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Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure
 

Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure

Article DOI: 10.3791/55386-v • 08:40 min • March 21st, 2017
March 21st, 2017 •
1,2, 1,2, 1,2,3, 1,2
1Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, 2Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 3UCL Institute of Neurology, Queen Square

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A reference measurement procedure for the absolute quantification of Aβ1-42 in human CSF based on solid-phase extraction and liquid chromatography tandem mass spectrometry is described.

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Keywords: Absolute Quantification A-beta 1-42 CSF Mass Spectrometric Reference Measurement Procedure Alzheimer's Disease Biomarker Amyloid Pathology Transgenic Mice Non-human Primates Hydrophobic Calibrator Solutions Internal Standard Response Factor Sample
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