Marion MacFarlane MRC Toxicology Unit Biography Publications Institution JoVE Articles Marion MacFarlane has not added a biography. If you are Marion MacFarlane and would like to personalize this page please email our Author Liaison for assistance. Publications Development of a Patient-derived Explant Model for Prediction of Drug Responses in Endometrial Cancer Gynecologic Oncology. Feb, 2021 | Pubmed ID: 33309417 Evaluating and Comparing Immunostaining and Computational Methods for Spatial Profiling of Drug Response in Patient-derived Explants Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2020 | Pubmed ID: 33318618 Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors Analytical Chemistry. 07, 2020 | Pubmed ID: 32545955 Identification of a Novel Toxicophore in Anti-cancer Chemotherapeutics That Targets Mitochondrial Respiratory Complex I ELife. 05, 2020 | Pubmed ID: 32432547 Patient-derived Explants (PDEs) As a Powerful Preclinical Platform for Anti-cancer Drug and Biomarker Discovery British Journal of Cancer. 03, 2020 | Pubmed ID: 31894140 Patient-derived Explants, Xenografts and Organoids: 3-dimensional Patient-relevant Pre-clinical Models in Endometrial Cancer Gynecologic Oncology. 01, 2020 | Pubmed ID: 31767187 Evaluation of Apoptosis Imaging Biomarkers in a Genetic Model of Cell Death EJNMMI Research. Feb, 2019 | Pubmed ID: 30783791 Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials Chemical Research in Toxicology. 10, 2018 | Pubmed ID: 30156102 N-glycosylation of Mouse TRAIL-R Restrains TRAIL-induced Apoptosis Cell Death & Disease. 05, 2018 | Pubmed ID: 29717117 Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018 Cell Death and Differentiation. Mar, 2018 | Pubmed ID: 29362479 Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf) Current Biology : CB. Nov, 2017 | Pubmed ID: 29112861 Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival Cell Reports. 04, 2017 | Pubmed ID: 28445729 Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy Cancer Research. 04, 2017 | Pubmed ID: 28202521 Targeting Cell Death Signalling in Cancer: Minimising 'Collateral Damage' British Journal of Cancer. Jun, 2016 | Pubmed ID: 27140313 Co-operative and Hierarchical Binding of C-FLIP and Caspase-8: A Unified Model Defines How C-FLIP Isoforms Differentially Control Cell Fate Molecular Cell. Mar, 2016 | Pubmed ID: 26990987 Biochemical Analysis of Initiator Caspase-Activating Complexes: The Apoptosome and the Death-Inducing Signaling Complex Cold Spring Harbor Protocols. Dec, 2015 | Pubmed ID: 26631130 Activation, Isolation, and Analysis of the Death-Inducing Signaling Complex Cold Spring Harbor Protocols. Dec, 2015 | Pubmed ID: 26631122 In Vitro Assembly and Analysis of the Apoptosome Complex Cold Spring Harbor Protocols. Dec, 2015 | Pubmed ID: 26631121 Autophagy Limits Proliferation and Glycolytic Metabolism in Acute Myeloid Leukemia Cell Death Discovery. Aug, 2015 | Pubmed ID: 26568842 Notch4 Signaling Confers Susceptibility to TRAIL-Induced Apoptosis in Breast Cancer Cells Journal of Cellular Biochemistry. Jul, 2015 | Pubmed ID: 25704336 Isolation, Characterisation and Reconstitution of Cell Death Signalling Complexes Methods (San Diego, Calif.). Jun, 2013 | Pubmed ID: 23485576 Glucose--a Sweet Way to Die: Metabolic Switching Modulates Tumor Cell Death Cell Cycle (Georgetown, Tex.). Nov, 2012 | Pubmed ID: 22983094 A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death Molecular Cell. Jul, 2012 | Pubmed ID: 22683266 The 'complexities' of Life and Death: Death Receptor Signalling Platforms Experimental Cell Research. Jul, 2012 | Pubmed ID: 22542855 CIAPs Block Ripoptosome Formation, a RIP1/caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by CFLIP Isoforms Molecular Cell. Aug, 2011 | Pubmed ID: 21737330 Mitochondrial Fragmentation and Neuronal Cell Death in Response to the Bcl-2/Bcl-x(L)/Bcl-w Antagonist ABT-737 Neuropharmacology. Jun, 2010 | Pubmed ID: 20307556 Cell Death Pathways--potential Therapeutic Targets Xenobiotica; the Fate of Foreign Compounds in Biological Systems. Aug, 2009 | Pubmed ID: 19622004 Recombinant TRAIL and TRAIL Receptor Analysis Methods in Enzymology. 2008 | Pubmed ID: 18603130 TRAIL Signals to Apoptosis in Chronic Lymphocytic Leukaemia Cells Primarily Through TRAIL-R1 Whereas Cross-linked Agonistic TRAIL-R2 Antibodies Facilitate Signalling Via TRAIL-R2 British Journal of Haematology. Nov, 2007 | Pubmed ID: 17922877 Apoptosis and Disease: a Life or Death Decision EMBO Reports. Jul, 2004 | Pubmed ID: 15218528 Caspase Activation Inhibits Proteasome Function During Apoptosis Molecular Cell. Apr, 2004 | Pubmed ID: 15068805 TRAIL-induced Signalling and Apoptosis Toxicology Letters. Apr, 2003 | Pubmed ID: 12628743 Mechanisms of Resistance to TRAIL-induced Apoptosis in Primary B Cell Chronic Lymphocytic Leukaemia Oncogene. Oct, 2002 | Pubmed ID: 12360407 C-Myc Protein Synthesis is Initiated from the Internal Ribosome Entry Segment During Apoptosis Molecular and Cellular Biology. Feb, 2000 | Pubmed ID: 10648601 Patient-afledt tumor explants som en "Live" præklinisk platform til forudsigelse af resistens hos patienter Giuditta Viticchié1, Ian Powley1, Constantinos Demetriou1, James Cooper1, Michael Butterworth1, Meeta Patel1, Naila Abid1, Gareth Miles1, Lynne Howells1, Howard Pringle1, Marion MacFarlane2, Catrin Pritchard1 1Leicester Cancer Research Center, University of Leicester, 2MRC Toxicology Unit JoVE 62130 Pesquisa do câncer
Patient-afledt tumor explants som en "Live" præklinisk platform til forudsigelse af resistens hos patienter Giuditta Viticchié1, Ian Powley1, Constantinos Demetriou1, James Cooper1, Michael Butterworth1, Meeta Patel1, Naila Abid1, Gareth Miles1, Lynne Howells1, Howard Pringle1, Marion MacFarlane2, Catrin Pritchard1 1Leicester Cancer Research Center, University of Leicester, 2MRC Toxicology Unit JoVE 62130 Pesquisa do câncer