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A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans
 

A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans

Article DOI: 10.3791/53083-v • 11:43 min • October 16th, 2015
October 16th, 2015 •
1, 1, 1
1Institute of Medical Sciences, University of Aberdeen

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A protocol is described for in vivo detection of effects of mitochondrial inhibitors in the model organism Caenorhabditis elegans and for identification of potential enhancing compounds. This protocol can be used to screen drug libraries for compounds modulating mitochondrial function.

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Keywords: Caenorhabditis Elegans Bioluminescent Luciferase ATP Levels Mitochondrial Modulators In Vivo Assay Screening Paraquat Rotenone Oxaloacetate Firefly Luciferase Inhibitors Oxidative Phosphorylation Drug Toxicity Multicellular Organism
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