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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
 

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Article DOI: 10.3791/53070-v • 09:41 min • July 15th, 2015
July 15th, 2015 •
1, 1, 1, 1, 1
1Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute

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We describe a high-throughput drug sensitivity assay for primary multiple myeloma cells. It consists of a reconstruction of the bone marrow microenvironment (including extracellular matrix and stroma) in multi-well plates, and a non-invasive method for longitudinal quantification of cell viability.

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Organotypic High Throughput System Drug Sensitivity Primary Multiple Myeloma Cells Ex Vivo Assays Digital Image Analysis Chemosensitivity Heterogeneity Microfluidic Chambers Bone Marrow Aspirates Extracellular Matrix Stroma Mesenchymal Stem Cells Endothelial Cells Drug Concentration Exposure Time Viability Curves Computational Model Tumor Population Sub-populations Therapeutic Regimens Clinical Response
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