (peel of Citrus Changshan-huyou) on Non-alcoholic Fatty Liver Disease in Rats Via Modulation of NF-κB and MAPKs Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Nov, 2019 | Pubmed ID: 31541796 Chondroprotective Effects of Platelet Lysate Towards Monoiodoacetate-induced Arthritis by Suppression of TNF-α-induced Activation of NF-ĸB Pathway in Chondrocytes Aging. 05, 2019 | Pubmed ID: 31089001 Agkistrodon Ameliorates Pain Response and Prevents Cartilage Degradation in Monosodium Iodoacetate-induced Osteoarthritic Rats by Inhibiting Chondrocyte Hypertrophy and Apoptosis Journal of Ethnopharmacology. Mar, 2019 | Pubmed ID: 30529425 [Effect of Huangdi Anxiao Capsules on Zebrafish Vascular Lesions Induced by High Glucose and High Fat] Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. Nov, 2018 | Pubmed ID: 30583635 In Vivo Acute Toxicity of Detoxified Fuzi (lateral Root of Aconitum Carmichaeli) After a Traditional Detoxification Process EXCLI Journal. 2018 | Pubmed ID: 30564068 Intra-Articular Injection of Extract Attenuates Pain Behavior and Cartilage Degeneration in Mono-Iodoacetate Induced Osteoarthritic Rats Frontiers in Pharmacology. 2018 | Pubmed ID: 30532708 Evaluation of Collagen Mixture on Promoting Skin Wound Healing in Zebrafish Caused by Acetic Acid Administration Biochemical and Biophysical Research Communications. Oct, 2018 | Pubmed ID: 30274782 Total Ginsenosides of Chinese Ginseng Induces Cell Cycle Arrest and Apoptosis in Colorectal Carcinoma HT-29 Cells Oncology Letters. Oct, 2018 | Pubmed ID: 30197678 Theabrownin Triggers DNA Damage to Suppress Human Osteosarcoma U2OS Cells by Activating P53 Signalling Pathway Journal of Cellular and Molecular Medicine. 09, 2018 | Pubmed ID: 29993186 Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis BioMed Research International. 2017 | Pubmed ID: 28840126 Epimedin C Promotes Vascularization During BMP2-Induced Osteogenesis and Tumor-Associated Angiogenesis The American Journal of Chinese Medicine. 2017 | Pubmed ID: 28659032 Theabrownin Inhibits Cell Cycle Progression and Tumor Growth of Lung Carcinoma Through C-myc-Related Mechanism Frontiers in Pharmacology. 2017 | Pubmed ID: 28289384 Total Coumarins of Hedyotis Diffusa Induces Apoptosis of Myelodysplastic Syndrome SKM-1 Cells by Activation of Caspases and Inhibition of PI3K/Akt Pathway Proteins Journal of Ethnopharmacology. Jan, 2017 | Pubmed ID: 27988397 Anti-Proliferative and Apoptosis-Inducing Effect of Theabrownin Against Non-small Cell Lung Adenocarcinoma A549 Cells Frontiers in Pharmacology. 2016 | Pubmed ID: 27994550 Biopiracy of Natural Products and Good Bioprospecting Practice Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Feb, 2016 | Pubmed ID: 26926178 In Vivo Cardiotoxicity Induced by Sodium Aescinate in Zebrafish Larvae Molecules (Basel, Switzerland). Feb, 2016 | Pubmed ID: 26907249 Medicinal Effect and Its JP2/RyR2-based Mechanism of Smilax Glabra Flavonoids on Angiotensin II-induced Hypertrophy Model of Cardiomyocytes Journal of Ethnopharmacology. Jul, 2015 | Pubmed ID: 25926285 Evaluation of Antioxidant-associated Efficacy of Flavonoid Extracts from a Traditional Chinese Medicine Hua Ju Hong (peels of Citrus Grandis (L.) Osbeck) Journal of Ethnopharmacology. Dec, 2014 | Pubmed ID: 25446585 Plasma Metabonomic Profiling of Lumbar Disc Herniation and Its Traditional Chinese Medicine Subtypes in Patients by Using Gas Chromatography Coupled with Mass Spectrometry Molecular BioSystems. Nov, 2014 | Pubmed ID: 25144444 Chondroprotective Activity of a Detoxicated Traditional Chinese Medicine (Fuzi) of Aconitum Carmichaeli Debx Against Severe-stage Osteoarthritis Model Induced by Mono-iodoacetate Journal of Ethnopharmacology. 2014 | Pubmed ID: 24315981 Antitumor Activity of Bacterial Exopolysaccharides from the Endophyte Isolated from Oncology Letters. Jun, 2013 | Pubmed ID: 23833642 Développement Et évaluation D'une Stratégie Complète-détoxication Pour Fuzi (racines Latérales De Aconitum Carmichaeli) Et Son Application Dans Le Traitement De La Polyarthrite Rhumatoïde Journal of Ethnopharmacology. Mar, 2013 | Pubmed ID: 23376046 Pharmacokinetic Profile of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in Mice After Oral Administration of Polygonum Multiflorum Extract Drug Development and Industrial Pharmacy. Feb, 2012 | Pubmed ID: 21892876 A PVP-extract Fungal Protein of Omphalia Lapideacens and Its Antitumor Activity on Human Gastric Tumors and Normal Cells Oncology Reports. Dec, 2011 | Pubmed ID: 21894437 Gene Expression Profile of Steroid-induced Necrosis of Femoral Head of Rats Calcified Tissue International. Oct, 2011 | Pubmed ID: 21833848 Pharmacokinetics and Tissue Distribution of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside from Traditional Chinese Medicine Polygonum Multiflorum Following Oral Administration to Rats Journal of Ethnopharmacology. Sep, 2011 | Pubmed ID: 21679759 Développement et évaluation d’un modèle de rats-de-cartilage de pleine épaisseur Haiyan Zhang*1, Ronghua Bao*2, Jiaan Xu3, Yanzhi Ge4, Zuxiang Chen1, Mengqiang Fan1, Guangping Yu5, Li Zhou1, Le Guo3, Letian Shan1, Hangxing Bao1 1The First Affiliated Hospital, Zhejiang Chinese Medical University, 2Fuyang Orthopaedics and Traumatology Affiliated Hospital, Zhejiang Chinese Medical University, 3College of Pharmaceutical Science, Zhejiang Chinese Medical University, 4Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, 5Xianju County Hospital of Chinese Medicine JoVE 64475 Medicina Modèle de douleur arthrosique induite par injection intra-articulaire de mono-iodoacétate chez le rat Jiaan Xu1,2, Li Yan1,2, Bo Yan1,2, Li Zhou1, Peijian Tong1, Letian Shan1 1The First Affiliated Hospital, Zhejiang Chinese Medical University, 2College of Pharmaceutical Science, Zhejiang Chinese Medical University JoVE 60649 Medicina
Développement et évaluation d’un modèle de rats-de-cartilage de pleine épaisseur Haiyan Zhang*1, Ronghua Bao*2, Jiaan Xu3, Yanzhi Ge4, Zuxiang Chen1, Mengqiang Fan1, Guangping Yu5, Li Zhou1, Le Guo3, Letian Shan1, Hangxing Bao1 1The First Affiliated Hospital, Zhejiang Chinese Medical University, 2Fuyang Orthopaedics and Traumatology Affiliated Hospital, Zhejiang Chinese Medical University, 3College of Pharmaceutical Science, Zhejiang Chinese Medical University, 4Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, 5Xianju County Hospital of Chinese Medicine JoVE 64475 Medicina
Modèle de douleur arthrosique induite par injection intra-articulaire de mono-iodoacétate chez le rat Jiaan Xu1,2, Li Yan1,2, Bo Yan1,2, Li Zhou1, Peijian Tong1, Letian Shan1 1The First Affiliated Hospital, Zhejiang Chinese Medical University, 2College of Pharmaceutical Science, Zhejiang Chinese Medical University JoVE 60649 Medicina