Michael R. Sierks School for Engineering of Matter, Transport and Energy Arizona State University Biography Publications Institution JoVE Articles Michael R. Sierks has not added a biography. If you are Michael R. Sierks and would like to personalize this page please email our Author Liaison for assistance. Publications Isolation and Characterization of Antibody Fragments Selective for Toxic Oligomeric Tau Neurobiology of Aging. Dec, 2014 | Pubmed ID: 25616912 A Sensitive Phage-based Capture ELISA for Sub-femtomolar Detection of Protein Variants Directly from Biological Samples Biotechnology Progress. Sep, 2014 | Pubmed ID: 25203940 Human α4β2 Nicotinic Acetylcholine Receptor As a Novel Target of Oligomeric α-synuclein PloS One. 2013 | Pubmed ID: 23437071 Isolation and Characterization of Antibody Fragments Selective for Specific Protein Morphologies from Nanogram Antigen Samples Biotechnology Progress. Mar-Apr, 2013 | Pubmed ID: 23359572 Bispecific Tandem Single Chain Antibody Simultaneously Inhibits β-secretase and Promotes α-secretase Processing of AβPP Journal of Alzheimer's Disease : JAD. 2012 | Pubmed ID: 22156046 Nanobody Specific for Oligomeric β-amyloid Stabilizes Nontoxic Form Neurobiology of Aging. Jul, 2012 | Pubmed ID: 21067847 CSF Levels of Oligomeric Alpha-synuclein and Beta-amyloid As Biomarkers for Neurodegenerative Disease Integrative Biology : Quantitative Biosciences from Nano to Macro. Dec, 2011 | Pubmed ID: 22076255 Inhibiting β-secretase Activity in Alzheimer's Disease Cell Models with Single-chain Antibodies Specifically Targeting APP Journal of Molecular Biology. Jan, 2011 | Pubmed ID: 21073877 Curcumin Reduces Alpha-synuclein Induced Cytotoxicity in Parkinson's Disease Cell Model BMC Neuroscience. 2010 | Pubmed ID: 20433710 Engineered Proteolytic Nanobodies Reduce Abeta Burden and Ameliorate Abeta-induced Cytotoxicity Biochemistry. Jun, 2010 | Pubmed ID: 20429609 Physico-chemical Determinants of Soluble Intrabody Expression in Mammalian Cell Cytoplasm Protein Engineering, Design & Selection : PEDS. Jun, 2010 | Pubmed ID: 20378699 Antifibrillizing Agents Catalyze the Formation of Unstable Intermediate Aggregates of Beta-amyloid Biotechnology Progress. Jul-Aug, 2010 | Pubmed ID: 20306540 Cyclodextrins Promote Protein Aggregation Posing Risks for Therapeutic Applications Biochemical and Biophysical Research Communications. Aug, 2009 | Pubmed ID: 19540204 Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity PloS One. 2009 | Pubmed ID: 19492089 Intracellular Targeting and Clearance of Oligomeric Alpha-synuclein Alleviates Toxicity in Mammalian Cells Neuroscience Letters. Jul, 2009 | Pubmed ID: 19394405 Detecting Morphologically Distinct Oligomeric Forms of Alpha-synuclein The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19141614 Characterizing Antibody Specificity to Different Protein Morphologies by AFM Langmuir : the ACS Journal of Surfaces and Colloids. Jan, 2009 | Pubmed ID: 19090748 Anti-oligomeric Abeta Single-chain Variable Domain Antibody Blocks Abeta-induced Toxicity Against Human Neuroblastoma Cells Journal of Molecular Biology. Dec, 2008 | Pubmed ID: 18929576 Anti-oligomeric Single Chain Variable Domain Antibody Differentially Affects Huntingtin and Alpha-synuclein Aggregates FEBS Letters. Feb, 2008 | Pubmed ID: 18230361 Characterization of an Antibody ScFv That Recognizes Fibrillar Insulin and Beta-amyloid Using Atomic Force Microscopy Nanomedicine : Nanotechnology, Biology, and Medicine. Mar, 2008 | Pubmed ID: 18201941 Single-molecule Selection and Recovery of Structure-specific Antibodies Using Atomic Force Microscopy Nanomedicine : Nanotechnology, Biology, and Medicine. Sep, 2007 | Pubmed ID: 17662669 Isolation of a Human Single Chain Antibody Fragment Against Oligomeric Alpha-synuclein That Inhibits Aggregation and Prevents Alpha-synuclein-induced Toxicity Journal of Molecular Biology. May, 2007 | Pubmed ID: 17391701 Insights into the Mechanisms of Action of Anti-Abeta Antibodies in Alzheimer's Disease Mouse Models FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2006 | Pubmed ID: 17068112 Isolating Recombinant Antibodies Against Specific Protein Morphologies Using Atomic Force Microscopy and Phage Display Technologies Protein Engineering, Design & Selection : PEDS. Nov, 2006 | Pubmed ID: 16984950 Single Chain Fv Antibodies Against the 25-35 Abeta Fragment Inhibit Aggregation and Toxicity of Abeta42 Biochemistry. Sep, 2006 | Pubmed ID: 16981713 Identification and Repair of Positive Binding Antibodies Containing Randomly Generated Amber Codons from Synthetic Phage Display Libraries Biotechnology Progress. May-Jun, 2006 | Pubmed ID: 16739981 Quantification of Cytokines Involved in Wound Healing Using Surface Plasmon Resonance Analytical Chemistry. Nov, 2005 | Pubmed ID: 16255604 Trehalose Differentially Inhibits Aggregation and Neurotoxicity of Beta-amyloid 40 and 42 Neurobiology of Disease. Oct, 2005 | Pubmed ID: 16137568 A Human Single-chain Fv Intrabody Blocks Aberrant Cellular Effects of Overexpressed Alpha-synuclein Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2004 | Pubmed ID: 15564134 Proteolytic Antibody Light Chains Alter Beta-amyloid Aggregation and Prevent Cytotoxicity Biochemistry. Aug, 2004 | Pubmed ID: 15287727 Single Chain Variable Fragments Against Beta-amyloid (Abeta) Can Inhibit Abeta Aggregation and Prevent Abeta-induced Neurotoxicity Biochemistry. Jun, 2004 | Pubmed ID: 15170333 Inhibiting Aggregation of Alpha-synuclein with Human Single Chain Antibody Fragments Biochemistry. Mar, 2004 | Pubmed ID: 15005622 Residues 17-20 and 30-35 of Beta-amyloid Play Critical Roles in Aggregation Journal of Neuroscience Research. Jan, 2004 | Pubmed ID: 14705137 Degradation of Beta-amyloid by Proteolytic Antibody Light Chains Biochemistry. Dec, 2003 | Pubmed ID: 14640701 Novel Atomic Force Mikros Basert Biopanning for isolering av morfologi spesifikke reagenser mot TDP-43 Varianter i Amyotrofisk lateral sklerose Stephanie M. Williams1, Lalitha Venkataraman1, Huilai Tian1, Galam Khan2, Brent T. Harris2,3, Michael R. Sierks1 1School for Engineering of Matter, Transport and Energy, Arizona State University, 2Department of Neurology, Georgetown University Medical Center, 3Department of Pathology, Georgetown University Medical Center Bioengenharia
Novel Atomic Force Mikros Basert Biopanning for isolering av morfologi spesifikke reagenser mot TDP-43 Varianter i Amyotrofisk lateral sklerose Stephanie M. Williams1, Lalitha Venkataraman1, Huilai Tian1, Galam Khan2, Brent T. Harris2,3, Michael R. Sierks1 1School for Engineering of Matter, Transport and Energy, Arizona State University, 2Department of Neurology, Georgetown University Medical Center, 3Department of Pathology, Georgetown University Medical Center Bioengenharia