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JoVE Journal Bioengineering
Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
 

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Article DOI: 10.3791/54202-v • 12:27 min • August 22nd, 2016
August 22nd, 2016 •
1, 2, 1, 1, 1, 1, 3,4, 5, 1,4
1Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 2Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway, 3Department of Bioengineering, Faculty of Engineering, National University of Singapore, 4Tissue Engineering Program, National University of Singapore, 5Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, University of California, Los Angeles

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Resumo
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Self-assembled polyelectrolyte complexes (PEC) fabricated from heparin and protamine were deposited on alginate beads to entrap and regulate the release of osteogenic growth factors. This delivery strategy enables a 20-fold reduction of BMP-2 dose in spinal fusion applications. This article illustrates the benefits and fabrication of PECs.

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Keywords: Polyelectrolyte Complex Heparin Binding Domain Osteogenic Growth Factor Delivery Alginate Microbead Cross-linking Strontium Chloride Tissue Engineering Growth Factor Entrapment Growth Factor Release
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