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A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
 

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Article DOI: 10.3791/3587-v • 09:59 min • January 31st, 2012
January 31st, 2012 •
1, 2, 1
1Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 2Department of Rheumatology, Tufts Medical Center

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A 3D system of culturing human articular chondrocytes in high levels of synovial fluid is described. Synovial fluid reflects the most natural microenvironment for articular cartilage, and can be easily obtained and stored. This system thus can be used for studying cartilage regeneration and for screening therapeutics for treating arthritis.

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3D System Culturing Human Articular Chondrocytes Synovial Fluid Cartilage Destruction Osteoarthritis Disability Cartilage Regeneration Chronic Pain Immobility Cartilage Tissue Engineering Scaffolds Balanced Medium Biochemically Mature Tissue In Vivo Transplantation Chondrocyte Growth Matrix Deposition Native Joint Cavity Synovial Fluid Avascular Articular Cartilage Growth Factors Cytokines Enzymes Chondrocyte Metabolism Hyaluronan Lubricin Artificial Media
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