Ronald L. Schnaar Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine Biography Publications Institution JoVE Articles Ronald L. Schnaar has not added a biography. If you are Ronald L. Schnaar and would like to personalize this page please email our Author Liaison for assistance. Publications Isolation, Identification, and Characterization of the Human Airway Ligand for the Eosinophil and Mast Cell Immunoinhibitory Receptor Siglec-8 The Journal of Allergy and Clinical Immunology. Aug, 2020 | Pubmed ID: 32791164 GT1b Functions As a Novel Endogenous Agonist of Toll-like Receptor 2 Inducing Neuropathic Pain The EMBO Journal. 03, 2020 | Pubmed ID: 32030804 Immunosuppressive Siglec-E Ligands on Mouse Aorta Are Up-regulated by LPS Via NF-κB Pathway Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Feb, 2020 | Pubmed ID: 31918287 A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and -F on Immune Cells Journal of the American Chemical Society. 09, 2019 | Pubmed ID: 31460762 The Biology of Gangliosides Advances in Carbohydrate Chemistry and Biochemistry. 2019 | Pubmed ID: 30851743 Immunoregulatory Siglec Ligands Are Abundant in Human and Mouse Aorta and Are Up-regulated by High Glucose Life Sciences. Jan, 2019 | Pubmed ID: 30471282 Host Membrane Glycosphingolipids and Lipid Microdomains Facilitate Histoplasma Capsulatum Internalisation by Macrophages Cellular Microbiology. 03, 2019 | Pubmed ID: 30427108 Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice International Journal of Molecular Sciences. Dec, 2018 | Pubmed ID: 30577572 Sialylated Keratan Sulfate Proteoglycans Are Siglec-8 Ligands in Human Airways Glycobiology. 10, 2018 | Pubmed ID: 29924315 Preface and Ganglioside Nomenclature Progress in Molecular Biology and Translational Science. 2018 | Pubmed ID: 29747826 Congenital Disorders of Ganglioside Biosynthesis Progress in Molecular Biology and Translational Science. 2018 | Pubmed ID: 29747824 Discoveries of the Structures of Sialic Acid and CMP-sialic Acid (1957-1960): a Letter from Saul Roseman Glycobiology. 06, 2017 | Pubmed ID: 28922867 Siglec-8 and Siglec-9 Binding Specificities and Endogenous Airway Ligand Distributions and Properties Glycobiology. 07, 2017 | Pubmed ID: 28369504 Physiological Exploration of the Long Term Evolutionary Selection Against Expression of -Glycolylneuraminic Acid in the Brain The Journal of Biological Chemistry. 02, 2017 | Pubmed ID: 28049733 Mice Lacking Sialyltransferase ST3Gal-II Develop Late-onset Obesity and Insulin Resistance Glycobiology. 01, 2017 | Pubmed ID: 27683310 Agenesis of the Corpus Callosum in Nogo Receptor Deficient Mice The Journal of Comparative Neurology. 02, 2017 | Pubmed ID: 27339102 Gangliosides of the Vertebrate Nervous System Journal of Molecular Biology. 08, 2016 | Pubmed ID: 27261254 Glycobiology Simplified: Diverse Roles of Glycan Recognition in Inflammation Journal of Leukocyte Biology. 06, 2016 | Pubmed ID: 27004978 Regulation of Airway Inflammation by Siglec-8 and Siglec-9 Sialoglycan Ligand Expression Current Opinion in Allergy and Clinical Immunology. Feb, 2016 | Pubmed ID: 26694037 Mouse Siglec-1 Mediates Trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner The Journal of Biological Chemistry. Nov, 2015 | Pubmed ID: 26370074 Sialylation Regulates Brain Structure and Function FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2015 | Pubmed ID: 25846372 Expression of Ligands for Siglec-8 and Siglec-9 in Human Airways and Airway Cells The Journal of Allergy and Clinical Immunology. Mar, 2015 | Pubmed ID: 25747723 Glycans and Glycan-binding Proteins in Immune Regulation: A Concise Introduction to Glycobiology for the Allergist The Journal of Allergy and Clinical Immunology. Mar, 2015 | Pubmed ID: 25649080 Ganglioside Regulation of AMPA Receptor Trafficking The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2014 | Pubmed ID: 25253868 Sialic Acids in the Brain: Gangliosides and Polysialic Acid in Nervous System Development, Stability, Disease, and Regeneration Physiological Reviews. Apr, 2014 | Pubmed ID: 24692354 Mice Deficient in the St3gal3 Gene Product α2,3 Sialyltransferase (ST3Gal-III) Exhibit Enhanced Allergic Eosinophilic Airway Inflammation The Journal of Allergy and Clinical Immunology. Jan, 2014 | Pubmed ID: 23830412 Sialidase, Chondroitinase ABC and Combination Therapy After Spinal Cord Contusion Injury Journal of Neurotrauma. Aug, 2012 | Pubmed ID: 22934782 Biosynthesis of the Major Brain Gangliosides GD1a and GT1b Glycobiology. Oct, 2012 | Pubmed ID: 22735313 Single Cell Ganglioside Catabolism in Primary Cerebellar Neurons and Glia Neurochemical Research. Jun, 2012 | Pubmed ID: 22407243 Anti-ganglioside Antibody-mediated Activation of RhoA Induces Inhibition of Neurite Outgrowth The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011 | Pubmed ID: 21289175 Myelin-associated Glycoprotein Protects Neurons from Excitotoxicity Journal of Neurochemistry. Mar, 2011 | Pubmed ID: 21214567 Characterization of Expression of Glycan Ligands for Siglec-F in Normal Mouse Lungs American Journal of Respiratory Cell and Molecular Biology. Feb, 2011 | Pubmed ID: 20395633 Brain Gangliosides in Axon-myelin Stability and Axon Regeneration FEBS Letters. May, 2010 | Pubmed ID: 19822144 Eosinophil-selective Binding and Proapoptotic Effect in Vitro of a Synthetic Siglec-8 Ligand, Polymeric 6'-sulfated Sialyl Lewis X The Journal of Pharmacology and Experimental Therapeutics. Aug, 2009 | Pubmed ID: 19458105 Axonal Protective Effects of the Myelin-associated Glycoprotein The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2009 | Pubmed ID: 19158290 Myelin-associated Glycoprotein and Its Axonal Receptors Journal of Neuroscience Research. Nov, 2009 | Pubmed ID: 19156870 E-selectin Receptors on Human Leukocytes Blood. Nov, 2008 | Pubmed ID: 18579791 A "glyconutrient Sham" Glycobiology. Sep, 2008 | Pubmed ID: 17855741 Effects of Detergents on the Redistribution of Gangliosides and GPI-anchored Proteins in Brain Tissue Sections The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Aug, 2007 | Pubmed ID: 17409378 Sialidase Enhances Spinal Axon Outgrowth in Vivo Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16847268 Glycan Array Screening Reveals a Candidate Ligand for Siglec-8 The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15563466 Glycolipid-mediated Cell-cell Recognition in Inflammation and Nerve Regeneration Archives of Biochemistry and Biophysics. Jun, 2004 | Pubmed ID: 15158667 Anti-ganglioside Antibodies Bind with Enhanced Affinity to Gangliosides Containing Very Long Chain Fatty Acids Neurochemical Research. Aug, 2002 | Pubmed ID: 12374222 Oligomers of Glycamino Acid Bioorganic & Medicinal Chemistry. Jun, 2002 | Pubmed ID: 11937360 Immunoglobulin G-class Mouse Monoclonal Antibodies to Major Brain Gangliosides Analytical Biochemistry. Mar, 2002 | Pubmed ID: 11878808 Mice Lacking Complex Gangliosides Develop Wallerian Degeneration and Myelination Defects Proceedings of the National Academy of Sciences of the United States of America. Jun, 1999 | Pubmed ID: 10377449 Complex Carbohydrates in Drug Development Advances in Pharmacology (San Diego, Calif.). 1992 | Pubmed ID: 1540539 Tunicamycin Inhibits Ganglioside Biosynthesis in Neuronal Cells Proceedings of the National Academy of Sciences of the United States of America. Mar, 1983 | Pubmed ID: 6572917 Ganglioside Extraction, Purification and Profiling Mitchell J. Porter*1, Gao-Lan Zhang*1, Ronald L. Schnaar1,2 1Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 2Department of Neuroscience, Johns Hopkins University School of Medicine JoVE 62385 Bioquímica
Ganglioside Extraction, Purification and Profiling Mitchell J. Porter*1, Gao-Lan Zhang*1, Ronald L. Schnaar1,2 1Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 2Department of Neuroscience, Johns Hopkins University School of Medicine JoVE 62385 Bioquímica