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JoVE Journal Neuroscience
Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
 

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Article DOI: 10.3791/55931-v • 10:13 min • July 31st, 2017
July 31st, 2017 •
*1, *1, 1, 1, 1, 1, 1
1Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Department of Pharmacology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University
* These authors contributed equally

Capítulos

Resumo
Automatic Translation

Acidic postconditioning protects against cerebral ischemia. Here we present two models to execute APC. They are achieved respectively by transferring corticostriatal slices to acidic buffer after oxygen-glucose deprivation in vitro and by inhaling 20% CO2 after middle cerebral artery occlusion in vivo.

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Keywords: Neuroprotection Acidic Postconditioning Cerebral Ischemia Cortico Striatal Slice Model Middle Cerebral Artery Occlusion Model Ischemic Brain Injury Stroke Therapy Acidosis Postconditioning Brain Slice Preparation Glucose-free ACSF Acidic ACSF Synaptic Function Recovery
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