William C. de Groat Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Biography Publications Institution JoVE Articles William C. de Groat has not added a biography. If you are William C. de Groat and would like to personalize this page please email our Author Liaison for assistance. Publications Somatic Modulation of Spinal Reflex Bladder Activity Mediated by Nociceptive Bladder Afferent Nerve Fibers in Cats American Journal of Physiology. Renal Physiology. Jul, 2014 | Pubmed ID: 25056352 Effect of Non-symmetric Waveform on Conduction Block Induced by High-frequency (kHz) Biphasic Stimulation in Unmyelinated Axon Journal of Computational Neuroscience. Jun, 2014 | Pubmed ID: 24928360 Poststimulation Inhibition of the Micturition Reflex Induced by Tibial Nerve Stimulation in Rats Physiological Reports. Jan, 2014 | Pubmed ID: 24744884 Effects of Duloxetine and WAY100635 on Pudendal Inhibition of Bladder Overactivity in Cats The Journal of Pharmacology and Experimental Therapeutics. Jun, 2014 | Pubmed ID: 24667547 Role of Spinal GABAA Receptors in Pudendal Inhibition of Nociceptive and Nonnociceptive Bladder Reflexes in Cats American Journal of Physiology. Renal Physiology. Apr, 2014 | Pubmed ID: 24523385 Modulation of Peripheral Na(+) Channels and Neuronal Firing by N-butyl-p-aminobenzoate European Journal of Pharmacology. Mar, 2014 | Pubmed ID: 24486399 Pudendal Nerve Stimulation and Block by a Wireless-controlled Implantable Stimulator in Cats Neuromodulation : Journal of the International Neuromodulation Society. Jul, 2014 | Pubmed ID: 24320615 Effects of Agonists for Estrogen Receptor α and β on Ovariectomy-induced Lower Urinary Tract Dysfunction in the Rat American Journal of Physiology. Renal Physiology. Jan, 2014 | Pubmed ID: 24259512 Nitro-oleic Acid Desensitizes TRPA1 and TRPV1 Agonist Responses in Adult Rat DRG Neurons Experimental Neurology. Jan, 2014 | Pubmed ID: 24212047 Electrical Stimulation of Somatic Afferent Nerves in the Foot Increases Bladder Capacity in Healthy Human Subjects The Journal of Urology. Apr, 2014 | Pubmed ID: 24113017 Effect of Botulinum Toxin A on Urothelial-release of ATP and Expression of SNARE Targets Within the Urothelium Neurourology and Urodynamics. Oct, 2013 | Pubmed ID: 24167028 Inhibition of Bladder Overactivity by Duloxetine in Combination with Foot Stimulation or WAY-100635 Treatment in Cats American Journal of Physiology. Renal Physiology. Dec, 2013 | Pubmed ID: 24154699 Combination of Foot Stimulation and Tolterodine Treatment Eliminates Bladder Overactivity in Cats Neurourology and Urodynamics. Aug, 2013 | Pubmed ID: 24038323 Roles of Adenosine A1 and A2A Receptors in the Control of Micturition in Rats Neurourology and Urodynamics. Sep, 2013 | Pubmed ID: 24014261 Hyperexcitability of Bladder Afferent Neurons Associated with Reduction of Kv1.4 α-subunit in Rats with Spinal Cord Injury The Journal of Urology. Dec, 2013 | Pubmed ID: 23896350 Involvement of 5-HT3 Receptors in Pudendal Inhibition of Bladder Overactivity in Cats American Journal of Physiology. Renal Physiology. Sep, 2013 | Pubmed ID: 23825079 Lower Urinary Tract Dysfunction: From Basic Science to Clinical Management. Foreword International Journal of Urology : Official Journal of the Japanese Urological Association. Jan, 2013 | Pubmed ID: 23819142 Future Direction in Pharmacotherapy for Non-neurogenic Male Lower Urinary Tract Symptoms European Urology. Oct, 2013 | Pubmed ID: 23711541 Effect of Methysergide on Pudendal Inhibition of Micturition Reflex in Cats Experimental Neurology. Sep, 2013 | Pubmed ID: 23688680 Highlights in Basic Autonomic Neuroscience: Contribution of the Urothelium to Sensory Mechanisms in the Urinary Bladder Autonomic Neuroscience : Basic & Clinical. Oct, 2013 | Pubmed ID: 23602550 Contribution of Opioid and Metabotropic Glutamate Receptor Mechanisms to Inhibition of Bladder Overactivity by Tibial Nerve Stimulation American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2013 | Pubmed ID: 23576608 Effects of Herpes Simplex Virus Vector-mediated Enkephalin Gene Therapy on Bladder Overactivity and Nociception Human Gene Therapy. Feb, 2013 | Pubmed ID: 23316929 Neural Pathways Involved in Sacral Neuromodulation of Reflex Bladder Activity in Cats American Journal of Physiology. Renal Physiology. Mar, 2013 | Pubmed ID: 23283999 Effects of Urethane on Reflex Activity of Lower Urinary Tract in Decerebrate Unanesthetized Rats American Journal of Physiology. Renal Physiology. Feb, 2013 | Pubmed ID: 23195677 Evidence for the Role of Mast Cells in Colon-bladder Cross Organ Sensitization Autonomic Neuroscience : Basic & Clinical. Jan, 2013 | Pubmed ID: 23182915 An Alpha1-adrenoceptor Blocker Terazosin Improves Urine Storage Function in the Spinal Cord in Spinal Cord Injured Rats Life Sciences. Feb, 2013 | Pubmed ID: 23178151 Nitric Oxide Modulates Bladder Afferent Nerve Activity in the in Vitro Urinary Bladder-pelvic Nerve Preparation from Rats with Cyclophosphamide Induced Cystitis Brain Research. Jan, 2013 | Pubmed ID: 23063886 Role of Opioid and Metabotropic Glutamate 5 Receptors in Pudendal Inhibition of Bladder Overactivity in Cats The Journal of Urology. Apr, 2013 | Pubmed ID: 23022006 Combination of Foot Stimulation and Tramadol Treatment Reverses Irritation Induced Bladder Overactivity in Cats The Journal of Urology. Dec, 2012 | Pubmed ID: 23088991 Percutaneous Tibial Nerve Stimulation: a Clinically and Cost Effective Addition to the Overactive Bladder Algorithm of Care Current Urology Reports. Oct, 2012 | Pubmed ID: 22893501 Inhibition of Micturition Reflex by Activation of Somatic Afferents in Posterior Femoral Cutaneous Nerve The Journal of Physiology. Oct, 2012 | Pubmed ID: 22869011 Involvement of Opioid Receptors in Inhibition of Bladder Overactivity Induced by Foot Stimulation in Cats The Journal of Urology. Sep, 2012 | Pubmed ID: 22819119 Activation of Neurokinin-1 Receptors Increases the Excitability of Guinea Pig Dorsal Root Ganglion Cells The Journal of Pharmacology and Experimental Therapeutics. Oct, 2012 | Pubmed ID: 22736506 Bladder Inhibition by Intermittent Pudendal Nerve Stimulation in Cat Using Transdermal Amplitude-modulated Signal (TAMS) Neurourology and Urodynamics. Sep, 2012 | Pubmed ID: 22517233 Inhibition of Bladder Overactivity by a Combination of Tibial Neuromodulation and Tramadol Treatment in Cats American Journal of Physiology. Renal Physiology. Jun, 2012 | Pubmed ID: 22496406 Botulinum Neurotoxin Serotype A Suppresses Neurotransmitter Release from Afferent As Well As Efferent Nerves in the Urinary Bladder European Urology. Dec, 2012 | Pubmed ID: 22480459 Suppression of Bladder Overactivity by Adenosine A2A Receptor Antagonist in a Rat Model of Parkinson Disease The Journal of Urology. May, 2012 | Pubmed ID: 22425056 Glycine Transporter Type 2 (GlyT2) Inhibitor Ameliorates Bladder Overactivity and Nociceptive Behavior in Rats European Urology. Oct, 2012 | Pubmed ID: 22341128 Prejunctional Facilitatory Effect of a Thiol-alkylating Agent N-Ethylmaleimide on Neurogenic Contractions in Rat Prostate Smooth Muscle Neurourology and Urodynamics. Apr, 2012 | Pubmed ID: 22275139 Differential Role of Opioid Receptors in Tibial Nerve Inhibition of Nociceptive and Nonnociceptive Bladder Reflexes in Cats American Journal of Physiology. Renal Physiology. May, 2012 | Pubmed ID: 22237803 Post-stimulation Inhibitory Effect on Reflex Bladder Activity Induced by Activation of Somatic Afferent Nerves in the Foot The Journal of Urology. Jan, 2012 | Pubmed ID: 22099982 Inhibition of Bladder Overactivity by Stimulation of Feline Pudendal Nerve Using Transdermal Amplitude-modulated Signal (TAMS) BJU International. Mar, 2012 | Pubmed ID: 21851548 Plasticity in Reflex Pathways to the Lower Urinary Tract Following Spinal Cord Injury Experimental Neurology. May, 2012 | Pubmed ID: 21596038 Involvement of Metabotropic Glutamate Receptor 5 in Pudendal Inhibition of Nociceptive Bladder Activity in Cats The Journal of Physiology. Dec, 2011 | Pubmed ID: 22005674 Effects of Ovariectomy and Estrogen Replacement on the Urethral Continence Reflex During Sneezing in Rats The Journal of Urology. Oct, 2011 | Pubmed ID: 21855912 Strain-dependent Urethral Response Neurourology and Urodynamics. Nov, 2011 | Pubmed ID: 21826722 Developmental and Spinal Cord Injury-induced Changes in Nitric Oxide-mediated Inhibition in Rat Urinary Bladder Neurourology and Urodynamics. Nov, 2011 | Pubmed ID: 21717503 Irritation Induced Bladder Overactivity is Suppressed by Tibial Nerve Stimulation in Cats The Journal of Urology. Jul, 2011 | Pubmed ID: 21600604 Effect of Ovariectomy on External Urethral Sphincter Activity in Anesthetized Female Rats The Journal of Urology. Jul, 2011 | Pubmed ID: 21600603 Mechanism of Conduction Block in Amphibian Myelinated Axon Induced by Biphasic Electrical Current at Ultra-high Frequency Journal of Computational Neuroscience. Nov, 2011 | Pubmed ID: 21523417 How Does Neuromodulation Work Neurourology and Urodynamics. Jun, 2011 | Pubmed ID: 21462243 Urethral Compensatory Mechanisms to Maintain Urinary Continence After Pudendal Nerve Injury in Female Rats International Urogynecology Journal. Aug, 2011 | Pubmed ID: 21445696 Neuromodulation of Bladder Activity by Stimulation of Feline Pudendal Nerve Using a Transdermal Amplitude Modulated Signal (TAMS) Neurourology and Urodynamics. Nov, 2011 | Pubmed ID: 21404324 Tadalafil for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: Pathophysiology and Mechanism(s) of Action Neurourology and Urodynamics. Mar, 2011 | Pubmed ID: 21284024 Plasticity of Urinary Bladder Reflexes Evoked by Stimulation of Pudendal Afferent Nerves After Chronic Spinal Cord Injury in Cats Experimental Neurology. Mar, 2011 | Pubmed ID: 21192927 Activation of CaMKII and ERK1/2 Contributes to the Time-dependent Potentiation of Ca2+ Response Elicited by Repeated Application of Capsaicin in Rat DRG Neurons American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Mar, 2011 | Pubmed ID: 21178121 Prolonged Poststimulation Inhibition of Bladder Activity Induced by Tibial Nerve Stimulation in Cats American Journal of Physiology. Renal Physiology. Feb, 2011 | Pubmed ID: 21106856 Urothelial Beta-3 Adrenergic Receptors in the Rat Bladder Neurourology and Urodynamics. Jan, 2011 | Pubmed ID: 21046653 Suppression of Bladder Overactivity by Activation of Somatic Afferent Nerves in the Foot BJU International. Jan, 2011 | Pubmed ID: 20394612 β-Adrenergic Receptor Subtype Expression in Myocyte and Non-myocyte Cells in Human Female Bladder Cell and Tissue Research. Nov, 2010 | Pubmed ID: 20953633 Effects of Stimulation of Muscarinic Receptors on Bladder Afferent Nerves in the in Vitro Bladder-pelvic Afferent Nerve Preparation of the Rat Brain Research. Nov, 2010 | Pubmed ID: 20840844 Suppression of Detrusor-sphincter Dyssynergia by Herpes Simplex Virus Vector Mediated Gene Delivery of Glutamic Acid Decarboxylase in Spinal Cord Injured Rats The Journal of Urology. Sep, 2010 | Pubmed ID: 20663524 Alpha2-adrenoceptor Blockade Potentiates the Effect of Duloxetine on Sneeze Induced Urethral Continence Reflex in Rats The Journal of Urology. Aug, 2010 | Pubmed ID: 20639053 Neural Control of the Female Urethral and Anal Rhabdosphincters and Pelvic Floor Muscles American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Aug, 2010 | Pubmed ID: 20484700 Ex Vivo Biomechanical, Functional, and Immunohistochemical Alterations of Adrenergic Responses in the Female Urethra in a Rat Model of Birth Trauma American Journal of Physiology. Renal Physiology. Aug, 2010 | Pubmed ID: 20444739 Influence of Naloxone on Inhibitory Pudendal-to-bladder Reflex in Cats Experimental Neurology. Jul, 2010 | Pubmed ID: 20382144 Effects of Bladder Outlet Obstruction on Properties of Ca2+-activated K+ Channels in Rat Bladder American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. May, 2010 | Pubmed ID: 20200132 Differential Effect of L-cysteine in Isolated Whole-bladder Preparations from Neonatal and Adult Rats The Journal of Pharmacology and Experimental Therapeutics. Apr, 2010 | Pubmed ID: 20051484 Role of 5-HT1A Receptors in Control of Lower Urinary Tract Function in Anesthetized Rats American Journal of Physiology. Renal Physiology. Mar, 2010 | Pubmed ID: 20042459 Changes in Afferent Activity After Spinal Cord Injury Neurourology and Urodynamics. 2010 | Pubmed ID: 20025033 Caveolin-3 Promotes Nicotinic Acetylcholine Receptor Clustering and Regulates Neuromuscular Junction Activity Molecular Biology of the Cell. Jan, 2010 | Pubmed ID: 19940021 Comparison of Voiding Function and Nociceptive Behavior in Two Rat Models of Cystitis Induced by Cyclophosphamide or Acetone Neurourology and Urodynamics. Mar, 2010 | Pubmed ID: 19618450 Excitatory and Inhibitory Influence of Pathways in the Pelvic Nerve on Bladder Activity in Rats with Bladder Outlet Obstruction Lower Urinary Tract Symptoms. Jun, 2009 | Pubmed ID: 21701700 Gene Therapy for Bladder Overactivity and Nociception with Herpes Simplex Virus Vectors Expressing Preproenkephalin Human Gene Therapy. Jan, 2009 | Pubmed ID: 20377371 Brain Switch for Reflex Micturition Control Detected by FMRI in Rats Journal of Neurophysiology. Nov, 2009 | Pubmed ID: 19741099 Afferent Nerve Regulation of Bladder Function in Health and Disease Handbook of Experimental Pharmacology. 2009 | Pubmed ID: 19655106 Role of Spinal Serotonergic Pathways in Sneeze-induced Urethral Continence Reflex in Rats American Journal of Physiology. Renal Physiology. Oct, 2009 | Pubmed ID: 19640898 Neurokinins Inhibit Low Threshold Inactivating K+ Currents in Capsaicin Responsive DRG Neurons Experimental Neurology. Oct, 2009 | Pubmed ID: 19631644 Effects of Beta3-adrenergic Receptor Activation on Rat Urinary Bladder Hyperactivity Induced by Ovariectomy The Journal of Pharmacology and Experimental Therapeutics. Sep, 2009 | Pubmed ID: 19515967 Activation of the Nitric Oxide-cGMP Pathway Reduces Phasic Contractions in Neonatal Rat Bladder Strips Via Protein Kinase G American Journal of Physiology. Renal Physiology. Aug, 2009 | Pubmed ID: 19493964 Muscarinic Receptor Activation in the Lumbosacral Spinal Cord Ameliorates Bladder Irritation in Rat Cystitis Models BJU International. Nov, 2009 | Pubmed ID: 19466955 Modulation of Axonal Excitability by High-frequency Biphasic Electrical Current IEEE Transactions on Bio-medical Engineering. Sep, 2009 | Pubmed ID: 19389692 Effects of Cholinesterase Inhibition in Supraspinal and Spinal Neural Pathways on the Micturition Reflex in Rats BJU International. Oct, 2009 | Pubmed ID: 19338542 Bladder Hyperactivity and Increased Excitability of Bladder Afferent Neurons Associated with Reduced Expression of Kv1.4 Alpha-subunit in Rats with Cystitis American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. May, 2009 | Pubmed ID: 19279288 Analysis of Nerve Conduction Block Induced by Direct Current Journal of Computational Neuroscience. Oct, 2009 | Pubmed ID: 19255835 The Role of Slow Potassium Current in Nerve Conduction Block Induced by High-frequency Biphasic Electrical Current IEEE Transactions on Bio-medical Engineering. Jan, 2009 | Pubmed ID: 19224727 Role of Alpha2-adrenoceptors and Glutamate Mechanisms in the External Urethral Sphincter Continence Reflex in Rats The Journal of Urology. Mar, 2009 | Pubmed ID: 19157445 Bladder Inhibition or Excitation by Electrical Perianal Stimulation in a Cat Model of Chronic Spinal Cord Injury BJU International. Feb, 2009 | Pubmed ID: 19007383 Relationship Between Temperature and Stimulation Frequency in Conduction Block of Amphibian Myelinated Axon Journal of Computational Neuroscience. Jun, 2009 | Pubmed ID: 18839298 Protein Kinase C Epsilon Contributes to Basal and Sensitizing Responses of TRPV1 to Capsaicin in Rat Dorsal Root Ganglion Neurons The European Journal of Neuroscience. Oct, 2008 | Pubmed ID: 18973552 The Role of Vasoactive Intestinal Polypeptide and Pituitary Adenylate Cyclase-activating Polypeptide in the Neural Pathways Controlling the Lower Urinary Tract Journal of Molecular Neuroscience : MN. Nov, 2008 | Pubmed ID: 18677446 Effects of Intrathecal Injection of a Hyperpolarization-activated Channel (Ih) Inhibitor ZD7288 on Bladder Function in Urethane-anesthetized Rats Neurourology and Urodynamics. 2008 | Pubmed ID: 18642373 Influence of Temperature on Pudendal Nerve Block Induced by High Frequency Biphasic Electrical Current The Journal of Urology. Sep, 2008 | Pubmed ID: 18639276 Neurokinin 2 Receptor-mediated Activation of Protein Kinase C Modulates Capsaicin Responses in DRG Neurons from Adult Rats The European Journal of Neuroscience. Jun, 2008 | Pubmed ID: 18598261 Suppression of Detrusor-sphincter Dysynergia by GABA-receptor Activation in the Lumbosacral Spinal Cord in Spinal Cord-injured Rats American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2008 | Pubmed ID: 18495826 The Neural Control of Micturition Nature Reviews. Neuroscience. Jun, 2008 | Pubmed ID: 18490916 Effect of Duloxetine, a Norepinephrine and Serotonin Reuptake Inhibitor, on Sneeze-induced Urethral Continence Reflex in Rats American Journal of Physiology. Renal Physiology. Jul, 2008 | Pubmed ID: 18480175 Drug Insight: Biological Effects of Botulinum Toxin A in the Lower Urinary Tract Nature Clinical Practice. Urology. Jun, 2008 | Pubmed ID: 18461049 Effects of Intrathecal Administration of Pituitary Adenylate Cyclase Activating Polypeptide on Lower Urinary Tract Functions in Rats with Intact or Transected Spinal Cords Experimental Neurology. Jun, 2008 | Pubmed ID: 18410926 Hindlimb Movement in the Cat Induced by Amplitude-modulated Stimulation Using Extra-spinal Electrodes Journal of Neural Engineering. Jun, 2008 | Pubmed ID: 18369283 Association of Overactive Bladder and Stress Urinary Incontinence in Rats with Pudendal Nerve Ligation Injury American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. May, 2008 | Pubmed ID: 18337317 Sensitization of Pelvic Afferent Nerves in the in Vitro Rat Urinary Bladder-pelvic Nerve Preparation by Purinergic Agonists and Cyclophosphamide Pretreatment American Journal of Physiology. Renal Physiology. May, 2008 | Pubmed ID: 18322018 Activation of Muscarinic Receptors in Rat Bladder Sensory Pathways Alters Reflex Bladder Activity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2008 | Pubmed ID: 18287514 GABA Receptor Activation in the Lumbosacral Spinal Cord Decreases Detrusor Overactivity in Spinal Cord Injured Rats The Journal of Urology. Mar, 2008 | Pubmed ID: 18206170 Inhibitory and Excitatory Perigenital-to-bladder Spinal Reflexes in the Cat American Journal of Physiology. Renal Physiology. Mar, 2008 | Pubmed ID: 18160624 Effects of Intravesical Instillation of Resiniferatoxin on Bladder Function and Nociceptive Behavior in Freely Moving, Conscious Rats The Journal of Urology. Jan, 2008 | Pubmed ID: 18006008 Reactive Oxygen Species Mediate Detrusor Overactivity Via Sensitization of Afferent Pathway in the Bladder of Anaesthetized Rats BJU International. Mar, 2008 | Pubmed ID: 18005207 Influence of Frequency and Temperature on the Mechanisms of Nerve Conduction Block Induced by High-frequency Biphasic Electrical Current Journal of Computational Neuroscience. Apr, 2008 | Pubmed ID: 17682929 Evaluation of Purinergic Mechanism for the Treatment of Voiding Dysfunction: a Study in Conscious Spinal Cord-injured Rats Journal of the Chinese Medical Association : JCMA. Oct, 2007 | Pubmed ID: 17962144 Bladder Volume-dependent Excitatory and Inhibitory Influence of Lumbosacral Dorsal and Ventral Roots on Bladder Activity in Rats Biomedical Research (Tokyo, Japan). Aug, 2007 | Pubmed ID: 17878597 Inhibitory Roles of Peripheral Nitrergic Mechanisms in Capsaicin-induced Detrusor Overactivity in the Rat BJU International. Oct, 2007 | Pubmed ID: 17822469 Effects of Ralfinamide, a Na+ Channel Blocker, on Firing Properties of Nociceptive Dorsal Root Ganglion Neurons of Adult Rats Experimental Neurology. Nov, 2007 | Pubmed ID: 17707373 An HSV Vector System for Selection of Ligand-gated Ion Channel Modulators Nature Methods. Sep, 2007 | Pubmed ID: 17676048 The Differential Contractile Responses to Capsaicin and Anandamide in Muscle Strips Isolated from the Rat Urinary Bladder European Journal of Pharmacology. Sep, 2007 | Pubmed ID: 17586490 Voiding Reflex in Chronic Spinal Cord Injured Cats Induced by Stimulating and Blocking Pudendal Nerves Neurourology and Urodynamics. 2007 | Pubmed ID: 17563108 Effects of Anaesthesia on the Nitrergic Pathway During the Micturition Reflex in Rats BJU International. Jul, 2007 | Pubmed ID: 17488309 Role of Spinal Metabotropic Glutamate Receptors in Regulation of Lower Urinary Tract Function in the Decerebrate Unanesthetized Rat Neuroscience Letters. Jun, 2007 | Pubmed ID: 17434674 Autonomic Nerve Stimulation Reverses Ventricular Repolarization Sequence in Rabbit Hearts Circulation Research. Apr, 2007 | Pubmed ID: 17363699 Non-neuronal Acetylcholine and Urinary Bladder Urothelium Life Sciences. May, 2007 | Pubmed ID: 17363007 Neurokinins Enhance Excitability in Capsaicin-responsive DRG Neurons Experimental Neurology. May, 2007 | Pubmed ID: 17362934 Bladder Inhibition or Voiding Induced by Pudendal Nerve Stimulation in Chronic Spinal Cord Injured Cats Neurourology and Urodynamics. 2007 | Pubmed ID: 17304521 Smooth Muscle and Neural Mechanisms Contributing to the Downregulation of Neonatal Rat Spontaneous Bladder Contractions During Postnatal Development American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. May, 2007 | Pubmed ID: 17234952 Mechanisms of Disease: Involvement of the Urothelium in Bladder Dysfunction Nature Clinical Practice. Urology. Jan, 2007 | Pubmed ID: 17211425 Ex Vivo Biomechanical Properties of the Female Urethra in a Rat Model of Birth Trauma American Journal of Physiology. Renal Physiology. Apr, 2007 | Pubmed ID: 17190909 Role of Noradrenergic Pathways in Sneeze-induced Urethral Continence Reflex in Rats American Journal of Physiology. Renal Physiology. Feb, 2007 | Pubmed ID: 17047168 Serotonergic Drugs and Spinal Cord Transections Indicate That Different Spinal Circuits Are Involved in External Urethral Sphincter Activity in Rats American Journal of Physiology. Renal Physiology. Mar, 2007 | Pubmed ID: 17047164 Mechanism of Nerve Conduction Block Induced by High-frequency Biphasic Electrical Currents IEEE Transactions on Bio-medical Engineering. Dec, 2006 | Pubmed ID: 17153201 Functional Analysis of Active Urethral Closure Mechanisms Under Sneeze Induced Stress Condition in a Rat Model of Birth Trauma The Journal of Urology. Dec, 2006 | Pubmed ID: 17085201 Bladder Overactivity and Hyperexcitability of Bladder Afferent Neurons After Intrathecal Delivery of Nerve Growth Factor in Rats The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2006 | Pubmed ID: 17050722 Expression of Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channels in Rat Dorsal Root Ganglion Neurons Innervating Urinary Bladder Brain Research. Nov, 2006 | Pubmed ID: 16979600 Simulation Analysis of Conduction Block in Myelinated Axons Induced by High-frequency Biphasic Rectangular Pulses IEEE Transactions on Bio-medical Engineering. Jul, 2006 | Pubmed ID: 16830949 Characterization of Hyperpolarization-activated Current (Ih) in Dorsal Root Ganglion Neurons Innervating Rat Urinary Bladder Brain Research. Jun, 2006 | Pubmed ID: 16765328 Roles of Peripheral and Central Nicotinic Receptors in the Micturition Reflex in Rats The Journal of Urology. Jul, 2006 | Pubmed ID: 16753446 Dopaminergic Mechanisms Controlling Urethral Function in Rats Neurourology and Urodynamics. 2006 | Pubmed ID: 16721842 Spinal Reflex Control of Micturition After Spinal Cord Injury Restorative Neurology and Neuroscience. 2006 | Pubmed ID: 16720943 Muscarinic Regulation of Neonatal Rat Bladder Spontaneous Contractions American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Oct, 2006 | Pubmed ID: 16709645 External Urethral Sphincter Activity in a Rat Model of Pudendal Nerve Injury Neurourology and Urodynamics. 2006 | Pubmed ID: 16637068 Suppression of Bladder Reflex Activity in Chronic Spinal Cord Injured Cats by Activation of Serotonin 5-HT1A Receptors Experimental Neurology. Jun, 2006 | Pubmed ID: 16488413 Roles of Glutamatergic and Serotonergic Mechanisms in Reflex Control of the External Urethral Sphincter in Urethane-anesthetized Female Rats American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2006 | Pubmed ID: 16469836 Maternal Separation Uncouples Reflex from Spontaneous Voiding in Rat Pups The Journal of Urology. Mar, 2006 | Pubmed ID: 16469642 Integrative Control of the Lower Urinary Tract: Preclinical Perspective British Journal of Pharmacology. Feb, 2006 | Pubmed ID: 16465182 Release of GABA from Sensory Neurons Transduced with a GAD67-expressing Vector Occurs by Non-vesicular Mechanisms Brain Research. Feb, 2006 | Pubmed ID: 16460707 Activation of Alpha1D Adrenergic Receptors in the Rat Urothelium Facilitates the Micturition Reflex The Journal of Urology. Jan, 2006 | Pubmed ID: 16406942 Biomechanical Characterization of the Urethral Musculature American Journal of Physiology. Renal Physiology. May, 2006 | Pubmed ID: 16368741 Expression of P2X and P2Y Receptors in the Intramural Parasympathetic Ganglia of the Cat Urinary Bladder American Journal of Physiology. Renal Physiology. May, 2006 | Pubmed ID: 16332929 Pudendal-to-bladder Reflex in Chronic Spinal-cord-injured Cats Experimental Neurology. Jan, 2006 | Pubmed ID: 16271266 Mechanisms Underlying the Recovery of Lower Urinary Tract Function Following Spinal Cord Injury Progress in Brain Research. 2006 | Pubmed ID: 16198694 Expression of Functional Nicotinic Acetylcholine Receptors in Rat Urinary Bladder Epithelial Cells American Journal of Physiology. Renal Physiology. Jan, 2006 | Pubmed ID: 16144967 Reflexes Evoked by Electrical Stimulation of Afferent Axons in the Pudendal Nerve Under Empty and Distended Bladder Conditions in Urethane-anesthetized Rats Journal of Neuroscience Methods. Jan, 2006 | Pubmed ID: 16039722 Detrusor Overactivity Induced by Intravesical Application of Adenosine 5'-triphosphate Under Different Delivery Conditions in Rats Urology. Dec, 2005 | Pubmed ID: 16360479 Simulation of Nerve Block by High-frequency Sinusoidal Electrical Current Based on the Hodgkin-Huxley Model IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society. Sep, 2005 | Pubmed ID: 16200764 Simulation Analysis of Conduction Block in Unmyelinated Axons Induced by High-frequency Biphasic Electrical Currents IEEE Transactions on Bio-medical Engineering. Jul, 2005 | Pubmed ID: 16041996 Response of External Urethral Sphincter to High Frequency Biphasic Electrical Stimulation of Pudendal Nerve The Journal of Urology. Aug, 2005 | Pubmed ID: 16006976 Differential Effects of Activation of Peripheral and Spinal Tachykinin Neurokinin(3) Receptors on the Micturition Reflex in Rats The Journal of Urology. Aug, 2005 | Pubmed ID: 16006975 Localization of P2X and P2Y Receptors in Dorsal Root Ganglia of the Cat The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Oct, 2005 | Pubmed ID: 15923368 Protein Kinase C Contributes to Abnormal Capsaicin Responses in DRG Neurons from Cats with Feline Interstitial Cystitis Neuroscience Letters. Jun 10-17, 2005 | Pubmed ID: 15882787 Abnormal Excitability in Capsaicin-responsive DRG Neurons from Cats with Feline Interstitial Cystitis Experimental Neurology. Jun, 2005 | Pubmed ID: 15869946 Improvement in Erectile Dysfunction After Neurotrophic Factor Gene Therapy in Diabetic Rats The Journal of Urology. May, 2005 | Pubmed ID: 15821595 Alpha1-Adrenergic Mechanism in Diabetic Urethral Dysfunction in Rats The Journal of Urology. Mar, 2005 | Pubmed ID: 15711370 Bladder Adelta Afferent Nerve Activity in Normal Cats and Cats with Feline Interstitial Cystitis The Journal of Urology. Mar, 2005 | Pubmed ID: 15711367 Elimination of Rat Spinal Neurons Expressing Neurokinin 1 Receptors Reduces Bladder Overactivity and Spinal C-fos Expression Induced by Bladder Irritation American Journal of Physiology. Renal Physiology. Mar, 2005 | Pubmed ID: 15692058 Expression and Function of Bradykinin B1 and B2 Receptors in Normal and Inflamed Rat Urinary Bladder Urothelium The Journal of Physiology. Feb, 2005 | Pubmed ID: 15576455 Effect of Neocuproine, a Copper(i) Chelator, on Rat Bladder Function The Journal of Pharmacology and Experimental Therapeutics. Mar, 2005 | Pubmed ID: 15501992 Biaxial Mechanical Properties of Muscle-derived Cell Seeded Small Intestinal Submucosa for Bladder Wall Reconstitution Biomaterials. Feb, 2005 | Pubmed ID: 15275818 The Urothelium in Overactive Bladder: Passive Bystander or Active Participant? Urology. Dec, 2004 | Pubmed ID: 15621221 Block of External Urethral Sphincter Contraction by High Frequency Electrical Stimulation of Pudendal Nerve The Journal of Urology. Nov, 2004 | Pubmed ID: 15540791 Bladder and Urethral Sphincter Responses Evoked by Microstimulation of S2 Sacral Spinal Cord in Spinal Cord Intact and Chronic Spinal Cord Injured Cats Experimental Neurology. Nov, 2004 | Pubmed ID: 15473990 Gene Therapy Using Replication-defective Herpes Simplex Virus Vectors Expressing Nerve Growth Factor in a Rat Model of Diabetic Cystopathy Diabetes. Oct, 2004 | Pubmed ID: 15448108 Differential Roles of Peripheral and Spinal Endothelin Receptors in the Micturition Reflex in Rats The Journal of Urology. Oct, 2004 | Pubmed ID: 15371886 Effects of Isolectin B4-conjugated Saporin, a Targeting Cytotoxin, on Bladder Overactivity Induced by Bladder Irritation The European Journal of Neuroscience. Jul, 2004 | Pubmed ID: 15233756 Sustained Intravesical Drug Delivery Using Thermosensitive Hydrogel Pharmaceutical Research. May, 2004 | Pubmed ID: 15180342 The Role of Capsaicin-sensitive Afferent Fibers in the Lower Urinary Tract Dysfunction Induced by Chronic Spinal Cord Injury in Rats Experimental Neurology. Jun, 2004 | Pubmed ID: 15144870 The Role of Bladder-to-urethral Reflexes in Urinary Continence Mechanisms in Rats American Journal of Physiology. Renal Physiology. Sep, 2004 | Pubmed ID: 15113743 Urethral Dysfunction in Diabetic Rats The Journal of Urology. May, 2004 | Pubmed ID: 15076321 Intraurethral Muscle-derived Cell Injections Increase Leak Point Pressure in a Rat Model of Intrinsic Sphincter Deficiency Urology. Apr, 2004 | Pubmed ID: 15072911 KW-7158 [(2S)-(+)-3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide] Enhances A-type K+ Currents in Neurons of the Dorsal Root Ganglion of the Adult Rat The Journal of Pharmacology and Experimental Therapeutics. Jul, 2004 | Pubmed ID: 15010502 A Model of Intrinsic Sphincteric Deficiency in the Rat: Electrocauterization Neurourology and Urodynamics. 2004 | Pubmed ID: 14983430 Effects of ZD6169, a K ATP Channel Opener, on Neurally-mediated Plasma Extravasation in the Rat Urinary Bladder Induced by Chemical or Electrical Stimulation of Nerves Brain Research. Jan, 2004 | Pubmed ID: 14670629 Urodynamic and Immunohistochemical Evaluation of Intravesical Capsaicin Delivery Using Thermosensitive Hydrogel and Liposomes The Journal of Urology. Jan, 2004 | Pubmed ID: 14665960 Suppression of Detrusor-sphincter Dyssynergia by Immunoneutralization of Nerve Growth Factor in Lumbosacral Spinal Cord in Spinal Cord Injured Rats The Journal of Urology. Jan, 2004 | Pubmed ID: 14665959 Development of an Experimental System for the Study of Urethral Biomechanical Function American Journal of Physiology. Renal Physiology. Feb, 2004 | Pubmed ID: 14506075 Multi-joint Movement of the Cat Hindlimb Evoked by Microstimulation of the Lumbosacral Spinal Cord Experimental Neurology. Oct, 2003 | Pubmed ID: 14552903 An Artificial Somatic-central Nervous System-autonomic Reflex Pathway for Controllable Micturition After Spinal Cord Injury: Preliminary Results in 15 Patients The Journal of Urology. Oct, 2003 | Pubmed ID: 14501733 Dopaminergic Mechanisms Underlying Bladder Hyperactivity in Rats with a Unilateral 6-hydroxydopamine (6-OHDA) Lesion of the Nigrostriatal Pathway British Journal of Pharmacology. Aug, 2003 | Pubmed ID: 12922929 Suppression of the Micturition Reflex in Urethane-anesthetized Rats by Intracerebroventricular Injection of WAY100635, a 5-HT(1A) Receptor Antagonist Brain Research. Aug, 2003 | Pubmed ID: 12867269 Effect of Stimulation Intensity and Botulinum Toxin Isoform on Rat Bladder Strip Contractions Brain Research Bulletin. Jul, 2003 | Pubmed ID: 12832003 Muscle-derived Stem Cells Seeded into Acellular Scaffolds Develop Calcium-dependent Contractile Activity That is Modulated by Nicotinic Receptors Urology. Jun, 2003 | Pubmed ID: 12809930 Histological and Electrical Properties of Rat Dorsal Root Ganglion Neurons Innervating the Lower Urinary Tract The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2003 | Pubmed ID: 12764124 Developmental Changes in Spontaneous Smooth Muscle Activity in the Neonatal Rat Urinary Bladder American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Oct, 2003 | Pubmed ID: 12750150 Urethral Closure Mechanisms Under Sneeze-induced Stress Condition in Rats: a New Animal Model for Evaluation of Stress Urinary Incontinence American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Aug, 2003 | Pubmed ID: 12750148 Effect of (+/-)-epibatidine, a Nicotinic Agonist, on the Central Pathways Controlling Voiding Function in the Rat American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2003 | Pubmed ID: 12689850 Effect of Botulinum Toxin A on the Autonomic Nervous System of the Rat Lower Urinary Tract The Journal of Urology. May, 2003 | Pubmed ID: 12686869 Protein Kinase C is Involved in Neurokinin Receptor Modulation of N- and L-type Ca2+ Channels in DRG Neurons of the Adult Rat Journal of Neurophysiology. Jul, 2003 | Pubmed ID: 12660348 Intravesical Protamine Sulfate and Potassium Chloride As a Model for Bladder Hyperactivity Urology. Mar, 2003 | Pubmed ID: 12639680 Intravesical Liposome Administration--a Novel Treatment for Hyperactive Bladder in the Rat Urology. Mar, 2003 | Pubmed ID: 12639679 Change in Muscarinic Modulation of Transmitter Release in the Rat Urinary Bladder After Spinal Cord Injury Neurochemistry International. Jul, 2003 | Pubmed ID: 12605884 Tetrodotoxin-resistant Sodium Channels Na(v)1.8/SNS and Na(v)1.9/NaN in Afferent Neurons Innervating Urinary Bladder in Control and Spinal Cord Injured Rats Brain Research. Feb, 2003 | Pubmed ID: 12560118 Identification of C-kit-positive Cells in the Mouse Ureter: the Interstitial Cells of Cajal of the Urinary Tract American Journal of Physiology. Renal Physiology. May, 2003 | Pubmed ID: 12540363 Excitatory Synaptic Currents in Lumbosacral Parasympathetic Preganglionic Neurons Evoked by Stimulation of the Dorsal Commissure Journal of Neurophysiology. Jan, 2003 | Pubmed ID: 12522187 Plasticity of Bladder Reflex Pathways During Postnatal Development Physiology & Behavior. Dec, 2002 | Pubmed ID: 12527020 Glat muskulatur i blæren Strip Kontraktilitet som en metode til at evaluere nedre urinveje Farmakologi F. Aura Kullmann1, Stephanie L. Daugherty2, William C. de Groat2, Lori A. Birder1,2 1Department of Medicine, Renal division, University of Pittsburgh School of Medicine, 2Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine JoVE 51807 Medicina
Glat muskulatur i blæren Strip Kontraktilitet som en metode til at evaluere nedre urinveje Farmakologi F. Aura Kullmann1, Stephanie L. Daugherty2, William C. de Groat2, Lori A. Birder1,2 1Department of Medicine, Renal division, University of Pittsburgh School of Medicine, 2Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine JoVE 51807 Medicina