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Journal / Medicine / An Orthotopic Murine Model of Human Prostate…
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JoVE Journal Medicine
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
 

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Article DOI: 10.3791/50873-v • 06:49 min • September 18th, 2013
September 18th, 2013 •
1, 1, 1,2,3
1Department of Medicine, Northwestern University, 2Robert H. Lurie Cancer Center, Northwestern University, 3Center for Molecular Innovation and Drug Discovery, Northwestern University

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This orthotopic model of human prostate cancer allows for quantification of tumor size, circulating tumor cells, and formation of distinct metastasis to the lung. As cells must escape the primary organ, enter the blood stream, and implant into a secondary site, this model effectively recapitulates the scenario in humans.

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Orthotopic Implantation Model Human Prostate Cancer Metastasis Primary Tumor Pre-clinical Modeling Balb/c Athymic Mice Progression Measurement Circulating Tumor Cells Bone Marrow Lung Metastasis Invasion Escape Circulatory System Secondary Site Protein Expression Changes Small Molecule Therapeutics
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