Takeshi Senga Department of Cancer Biology Nagoya University Graduate School of Medicine Biography Publications Institution JoVE Articles Takeshi Senga has not added a biography. If you are Takeshi Senga and would like to personalize this page please email our Author Liaison for assistance. Publications An Immuno-wall Microdevice Exhibits Rapid and Sensitive Detection of IDH1-R132H Mutation Specific to Grade II and III Gliomas Science and Technology of Advanced Materials. 2016 | Pubmed ID: 27877908 A Regulatory Subunit of Protein Phosphatase 2A, PPP2R5E, Regulates the Abundance of Microtubule Crosslinking Factor 1 The FEBS Journal. Oct, 2016 | Pubmed ID: 27521566 Nek2 SiRNA Therapy Using a Portal Venous Port-catheter System for Liver Metastasis in Pancreatic Cancer Cancer Science. Sep, 2016 | Pubmed ID: 27316377 α-Bisabolol Inhibits Invasiveness and Motility in Pancreatic Cancer Through KISS1R Activation Anticancer Research. Feb, 2016 | Pubmed ID: 26851012 Erratum To: FAM98A is a Novel Substrate of PRMT1 Required for Tumor Cell Migration, Invasion and Colony Formation Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. May, 2016 | Pubmed ID: 26825979 Erratum To: UBE2S is Associated with Malignant Characteristics of Breast Cancer Cells Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. May, 2016 | Pubmed ID: 26825978 CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains Cancer Immunology Research. Mar, 2016 | Pubmed ID: 26822025 SATB1 and SATB2 Play Opposing Roles in C-Myc Expression and Progression of Colorectal Cancer Oncotarget. Jan, 2016 | Pubmed ID: 26701851 FAM98A is a Novel Substrate of PRMT1 Required for Tumor Cell Migration, Invasion, and Colony Formation Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Apr, 2016 | Pubmed ID: 26503212 Arginine Methylation of Ubiquitin-associated Protein 2-like is Required for the Accurate Distribution of Chromosomes FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2016 | Pubmed ID: 26381755 UBE2S is Associated with Malignant Characteristics of Breast Cancer Cells Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Jan, 2016 | Pubmed ID: 26245992 Treatment with Near-infrared Radiation Promotes Apoptosis in Pancreatic Cancer Cells Oncology Letters. Sep, 2015 | Pubmed ID: 26622761 Activation of Yes-Associated Protein in Low-Grade Meningiomas Is Regulated by Merlin, Cell Density, and Extracellular Matrix Stiffness Journal of Neuropathology and Experimental Neurology. Jul, 2015 | Pubmed ID: 26049897 HOXB13 and ALX4 Induce SLUG Expression for the Promotion of EMT and Cell Invasion in Ovarian Cancer Cells Oncotarget. May, 2015 | Pubmed ID: 25944620 EML4 Promotes the Loading of NUDC to the Spindle for Mitotic Progression Cell Cycle (Georgetown, Tex.). 2015 | Pubmed ID: 25789526 YAP is Essential for Tissue Tension to Ensure Vertebrate 3D Body Shape Nature. May, 2015 | Pubmed ID: 25778702 SATB2 Suppresses the Progression of Colorectal Cancer Cells Via Inactivation of MEK5/ERK5 Signaling The FEBS Journal. Apr, 2015 | Pubmed ID: 25662172 Plasma-activated Medium Suppresses Choroidal Neovascularization in Mice: a New Therapeutic Concept for Age-related Macular Degeneration Scientific Reports. Jan, 2015 | Pubmed ID: 25573059 Special AT-rich Sequence-binding Protein 2 Suppresses Invadopodia Formation in HCT116 Cells Via Palladin Inhibition Experimental Cell Research. Mar, 2015 | Pubmed ID: 25523619 Paired Related Homeobox 1 is Associated with the Invasive Properties of Glioblastoma Cells Oncology Reports. Mar, 2015 | Pubmed ID: 25522823 Inhibition of SNW1 Association with Spliceosomal Proteins Promotes Apoptosis in Breast Cancer Cells Cancer Medicine. Feb, 2015 | Pubmed ID: 25450007 SHCBP1 is Required for Midbody Organization and Cytokinesis Completion Cell Cycle (Georgetown, Tex.). 2014 | Pubmed ID: 25486361 Silencing of STRN4 Suppresses the Malignant Characteristics of Cancer Cells Cancer Science. Dec, 2014 | Pubmed ID: 25250919 GPC3 Expression in Mouse Ovarian Cancer Induces GPC3‑specific T Cell-mediated Immune Response Through M1 Macrophages and Suppresses Tumor Growth Oncology Reports. Sep, 2014 | Pubmed ID: 24992906 Expression of the MiR200 Family of MicroRNAs in Mesothelial Cells Suppresses the Dissemination of Ovarian Cancer Cells Molecular Cancer Therapeutics. Aug, 2014 | Pubmed ID: 24928850 PLAGL2 Regulates Actin Cytoskeletal Architecture and Cell Migration Carcinogenesis. Sep, 2014 | Pubmed ID: 24675530 B7-H4 Overexpression Correlates with a Poor Prognosis for Cervical Cancer Patients Molecular and Clinical Oncology. Mar, 2014 | Pubmed ID: 24649336 Quantitative Metabolome Analysis Profiles Activation of Glutaminolysis in Glioma with IDH1 Mutation Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Jun, 2014 | Pubmed ID: 24590270 Silencing of TBC1D15 Promotes RhoA Activation and Membrane Blebbing Molecular and Cellular Biochemistry. Apr, 2014 | Pubmed ID: 24337944 Peptide-based Inhibition of the HOXA9/PBX Interaction Retards the Growth of Human Meningioma Cancer Chemotherapy and Pharmacology. Jan, 2014 | Pubmed ID: 24141373 The Role of PLK1-phosphorylated SVIL in Myosin II Activation and Cytokinetic Furrowing Journal of Cell Science. Aug, 2013 | Pubmed ID: 23750008 The Aurora-B-mediated Phosphorylation of SHCBP1 Regulates Cytokinetic Furrow Ingression Journal of Cell Science. Aug, 2013 | Pubmed ID: 23704356 The Expression and Characterization of Endoglin in Uterine Leiomyosarcoma Clinical & Experimental Metastasis. Aug, 2013 | Pubmed ID: 23397382 ALX1 Induces Snail Expression to Promote Epithelial-to-mesenchymal Transition and Invasion of Ovarian Cancer Cells Cancer Research. Mar, 2013 | Pubmed ID: 23288509 S100A10 is Required for the Organization of Actin Stress Fibers and Promotion of Cell Spreading Molecular and Cellular Biochemistry. Feb, 2013 | Pubmed ID: 23129259 Plant Lectin Can Target Receptors Containing Sialic Acid, Exemplified by Podoplanin, to Inhibit Transformed Cell Growth and Migration PloS One. 2012 | Pubmed ID: 22844530 Misshapen-like Kinase 1 (MINK1) is a Novel Component of Striatin-interacting Phosphatase and Kinase (STRIPAK) and is Required for the Completion of Cytokinesis The Journal of Biological Chemistry. Jul, 2012 | Pubmed ID: 22665485 Role of Palladin Phosphorylation by Extracellular Signal-regulated Kinase in Cell Migration PloS One. 2011 | Pubmed ID: 22216253 The Loss of Endoglin Promotes the Invasion of Extravillous Trophoblasts Endocrinology. Nov, 2011 | Pubmed ID: 21914777 ARHGAP18, a GTPase-activating Protein for RhoA, Controls Cell Shape, Spreading, and Motility Molecular Biology of the Cell. Oct, 2011 | Pubmed ID: 21865595 Recovery of Anoikis in Src-transformed Cells and Human Breast Carcinoma Cells by Restoration of the SIRP α1/SHP-2 Signaling System Cancer Research. Feb, 2011 | Pubmed ID: 21169408 FLT3/ ITD Regulates Leukaemia Cell Adhesion Through α4β1 Integrin and Pyk2 Signalling European Journal of Haematology. Mar, 2011 | Pubmed ID: 21114537 Disruption of Cell Spreading by the Activation of MEK/ERK Pathway is Dependent on AP-1 Activity Nagoya Journal of Medical Science. Aug, 2010 | Pubmed ID: 20942268 The Roles of Two Distinct Regions of PINCH-1 in the Regulation of Cell Attachment and Spreading Molecular Biology of the Cell. Dec, 2010 | Pubmed ID: 20926685 PI3K/Akt Signaling is Involved in the Disruption of Gap Junctional Communication Caused by V-Src and TNF-α Biochemical and Biophysical Research Communications. Sep, 2010 | Pubmed ID: 20727856 Cas Utilizes Nck2 to Activate Cdc42 and Regulate Cell Polarization During Cell Migration in Response to Wound Healing The FEBS Journal. Sep, 2010 | Pubmed ID: 20637038 Silencing of Tousled-like Kinase 1 Sensitizes Cholangiocarcinoma Cells to Cisplatin-induced Apoptosis Cancer Letters. Oct, 2010 | Pubmed ID: 20381954 Novel Combination Treatment for Colorectal Cancer Using Nek2 SiRNA and Cisplatin Cancer Science. May, 2010 | Pubmed ID: 20345485 S-nitrosylation at Cysteine 498 of C-Src Tyrosine Kinase Regulates Nitric Oxide-mediated Cell Invasion The Journal of Biological Chemistry. Feb, 2010 | Pubmed ID: 19948721 Gene Silencing of Glypican-3 in Clear Cell Carcinoma of the Ovary Renders It More Sensitive to the Apoptotic Agent Paclitaxel in Vitro and in Vivo Cancer Science. Jan, 2010 | Pubmed ID: 19860840 Three-dimensional Cell Culture Array Using Magnetic Force-based Cell Patterning for Analysis of Invasive Capacity of BALB/3T3/v-src Lab on a Chip. Dec, 2009 | Pubmed ID: 19904404 Human Papillomavirus Type 16 Oncoprotein E7 Suppresses Cadherin-mediated Cell Adhesion Via ERK and AP-1 Signaling International Journal of Oncology. Aug, 2009 | Pubmed ID: 19578744 Phosphorylation of Histone H3 at Ser10: Its Role in Cell Transformation by V-Src Biochemical and Biophysical Research Communications. Sep, 2009 | Pubmed ID: 19540193 Characterization of Interaction Between CLP36 and Palladin The FEBS Journal. May, 2009 | Pubmed ID: 19366376 A Role for AP-1 in Matrix Metalloproteinase Production and Invadopodia Formation of V-Crk-transformed Cells Experimental Cell Research. May, 2009 | Pubmed ID: 19268464 Nek2 As a Novel Molecular Target for the Treatment of Breast Carcinoma Cancer Science. Jan, 2009 | Pubmed ID: 19038001 The Cysteine-cluster Motif of C-Yes, Lyn and FAK As a Suppressive Module for the Kinases Oncology Reports. Apr, 2008 | Pubmed ID: 18357384 MEK Inhibitor Enhances the Inhibitory Effect of Imatinib on Pancreatic Cancer Cell Growth Cancer Letters. Jun, 2008 | Pubmed ID: 18346844 The Cysteine-cluster Motif of C-Src: Its Role for the Heavy Metal-mediated Activation of Kinase Cancer Science. Mar, 2008 | Pubmed ID: 18177487 Nek2 As an Effective Target for Inhibition of Tumorigenic Growth and Peritoneal Dissemination of Cholangiocarcinoma Cancer Research. Oct, 2007 | Pubmed ID: 17942892 A Role for SHPS-1/SIRPalpha in Concanavalin A-dependent Production of MMP-9 Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Sep, 2007 | Pubmed ID: 17825046 Mcm10 and And-1/CTF4 Recruit DNA Polymerase Alpha to Chromatin for Initiation of DNA Replication Genes & Development. Sep, 2007 | Pubmed ID: 17761813 SIRPalpha1 and SIRPalpha2: Their Role As Tumor Suppressors in Breast Carcinoma Cells Biochemical and Biophysical Research Communications. Sep, 2007 | Pubmed ID: 17632076 FAK Signaling in Neoplastic Disorders: a Linkage Between Inflammation and Cancer Annals of the New York Academy of Sciences. Nov, 2006 | Pubmed ID: 17185517 SHP-2-Erk Signaling Regulates Concanavalin A-dependent Production of TIMP-2 Biochemical and Biophysical Research Communications. Sep, 2006 | Pubmed ID: 16904070 A Role for Focal Adhesion Kinase Signaling in Tumor Necrosis Factor-alpha-dependent Matrix Metalloproteinase-9 Production in a Cholangiocarcinoma Cell Line, CCKS1 Cancer Research. Jul, 2006 | Pubmed ID: 16818654 PCNA is a Cofactor for Cdt1 Degradation by CUL4/DDB1-mediated N-terminal Ubiquitination The Journal of Biological Chemistry. Mar, 2006 | Pubmed ID: 16407252 A Role for PI3K-Akt Signaling in Pulmonary Metastatic Nodule Formation of the Osteosarcoma Cell Line, LM8 Oncology Reports. Oct, 2005 | Pubmed ID: 16142341 A Dimerized Coiled-coil Domain and an Adjoining Part of Geminin Interact with Two Sites on Cdt1 for Replication Inhibition Molecular Cell. Jul, 2004 | Pubmed ID: 15260975 Tyrosine Phosphorylation of NOS3 in a Breast Cancer Cell Line and Src-transformed Cells Oncology Reports. May, 2004 | Pubmed ID: 15069547 Stat3-dependent Induction of Interleukin-3 Receptor Expression in Leukemia Inhibitory Factor-stimulated M1 Mouse Leukemia Cells Cytokine. Feb, 2004 | Pubmed ID: 14698140 SH2 Domain Containing Protein Tyrosine Phosphatase 2 Regulates Concanavalin A-dependent Secretion and Activation of Matrix Metalloproteinase 2 Via the Extracellular Signal-regulated Kinase and P38 Pathways Cancer Research. Oct, 2003 | Pubmed ID: 14559821 Secretion of Matrix Metalloproteinase-9 by the Proinflammatory Cytokine, IL-1beta: a Role for the Dual Signalling Pathways, Akt and Erk Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jun, 2003 | Pubmed ID: 12786942 Cysteine Residues in the C-terminal Lobe of Src: Their Role in the Suppression of the Src Kinase Oncogene. Mar, 2003 | Pubmed ID: 12618767 Profiling of Gene Expression Associated with Hepatolithiasis by Complementary DNA Expression Array International Journal of Oncology. Jan, 2003 | Pubmed ID: 12469201 LSSIG is a Novel Murine Leukocyte-specific GPCR That is Induced by the Activation of STAT3 Blood. Feb, 2003 | Pubmed ID: 12393494 A Role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent Signaling Oncogene. Dec, 2002 | Pubmed ID: 12483539 Stat3-dependent Induction of BATF in M1 Mouse Myeloid Leukemia Cells Oncogene. Nov, 2002 | Pubmed ID: 12444555 Hyaluronan-CD44s Signaling Regulates Matrix Metalloproteinase-2 Secretion in a Human Lung Carcinoma Cell Line QG90 Cancer Research. Jul, 2002 | Pubmed ID: 12124327 Repair by Src Kinase of Function-impaired RET with Multiple Endocrine Neoplasia Type 2A Mutation with Substitutions of Tyrosines in the COOH-terminal Kinase Domain for Phenylalanine Cancer Research. Apr, 2002 | Pubmed ID: 11956105 Possible Activation of the Renin-angiotensin System in the Feto-placental Unit in Preeclampsia The Journal of Clinical Endocrinology and Metabolism. Apr, 2002 | Pubmed ID: 11932332 Abnormal Accumulation of Hyaluronan Matrix Diminishes Contact Inhibition of Cell Growth and Promotes Cell Migration Proceedings of the National Academy of Sciences of the United States of America. Mar, 2002 | Pubmed ID: 11891291 Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells Yoshihiro Koya1,2, Hiroaki Kajiyama2, Wenting Liu1,2, Kiyosumi Shibata2, Takeshi Senga3, Fumitaka Kikkawa2 1Bell Research Center for Reproductive Health and Cancer, 2Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 3Department of Cancer Biology, Nagoya University Graduate School of Medicine JoVE 54353 Pesquisa do câncer
Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells Yoshihiro Koya1,2, Hiroaki Kajiyama2, Wenting Liu1,2, Kiyosumi Shibata2, Takeshi Senga3, Fumitaka Kikkawa2 1Bell Research Center for Reproductive Health and Cancer, 2Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 3Department of Cancer Biology, Nagoya University Graduate School of Medicine JoVE 54353 Pesquisa do câncer