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Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
 

Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Article DOI: 10.3791/54334-v • 11:22 min • August 17th, 2016
August 17th, 2016 •
1, 1, 2, 1
1Clinic of Nuclear Medicine, University Hospital Jena, 2Friedrich Schiller University

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A procedure for the isolation of EOB-DTPA and subsequent complexation with natural Ga(III) and 68Ga is presented herein, as well as a thorough analysis of all compounds and investigations on labeling efficiency, in vitro stability and the n-octanol/water distribution coefficient of the radiolabeled complex.

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Keywords: Ga(III) Complex EOB-DTPA 68Ga Radiolabeling Gallium-68 Tracer Chemistry Labeling Conditions Tracer Stability Lipophilicity Gadoxetic Acid Oxalic Acid Hydrochloric Acid Sodium Hydroxide Gallium Trichloride Ammonia Ammonium Chloride PSH Plus Cartridge Silica Column Generator
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