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Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
 

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Article DOI: 10.3791/52236-v • 10:37 min • January 16th, 2015
January 16th, 2015 •
1, 1, 2, 3, 1,4
1Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital - Harvard Medical School, 2Department of Respiratory Medicine, University of Cambridge - Addenbrooke's Hospital, 3Lung Transplant Program, Brigham and Women's Hospital - Harvard Medical School, 4COPD and IPF Programs, Lovelace Respiratory Research Institute

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The goal of this protocol is to provide automated methods to quantify chronic lung pathologies in a murine model of COPD. The protocol includes exposing mice to cigarette smoke (CS), measuring pulmonary function, inflating the lungs, and using morphometry methods to measure emphysema and small airway remodeling in mice.

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Automated Measurement Pulmonary Emphysema Small Airway Remodeling Cigarette Smoke-exposed Mice COPD Animal Models Disease Process Novel Therapies Cigarette Smoke Exposure Gene-targeted Mice Emphysema Development Airflow Obstruction Small Airway Fibrosis Smoke-exposed Animals Protocol Whole-body Exposure Technique
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