Robert J. Vassar Department of Neurology Northwestern University Feinberg School of Medicine Biography Publications Institution JoVE Articles Robert J. Vassar has not added a biography. If you are Robert J. Vassar and would like to personalize this page please email our Author Liaison for assistance. Publications The Case for Low-level BACE1 Inhibition for the Prevention of Alzheimer Disease Nature Reviews. Neurology. 11, 2021 | Pubmed ID: 34548654 A Promising New γ-secretase Modulator for Alzheimer's Disease The Journal of Experimental Medicine. 04, 2021 | Pubmed ID: 33683299 Early Detection and Personalized Medicine: Future Strategies Against Alzheimer's Disease Progress in Molecular Biology and Translational Science. 2021 | Pubmed ID: 33453940 Aβ-accelerated Neurodegeneration Caused by Alzheimer's-associated Variant R1279Q is Rescued by Angiotensin System Inhibition in Mice Science Translational Medicine. 09, 2020 | Pubmed ID: 32998969 Death by Microglia The Journal of Experimental Medicine. 11, 2019 | Pubmed ID: 31645368 Editorial: Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus The Journal of Prevention of Alzheimer's Disease. 2019 | Pubmed ID: 30756113 A Promising, Novel, and Unique BACE1 Inhibitor Emerges in the Quest to Prevent Alzheimer's Disease EMBO Molecular Medicine. 11, 2018 | Pubmed ID: 30322841 ER Stress is Not Elevated in the 5XFAD Mouse Model of Alzheimer's Disease The Journal of Biological Chemistry. 11, 2018 | Pubmed ID: 30315100 Axonal Organization Defects in the Hippocampus of Adult Conditional BACE1 Knockout Mice Science Translational Medicine. 09, 2018 | Pubmed ID: 30232227 Seeds of Destruction: New Mechanistic Insights into the Role of Apolipoprotein E4 in Alzheimer's Disease Neuron. 12, 2017 | Pubmed ID: 29216455 Inhibiting BACE1 to Reverse Synaptic Dysfunctions in Alzheimer's Disease Neuroscience and Biobehavioral Reviews. Jun, 2016 | Pubmed ID: 27044452 Presynaptic Dystrophic Neurites Surrounding Amyloid Plaques Are Sites of Microtubule Disruption, BACE1 Elevation, and Increased Aβ Generation in Alzheimer's Disease Acta Neuropathologica. 08, 2016 | Pubmed ID: 26993139 Aβ Reduction in BACE1 Heterozygous Null 5XFAD Mice is Associated with Transgenic APP Level Molecular Neurodegeneration. Jan, 2015 | Pubmed ID: 25567526 Molecular Neurodegeneration: Basic Biology and Disease Pathways Molecular Neurodegeneration. Sep, 2014 | Pubmed ID: 25248568 The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1 Current Alzheimer Research. 2014 | Pubmed ID: 24893886 Increased MtDNA Mutations with Aging Promotes Amyloid Accumulation and Brain Atrophy in the APP/Ld Transgenic Mouse Model of Alzheimer's Disease Molecular Neurodegeneration. May, 2014 | Pubmed ID: 24885175 Targeting the β Secretase BACE1 for Alzheimer's Disease Therapy The Lancet. Neurology. Mar, 2014 | Pubmed ID: 24556009 ADAM10 Prodomain Mutations Cause Late-onset Alzheimer's Disease: Not Just the Latest FAD Neuron. Oct, 2013 | Pubmed ID: 24139026 Elevated Aβ42 in Aged, Non-demented Individuals with Cerebral Atherosclerosis Current Alzheimer Research. Oct, 2013 | Pubmed ID: 23919773 The β-secretase Enzyme BACE1 As a Therapeutic Target for Alzheimer's Disease Alzheimer's Research & Therapy. May, 2011 | Pubmed ID: 21639952 BACE1-/- Mice Exhibit Seizure Activity That Does Not Correlate with Sodium Channel Level or Axonal Localization Molecular Neurodegeneration. Aug, 2010 | Pubmed ID: 20731874 The Beta-secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19828790 Purificación bioquímica y caracterización proteómica de núcleos de fibrillas amiloides del cerebro Arun Upadhyay1, Robert J. Vassar1, Jeffrey N. Savas1 1Department of Neurology, Northwestern University Feinberg School of Medicine JoVE 63816 Neurociência
Purificación bioquímica y caracterización proteómica de núcleos de fibrillas amiloides del cerebro Arun Upadhyay1, Robert J. Vassar1, Jeffrey N. Savas1 1Department of Neurology, Northwestern University Feinberg School of Medicine JoVE 63816 Neurociência