Michel Versluis Physics of Fluids group, Technical Medical (TechMed) Centre, Mesa+ Institue for Nanotechnology University of Twente Biography Publications Institution JoVE Articles Michel Versluis Michel Versluis graduated with a degree in Physics in 1988 from the University of Nijmegen, The Netherlands, with an interest in molecular physics and astrophysics. He specialized in the application of lasers for flame diagnostics, completing his PhD in 1992. After a research position working on molecular dynamics at Griffith University (Brisbane, Australia) he worked on developing laser diagnostic techniques for internal combustion engines (Lund, Sweden) and industrial jet flames and solid rocket propellants (TUDelft, The Netherlands). Dr. Versluis is now full professor Physical and Medical Acoustics at the University of Twente, The Netherlands, in the Physics of Fluids group. He is an expert in ultra high-speed imaging with a particular interest in the use of microbubbles and microdroplets for medical applications, both in imaging and in therapy, and in the physics and control of bubbles and droplets in microfluidic applications in medicine and the nanotechnology industry. Publications Hemodynamic Comparison of Stent-Grafts for the Treatment of Aortoiliac Occlusive Disease Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists. Jun, 2021 | Pubmed ID: 34076554 Corrigendum for "Intravital Microscopy of Localized Stem Cell Delivery Using Microbubbles and Acoustic Radiation Force" (Vol. 112, Issue 1, Pp. 220-227) Biotechnology and Bioengineering. Jun, 2021 | Pubmed ID: 34014566 Blood Flow Quantification in Peripheral Arterial Disease: Emerging Diagnostic Techniques in Vascular Surgery Surgical Technology International. May, 2021 | Pubmed ID: 33970476 Feedback-controlled Microbubble Generator Producing One Million Monodisperse Bubbles Per Second The Review of Scientific Instruments. Mar, 2021 | Pubmed ID: 33820052 Corrigendum to "Secondary Bjerknes Forces Deform Targeted Microbubbles" (Ultrasound Med Biol 2013;39:490-506) Ultrasound in Medicine & Biology. Jun, 2021 | Pubmed ID: 33731258 Corrigendum to "Non-linear Response and Viscoelastic Properties of Lipid-Coated Microbubbles: DSPC Versus DPPC" (Ultrasound Med Biol 2015;41:1432-1445) Ultrasound in Medicine & Biology. Jun, 2021 | Pubmed ID: 33731257 Corrigendum to "In Vivo Characterization of Ultrasound Contrast Agents: Microbubble Spectroscopy in a Chicken Embryo" (Ultrasound Med Biol 2012;38:1608-1617) Ultrasound in Medicine & Biology. Jun, 2021 | Pubmed ID: 33731256 High-Frequency Acoustic Droplet Vaporization is Initiated by Resonance Physical Review Letters. Jan, 2021 | Pubmed ID: 33543968 Three-phase Vaporization Theory for Laser-activated Microcapsules Photoacoustics. Sep, 2020 | Pubmed ID: 32775197 Evaporating Droplets on Oil-wetted Surfaces: Suppression of the Coffee-stain Effect Proceedings of the National Academy of Sciences of the United States of America. 07, 2020 | Pubmed ID: 32616571 Ultrasound Contrast Agent Modeling: A Review Ultrasound in Medicine & Biology. Sep, 2020 | Pubmed ID: 32546411 Evaporation-Induced Crystallization of Surfactants in Sessile Multicomponent Droplets Langmuir : the ACS Journal of Surfaces and Colloids. Jul, 2020 | Pubmed ID: 32538631 Focused Ultrasound for Opening Blood-brain Barrier and Drug Delivery Monitored with Positron Emission Tomography Journal of Controlled Release : Official Journal of the Controlled Release Society. 08, 2020 | Pubmed ID: 32428519 Validation of a Novel Methodology to Evaluate Changes in the Flare Geometry of Renovisceral Bridging Stent-Grafts After Fenestrated Endovascular Aneurysm Repair Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists. Jun, 2020 | Pubmed ID: 32314657 Microbubble Agents: New Directions Ultrasound in Medicine & Biology. Jun, 2020 | Pubmed ID: 32169397 A Novel Roller Pump for Physiological Flow Artificial Organs. Aug, 2020 | Pubmed ID: 32065666 Multicore Liquid Perfluorocarbon-Loaded Multimodal Nanoparticles for Stable Ultrasound and F MRI Applied to In Vivo Cell Tracking Advanced Functional Materials. May, 2019 | Pubmed ID: 32132881 Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation and Characterization Frontiers in Pharmacology. Month, 2019 | Pubmed ID: 31866867 Assessment of Changes in Stent Graft Geometry After Chimney Endovascular Aneurysm Sealing Journal of Vascular Surgery. 12, 2019 | Pubmed ID: 31153698 Haemodynamics in Different Flow Lumen Configurations of Customised Aortic Repair for Infrarenal Aortic Aneurysms European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery. 05, 2019 | Pubmed ID: 31000458 Gravitational Effect in Evaporating Binary Microdroplets Physical Review Letters. Mar, 2019 | Pubmed ID: 30951342 The Role of Ultrasound-Driven Microbubble Dynamics in Drug Delivery: From Microbubble Fundamentals to Clinical Translation Langmuir : the ACS Journal of Surfaces and Colloids. 08, 2019 | Pubmed ID: 30653325 Laser-activated Microparticles for Multimodal Imaging: Ultrasound and Photoacoustics Physics in Medicine and Biology. 01, 2019 | Pubmed ID: 30523821 Meta-analysis of Individual Patient Data After Kissing Stent Treatment for Aortoiliac Occlusive Disease Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists. 02, 2019 | Pubmed ID: 30499352 High-Frame-Rate Contrast-enhanced US Particle Image Velocimetry in the Abdominal Aorta: First Human Results Radiology. 10, 2018 | Pubmed ID: 30015586 Giant and Explosive Plasmonic Bubbles by Delayed Nucleation Proceedings of the National Academy of Sciences of the United States of America. 07, 2018 | Pubmed ID: 29997175 Evaporation-Triggered Segregation of Sessile Binary Droplets Physical Review Letters. Jun, 2018 | Pubmed ID: 29906161 Monodisperse Versus Polydisperse Ultrasound Contrast Agents: Non-Linear Response, Sensitivity, and Deep Tissue Imaging Potential Ultrasound in Medicine & Biology. 07, 2018 | Pubmed ID: 29705522 Three-year Outcome of the Covered Endovascular Reconstruction of the Aortic Bifurcation Technique for Aortoiliac Occlusive Disease Journal of Vascular Surgery. 05, 2018 | Pubmed ID: 29169878 Partial Renal Coverage in Endovascular Aneurysm Repair Causes Unfavorable Renal Flow Patterns in an Infrarenal Aneurysm Model Journal of Vascular Surgery. 05, 2018 | Pubmed ID: 28893490 Optical Verification and In-vitro Characterization of Two Commercially Available Acoustic Bubble Counters for Cardiopulmonary Bypass Systems Perfusion. Jan, 2018 | Pubmed ID: 28766987 Apparatus to Control and Visualize the Impact of a High-energy Laser Pulse on a Liquid Target The Review of Scientific Instruments. Sep, 2017 | Pubmed ID: 28964175 Influence of Iliac Stenotic Lesions on Blood Flow Patterns Near a Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) Stent Configuration Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists. Dec, 2017 | Pubmed ID: 28934888 Universal Equations for the Coalescence Probability and Long-Term Size Stability of Phospholipid-Coated Monodisperse Microbubbles Formed by Flow Focusing Langmuir : the ACS Journal of Surfaces and Colloids. 10, 2017 | Pubmed ID: 28872315 The Influence of Positioning of the Nellix Endovascular Aneurysm Sealing System on Suprarenal and Renal Flow: An In Vitro Study Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists. 10, 2017 | Pubmed ID: 28689483 Focal Areas of Increased Lipid Concentration on the Coating of Microbubbles During Short Tone-burst Ultrasound Insonification PloS One. Month, 2017 | Pubmed ID: 28686673 Laser-driven Resonance of Dye-doped Oil-coated Microbubbles: Experimental Study The Journal of the Acoustical Society of America. 06, 2017 | Pubmed ID: 28679262 Laser-Activated Polymeric Microcapsules for Ultrasound Imaging and Therapy: In Vitro Feasibility Biophysical Journal. May, 2017 | Pubmed ID: 28494960 Laser-driven Resonance of Dye-doped Oil-coated Microbubbles: A Theoretical and Numerical Study The Journal of the Acoustical Society of America. 04, 2017 | Pubmed ID: 28464648 Self-wrapping of an Ouzo Drop Induced by Evaporation on a Superamphiphobic Surface Soft Matter. Apr, 2017 | Pubmed ID: 28295107 Flow and Wall Shear Stress Characterization After Endovascular Aneurysm Repair and Endovascular Aneurysm Sealing in an Infrarenal Aneurysm Model Journal of Vascular Surgery. 12, 2017 | Pubmed ID: 28285931 Temperature Evolution of Preheated Irrigant Injected into a Root Canal Ex Vivo Clinical Oral Investigations. Dec, 2017 | Pubmed ID: 28283825 Hemodynamic Comparison of Stent Configurations Used for Aortoiliac Occlusive Disease Journal of Vascular Surgery. 07, 2017 | Pubmed ID: 27743806 Loss of Gas from Echogenic Liposomes Exposed to Pulsed Ultrasound Physics in Medicine and Biology. 12, 2016 | Pubmed ID: 27811382 Stability of Monodisperse Phospholipid-Coated Microbubbles Formed by Flow-Focusing at High Production Rates Langmuir : the ACS Journal of Surfaces and Colloids. 04, 2016 | Pubmed ID: 27006083 In Vitro Methods to Study Bubble-cell Interactions: Fundamentals and Therapeutic Applications Biomicrofluidics. Jan, 2016 | Pubmed ID: 26865903 Sonoprinting and the Importance of Microbubble Loading for the Ultrasound Mediated Cellular Delivery of Nanoparticles Biomaterials. Mar, 2016 | Pubmed ID: 26796042 Droplets, Bubbles and Ultrasound Interactions Advances in Experimental Medicine and Biology. Month, 2016 | Pubmed ID: 26486337 Impulse Response Method for Characterization of Echogenic Liposomes The Journal of the Acoustical Society of America. Apr, 2015 | Pubmed ID: 25920822 Non-linear Response and Viscoelastic Properties of Lipid-coated Microbubbles: DSPC Versus DPPC Ultrasound in Medicine & Biology. May, 2015 | Pubmed ID: 25724308 Enhancing Acoustic Cavitation Using Artificial Crevice Bubbles Ultrasonics. Feb, 2015 | Pubmed ID: 25455191 Influence of the Dentinal Wall on the PH of Sodium Hypochlorite During Root Canal Irrigation Journal of Endodontics. Jul, 2014 | Pubmed ID: 24935553 Lipid Shedding from Single Oscillating Microbubbles Ultrasound in Medicine & Biology. Aug, 2014 | Pubmed ID: 24798388 Ultrafast Vapourization Dynamics of Laser-activated Polymeric Microcapsules Nature Communications. Apr, 2014 | Pubmed ID: 24752357 High-efficiency Ballistic Electrostatic Generator Using Microdroplets Nature Communications. Month, 2014 | Pubmed ID: 24709899 Acoustic Behavior of Microbubbles and Implications for Drug Delivery Advanced Drug Delivery Reviews. Jun, 2014 | Pubmed ID: 24667643 Cavitation Measurement During Sonic and Ultrasonic Activated Irrigation Journal of Endodontics. Apr, 2014 | Pubmed ID: 24666916 On the Acoustic Properties of Vaporized Submicron Perfluorocarbon Droplets Ultrasound in Medicine & Biology. Jun, 2014 | Pubmed ID: 24462162 Acoustic Droplet Vaporization is Initiated by Superharmonic Focusing Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014 | Pubmed ID: 24449879 Ultrafast Dynamics of the Acoustic Vaporization of Phase-change Microdroplets The Journal of the Acoustical Society of America. Aug, 2013 | Pubmed ID: 23927201 Ultra-fast Bright Field and Fluorescence Imaging of the Dynamics of Micrometer-sized Objects The Review of Scientific Instruments. Jun, 2013 | Pubmed ID: 23822346 The Role of Gas in Ultrasonically Driven Vapor Bubble Growth Physics in Medicine and Biology. Apr, 2013 | Pubmed ID: 23528293 Localized Removal of Layers of Metal, Polymer, or Biomaterial by Ultrasound Cavitation Bubbles Biomicrofluidics. Sep, 2012 | Pubmed ID: 23964308 Oscillation Characteristics of Endodontic Files: Numerical Model and Its Validation IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Nov, 2012 | Pubmed ID: 23192808 Brandaris 128 Ultra-high-speed Imaging Facility: 10 Years of Operation, Updates, and Enhanced Features The Review of Scientific Instruments. Oct, 2012 | Pubmed ID: 23126773 Combined Optical and Acoustical Detection of Single Microbubble Dynamics The Journal of the Acoustical Society of America. Nov, 2011 | Pubmed ID: 22087999 Dynamics of Coated Microbubbles Adherent to a Wall Ultrasound in Medicine & Biology. Sep, 2011 | Pubmed ID: 21816289 "Compression-only" Behavior: a Second-order Nonlinear Response of Ultrasound Contrast Agent Microbubbles The Journal of the Acoustical Society of America. Apr, 2011 | Pubmed ID: 21476630 Subharmonic Behavior of Phospholipid-coated Ultrasound Contrast Agent Microbubbles The Journal of the Acoustical Society of America. Nov, 2010 | Pubmed ID: 21110619 Nonlinear Shell Behavior of Phospholipid-coated Microbubbles Ultrasound in Medicine & Biology. Dec, 2010 | Pubmed ID: 21030140 Microbubble Shape Oscillations Excited Through Ultrasonic Parametric Driving Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Aug, 2010 | Pubmed ID: 20866919 Acoustic Measurement of Bubble Size in an Inkjet Printhead The Journal of the Acoustical Society of America. Nov, 2009 | Pubmed ID: 19894798 Ultrasonic Characterization of Ultrasound Contrast Agents Medical & Biological Engineering & Computing. Aug, 2009 | Pubmed ID: 19468770 Acoustic Characterization of Single Ultrasound Contrast Agent Microbubbles The Journal of the Acoustical Society of America. Dec, 2008 | Pubmed ID: 19206831 Effect of an Entrained Air Bubble on the Acoustics of an Ink Channel The Journal of the Acoustical Society of America. May, 2008 | Pubmed ID: 18529168 Nonspherical Oscillations of Ultrasound Contrast Agent Microbubbles Ultrasound in Medicine & Biology. Sep, 2008 | Pubmed ID: 18450362 Role of the Channel Geometry on the Bubble Pinch-off in Flow-focusing Devices Physical Review Letters. Jan, 2008 | Pubmed ID: 18232987 Microbubble Spectroscopy of Ultrasound Contrast Agents The Journal of the Acoustical Society of America. Jan, 2007 | Pubmed ID: 17297818 Sonoporation from Jetting Cavitation Bubbles Biophysical Journal. Dec, 2006 | Pubmed ID: 16950843 Impact on Soft Sand: Void Collapse and Jet Formation Physical Review Letters. Nov, 2004 | Pubmed ID: 15600883 Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release Charlotte Nawijn1, Tim Segers1,2, Guillaume Lajoinie1, Ýrr Mørch3, Sigrid Berg4,5,6, Sofie Snipstad3,6,7, Catharina de Lange Davies7, Michel Versluis1 1Physics of Fluids group, Department of Science and Technology, MESA+ Institute for Nanotechnology and Technical Medical (TechMed) Center, University of Twente, 2BIOS Lab-on-a-Chip group, Max Planck Center Twente for Complex Fluid Dynamics, MESA+ Institute for Nanotechnology and Technical Medical (TechMed) Center, University of Twente, 3Department of Biotechnology and Nanomedicine, SINTEF Industry, 4Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 5Department of Health Research, SINTEF Digital, 6Cancer Clinic, St. Olav’s Hospital, 7Department of Physics, Norwegian University of Science and Technology JoVE 62251 Bioengenharia
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release Charlotte Nawijn1, Tim Segers1,2, Guillaume Lajoinie1, Ýrr Mørch3, Sigrid Berg4,5,6, Sofie Snipstad3,6,7, Catharina de Lange Davies7, Michel Versluis1 1Physics of Fluids group, Department of Science and Technology, MESA+ Institute for Nanotechnology and Technical Medical (TechMed) Center, University of Twente, 2BIOS Lab-on-a-Chip group, Max Planck Center Twente for Complex Fluid Dynamics, MESA+ Institute for Nanotechnology and Technical Medical (TechMed) Center, University of Twente, 3Department of Biotechnology and Nanomedicine, SINTEF Industry, 4Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 5Department of Health Research, SINTEF Digital, 6Cancer Clinic, St. Olav’s Hospital, 7Department of Physics, Norwegian University of Science and Technology JoVE 62251 Bioengenharia