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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
 

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Article DOI: 10.3791/51740-v • 07:20 min • May 28th, 2014
May 28th, 2014 •
1, 2, 3, 4, 1
1Faculty of Pharmacy, The University of Sydney, 2School of Science and Health, University of Western Sydney, 3Division of Chemistry and Environmental Science, School of Science and the Environment, Manchester Metropolitan University, 4Nature Publishing Group

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This protocol describes the use of amide coupling reactions of isonicotinic acid and diaminoalkanes to form bridging ligands suitable for use in the synthesis of multinuclear platinum complexes, which combine aspects of the anticancer drugs BBR3464 and picoplatin.

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Keywords: Amide Coupling Bispyridine Ligands Platinum Anticancer Agents Dinuclear Complexes 1H NMR Isonicotinic Acid Diaminoalkane Triethylamine 1-propylphosphonic Anhydride Transplatin Multinuclear Complexes Hydrogen Bonding
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