Rafael M. Rezende Neurology Brigham and Women's Hospital/Harvard Medical School Biography Publications Institution JoVE Articles Rafael M. RezendeDr. Rafael Rezende, PhD Dr. Rezende has a PharmD degree, MSc and PhD degrees in Biological Sciences with emphasis in Pharmacology by the Federal University of Minas Gerais (UFMG), Brazil. In 2012 he finished his first postdoctoral fellowship in Immunology, also at UFMG and joined the Weiner’s lab for his second postdoctoral fellowship. Dr. Rezende’s primary goal is to understand the mechanisms underlying the immunological tolerance breakdown, a major factor that contributes to the development of autoimmune diseases. He is particularly interested in a subtype of T cells that express the gamma-delta (gd) chains of the T cells receptor (TCR) instead of the conventional alpha-beta (ab) TCR chains. He discovered a new subset of gd T cells that express the latency-associated peptide (LAP), a membrane-bound TGF-b, that are involved in gut homeostasis control with the ability to suppress colitis in a mouse model of Crohn’s disease. He also discovered that another subtype of gd T cells that express the chemokine receptor CXCR5 contributes to the humoral immunity by inducing T follicular helper (Tfh) cells. In 2016 Dr. Rezende was promoted to Instructor in Neurology and he is currently investigating the involvement of gd T cells in shaping the gut microbiota and its consequences in oral tolerance induction. Publications Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy Rafael M. Rezende*1, Mateus E. Lopes*2, Gustavo B Menezes2, Howard L. Weiner1 1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 2Center for Gastrointestinal Biology, Federal University of Minas Gerais JoVE 59335 Biologia
Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy Rafael M. Rezende*1, Mateus E. Lopes*2, Gustavo B Menezes2, Howard L. Weiner1 1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 2Center for Gastrointestinal Biology, Federal University of Minas Gerais JoVE 59335 Biologia