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Inferior Vena Cava (IVC) Ligation for Venous Thrombosis Analysis in Mouse (Video) | JoVE

Inferior Vena Cava (IVC) Ligation for Venous Thrombosis Analysis in Mouse (Video) | JoVE

Optimized Venous Thrombosis Assay in a Mouse Cancer Model Using Vascular Clips

Article DOI: 10.3791/200639-v • 02:37 min • January 5th, 2024

January 5th, 2024 •

Saran Lotfollahzadeh¹, Xiaosheng Yang¹, David Jasen Wu Wong¹, Jingyan Han², Francesca Seta², Suvranu Ganguli³, Asha Jose¹, Katya Ravid^4,5, Vipul C. Chitalia^1,6,7,8

¹Renal Section, Department of Medicine, Chobanian and Avedisian School of Medicine, Boston University, ²Vascular Biology Section, Department of Medicine, Chobanian and Avedisian School of Medicine, Boston University, ³Division of Interventional Radiology, Department of Radiology, Chobanian and Avedisian School of Medicine, Boston University, ⁴Department of Medicine, Whitaker Cardiovascular Institute, Chobanian and Avedisian School of Medicine, Boston University, ⁵Department of Biochemistry and Cell Biology, Chobanian and Avedisian School of Medicine, Boston University, ⁶Veterans Affairs Boston Healthcare System, ⁷Institute of Medical Engineering and Sciences, Massachusetts Institute of Technology, ⁸Center of Cross-Organ Vascular Pathology, Department of Medicine, Chobanian and Avedisian School of Medicine, Boston University

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Keywords: Venous Thrombosis Mouse Model Cancer-associated Thrombosis Syngeneic Colon Cancer Xenograft Vascular Clips Inferior Vena Cava Surgical Technique Mechanistic Understanding Drug Discovery Cancer Survivors Deep Venous Thrombosis Surgical Refinements Endothelial Damage Thrombogenesis Reproducibility Translational Research

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