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Immunology and Infection

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JoVE Journal Immunology and Infection
Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
 

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

Article DOI: 10.3791/55235-v • 09:07 min • January 20th, 2017
January 20th, 2017 •
1,2, 1, 3, 4, 1, 2,5, 1,2
1Department of Molecular and Biomedical Sciences, University of Maine, 2Graduate School of Biomedical Sciences and Engineering, University of Maine, 3School of Biology and Ecology, University of Maine, 4Division of Intramural Research, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, 5Department of Chemical and Biological Engineering, University of Maine

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Resumo
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Systemic and localized zebrafish infection models for human influenza A virus are demonstrated. Using a systemic infection model, zebrafish can be used to screen antiviral drugs. Using a localized infection model, zebrafish can be used to characterize host immune cell responses.

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Keywords: Zebrafish Influenza Virus Antiviral Immune Response Phagocytes Inflammation High-throughput APR-8 X31 NS1-GFP Microinjection Duct Of Cuvier Posterior Cardinal Vein Circulatory System Systemic Infection
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