Mitchell J. Weiss Department of Hematology St. Jude Children's Research Hospital Biography Publications Institution JoVE Articles Mitchell J. Weiss has not added a biography. If you are Mitchell J. Weiss and would like to personalize this page please email our Author Liaison for assistance. Publications UBE2O Remodels the Proteome During Terminal Erythroid Differentiation Science (New York, N.Y.). Aug, 2017 | Pubmed ID: 28774900 MiR-144 Attenuates the Host Response to Influenza Virus by Targeting the TRAF6-IRF7 Signaling Axis PLoS Pathogens. Apr, 2017 | Pubmed ID: 28380049 A Genome-editing Strategy to Treat β-hemoglobinopathies That Recapitulates a Mutation Associated with a Benign Genetic Condition Nature Medicine. Sep, 2016 | Pubmed ID: 27525524 The Severity of Hereditary Porphyria is Modulated by the Porphyrin Exporter and Lan Antigen ABCB6 Nature Communications. Aug, 2016 | Pubmed ID: 27507172 Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease Pediatrics. Jul, 2016 | Pubmed ID: 27335380 Welcoming a New Age for Gene Therapy in Hematology Blood. May, 2016 | Pubmed ID: 27053534 Unlinking an LncRNA from Its Associated Cis Element Molecular Cell. Apr, 2016 | Pubmed ID: 27041223 Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells Cell Stem Cell. Jan, 2016 | Pubmed ID: 26607381 Amelioration of Murine Sickle Cell Disease by Nonablative Conditioning and γ-globin Gene-corrected Bone Marrow Cells Molecular Therapy. Methods & Clinical Development. 2015 | Pubmed ID: 26665131 The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development Molecular and Cellular Biology. Nov, 2015 | Pubmed ID: 26527618 Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia PloS One. 2015 | Pubmed ID: 26258650 Occupancy by Key Transcription Factors is a More Accurate Predictor of Enhancer Activity Than Histone Modifications or Chromatin Accessibility Epigenetics & Chromatin. 2015 | Pubmed ID: 25984238 Inducible Gata1 Suppression Expands Megakaryocyte-erythroid Progenitors from Embryonic Stem Cells The Journal of Clinical Investigation. Jun, 2015 | Pubmed ID: 25961454 Anemia: Progress in Molecular Mechanisms and Therapies Nature Medicine. Mar, 2015 | Pubmed ID: 25742458 Dynamics of GATA1 Binding and Expression Response in a GATA1-induced Erythroid Differentiation System Genomics Data. Jun, 2015 | Pubmed ID: 25729644 Pluripotent Stem Cells Reveal Erythroid-specific Activities of the GATA1 N-terminus The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25621499 MicroRNA-486-5p is an Erythroid OncomiR of the Myeloid Leukemias of Down Syndrome Blood. Feb, 2015 | Pubmed ID: 25533034 Level of RUNX1 Activity is Critical for Leukemic Predisposition but Not for Thrombocytopenia Blood. Feb, 2015 | Pubmed ID: 25490895 A Comparative Encyclopedia of DNA Elements in the Mouse Genome Nature. Nov, 2014 | Pubmed ID: 25409824 Divergent Functions of Hematopoietic Transcription Factors in Lineage Priming and Differentiation During Erythro-megakaryopoiesis Genome Research. Dec, 2014 | Pubmed ID: 25319996 Dynamic Shifts in Occupancy by TAL1 Are Guided by GATA Factors and Drive Large-scale Reprogramming of Gene Expression During Hematopoiesis Genome Research. Dec, 2014 | Pubmed ID: 25319994 Trim58 Degrades Dynein and Regulates Terminal Erythropoiesis Developmental Cell. Sep, 2014 | Pubmed ID: 25241935 Hematopoietic Differentiation of Pluripotent Stem Cells in Culture Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25062629 Update on the Diagnosis and Management of Thalassemia Clinical Advances in Hematology & Oncology : H&O. Jan, 2014 | Pubmed ID: 25000317 Post-translational Transformation of Methionine to Aspartate is Catalyzed by Heme Iron and Driven by Peroxide: a Novel Subunit-specific Mechanism in Hemoglobin The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 24939847 MiR-451 Deficiency is Associated with Altered Endometrial Fibrinogen Alpha Chain Expression and Reduced Endometriotic Implant Establishment in an Experimental Mouse Model PloS One. 2014 | Pubmed ID: 24937656 Immune Hemolytic Anemia with Drug-induced Antibodies to Carboplatin and Vincristine in a Pediatric Patient with an Optic Pathway Glioma Transfusion. Nov, 2014 | Pubmed ID: 24860959 Personalized Platelet Transfusions: One Step Closer to the Clinic Cell Stem Cell. Apr, 2014 | Pubmed ID: 24702993 Erythro-megakaryocytic Transcription Factors Associated with Hereditary Anemia Blood. May, 2014 | Pubmed ID: 24652993 Iron-laden Macrophage in Autoimmune Disease Blood. Jan, 2014 | Pubmed ID: 24605366 Lineage and Species-specific Long Noncoding RNAs During Erythro-megakaryocytic Development Blood. Mar, 2014 | Pubmed ID: 24497530 Development of Acute Megakaryoblastic Leukemia in Down Syndrome is Associated with Sequential Epigenetic Changes Blood. Oct, 2013 | Pubmed ID: 23980066 Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines Blood. Sep, 2013 | Pubmed ID: 23940280 Ribosomal and Hematopoietic Defects in Induced Pluripotent Stem Cells Derived from Diamond Blackfan Anemia Patients Blood. Aug, 2013 | Pubmed ID: 23744582 Congenital Dyserythropoietic Anemias: III's a Charm Blood. Jun, 2013 | Pubmed ID: 23744492 α-Hemoglobin-stabilizing Protein (AHSP) Perturbs the Proximal Heme Pocket of Oxy-α-hemoglobin and Weakens the Iron-oxygen Bond The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23696640 Long Noncoding RNAs in Biology and Hematopoiesis Blood. Jun, 2013 | Pubmed ID: 23645840 Patient-derived Induced Pluripotent Stem Cells Recapitulate Hematopoietic Abnormalities of Juvenile Myelomonocytic Leukemia Blood. Apr, 2013 | Pubmed ID: 23620576 The Calcineurin-NFAT Pathway Negatively Regulates Megakaryopoiesis Blood. Apr, 2013 | Pubmed ID: 23446734 The Secreted Lymphangiogenic Factor CCBE1 is Essential for Fetal Liver Erythropoiesis Blood. Apr, 2013 | Pubmed ID: 23426945 Hemoglobin Variants: Biochemical Properties and Clinical Correlates Cold Spring Harbor Perspectives in Medicine. Mar, 2013 | Pubmed ID: 23388674 α-Hemoglobin Stabilizing Protein (AHSP) Markedly Decreases the Redox Potential and Reactivity of α-subunits of Human HbA with Hydrogen Peroxide The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23264625 MiR-451 Regulates Dendritic Cell Cytokine Responses to Influenza Infection Journal of Immunology (Baltimore, Md. : 1950). Dec, 2012 | Pubmed ID: 23169590 Trisomy 21-associated Defects in Human Primitive Hematopoiesis Revealed Through Induced Pluripotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045704 Perturbation of Fetal Liver Hematopoietic Stem and Progenitor Cell Development by Trisomy 21 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045701 α-Hemoglobin-stabilizing Protein is a Sensitive and Specific Marker of Erythroid Precursors The American Journal of Surgical Pathology. Oct, 2012 | Pubmed ID: 22982896 An Encyclopedia of Mouse DNA Elements (Mouse ENCODE) Genome Biology. Aug, 2012 | Pubmed ID: 22889292 What's in a Name? The Journal of Clinical Investigation. Jul, 2012 | Pubmed ID: 22706300 SLC35D3 Delivery from Megakaryocyte Early Endosomes is Required for Platelet Dense Granule Biogenesis and is Differentially Defective in Hermansky-Pudlak Syndrome Models Blood. Jul, 2012 | Pubmed ID: 22611153 CD19 is a Major B Cell Receptor-independent Activator of MYC-driven B-lymphomagenesis The Journal of Clinical Investigation. Jun, 2012 | Pubmed ID: 22546857 Self-renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 Integrated Protein Quality-control Pathways Regulate Free α-globin in Murine β-thalassemia Blood. May, 2012 | Pubmed ID: 22427201 Loss of the MiR-144/451 Cluster Impairs Ischaemic Preconditioning-mediated Cardioprotection by Targeting Rac-1 Cardiovascular Research. May, 2012 | Pubmed ID: 22354898 Kinetics of α-globin Binding to α-hemoglobin Stabilizing Protein (AHSP) Indicate Preferential Stabilization of Hemichrome Folding Intermediate The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22298770 Insights into Hemoglobin Assembly Through in Vivo Mutagenesis of α-hemoglobin Stabilizing Protein The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22287545 Functional Regulation of Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1/HPIP) in Erythroid Differentiation The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22187427 A New 'Linc' Between Noncoding RNAs and Blood Development Genes & Development. Dec, 2011 | Pubmed ID: 22190456 Dynamics of the Epigenetic Landscape During Erythroid Differentiation After GATA1 Restoration Genome Research. Oct, 2011 | Pubmed ID: 21795386 A Hemoglobin Variant Associated with Neonatal Cyanosis and Anemia The New England Journal of Medicine. May, 2011 | Pubmed ID: 21561349 Identification of Distal Cis-regulatory Elements at Mouse Mitoferrin Loci Using Zebrafish Transgenesis Molecular and Cellular Biology. Apr, 2011 | Pubmed ID: 21248200 Protein Quality Control During Erythropoiesis and Hemoglobin Synthesis Hematology/oncology Clinics of North America. Dec, 2010 | Pubmed ID: 21075281 AHSP (α-haemoglobin-stabilizing Protein) Stabilizes Apo-α-haemoglobin in a Partially Folded State The Biochemical Journal. Dec, 2010 | Pubmed ID: 20860551 Analysis of Alpha Hemoglobin Stabilizing Protein Overexpression in Murine β-thalassemia American Journal of Hematology. Oct, 2010 | Pubmed ID: 20815047 MicroRNA Expression in Maturing Murine Megakaryocytes Blood. Dec, 2010 | Pubmed ID: 20720187 MiR-451 Protects Against Erythroid Oxidant Stress by Repressing 14-3-3zeta Genes & Development. Aug, 2010 | Pubmed ID: 20679398 MicroRNAs in Erythropoiesis Current Opinion in Hematology. May, 2010 | Pubmed ID: 20216213 Getting by with a Little Help from Our Friends Current Opinion in Pediatrics. Feb, 2010 | Pubmed ID: 20068412 The Role of Alpha-hemoglobin Stabilizing Protein in Redox Chemistry, Denaturation, and Hemoglobin Assembly Antioxidants & Redox Signaling. Feb, 2010 | Pubmed ID: 19659437 Insights into GATA-1-mediated Gene Activation Versus Repression Via Genome-wide Chromatin Occupancy Analysis Molecular Cell. Nov, 2009 | Pubmed ID: 19941827 Erythroid GATA1 Function Revealed by Genome-wide Analysis of Transcription Factor Occupancy, Histone Modifications, and MRNA Expression Genome Research. Dec, 2009 | Pubmed ID: 19887574 LRF is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-dependent Apoptosis Developmental Cell. Oct, 2009 | Pubmed ID: 19853566 Mammalian Casein Kinase 1alpha and Its Leishmanial Ortholog Regulate Stability of IFNAR1 and Type I Interferon Signaling Molecular and Cellular Biology. Dec, 2009 | Pubmed ID: 19805514 A Cis-proline in Alpha-hemoglobin Stabilizing Protein Directs the Structural Reorganization of Alpha-hemoglobin The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19706593 Stem Cells Unscramble Yolk Sac Hematopoiesis Blood. Aug, 2009 | Pubmed ID: 19696206 Graded Repression of PU.1/Sfpi1 Gene Transcription by GATA Factors Regulates Hematopoietic Cell Fate Blood. Jul, 2009 | Pubmed ID: 19491391 Analysis of Human Alpha Globin Gene Mutations That Impair Binding to the Alpha Hemoglobin Stabilizing Protein Blood. Jun, 2009 | Pubmed ID: 19349619 Chaperoning Erythropoiesis Blood. Mar, 2009 | Pubmed ID: 19109556 Transcriptional Enhancement by GATA1-occupied DNA Segments is Strongly Associated with Evolutionary Constraint on the Binding Site Motif Genome Research. Dec, 2008 | Pubmed ID: 18818370 Trisomy 21 Enhances Human Fetal Erythro-megakaryocytic Development Blood. Dec, 2008 | Pubmed ID: 18812473 An Iron Responsive Element-like Stem-loop Regulates Alpha-hemoglobin-stabilizing Protein MRNA The Journal of Biological Chemistry. Oct, 2008 | Pubmed ID: 18676996 A GATA-1-regulated MicroRNA Locus Essential for Erythropoiesis Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18303114 Population Analysis of the Alpha Hemoglobin Stabilizing Protein (AHSP) Gene Identifies Sequence Variants That Alter Expression and Function American Journal of Hematology. Feb, 2008 | Pubmed ID: 17874450 STAT1 Promotes Megakaryopoiesis Downstream of GATA-1 in Mice The Journal of Clinical Investigation. Dec, 2007 | Pubmed ID: 18060035 Diseased Red Blood Cells Topple Iron Balance Nature Medicine. Sep, 2007 | Pubmed ID: 17828218 An Erythroid Chaperone That Facilitates Folding of Alpha-globin Subunits for Hemoglobin Synthesis The Journal of Clinical Investigation. Jul, 2007 | Pubmed ID: 17607360 Assembly of Recently Translated Full-length and C-terminal Truncated Human Gamma-globin Chains with a Pool of Alpha-globin Chains to Form Hb F in a Cell-free System Archives of Biochemistry and Biophysics. Jul, 2007 | Pubmed ID: 17418086 Experimental Validation of Predicted Mammalian Erythroid Cis-regulatory Modules Genome Research. Dec, 2006 | Pubmed ID: 17038566 A Novel Haem-binding Interface in the 22 KDa Haem-binding Protein P22HBP Journal of Molecular Biology. Sep, 2006 | Pubmed ID: 16905148 Biochemical Fates of Alpha Hemoglobin Bound to Alpha Hemoglobin-stabilizing Protein AHSP The Journal of Biological Chemistry. Oct, 2006 | Pubmed ID: 16901899 Alpha-haemoglobin Stabilising Protein is a Quantitative Trait Gene That Modifies the Phenotype of Beta-thalassaemia British Journal of Haematology. Jun, 2006 | Pubmed ID: 16704446 Mitoferrin is Essential for Erythroid Iron Assimilation Nature. Mar, 2006 | Pubmed ID: 16511496 Designer Blood: Creating Hematopoietic Lineages from Embryonic Stem Cells Blood. Feb, 2006 | Pubmed ID: 16254136 Early Block to Erythromegakaryocytic Development Conferred by Loss of Transcription Factor GATA-1 Blood. Jan, 2006 | Pubmed ID: 16144799 Role of Alpha-hemoglobin-stabilizing Protein in Normal Erythropoiesis and Beta-thalassemia Annals of the New York Academy of Sciences. 2005 | Pubmed ID: 16339656 Megakaryocyte Biology and Related Disorders The Journal of Clinical Investigation. Dec, 2005 | Pubmed ID: 16322777 GATA-1 and Oct-1 Are Required for Expression of the Human Alpha-hemoglobin-stabilizing Protein Gene The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16186125 Repression of C-kit and Its Downstream Substrates by GATA-1 Inhibits Cell Proliferation During Erythroid Maturation Molecular and Cellular Biology. Aug, 2005 | Pubmed ID: 16024808 Structure of Oxidized Alpha-haemoglobin Bound to AHSP Reveals a Protective Mechanism for Haem Nature. Jun, 2005 | Pubmed ID: 15931225 Proximity Among Distant Regulatory Elements at the Beta-globin Locus Requires GATA-1 and FOG-1 Molecular Cell. Feb, 2005 | Pubmed ID: 15694345 Molecular Mechanism of AHSP-mediated Stabilization of Alpha-hemoglobin Cell. Nov, 2004 | Pubmed ID: 15550245 Loss of Alpha-hemoglobin-stabilizing Protein Impairs Erythropoiesis and Exacerbates Beta-thalassemia The Journal of Clinical Investigation. Nov, 2004 | Pubmed ID: 15545996 Global Regulation of Erythroid Gene Expression by Transcription Factor GATA-1 Blood. Nov, 2004 | Pubmed ID: 15297311 Evaluation of Alpha Hemoglobin Stabilizing Protein (AHSP) As a Genetic Modifier in Patients with Beta Thalassemia Blood. May, 2004 | Pubmed ID: 14715623 Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14613934 New Insights into Erythropoietin and Epoetin Alfa: Mechanisms of Action, Target Tissues, and Clinical Applications The Oncologist. 2003 | Pubmed ID: 14671225 GATA-1-dependent Transcriptional Repression of GATA-2 Via Disruption of Positive Autoregulation and Domain-wide Chromatin Remodeling Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003 | Pubmed ID: 12857954 GATA-1-mediated Proliferation Arrest During Erythroid Maturation Molecular and Cellular Biology. Jul, 2003 | Pubmed ID: 12832487 Formation of a Tissue-specific Histone Acetylation Pattern by the Hematopoietic Transcription Factor GATA-1 Molecular and Cellular Biology. Feb, 2003 | Pubmed ID: 12556492 Cooperative Activities of Hematopoietic Regulators Recruit RNA Polymerase II to a Tissue-specific Chromatin Domain Proceedings of the National Academy of Sciences of the United States of America. Sep, 2002 | Pubmed ID: 12193659 Biophysical Characterization of the Alpha-globin Binding Protein Alpha-hemoglobin Stabilizing Protein The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12192002 An Abundant Erythroid Protein That Stabilizes Free Alpha-haemoglobin Nature. Jun, 2002 | Pubmed ID: 12066189 A Cell Culture Model of Resistance Arteries Lauren A. Biwer1,2, Christophe Lechauve3, Sheri Vanhoose4, Mitchell J. Weiss3, Brant E. Isakson1,2 1Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine, 2Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, 3Department of Hematology, St. Jude Children's Research Hospital, 4Research Histology Core, University of Virginia School of Medicine JoVE 55992 Medicina
A Cell Culture Model of Resistance Arteries Lauren A. Biwer1,2, Christophe Lechauve3, Sheri Vanhoose4, Mitchell J. Weiss3, Brant E. Isakson1,2 1Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine, 2Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, 3Department of Hematology, St. Jude Children's Research Hospital, 4Research Histology Core, University of Virginia School of Medicine JoVE 55992 Medicina