Louis H. Philipson Committee on Molecular Metabolism and Nutrition The University of Chicago Biography Publications Institution JoVE Articles Louis H. Philipson has not added a biography. If you are Louis H. Philipson and would like to personalize this page please email our Author Liaison for assistance. Publications SUMO Down-regulates GLP-1 Stimulated CAMP Generation and Insulin Secretion American Journal of Physiology. Endocrinology and Metabolism. Jan, 2012 | Pubmed ID: 22234371 Neonatal Diabetes: an Expanding List of Genes Allows for Improved Diagnosis and Treatment Current Diabetes Reports. Dec, 2011 | Pubmed ID: 21993633 Coupling of Metabolic, Second Messenger Pathways and Insulin Granule Dynamics in Pancreatic Beta-cells: a Computational Analysis Progress in Biophysics and Molecular Biology. Nov, 2011 | Pubmed ID: 21920379 Creation of the Web-based University of Chicago Monogenic Diabetes Registry: Using Technology to Facilitate Longitudinal Study of Rare Subtypes of Diabetes Journal of Diabetes Science and Technology. Jul, 2011 | Pubmed ID: 21880229 Who Should Have Genetic Testing for Maturity-onset Diabetes of the Young? Clinical Endocrinology. Oct, 2011 | Pubmed ID: 21521318 Erratum To: Clinical and Molecular Genetics of Neonatal Diabetes Due to Mutations in the Insulin Gene Reviews in Endocrine & Metabolic Disorders. Feb, 2011 | Pubmed ID: 21286820 The Cost-effectiveness of Personalized Genetic Medicine: the Case of Genetic Testing in Neonatal Diabetes Diabetes Care. Mar, 2011 | Pubmed ID: 21273495 Clinical and Molecular Genetics of Neonatal Diabetes Due to Mutations in the Insulin Gene Reviews in Endocrine & Metabolic Disorders. Sep, 2010 | Pubmed ID: 20938745 Conditional Gene Targeting in Mouse Pancreatic ß-Cells: Analysis of Ectopic Cre Transgene Expression in the Brain Diabetes. Dec, 2010 | Pubmed ID: 20802254 Glucose-induced ERM Protein Activation and Translocation Regulates Insulin Secretion American Journal of Physiology. Endocrinology and Metabolism. Nov, 2010 | Pubmed ID: 20739507 Calcium-activated and Voltage-gated Potassium Channels of the Pancreatic Islet Impart Distinct and Complementary Roles During Secretagogue Induced Electrical Responses The Journal of Physiology. Sep, 2010 | Pubmed ID: 20643768 Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinaemia and Diabetes Nature. Jul, 2010 | Pubmed ID: 20562852 Blood Sugar Measurement in Zebrafish Reveals Dynamics of Glucose Homeostasis Zebrafish. Jun, 2010 | Pubmed ID: 20515318 Glucose Sensing in the Pancreatic Beta Cell: a Computational Systems Analysis Theoretical Biology & Medical Modelling. 2010 | Pubmed ID: 20497556 Neonatal Diabetes Mellitus: a Model for Personalized Medicine Trends in Endocrinology and Metabolism: TEM. Aug, 2010 | Pubmed ID: 20434356 Update in Neonatal Diabetes Current Opinion in Endocrinology, Diabetes, and Obesity. Feb, 2010 | Pubmed ID: 19952737 In Vitro Processing and Secretion of Mutant Insulin Proteins That Cause Permanent Neonatal Diabetes American Journal of Physiology. Endocrinology and Metabolism. Mar, 2010 | Pubmed ID: 19952343 The Granular Chloride Channel ClC-3 is Permissive for Insulin Secretion Cell Metabolism. Oct, 2009 | Pubmed ID: 19808024 A Nanoporous, Transparent Microcontainer for Encapsulated Islet Therapy Journal of Diabetes Science and Technology. Mar, 2009 | Pubmed ID: 19746206 Tooth Discoloration in Patients with Neonatal Diabetes After Transfer Onto Glibenclamide: a Previously Unreported Side Effect Diabetes Care. Aug, 2009 | Pubmed ID: 19435956 Leptin Deficiency and Beta-cell Dysfunction Underlie Type 2 Diabetes in Compound Akt Knockout Mice Molecular and Cellular Biology. Jun, 2009 | Pubmed ID: 19289493 The Alpha-cell Conundrum: ATP-sensitive K+ Channels and Glucose Sensing Diabetes. Feb, 2009 | Pubmed ID: 19171747 The Chemistrode: a Droplet-based Microfluidic Device for Stimulation and Recording with High Temporal, Spatial, and Chemical Resolution Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008 | Pubmed ID: 18974218 Diagnosis and Treatment of Neonatal Diabetes: a United States Experience Pediatric Diabetes. Oct, 2008 | Pubmed ID: 18662362 Reversible Translocation of EYFP-tagged STIM1 is Coupled to Calcium Influx in Insulin Secreting Beta-cells Cell Calcium. Dec, 2008 | Pubmed ID: 18452988 When BAD is Good for Beta Cells Cell Metabolism. Apr, 2008 | Pubmed ID: 18396130 Mutations in the Insulin Gene Can Cause MODY and Autoantibody-negative Type 1 Diabetes Diabetes. Apr, 2008 | Pubmed ID: 18192540 Insulin Mutation Screening in 1,044 Patients with Diabetes: Mutations in the INS Gene Are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood Diabetes. Apr, 2008 | Pubmed ID: 18162506 Glucose Homeostasis, Insulin Secretion, and Islet Phospholipids in Mice That Overexpress IPLA2beta in Pancreatic Beta-cells and in IPLA2beta-null Mice American Journal of Physiology. Endocrinology and Metabolism. Feb, 2008 | Pubmed ID: 17895289 Regulation of CAMP Dynamics by Ca2+ and G Protein-coupled Receptors in the Pancreatic Beta-cell: a Computational Approach American Journal of Physiology. Cell Physiology. Dec, 2007 | Pubmed ID: 17928534 Insulin Gene Mutations As a Cause of Permanent Neonatal Diabetes Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17855560 Kv2.1 Ablation Alters Glucose-induced Islet Electrical Activity, Enhancing Insulin Secretion Cell Metabolism. Sep, 2007 | Pubmed ID: 17767909 Ethics of Hematopoietic Stem Cell Transplantation in Type 1 Diabetes Mellitus JAMA : the Journal of the American Medical Association. Jul, 2007 | Pubmed ID: 17635886 Protective Role for Nitric Oxide During the Endoplasmic Reticulum Stress Response in Pancreatic Beta-cells American Journal of Physiology. Endocrinology and Metabolism. Jun, 2007 | Pubmed ID: 17264231 Modulation of the Pancreatic Islet Beta-cell-delayed Rectifier Potassium Channel Kv2.1 by the Polyunsaturated Fatty Acid Arachidonate The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17197450 Reactive Species, Cellular Repair and Risk Factors in the Onset of Type 2 Diabetes Mellitus: Review and Hypothesis Current Diabetes Reviews. May, 2006 | Pubmed ID: 18220630 Recovery of Islet Beta-cell Function in Streptozotocin- Induced Diabetic Mice: an Indirect Role for the Spleen Diabetes. Dec, 2006 | Pubmed ID: 17130468 Cold Climate Genes and the Prevalence of Type 2 Diabetes Mellitus Medical Hypotheses. 2006 | Pubmed ID: 16797871 Visualizing Calcium Signaling in Cells by Digitized Wide-field and Confocal Fluorescent Microscopy Methods in Molecular Biology (Clifton, N.J.). 2006 | Pubmed ID: 16719350 Functional MR Microimaging of Pancreatic Beta-cell Activation Cell Transplantation. 2006 | Pubmed ID: 16719054 Downstream Regulatory Element Antagonistic Modulator Regulates Islet Prodynorphin Expression American Journal of Physiology. Endocrinology and Metabolism. Sep, 2006 | Pubmed ID: 16621893 Reversal of Diabetes in Non-obese Diabetic Mice Without Spleen Cell-derived Beta Cell Regeneration Science (New York, N.Y.). Mar, 2006 | Pubmed ID: 16556844 Oxidative Reactive Species in Cell Injury: Mechanisms in Diabetes Mellitus and Therapeutic Approaches Annals of the New York Academy of Sciences. Dec, 2005 | Pubmed ID: 16533924 Inositol (1,4,5)-trisphosphate Dynamics and Intracellular Calcium Oscillations in Pancreatic Beta-cells Diabetes. Nov, 2005 | Pubmed ID: 16249428 Delayed-rectifier (KV2.1) Regulation of Pancreatic Beta-cell Calcium Responses to Glucose: Inhibitor Specificity and Modeling American Journal of Physiology. Endocrinology and Metabolism. Oct, 2005 | Pubmed ID: 16014354 Adenine Nucleotide Regulation in Pancreatic Beta-cells: Modeling of ATP/ADP-Ca2+ Interactions American Journal of Physiology. Endocrinology and Metabolism. Nov, 2005 | Pubmed ID: 15985450 5-amino-imidazole Carboxamide Riboside Acutely Potentiates Glucose-stimulated Insulin Secretion from Mouse Pancreatic Islets by KATP Channel-dependent and -independent Pathways Biochemical and Biophysical Research Communications. May, 2005 | Pubmed ID: 15823553 FRET-based Voltage Probes for Confocal Imaging: Membrane Potential Oscillations Throughout Pancreatic Islets American Journal of Physiology. Cell Physiology. Jul, 2005 | Pubmed ID: 15758044 Does the Glucose-dependent Insulin Secretion Mechanism Itself Cause Oxidative Stress in Pancreatic Beta-cells? Diabetes. Aug, 2004 | Pubmed ID: 15277370 Direct Imaging Shows That Insulin Granule Exocytosis Occurs by Complete Vesicle Fusion Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15197259 Small-conductance Calcium-activated K+ Channels Are Expressed in Pancreatic Islets and Regulate Glucose Responses Diabetes. Aug, 2003 | Pubmed ID: 12882916 Modeling of Ca2+ Flux in Pancreatic Beta-cells: Role of the Plasma Membrane and Intracellular Stores American Journal of Physiology. Endocrinology and Metabolism. Jul, 2003 | Pubmed ID: 12644446 Visualizing Superoxide Production in Normal and Diabetic Rat Islets of Langerhans The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12514170 Insulin Secretory Deficiency and Glucose Intolerance in Rab3A Null Mice The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12510060 TRP Genes: Candidates for Nonselective Cation Channels and Store-operated Channels in Insulin-secreting Cells Diabetes. Feb, 2002 | Pubmed ID: 11815479 Intraperitoneal Injection into Adult Zebrafish Mary D. Kinkel1, Stefani C. Eames2, Louis H. Philipson2,3, Victoria E. Prince1 1Department of Organismal Biology and Anatomy, The University of Chicago, 2Committee on Molecular Metabolism and Nutrition, The University of Chicago, 3Department of Medicine, The University of Chicago JoVE 2126 Biologia
Intraperitoneal Injection into Adult Zebrafish Mary D. Kinkel1, Stefani C. Eames2, Louis H. Philipson2,3, Victoria E. Prince1 1Department of Organismal Biology and Anatomy, The University of Chicago, 2Committee on Molecular Metabolism and Nutrition, The University of Chicago, 3Department of Medicine, The University of Chicago JoVE 2126 Biologia