Peng Yin Wyss Institute for Biologically Inspired Engineering Harvard University Biography Publications Institution JoVE Articles Peng Yin has not added a biography. If you are Peng Yin and would like to personalize this page please email our Author Liaison for assistance. Publications Determining the Functions of HIV-1 Tat and a Second Magnesium Ion in the CDK9/Cyclin T1 Complex: A Molecular Dynamics Simulation Study PloS One. 2015 | Pubmed ID: 25909811 Infected Nonunion of Tibia and Femur Treated by Bone Transport Journal of Orthopaedic Surgery and Research. 2015 | Pubmed ID: 25889513 Tau-dependent Kv4.2 Depletion and Dendritic Hyperexcitability in a Mouse Model of Alzheimer's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2015 | Pubmed ID: 25878292 [Hoarse Voice As the First Symptom of the Thyroglossal Cyst: a Case Report] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Chinese Journal of Otorhinolaryngology Head and Neck Surgery. Jan, 2015 | Pubmed ID: 25764934 An ESIPT-based Fluorescent Probe for Highly Selective and Ratiometric Detection of Mercury(ii) in Solution and in Cells The Analyst. Apr, 2015 | Pubmed ID: 25715950 Usage of FMRI for Pre-surgical Planning in Brain Tumor and Vascular Lesion Patients: Task and Statistical Threshold Effects on Language Lateralization NeuroImage. Clinical. 2015 | Pubmed ID: 25685705 The Associations Between Ambient Air Pollution and Adult Respiratory Mortality in 32 Major Chinese Cities, 2006-2010 Environmental Research. Feb, 2015 | Pubmed ID: 25601729 Quantitative Proteomic Analysis Reveals Heat Stress-induced Injury in Rat Small Intestine Via Activation of the MAPK and NF-κB Signaling Pathways Molecular BioSystems. Mar, 2015 | Pubmed ID: 25537883 A "turn-on" Fluorescent Sensor for Ultrasensitive Detection of Melamine Based on a New Fluorescence Probe and AuNPs The Analyst. Feb, 2015 | Pubmed ID: 25512948 Aged Monkey Brains Reveal the Role of Ubiquitin-conjugating Enzyme UBE2N in the Synaptosomal Accumulation of Mutant Huntingtin Human Molecular Genetics. Mar, 2015 | Pubmed ID: 25343992 Monitoring and Risk Assessment of 74 Pesticide Residues in Pu-erh Tea Produced in Yunnan, China Food Additives & Contaminants. Part B, Surveillance. 2015 | Pubmed ID: 25308103 Detection of Inherited Mutations for Hereditary Cancer Using Target Enrichment and Next Generation Sequencing Familial Cancer. Mar, 2015 | Pubmed ID: 25151137 Transport Stress Induces Apoptosis in Rat Myocardial Tissue Via Activation of the Mitogen-activated Protein Kinase Signaling Pathways Heart and Vessels. Dec, 2014 | Pubmed ID: 25448624 Paper-based Synthetic Gene Networks Cell. Nov, 2014 | Pubmed ID: 25417167 Toehold Switches: De-novo-designed Regulators of Gene Expression Cell. Nov, 2014 | Pubmed ID: 25417166 α(2A) Adrenergic Receptor Promotes Amyloidogenesis Through Disrupting APP-SorLA Interaction Proceedings of the National Academy of Sciences of the United States of America. Dec, 2014 | Pubmed ID: 25404298 DNA Brick Crystals with Prescribed Depths Nature Chemistry. Nov, 2014 | Pubmed ID: 25343605 Casting Inorganic Structures with DNA Molds Science (New York, N.Y.). Nov, 2014 | Pubmed ID: 25301973 Wnt/β-catenin Signaling Induces the Transcription of Cystathionine-γ-lyase, a Stimulator of Tumor in Colon Cancer Cellular Signalling. Dec, 2014 | Pubmed ID: 25193114 Bone Transport for the Treatment of Infected Forearm Nonunion Injury. Dec, 2014 | Pubmed ID: 25172529 A Prospective Randomized Trial of Selective Versus Nonselective Esophagogastric Devascularization for Portal Hypertension Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban. Aug, 2014 | Pubmed ID: 25135728 Sensitive Detection of Acetylcholine Based on a Novel Boronate Intramolecular Charge Transfer Fluorescence Probe Analytical Biochemistry. Nov, 2014 | Pubmed ID: 25132563 Determination of 16 Phthalate Esters in Tea Samples Using a Modified QuEChERS Sample Preparation Method Combined with GC-MS/MS Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment. 2014 | Pubmed ID: 24983158 Altered β1,6-GlcNAc Branched N-glycans Impair TGF-β-mediated Epithelial-to-mesenchymal Transition Through Smad Signalling Pathway in Human Lung Cancer Journal of Cellular and Molecular Medicine. Oct, 2014 | Pubmed ID: 24913443 Nanolithography Based on Metalized DNA Templates for Graphene Patterning Current Protocols in Chemical Biology. 2014 | Pubmed ID: 24903883 Complex Reconfiguration of DNA Nanostructures Angewandte Chemie (International Ed. in English). Jul, 2014 | Pubmed ID: 24899518 β1,6 GlcNAc Branches-modified PTPRT Attenuates Its Activity and Promotes Cell Migration by STAT3 Pathway PloS One. 2014 | Pubmed ID: 24846175 Critical Roles of MiRNA-mediated Regulation of TGFβ Signalling During Mouse Cardiogenesis Cardiovascular Research. Jul, 2014 | Pubmed ID: 24835278 The Bifunctional Liposomes Constructed by Poly(2-ethyl-oxazoline)-cholesteryl Methyl Carbonate: an Effectual Approach to Enhance Liposomal Circulation Time, PH-sensitivity and Endosomal Escape Pharmaceutical Research. Nov, 2014 | Pubmed ID: 24805279 Developmental Self-assembly of a DNA Tetrahedron ACS Nano. Apr, 2014 | Pubmed ID: 24720462 Comparison of Lateral and Posterior Surgical Approach in Management of Extra-articular Distal Humeral Shaft Fractures Injury. Jul, 2014 | Pubmed ID: 24685053 Polyhedra Self-assembled from DNA Tripods and Characterized with 3D DNA-PAINT Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24625926 The Protective Effect of Caffeic Acid Against Inflammation Injury of Primary Bovine Mammary Epithelial Cells Induced by Lipopolysaccharide Journal of Dairy Science. May, 2014 | Pubmed ID: 24612802 Ultraspecific and Highly Sensitive Nucleic Acid Detection by Integrating a DNA Catalytic Network with a Label-free Microcavity Small (Weinheim an Der Bergstrasse, Germany). May, 2014 | Pubmed ID: 24585636 Effect of Simulated Transport Stress on the Rat Small Intestine: A Morphological and Gene Expression Study Research in Veterinary Science. Apr, 2014 | Pubmed ID: 24560020 Multiplexed 3D Cellular Super-resolution Imaging with DNA-PAINT and Exchange-PAINT Nature Methods. Mar, 2014 | Pubmed ID: 24487583 Punicalagin Inhibits Inflammation in LPS-induced RAW264.7 Macrophages Via the Suppression of TLR4-mediated MAPKs and NF-κB Activation Inflammation. Jun, 2014 | Pubmed ID: 24473904 The Prevalence of Mild Cognitive Impairment and Its Etiological Subtypes in Elderly Chinese Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jul, 2014 | Pubmed ID: 24418053 CHD7 Interacts with BMP R-SMADs to Epigenetically Regulate Cardiogenesis in Mice Human Molecular Genetics. Apr, 2014 | Pubmed ID: 24293546 Simultaneous Determination of Thiophanate-methyl and Its Metabolite Carbendazim in Tea Using Isotope Dilution Ultra Performance Liquid Chromatography-tandem Mass Spectrometry Journal of Chromatographic Science. Nov-Dec, 2014 | Pubmed ID: 24256946 The Prevalence of Dementia in Urban and Rural Areas of China Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jan, 2014 | Pubmed ID: 23871765 [Effectiveness Comparison Between Locking Compression Plate Fixation and Locked Intramedullary Nail Fixation for Humeral Shaft Fracture of Types B and C] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery. Dec, 2013 | Pubmed ID: 24640365 Inhibition of Heat-induced Apoptosis in Rat Small Intestine and IEC-6 Cells Through the AKT Signaling Pathway BMC Veterinary Research. 2013 | Pubmed ID: 24295139 Design Space for Complex DNA Structures Journal of the American Chemical Society. Dec, 2013 | Pubmed ID: 24256506 Conditional Dicer Substrate Formation Via Shape and Sequence Transduction with Small Conditional RNAs Journal of the American Chemical Society. Nov, 2013 | Pubmed ID: 24219616 Sertad1 Encodes a Novel Transcriptional Co-activator of SMAD1 in Mouse Embryonic Hearts Biochemical and Biophysical Research Communications. Nov, 2013 | Pubmed ID: 24211589 Comments on Mahaluxmivala Et Al. "Ilizarov External Fixator: Acute Shortening and Lengthening Versus Bone Transport in the Management of Tibial Non-unions" Injury. Dec, 2013 | Pubmed ID: 24094555 [Effect of the Near Infrared Spectrum Resolution on the Nitrogen Content Model in Green Tea] Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu. Jul, 2013 | Pubmed ID: 24059175 DNA-directed Self-assembly of Shape-controlled Hydrogels Nature Communications. 2013 | Pubmed ID: 24013352 Isothermal Self-assembly of Complex DNA Structures Under Diverse and Biocompatible Conditions Nano Letters. Sep, 2013 | Pubmed ID: 23978049 Molecular Computing: in Situ Computation of Cell Identity Nature Nanotechnology. Aug, 2013 | Pubmed ID: 23912106 BMI, WC, WHtR, VFI and BFI: Which Indictor is the Most Efficient Screening Index on Type 2 Diabetes in Chinese Community Population Biomedical and Environmental Sciences : BES. Jun, 2013 | Pubmed ID: 23816582 Comparative Study of Perpendicular Versus Parallel Double Plating Methods for Type C Distal Humeral Fractures Chinese Medical Journal. Jun, 2013 | Pubmed ID: 23786950 MAGI2 Enhances the Sensitivity of BEL-7404 Human Hepatocellular Carcinoma Cells to Staurosporine-induced Apoptosis by Increasing PTEN Stability International Journal of Molecular Medicine. Jun, 2013 | Pubmed ID: 23754155 Facile Preparation of Magnetic Graphene Double-sided Mesoporous Composites for the Selective Enrichment and Analysis of Endogenous Peptides Proteomics. Aug, 2013 | Pubmed ID: 23716354 A New Turn-on Fluorescent Probe for Selective Detection of Glutathione and Cysteine in Living Cells Chemical Communications (Cambridge, England). Apr, 2013 | Pubmed ID: 23579416 Metallized DNA Nanolithography for Encoding and Transferring Spatial Information for Graphene Patterning Nature Communications. Apr, 2013 | Pubmed ID: 23575667 Nanoscale Growth and Patterning of Inorganic Oxides Using DNA Nanostructure Templates Journal of the American Chemical Society. Apr, 2013 | Pubmed ID: 23574340 Degradation Pattern of Gibberellic Acid During the Whole Process of Tea Production Food Chemistry. Jun, 2013 | Pubmed ID: 23411203 Down-regulation of DNA Methyltransferase 3B in Staurosporine-induced Apoptosis and Its Mechanism in Human Hepatocarcinoma Cell Lines Molecular and Cellular Biochemistry. Apr, 2013 | Pubmed ID: 23397112 Direct Proteomic Mapping of Streptomyces Avermitilis Wild and Industrial Strain and Insights into Avermectin Production Journal of Proteomics. Feb, 2013 | Pubmed ID: 23201115 Myocardial Mycn is Essential for Mouse Ventricular Wall Morphogenesis Developmental Biology. Jan, 2013 | Pubmed ID: 23063798 [Anti-motion Sickness Efficacy of the Extracted Mixture of Chinese Medical Herbs and Its Influence on the Blood Level of Hormones] Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology. Sep, 2012 | Pubmed ID: 23252288 Three-dimensional Structures Self-assembled from DNA Bricks Science (New York, N.Y.). Nov, 2012 | Pubmed ID: 23197527 [Survey of Dietary Intake of Chinese Adults in 2010] Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]. Aug, 2012 | Pubmed ID: 23157861 Quantitative Analysis of Neurochemical Panel in Rat Brain and Plasma by Liquid Chromatography-tandem Mass Spectrometry Analytical Chemistry. Nov, 2012 | Pubmed ID: 23098234 Submicrometre Geometrically Encoded Fluorescent Barcodes Self-assembled from DNA Nature Chemistry. Oct, 2012 | Pubmed ID: 23000997 Application of Next-generation Sequencing in Clinical Oncology to Advance Personalized Treatment of Cancer Chinese Journal of Cancer. Oct, 2012 | Pubmed ID: 22980418 High Efficiency Enrichment of Low-abundance Peptides by Novel Dual-platform Graphene@SiO2@PMMA Nanoscale. Nov, 2012 | Pubmed ID: 22964978 [Influence of CO2 Pneumoperitoneum Pressures on the Expression of Adhesion Molecules of Gastric Cancer Cells] Zhonghua Wei Chang Wai Ke Za Zhi = Chinese Journal of Gastrointestinal Surgery. Aug, 2012 | Pubmed ID: 22941688 [Comparison of Three Different Bone Grafts for Spinal Fusion of Degenerative Lumbar Disease] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery. Jul, 2012 | Pubmed ID: 22905609 Preparation of Sandwich-structured Graphene/mesoporous Silica Composites with C8-modified Pore Wall for Highly Efficient Selective Enrichment of Endogenous Peptides for Mass Spectrometry Analysis Proteomics. Sep, 2012 | Pubmed ID: 22837154 Past Dust and GAS/FUME Exposure and COPD in Chinese: the Guangzhou Biobank Cohort Study Respiratory Medicine. Jul, 2012 | Pubmed ID: 22795505 Complex Shapes Self-assembled from Single-stranded DNA Tiles Nature. May, 2012 | Pubmed ID: 22660323 Einbeziehung Von Oxidativem Stress Und Mitogen-aktivierte Proteinkinase, Die Signalisierung Wegen Hitze-Stress-induced-Verletzungen Im Dünndarm Ratte Stress (Amsterdam, Netherlands). Mar, 2012 | Pubmed ID: 22452662 SP1 Ist Verordnung Von Cystathionin-γ-Lyase-Genexpression Und Biologische Funktion Von PI3K/Akt-Signalweg in Menschlichen Hepatozelluläres Karzinom Zelllinien Beteiligt Cellular Signalling. Jun, 2012 | Pubmed ID: 22360859 Optimizing the Specificity of Nucleic Acid Hybridization Nature Chemistry. Mar, 2012 | Pubmed ID: 22354435 [Association Between Frequency of Fruit and Vegetable Intake and Chronic Obstructive Pulmonary Disease] Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]. Aug, 2011 | Pubmed ID: 22169691 High Throughput Identification of Components from Traditional Chinese Medicine Herbs by Utilizing Graphene or Graphene Oxide As MALDI-TOF-MS Matrix Journal of Mass Spectrometry : JMS. Aug, 2011 | Pubmed ID: 21834019 Prevalence of COPD and Its Association with Socioeconomic Status in China: Findings from China Chronic Disease Risk Factor Surveillance 2007 BMC Public Health. 2011 | Pubmed ID: 21781320 Genetic Variations of α(2)-adrenergic Receptors Illuminate the Diversity of Receptor Functions Current Topics in Membranes. 2011 | Pubmed ID: 21771490 Trinken Verhalten Bei Männern Und Frauen in China: Der 2007 China Chronische Krankheit Und Risikofaktor Überwachung Addiction (Abingdon, England). Nov, 2011 | Pubmed ID: 21771141 Profilin1 Erleichtert Staurosporine Ausgelöste Apoptose Durch Stabilisierung Der Integrin-β1-Actin-Komplex in Brustkrebszellen Journal of Cellular and Molecular Medicine. Jun, 2011 | Pubmed ID: 21692986 [Latent Membrane Protein-1 of EB Virus and the Phenotype of Epithelial-mesenchymal Transition and Cervical Lymph Node Metastasis in Nasopharyngeal Carcinoma] Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery. Mar, 2011 | Pubmed ID: 21650062 Die PI3K-Akt-Pathway Regelt Calpain 6 Ausdruck, Proliferation Und Apoptose Cellular Signalling. May, 2011 | Pubmed ID: 21255642 Integration Von MiRNA Und MRNA Ausdruck-Profile Als Reaktion Auf Wärme Stress-induzierte Schädigung Im Dünndarm Ratte Functional & Integrative Genomics. Jun, 2011 | Pubmed ID: 21057845 Einbeziehung Von ERK1/2 Signalgebung Und Growth-ähnliche Moleküle Ausdruck Als Reaktion Auf Stress-induced Hitzeschäden in Ratte Jejunum Und IEC-6 Zellen International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 2010 | Pubmed ID: 20707649 Development of Mesoporous TiO(2) Microspheres with High Specific Surface Area for Selective Enrichment of Phosphopeptides by Mass Spectrometric Analysis Journal of Chromatography. A. Apr, 2010 | Pubmed ID: 20219200 Concanavalin A-immobilized Magnetic Nanoparticles for Selective Enrichment of Glycoproteins and Application to Glycoproteomics in Hepatocelluar Carcinoma Cell Line Proteomics. May, 2010 | Pubmed ID: 20217867 Effect of Heat Stress on the Porcine Small Intestine: a Morphological and Gene Expression Study Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. May, 2010 | Pubmed ID: 20096800 Selective Data Pruning-based Compression Using High-order Edge-directed Interpolation IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society. Feb, 2010 | Pubmed ID: 19887318 Resistin Up-regulates COX-2 Expression Via TAK1-IKK-NF-kappaB Signaling Pathway Inflammation. Feb, 2010 | Pubmed ID: 19774455 Lipid Accumulation Mediated by Adiponectin in C2C12 Myogenesis BMB Reports. Oct, 2009 | Pubmed ID: 19874712 Arachidonic Acid Induces Acetyl-CoA Carboxylase 1 Expression Via Activation of CREB1 Endocrine. Dec, 2009 | Pubmed ID: 19842072 Intermolecular Hydroamination Between Nonactivated Alkenes and Aniline Catalyzed by Lanthanide Salts in Ionic Solvents Organic Letters. Sep, 2009 | Pubmed ID: 19708694 Smoking, Smoking Cessation and Aortic Arch Calcification in Older Chinese: the Guangzhou Biobank Cohort Study Atherosclerosis. Feb, 2009 | Pubmed ID: 18436226 Programming DNA Tube Circumferences Science (New York, N.Y.). Aug, 2008 | Pubmed ID: 18687961 An Assessment of the Quality of Randomised Controlled Trials Conducted in China Trials. 2008 | Pubmed ID: 18435861 Isolation of Soluble Proteins from an Industrial Strain Streptomyces Avermitilis in Complex Culture Medium for Two-dimensional Gel Electrophoresis Journal of Microbiological Methods. May, 2008 | Pubmed ID: 18378344 Identification and Purification of the Main Components of Cellulases from a Mutant Strain of Trichoderma Viride T 100-14 Bioresource Technology. Oct, 2008 | Pubmed ID: 18331790 Molecular Characterization, Chromosomal and Expression Patterns of Three Aquaglyceroporins (AQP3, 7, 9) from Pig Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. Mar, 2008 | Pubmed ID: 18249020 Programming Biomolecular Self-assembly Pathways Nature. Jan, 2008 | Pubmed ID: 18202654 [The Prevalence and Characteristics of Aortic Arch Calcification Among Middle and Elderly Population in Guangzhou] Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi. Feb, 2007 | Pubmed ID: 17649691 Gene Organization, Alternate Splicing and Expression Pattern of Porcine Visfatin Gene Domestic Animal Endocrinology. Apr, 2007 | Pubmed ID: 16857338 Polymer-controlled Crystallization of Zinc Oxide Hexagonal Nanorings and Disks The Journal of Physical Chemistry. B. Feb, 2006 | Pubmed ID: 16494299 Transcriptional Regulation of the Resistin Gene Domestic Animal Endocrinology. Feb, 2006 | Pubmed ID: 16076545 A DNAzyme That Walks Processively and Autonomously Along a One-dimensional Track Angewandte Chemie (International Ed. in English). Jul, 2005 | Pubmed ID: 15945114 Programmable DNA Self-assemblies for Nanoscale Organization of Ligands and Proteins Nano Letters. Apr, 2005 | Pubmed ID: 15826117 On Assembling Polychlorinated Aromatic Hydrocarbons from Carbon Tetrachloride Via Dichlorocarbene Intermediary by a Solvothermal Reaction: a Reaction Pattern from Carbene-ylide Interconversion The Journal of Organic Chemistry. Feb, 2005 | Pubmed ID: 15704976 Theoretical and Practical Advances in Genome Halving Bioinformatics (Oxford, England). Apr, 2005 | Pubmed ID: 15513986 Comparisons of the M1 Genome Segments and Encoded Mu2 Proteins of Different Reovirus Isolates Virology Journal. 2004 | Pubmed ID: 15507160 A Unidirectional DNA Walker That Moves Autonomously Along a Track Angewandte Chemie (International Ed. in English). Sep, 2004 | Pubmed ID: 15372637 Yin Yang 1 is a Negative Regulator of P53 Cell. Jun, 2004 | Pubmed ID: 15210108 Structures and Stability of N13+ and N13- Clusters Journal of Molecular Modeling. Feb, 2004 | Pubmed ID: 14677050 Characterization of Polychlorinated Aromatic Hydrocarbons by Reversed-phase Liquid Chromatography with Ultraviolet Absorbance and Mass Spectrometric Detection Journal of Chromatography. A. Oct, 2003 | Pubmed ID: 14601828 [Analysis on Quality Control of Blood in Blood Banks in a Five-year Program in Hunan Province] Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi. Jul, 2003 | Pubmed ID: 12975011 Inhibition of NF-kappaB Activity by Plasmid Expressed AlphaMSH Peptide Journal of Neuroimmunology. Apr, 2002 | Pubmed ID: 11960637 Die Selbstorganisation von Complex zweidimensionale Formen von Einzelstrang-DNA-Fliesen Bryan Wei1, Michelle K. Vhudzijena2, Joanna Robaszewski2, Peng Yin2,3 1Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, 2Wyss Institute for Biologically Inspired Engineering, Harvard University, 3Department of Systems Biology, Harvard Medical School Química
Die Selbstorganisation von Complex zweidimensionale Formen von Einzelstrang-DNA-Fliesen Bryan Wei1, Michelle K. Vhudzijena2, Joanna Robaszewski2, Peng Yin2,3 1Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, 2Wyss Institute for Biologically Inspired Engineering, Harvard University, 3Department of Systems Biology, Harvard Medical School Química