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Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
 

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

Article DOI: 10.3791/51807-v • 10:26 min • August 18th, 2014
August 18th, 2014 •
1, 2, 2, 1,2
1Department of Medicine, Renal division, University of Pittsburgh School of Medicine, 2Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine

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This manuscript presents a simple, yet powerful, in vitro method for evaluating smooth muscle contractility in response to pharmacological agents or nerve stimulation. Main applications are drug screening and understanding tissue physiology, pharmacology, and pathology.

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Bladder Smooth Muscle In Vitro Contractility Lower Urinary Tract Pharmacology Bladder Function Muscle Strip Isometric Tension Transducer Krebs Solution Electric Field Stimulation Neurotransmission Spinal Cord Injury Intracellular Pathways Drug Development
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