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An Ex vivo Model to Study Hormone Action in the Human Breast
 

An Ex vivo Model to Study Hormone Action in the Human Breast

Article DOI: 10.3791/52436-v • 12:31 min • January 8th, 2015
January 8th, 2015 •
1, 1, 1
1Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole polytechnique fédérale de Lausanne

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We have developed a novel ex vivo model to study hormone action in the human breast. It is based on tissue microstructures isolated from surgical breast tissue specimens which preserve tissue architecture, intercellular interactions, and paracrine signaling.

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Keywords: Ex Vivo Model Human Breast Hormone Action Mammary Epithelial Cells Hormone Receptor Breast Cancer Tissue Fragments Ducts Lobules Stromal Cells RNA Extraction Protein Extraction Histological Analysis FACS
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