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Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
 

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Article DOI: 10.3791/4206-v • 12:42 min • August 28th, 2012
August 28th, 2012 •
1, 2, 1
1Department of Preventive Medicine, University of Southern California, 2Institute for Women's Health, University College London

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We describe methodologies for establishing in vitro heterotypic three-dimensional models comprising ovarian fibroblasts and normal ovarian surface or ovarian cancer epithelial cells. We discuss the use of these models to study stromal-epithelial interactions that occur during ovarian cancer development.

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Heterotypic Three-dimensional In Vitro Modeling Stromal-epithelial Interactions Ovarian Cancer Initiation Ovarian Cancer Progression Epithelial Ovarian Cancers Gynecological Malignancy Surgical Treatments Platinum-based Chemotherapies EOC Survival Rates Stage I Tumors Stage III/IV Disease Mortality Rates Molecular Genetic Basis Biological Basis Early Stage Disease Development Microenvironment Role Risk Factors For EOCs Normal Ovary Co-culture Ovarian Surface Epithelial Cells Stromal Fibroblast Cells
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