Wolf Reik Epigenetics Programme The Babraham Institute Biography Publications Institution JoVE Articles Wolf Reik has not added a biography. If you are Wolf Reik and would like to personalize this page please email our Author Liaison for assistance. Publications FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency Cell Stem Cell. Jul, 2013 | Pubmed ID: 23850245 Regulation of Lineage Specific DNA Hypomethylation in Mouse Trophectoderm PloS One. 2013 | Pubmed ID: 23825703 Dnmt2-dependent Methylomes Lack Defined DNA Methylation Patterns Proceedings of the National Academy of Sciences of the United States of America. May, 2013 | Pubmed ID: 23641003 Reprogramming by Cell Fusion: Boosted by Tets Molecular Cell. Mar, 2013 | Pubmed ID: 23541036 Conceptual Links Between DNA Methylation Reprogramming in the Early Embryo and Primordial Germ Cells Current Opinion in Cell Biology. Jun, 2013 | Pubmed ID: 23510682 NANOG-abhängige Funktion Von TET1 Und TET2 Bei Festlegung Der Pluripotenz Nature. Feb, 2013 | Pubmed ID: 23395962 Reprogramming DNA Methylation in the Mammalian Life Cycle: Building and Breaking Epigenetic Barriers Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jan, 2013 | Pubmed ID: 23166394 Direct Sequencing of Small Genomes on the Pacific Biosciences RS Without Library Preparation BioTechniques. Dec, 2012 | Pubmed ID: 23227987 The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells Molecular Cell. Dec, 2012 | Pubmed ID: 23219530 Promoter DNA Methylation Couples Genome-defence Mechanisms to Epigenetic Reprogramming in the Mouse Germline Development (Cambridge, England). Oct, 2012 | Pubmed ID: 22949617 Incomplete Methylation Reprogramming in SCNT Embryos Nature Genetics. Sep, 2012 | Pubmed ID: 22932499 Genome-wide Distribution of 5-formylcytosine in Embryonic Stem Cells is Associated with Transcription and Depends on Thymine DNA Glycosylase Genome Biology. Aug, 2012 | Pubmed ID: 22902005 Pairing of Homologous Regions in the Mouse Genome is Associated with Transcription but Not Imprinting Status PloS One. 2012 | Pubmed ID: 22802932 The H19 LincRNA is a Developmental Reservoir of MiR-675 That Suppresses Growth and Igf1r Nature Cell Biology. Jul, 2012 | Pubmed ID: 22684254 Quantitative Sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at Single-base Resolution Science (New York, N.Y.). May, 2012 | Pubmed ID: 22539555 Shifting Behaviour: Epigenetic Reprogramming in Eusocial Insects Current Opinion in Cell Biology. Jun, 2012 | Pubmed ID: 22429916 Methylome Analysis Using MeDIP-seq with Low DNA Concentrations Nature Protocols. Apr, 2012 | Pubmed ID: 22402632 BLUEPRINT to Decode the Epigenetic Signature Written in Blood Nature Biotechnology. Mar, 2012 | Pubmed ID: 22398613 Uncovering the Role of 5-hydroxymethylcytosine in the Epigenome Nature Reviews. Genetics. Jan, 2012 | Pubmed ID: 22083101 DNA Demethylases: a New Epigenetic Frontier in Drug Discovery Drug Discovery Today. Aug, 2011 | Pubmed ID: 21601651 Dynamic Regulation of 5-hydroxymethylcytosine in Mouse ES Cells and During Differentiation Nature. May, 2011 | Pubmed ID: 21460836 5-Hydroxymethylcytosine in the Mammalian Zygote is Linked with Epigenetic Reprogramming Nature Communications. 2011 | Pubmed ID: 21407207 Increased Placental Glucose Transport Rates in Pregnant Mice Carrying Fetuses with Targeted Disruption of Their Placental-specific Igf2 Transcripts Are Not Associated with Raised Circulating Glucose Concentrations Experimental Diabetes Research. 2011 | Pubmed ID: 21331382 Developmental Adaptations to Increased Fetal Nutrient Demand in Mouse Genetic Models of Igf2-mediated Overgrowth FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2011 | Pubmed ID: 21282203 Epigenetic Reprogramming in Plant and Animal Development Science (New York, N.Y.). Oct, 2010 | Pubmed ID: 21030646 Retrotransposons and Germ Cells: Reproduction, Death, and Diversity F1000 Biology Reports. 2010 | Pubmed ID: 20948789 Evaluation of Epigenetic Marks in Human Embryos Derived from IVF and ICSI Human Reproduction (Oxford, England). Sep, 2010 | Pubmed ID: 20634187 Wolf Reik: Inheritance Beyond DNA. Interview by Nicole Lebrasseur The Journal of Cell Biology. Feb, 2010 | Pubmed ID: 20142419 Genome-wide Erasure of DNA Methylation in Mouse Primordial Germ Cells is Affected by AID Deficiency Nature. Feb, 2010 | Pubmed ID: 20098412 Raised Late Pregnancy Glucose Concentrations in Mice Carrying Pups with Targeted Disruption of H19delta13 Diabetes. Jan, 2010 | Pubmed ID: 19794064 Cohesin is Required for Higher-order Chromatin Conformation at the Imprinted IGF2-H19 Locus PLoS Genetics. Nov, 2009 | Pubmed ID: 19956766 Epigenetic Dynamics of Stem Cells and Cell Lineage Commitment: Digging Waddington's Canal Nature Reviews. Molecular Cell Biology. Aug, 2009 | Pubmed ID: 19603040 Germline Mutation in NLRP2 (NALP2) in a Familial Imprinting Disorder (Beckwith-Wiedemann Syndrome) PLoS Genetics. Mar, 2009 | Pubmed ID: 19300480 Evolution and Functions of Long Noncoding RNAs Cell. Feb, 2009 | Pubmed ID: 19239885 The Long Noncoding RNA Kcnq1ot1 Organises a Lineage-specific Nuclear Domain for Epigenetic Gene Silencing Development (Cambridge, England). Feb, 2009 | Pubmed ID: 19144718 DNA Demethylation by DNA Repair Trends in Genetics : TIG. Feb, 2009 | Pubmed ID: 19144439 Clinical and Molecular Genetic Features of Beckwith-Wiedemann Syndrome Associated with Assisted Reproductive Technologies Human Reproduction (Oxford, England). Mar, 2009 | Pubmed ID: 19073614 Epigenetic Restriction of Embryonic Cell Lineage Fate by Methylation of Elf5 Nature Cell Biology. Nov, 2008 | Pubmed ID: 18836439 Conservation of the H19 Noncoding RNA and H19-IGF2 Imprinting Mechanism in Therians Nature Genetics. Aug, 2008 | Pubmed ID: 18587395 Global Mapping of DNA Methylation in Mouse Promoters Reveals Epigenetic Reprogramming of Pluripotency Genes PLoS Genetics. Jun, 2008 | Pubmed ID: 18584034 Safeguarding Parental Identity: Dnmt1 Maintains Imprints During Epigenetic Reprogramming in Early Embryogenesis Genes & Development. Jun, 2008 | Pubmed ID: 18559472 Non-coding Transcripts in the H19 Imprinting Control Region Mediate Gene Silencing in Transgenic Drosophila EMBO Reports. Nov, 2007 | Pubmed ID: 17948025 Stability and Flexibility of Epigenetic Gene Regulation in Mammalian Development Nature. May, 2007 | Pubmed ID: 17522676 Structural Differences in Centromeric Heterochromatin Are Spatially Reconciled on Fertilisation in the Mouse Zygote Chromosoma. Aug, 2007 | Pubmed ID: 17447080 A Developmental Window of Opportunity for Imprinted Gene Silencing Mediated by DNA Methylation and the Kcnq1ot1 Noncoding RNA Mammalian Genome : Official Journal of the International Mammalian Genome Society. Jan, 2007 | Pubmed ID: 17245608 Epigenetic Dynamics of the Kcnq1 Imprinted Domain in the Early Embryo Development (Cambridge, England). Nov, 2006 | Pubmed ID: 17021040 Artificial Sperm and Epigenetic Reprogramming Nature Biotechnology. Sep, 2006 | Pubmed ID: 16964217 CTCF Binding at the H19 Imprinting Control Region Mediates Maternally Inherited Higher-order Chromatin Conformation to Restrict Enhancer Access to Igf2 Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16815976 Adaptation of Nutrient Supply to Fetal Demand in the Mouse Involves Interaction Between the Igf2 Gene and Placental Transporter Systems Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005 | Pubmed ID: 16365304 Developmental Biology: the X-inactivation Yo-yo Nature. Nov, 2005 | Pubmed ID: 16292295 Mice Deficient in APOBEC2 and APOBEC3 Molecular and Cellular Biology. Aug, 2005 | Pubmed ID: 16055735 Molecular Subtypes and Phenotypic Expression of Beckwith-Wiedemann Syndrome European Journal of Human Genetics : EJHG. Sep, 2005 | Pubmed ID: 15999116 Common Polymorphism in H19 Associated with Birthweight and Cord Blood IGF-II Levels in Humans BMC Genetics. 2005 | Pubmed ID: 15885138 Co-evolution of X-chromosome Inactivation and Imprinting in Mammals Nature Reviews. Genetics. May, 2005 | Pubmed ID: 15818385 Epigenetic Reprogramming in Mammals Human Molecular Genetics. Apr, 2005 | Pubmed ID: 15809273 Dynamic Chromatin Modifications Characterise the First Cell Cycle in Mouse Embryos Developmental Biology. Apr, 2005 | Pubmed ID: 15766761 The Two-domain Hypothesis in Beckwith-Wiedemann Syndrome: Autonomous Imprinting of the Telomeric Domain of the Distal Chromosome 7 Cluster Human Molecular Genetics. Feb, 2005 | Pubmed ID: 15640248 Resourceful Imprinting Nature. Nov, 2004 | Pubmed ID: 15525980 Imprinting on Distal Chromosome 7 in the Placenta Involves Repressive Histone Methylation Independent of DNA Methylation Nature Genetics. Dec, 2004 | Pubmed ID: 15516931 Activation-induced Cytidine Deaminase Deaminates 5-methylcytosine in DNA and is Expressed in Pluripotent Tissues: Implications for Epigenetic Reprogramming The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15448152 Active Genes Dynamically Colocalize to Shared Sites of Ongoing Transcription Nature Genetics. Oct, 2004 | Pubmed ID: 15361872 Interaction Between Differentially Methylated Regions Partitions the Imprinted Genes Igf2 and H19 into Parent-specific Chromatin Loops Nature Genetics. Aug, 2004 | Pubmed ID: 15273689 Tandem Repeat Hypothesis in Imprinting: Deletion of a Conserved Direct Repeat Element Upstream of H19 Has No Effect on Imprinting in the Igf2-H19 Region Molecular and Cellular Biology. Jul, 2004 | Pubmed ID: 15199123 An Association Between Variants in the IGF2 Gene and Beckwith-Wiedemann Syndrome: Interaction Between Genotype and Epigenotype Human Molecular Genetics. Jan, 2004 | Pubmed ID: 14645199 Genomic Imprinting Controls Matrix Attachment Regions in the Igf2 Gene Molecular and Cellular Biology. Dec, 2003 | Pubmed ID: 14645508 Paternal Imprints Can Be Established on the Maternal Igf2-H19 Locus Without Altering Replication Timing of DNA Human Molecular Genetics. Dec, 2003 | Pubmed ID: 14532328 Epigenetic Asymmetry in the Mammalian Zygote and Early Embryo: Relationship to Lineage Commitment? Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Aug, 2003 | Pubmed ID: 14511488 Asymmetric Regulation of Imprinting on the Maternal and Paternal Chromosomes at the Dlk1-Gtl2 Imprinted Cluster on Mouse Chromosome 12 Nature Genetics. Sep, 2003 | Pubmed ID: 12937418 Epigenetic Marking Correlates with Developmental Potential in Cloned Bovine Preimplantation Embryos Current Biology : CB. Jul, 2003 | Pubmed ID: 12842010 Gene Expression: Silent Clones Speak Up Nature. May, 2003 | Pubmed ID: 12761530 The Need for Eed Nature Genetics. Apr, 2003 | Pubmed ID: 12665859 Regulation of Supply and Demand for Maternal Nutrients in Mammals by Imprinted Genes The Journal of Physiology. Feb, 2003 | Pubmed ID: 12562908 Epigenetic Modifications in an Imprinting Cluster Are Controlled by a Hierarchy of DMRs Suggesting Long-range Chromatin Interactions Human Molecular Genetics. Feb, 2003 | Pubmed ID: 12554683 Resistance of IAPs to Methylation Reprogramming May Provide a Mechanism for Epigenetic Inheritance in the Mouse Genesis (New York, N.Y. : 2000). Feb, 2003 | Pubmed ID: 12533790 Epigenetic Reprogramming in Early Mammalian Development and Following Somatic Nuclear Transfer Seminars in Cell & Developmental Biology. Feb, 2003 | Pubmed ID: 12524012 Evidence That Paternal Expression of the Epsilon-sarcoglycan Gene Accounts for Reduced Penetrance in Myoclonus-dystonia American Journal of Human Genetics. Dec, 2002 | Pubmed ID: 12444570 Back to the Beginning Nature. Nov, 2002 | Pubmed ID: 12432368 Häufige RASSF1A Tumorsuppressorgen-Promotor-Methylierung in Wilms-Tumor-und Darmkrebs Oncogene. Oct, 2002 | Pubmed ID: 12370819 Epigenetic Reprogramming in Mouse Primordial Germ Cells Mechanisms of Development. Sep, 2002 | Pubmed ID: 12204247 Replication Timing Properties Within the Mouse Distal Chromosome 7 Imprinting Cluster Bioscience, Biotechnology, and Biochemistry. May, 2002 | Pubmed ID: 12092814 Placental-specific IGF-II is a Major Modulator of Placental and Fetal Growth Nature. Jun, 2002 | Pubmed ID: 12087403 Placental Overgrowth in Mice Lacking the Imprinted Gene Ipl Proceedings of the National Academy of Sciences of the United States of America. May, 2002 | Pubmed ID: 12032310 Disruption of Mesodermal Enhancers for Igf2 in the Minute Mutant Development (Cambridge, England). Apr, 2002 | Pubmed ID: 11923202 Dynamic Reprogramming of DNA Methylation in the Early Mouse Embryo Developmental Biology. Jan, 2002 | Pubmed ID: 11784103 Robust 3D DNA FISH Mit Direkt markierten Sonden Daniel J. Bolland1, Michelle R. King2, Wolf Reik2,3, Anne E. Corcoran1, Christel Krueger2 1Nuclear Dynamics Programme, The Babraham Institute, 2Epigenetics Programme, The Babraham Institute, 3Centre for Trophoblast Research, University of Cambridge JoVE 50587 Biologia
Robust 3D DNA FISH Mit Direkt markierten Sonden Daniel J. Bolland1, Michelle R. King2, Wolf Reik2,3, Anne E. Corcoran1, Christel Krueger2 1Nuclear Dynamics Programme, The Babraham Institute, 2Epigenetics Programme, The Babraham Institute, 3Centre for Trophoblast Research, University of Cambridge JoVE 50587 Biologia